Bloqueadores Alfa
Os bloqueadores alfa são compostos farmacêuticos que atuam inibindo a atividade dos receptores alfa-adrenérgicos, responsáveis pela contração dos músculos lisos. Esses medicamentos são comumente usados para tratar condições como pressão alta e hiperplasia prostática benigna, causando o relaxamento e a dilatação dos vasos sanguíneos. Na CymitQuimica, oferecemos uma gama de bloqueadores alfa adequados para pesquisas em farmacologia e saúde cardiovascular.
Foram encontrados 658 produtos de "Bloqueadores Alfa"
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N-Nitroso Terazosin EP Impurity L (N-Nitroso Prazosin EP Impurity D)
Fórmula:C9H11N3O3Peso molecular:209.21Trazodone
CAS:<p>Trazodone (AF-1161), a 5-HT 2A/2C receptor antagonist, is used as an antidepressant for treating major anxiety disorders and depressive disorder.</p>Fórmula:C19H22ClN5OPureza:99.79% - 99.92%Cor e Forma:White To Off-White Crystalline PowderPeso molecular:371.86Yohimbine hydrochloride
CAS:<p>Yohimbine hydrochloride (Antagonil) is a plant alkaloid with α-2-adrenergic blocking activity, used as a mydriatic and in the treatment of erectile dysfunction</p>Fórmula:C21H27ClN2O3Pureza:99.86% - >99.99%Cor e Forma:Very Slightly Yellow NeedlesPeso molecular:390.90Phentolamine
CAS:<p>Phentolamine mesylate is an alpha-1 and alpha-2 selective adrenergic receptor antagonist</p>Fórmula:C17H19N3OPureza:99.86% - 99.94%Cor e Forma:Crystals SolidPeso molecular:281.35N-Nitroso Mirtazapine EP Impurity D-d4 (N-Nitroso Mirtazapine USP Related Compound A-d4, N-Nitroso-N-Desmethyl Mirtazapine-d4)
Fórmula:C16H12D4N4OPeso molecular:284.361-Methyl-3-phenylpiperazine
CAS:Produto Controlado<p>Applications Piperazine derivative used as reference materials for forensic laboratories. They affect the central and the autonomic nervous systems, the blood pressure, and smooth muscle.<br>References Brady, J., et al.: Drug Dev. Res., 20, 231 (1990), Winter, J., et al.: J. Pharmacol. Exp. Ther., 262, 682 (1992), Ator, N., et al.: Eur. J. Pharmacol., 241, 237 (1993), Forster, E., et al.: Eur. J. Pharmacol., 281, 81 (1995),<br></p>Fórmula:C11H16N2Cor e Forma:Off WhitePeso molecular:176.262-Phenylphenol
CAS:<p>Applications 2-Phenylphenol is an agricultural fungicide and is no longer used as a food additive (1). It has been associated with the incidence of bladder cancer in male rats which may be related to its primary metabolite, phenylhydroquinone (2). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA). Environmental contaminants; Food contaminants.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. Gouin T. et al.: Environ Pollut. 2012 Jun;165:208-14. 2. Balakrishnan, S. et al.: Environ Mol Mutagen. 2016 Apr;57(3):210-9<br></p>Fórmula:C12H10OCor e Forma:Light PinkPeso molecular:170.212-(4-Methyl-2-phenyl-1-piperazinyl)-3-pyridinemethanol
CAS:Produto Controlado<p>Applications 2-(4-Methyl-2-phenyl-1-piperazinyl)-3-pyridinemethanol is an impurity found in Mirtazapine (M365000). Mirtazapine Impurity B.<br></p>Fórmula:C17H21N3OCor e Forma:White To Off-WhitePeso molecular:283.37(R)-(+)-5’-Hydroxyphenyl Carvedilol
CAS:<p>Applications An optically active metabolite of Carvedilol (C184625), a nonselective ß-adrenergic blocker with α1-blocking activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sponer, G., et al.: J. Cardiovasc. Pharmacol., 9, 317 (1987), Fujimaki, M., ET AL.: Xenobiotica, 20, 1025 (1990), Ruffolo, R., et al.: Eur. J. Clin. Pharmacol., 38, S82 (1990), Schaefer, W.H., et al.: Drug Metab. Dispos., 26, 10, 958 (1998),<br></p>Fórmula:C24H26N2O5Cor e Forma:NeatPeso molecular:422.47(R)-Tamsulosin Hydrochloride
