Modulador de Interacção Proteína-Proteína
Os moduladores de interações proteína-proteína são compostos que influenciam a interação entre proteínas, seja aumentando ou interrompendo sua ligação. Esses moduladores são ferramentas valiosas para estudar redes de proteínas, entender mecanismos de doenças e desenvolver novas estratégias terapêuticas. As interações proteína-proteína são fundamentais para muitos processos biológicos, incluindo transdução de sinal, resposta imunológica e regulação celular. Na CymitQuimica, oferecemos uma ampla gama de moduladores de interações proteína-proteína de alta qualidade para apoiar sua pesquisa em bioquímica, biologia molecular e descoberta de medicamentos.
Foram encontrados 63 produtos de "Modulador de Interacção Proteína-Proteína"
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RCM 1
CAS:Inhibitor of the Forkhead box M1 (FOXM1), an oncogene and a transcription factor regulating cell cycle progression, DNA damage repair and cell renewal. RCM 1 weakens the FOXM1 activity by inhibiting its nuclear localisation and increasing its degradation in proteasomes. The compound showed potential for asthma treatment since it inhibited goblet cell metaplasia and IL-13 signalling in mice.Fórmula:C20H12N2OS4Pureza:Min. 95%Cor e Forma:SolidPeso molecular:424.59 g/molRVX 208
CAS:Inhibitor of BET bromodomainFórmula:C20H22N2O5Pureza:Min. 95%Cor e Forma:PowderPeso molecular:370.4 g/molSR 18292
CAS:Inhibitor of transcriptional coactivator PGC-1a; anti-diabetic agentFórmula:C23H30N2O2Pureza:Min. 95%Cor e Forma:PowderPeso molecular:366.5 g/molMCC 950 sodium
CAS:Inhibitor of NLRP3 inflammasome and suppressor of the inflammatory cytokine IL-1β secretion. The compound was tested in diabetic mice and was shown to decrease the incidence of cardiac arrythmias, which are common secondary complications in diabetes mellitus. MCC 950 has potential to reverse diabetes-induced pathologies in cardiac electrophysiology.Fórmula:C20H23N2O5S·NaPureza:Min. 98 Area-%Cor e Forma:White PowderPeso molecular:426.46 g/molNAcM-OPT
CAS:Inhibits N-Acetyl-mediated interaction between BE2M (E2 conjugating enzyme) and DCN1 (a component of E3 ligase complex). Also has inhibitory action on DCN2 and NEDD8 ubiquitin-like protein. Reduces anchorage-independent growth in DCN1-amplified cell line.Fórmula:C23H29Cl2N3OPureza:Min. 95%Cor e Forma:solid.Peso molecular:434.4 g/mol(2R-)Arimoclomol
CAS:A co-inducer of HSP that acts through heat shock factor 1 (HSF1) in cells undergoing cellular stress. Has therapeutic potential in motor neuron degenerative diseases. Potential treatment for liposomal storage disorders, such as Niemann-Pick disease type C.Fórmula:C14H20ClN3O3Pureza:Min. 95%Cor e Forma:White PowderPeso molecular:313.78 g/molCBR 470-1
CAS:Activates NRF2 signallingFórmula:C14H20ClNO4S2Pureza:Min. 95%Cor e Forma:PowderPeso molecular:365.9 g/molBardoxolone methyl
CAS:Activater of the Nrf2 pathway and an inhibitor of the NF-κB pathway. Possible applications have extended to anti-viral treatment of COVID-19.Fórmula:C32H43NO4Pureza:Min. 95%Cor e Forma:White PowderPeso molecular:505.69 g/molNL 1
CAS:Inhibits the mitochondrial outer mebrane protein mitoNEET, anti-leukaemicFórmula:C18H25NO3SPureza:Min. 95%Cor e Forma:SolidPeso molecular:335.46 g/molCCG 63808
CAS:Reversible inhibitor of RGS proteins
Fórmula:C25H15FN4O2SPureza:Min. 95%Peso molecular:454.08998LF3
CAS:A potent inhibitor of Wnt/β-catenin signalling pathway that interferes with β-catenin/TFC4 interaction. Reduces growth and motility of colon cancer cells. Inhibits self-renewal, whilst inducing differentiation in cancer stem cells.