CAS:<p>Applications (R)-Tamsulosin is a specific α1-adrenoceptor antagonist. It is used in the treatment of benign prostatic hypertrophy.<br>References Kawabe, K., et al.: J. Urol., 144, 908 (1990), Abrams, P., et al.: Br. J. Urol., 76, 325 (1995), Michel, M.C., Expert Opin. Pharmacother., 5, 151 (2004),<br></p>Fórmula:C20H28N2O5S·ClHCor e Forma:White To Off-WhitePeso molecular:444.97N-(4-Amino-6,7-dimethoxyquinazol-2-yl)-N-methylpropylenediamine Formamide Hydrochloride
CAS:Produto Controlado<p>Impurity Alfuzosin Hydrochloride EP Impurity E<br>Applications Alfuzosin (A532000) impurity. Alfuzosin (A532000) is an α1-Adrenoceptor antagonist structurally similar to Prozosin. Antihypertensive. Used in treatment of benign prostatic hypertrophy. (Alfuzosin Hydrochloride EP Impurity E )<br>References Ramage, A.G., et al.: Eur. J. Pharmacol., 129, 307 (1986), Deering, A.H.,: Brit. J. Clin. Pharmacol., 25, 417 (1988), Priolo, L.D., et al.: Eur. J. Clin. Pharmacol., 35, 25 (1988),<br></p>Fórmula:C15H21N5O3·HClCor e Forma:White To Off-WhitePeso molecular:319.37 + (36.46)rac Tamsulosin Hydrochloride
CAS:Produto Controlado<p>Applications Tamsulosin is a specific α1-adrenoceptor antagonist. Used in the treatment of benign prostatic hypertrophy.<br>References Kawabe, K., et al.: J. Urol., 144, 908 (1990), Abrams, P., et al.: Br. J. Urol., 76, 325 (1995), Michel, M.C., Expert Opin. Pharmacother., 5, 151 (2004),<br></p>Fórmula:C20H28N2O5S·ClHCor e Forma:NeatPeso molecular:444.9733-(9H-Carbazol-4-yloxy)-1,2-propanediol
CAS:Produto Controlado<p>Applications 3-(9H-Carbazol-4-yloxy)-1,2-propanediol is used in the synthesis of carvedilol, a β-adrenergic blocking agent.<br>References Naidu, K. et al.: Org. Chem. An Indian J., 6, 171 (2010);<br></p>Fórmula:C15H15NO3Cor e Forma:NeatPeso molecular:257.28Mirtazapine N-Glucuronide (Mixture of Diastereomers) Contains Unknown Inorganics >80%
CAS:Produto Controlado<p>Applications Mirtazapine N-Glucuronide is a metabolite of Mirtazapine (M365000), an α2-Adrenergic blocker; analogue of Mianserin. Antidepressant.<br>References Smith, D.A., RSC Drug Discovery Series, 1, 193 (2010); De Boer, T., et al.: Neuropharmacology, 27, 399 (1988); Smith, W.T., et al.: Psychopharmacol. Bull., 26, 191 (1990)<br></p>Fórmula:C23H28N3O6Pureza:>80%Cor e Forma:NeatPeso molecular:442.48S-Mirtazapine
CAS:Produto Controlado<p>Applications S-Mirtazapine is an enantiomer of Mirtazapine (M365000); an antidepressant. R-Mirtazapine showed antinociceptive effects in acute thermal nociception, whereas S-Mirtazapine showed pronociceptive effects.<br>References Muth-Selbach, Uta., et al.: Brain Res. Bull., 79(1), 63-68 (2009); Smith, Donald F., et al.: Psychopharmacology, 200(2), 273-279 (2008); Freynhagen, Rainer., et al.: Brain Res. Bull., 69(2), 168-173 (2006)<br></p>Fórmula:C17H19N3Cor e Forma:NeatPeso molecular:265.356,7,8,9-Tetrahydro Carvedilol
CAS:Produto Controlado<p>Applications Carvedilol (C184625) derivative.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>Fórmula:C24H30N2O4Cor e Forma:NeatPeso molecular:410.51Carvedilol
CAS:Produto Controlado<p>Applications Carvedilol is a nonselective β-adrenergic blocker with α1-blocking activity. Carvedilol is an antihypertensive used in the treatment of congestive heart failure.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hirohashi, M., et al.: Arzneim.-Forsch., 40, 735 (1990); Packer, M., et al.: N. Engl. J. Med., 334, 1349 (1996);<br></p>Fórmula:C24H26N2O4Cor e Forma:WhitePeso molecular:406.47(R)-(+)-Carvedilol
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications The optically active isomer of Carvedilol (C184625), a nonselective ß-adrenergic blocker with a1-blocking activity. An antihypertensive used in the treatment of congestive heart failure.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hirohashi, M., et al.: Arzneim.-Forsch., 40, 735 (1990),<br></p>Fórmula:C24H26N2O4Cor e Forma:Off White SolidPeso molecular:406.47Tamsulosin
CAS:<p>Tamsulosin: an alpha1A blocker for easing urination in BPH by relaxing prostate and bladder muscles.</p>Fórmula:C20H28N2O5SPureza:99.93%Cor e Forma:White CrystalsPeso molecular:408.514-(2,3-Epoxypropoxy)carbazole
CAS:Produto Controlado<p>Impurity Carvedilol EP Impurity D; Carvedilol USP-D<br>Applications 4-(2,3-Epoxypropoxy)carbazole (Carvedilol EP Impurity D; Carvedilol USP-D) is an intermediate in the synthesis of Carvedilol (C184625).<br></p>Fórmula:C15H13NO2Cor e Forma:Beige SolidPeso molecular:239.272-(2-Ethoxyphenoxy)ethanamine
CAS:Produto Controlado<p>Impurity Tamsulosin EP Impurity F<br>Applications 2-(2-Ethoxyphenoxy)ethanamine (Tamsulosin EP Impurity F) is an impurity of Tamsulosin (T006350), a specific α1-adrenoceptor antagonist (1,2). It is used in the treatment of benign prostatic hypertrophy.<br>References 1. Kawabe, K. et al.: J. Urol. 1990 Oct;144(4):908-11;2. Abrams, P. et al.: Br. J. Urol. 1995 Sep;76(3):325-36.<br></p>Fórmula:C10H15NO2Cor e Forma:NeatPeso molecular:181.238-Hydroxy Mirtazapine β-D-Glucuronide 90%
CAS:<p>Applications A metabolite of Mirtazapine (M365000). This compounds contains some of the alpha anomer.<br>References Sandker, G., et al.: Xenobiotica, 24, 143 (1994), Dahl, M., et al.: Clin. Drug Invest., 13, 37 (1997),<br></p>Fórmula:C23H27N3O7Pureza:90%Cor e Forma:NeatPeso molecular:457.485-Formyl-2-methoxy-benzenesulfonamide
CAS:Produto Controlado<p>Impurity Tamsulosin EP Impurity E<br>Applications 5-Formyl-2-methoxy-benzenesulfonamide (Tamsulosin EP Impurity E) is an impurity of Tamsulosin (T006350), a specific α1-adrenoceptor antagonist used in the treatment of benign prostatic hypertrophy.<br>References Kawabe, K., et al.: J. Urol., 144, 908 (1990), Abrams, P., et al.: Br. J. Urol., 76, 325 (1995), Michel, M.C., Expert Opin. Pharmacother., 5, 151 (2004),<br></p>Fórmula:C8H9NO4SCor e Forma:NeatPeso molecular:215.231-(3-Carboxy-2-pyridyl)-4-methyl-2-phenylpiperazine
CAS:Produto Controlado<p>Applications Mirtazapine (M365000) impurity.<br>References Reddy, T. et al.; J. Liq. Chromatogr. R. T. 31, 1204 (2008)<br></p>Fórmula:C17H19N3O2Cor e Forma:NeatPeso molecular:297.353-Hydroxy Carvedilol
CAS:Produto Controlado<p>Applications A vascularly inactive metabolite of Carvedilol (C184625). A novel antihypertensive agent, is a potent antioxidant.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sponer, G., et al.: J. Cardiovasc. Pharmacol., 9, 317 (1987), Rapola, J., et al.: Lancet, 349, 1715 (1997), Gao, F., et al.: Eur. J. Pharmacol., 406, 109 (2000),<br></p>Fórmula:C24H26N2O5Cor e Forma:NeatPeso molecular:422.472-(2-Methoxyphenoxy)ethylamine Hydrochloride