Fórmula:C20H24N4O2S2Pureza:Min. 95%Cor e Forma:PowderPeso molecular:416.56 g/molDocetaxel - Bio-X ™
CAS:Docetaxel is an antineoplastic agent that is used to treat various cancers such as breast and prostate cancer. This drug interferes with the normal function of microtubule growth. It is an anti-mitotic drug used in chemotherapy. Research has shown that this drug also induces programmed cell death in cancer cells.Fórmula:C43H53NO14Pureza:Min. 90 Area-%Cor e Forma:White/Off-White SolidPeso molecular:807.88 g/molVinorelbine
CAS:Produto ControladoMicrotubule disrupter; anti-mitotic drug; anti-cancer alkaloid
Fórmula:C45H54N4O8Pureza:Min. 95%Cor e Forma:SolidPeso molecular:778.93 g/molPaquinimod
CAS:A calcium-binding protein S100A9 inhibitor with immunomodulatory activity that reduces pathology in experimental collagenase-induced osteoarthritis.Fórmula:C21H22N2O3Pureza:Min. 98 Area-%Cor e Forma:White Off-White PowderPeso molecular:350.41 g/molH 151
CAS:A potent inhibitor of STING protein (stimulator of interferon genes), a protein that partakes in intracellular DNA sensing pathway. H 151 blocks palmitoylation of STING, which is required for the formation of multimeric complexes for recruiting downstream signalling molecules. Inhibition of STING by H 151 reduces pro-inflammatory cytokine synthesis.Fórmula:C17H17N3OPureza:Min. 95%Cor e Forma:SolidPeso molecular:279.34 g/molGNE 371
CAS:A chemical probe for the dual bromodomains of human transcription-initiation-factor TFIID subunit 1 (TAF1). GNE 371 binds TAF1 with an IC50 of 10 nM and is selective over other bromodomain family members. Exerts anti-proliferative effects in synergy with BET inhibitor JQ1.
Fórmula:C24H25N5O3Pureza:(Hplc-Ms) Min. 98 Area-%Peso molecular:431.49 g/molES9-17
CAS:Inhibitor of clathrin-mediated endocytosis (CME) and ligand to the clathrin heavy chain (CHC). ES9-17 is an inhibitor of the CHC function with EC50 of 13 μM in plant model Arabidopsis thaliana. ES9-17 is a non-protonophoric CME inhibitor and it does not alter the cytoplasmic pH levels substantially. In a mammalian cell line HeLa, ES9-17 reduced the uptake of transferrin, which is a CME-driven process.
Fórmula:C10H8BrNO2S2Pureza:Min. 95%Cor e Forma:Off-White PowderPeso molecular:318.21 g/molCytochalasin D
CAS:Inhibits actin polymerizationFórmula:C30H37NO6Pureza:Min. 95%Cor e Forma:PowderPeso molecular:507.62 g/molEED 226 monohydrate
CAS:Potent and selective inhibitor of polycomb repressive complex 2 (PRC2), by binding to the K27me3-pocket of the regulatory EED subunit. Inhibits H3K27 methylation in histone 3. Has anti-tumor activity in murine xenograft models. Synergistic with EZH2 inhibitor against cancer cell growth.
Fórmula:C17H15N5O3S·H2OPureza:Min. 95%Cor e Forma:White To Yellow SolidPeso molecular:387.41 g/molSirt-IN-1
CAS:Inhibitor of pan-sirtuins (IC50 = 15, 10, 33 µM for SIRT1, 2 and 3 respectively), by binding to the active catalytic site. Selectivity for sirtuins was demonstrated when tested for activity on a panel of kinases, nuclear receptors, ion channels, transporters and GPCRs.Fórmula:C19H27N5O2SPureza:Min. 95%Peso molecular:389.52 g/mol