CAS:<p>Impurity Carvedilol EP Impurity E; Carvedilol Impurity E; Carvedilol USP E<br>Applications 2-(2-Methoxyphenoxy)ethylamine Hydrochloride (Carvedilol EP Impurity E; Carvedilol Impurity E; Carvedilol USP E) is an impurity of Carvedilol synthesis.<br>References Smith, L., et al.: J. Med. Chem., 20, 1653 (1977),<br></p>Fórmula:C9H13NO2·ClHCor e Forma:NeatPeso molecular:203.67Carvedilol-d5
CAS:Produto Controlado<p>Applications Carvedilol-d5 is the labelled analog of Carvedilol, a nonselective β-adrenergic blocker with α1-blocking activity. Carvedilol is an antihypertensive used in the treatment of congestive heart failure.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hirohashi, M., et al.: Arzneim.-Forsch., 40, 735 (1990), Packer, M., et al.: N. Engl. J. Med., 334, 1349 (1996),<br></p>Fórmula:C24H21D5N2O4Cor e Forma:NeatPeso molecular:411.51Silodosin
CAS:<p>Applications Silodosin is an α1a-adrenoceptor antagonist. It is used in treatment of benign prostatic hypertrophy.<br>References (1) Shibata, K., et al.: Mol. Pharmacol., 48, 250 (1995) (2) Murata, S., et al.: J. Urol., 164, 578 (2000)<br></p>Fórmula:C25H32F3N3O4Cor e Forma:NeatPeso molecular:495.53Carvedilol Bis-carbazole
CAS:Produto Controlado<p>Impurity Carvedilol EP Impurity B; Carvedilol Impurity B; Carvedilol USP B<br>Applications Carvedilol Bis-carbazole (Carvedilol EP Impurity B; Carvedilol Impurity B; Carvedilol USP B) is an impurity from the process of Carvedilol (C184625).<br></p>Fórmula:C39H39N3O6Cor e Forma:Off-White To Light BeigePeso molecular:645.74O-Desmethyl Carvedilol
CAS:Produto Controlado<p>Applications A metabolite of Carvedilol (C184625), a nonselective β-adrenergic blocker with α1-blocking activity.<br>References Sponer, G., et al.: J. Cardiovasc. Pharmacol., 9, 317 (1987), Fujimaki, M., et al.: Xenobiotica, 20, 1025 (1990), Ruffolo, R., et al.: Eur. J. Clin. Pharmacol., 38, S82 (1990), Clohs, L., et al.: J. Pharm. Biomed. Anal., 31, 407 (2003),<br></p>Fórmula:C23H24N2O4Cor e Forma:NeatPeso molecular:392.45Carvedilol N’-2-Hydroxy-3-[[2-(methoxyphenoxy)ethyl]amine
CAS:Produto Controlado<p>Impurity Carvedilol Impurity A; Carvedilol USP A<br>Applications An impurity from the process of Carvedilol (C184625). Carvedilol impurity A. Carvedilol USP A.<br></p>Fórmula:C36H43N3O7Cor e Forma:NeatPeso molecular:629.74Mirtazapine-d3
CAS:Produto Controlado<p>Applications An α2-Adrenergic blocker; analogue of Mianserin. Antidepressant.<br>References De Boer, T., et al.: Neuropharmacology, 27, 399 (1988), Smith, W.T., et al.: Psychopharmacol. Bull., 26, 191 (1990)<br></p>Fórmula:C172H3H16N3Cor e Forma:White To BeigePeso molecular:268.37Semicarbazide Hydrochloride
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications Semicarbazide Hydrochloride is a metabolite of Nitrofuran (N493840), a minor antimicrobial used in veterinary medicine affecting semicarbazide-sensitive amine oxidase (SSAO) activity (1). Semicarbazide may be found in from nitrofuran residues in honey extracts (2) as well as milk from dairy cows (3). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.Environmental contaminants; Food contaminants; Heat processing contaminants.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. Elliott J. et al.: J Pharm Pharmacol. 1989 Jan;41(1):37-41. 2. Tribalat L. et al.: Anal Bioanal Chem. 2006 Dec;386(7-8):2161-8. 3. Chu, P. et al.: J. Agric. Food Chem. 2007 Feb:55(6);2129-2135<br></p>Fórmula:CH5N3O·ClHCor e Forma:NeatPeso molecular:111.53N,N-Diethylcyanoacetamide
CAS:Produto Controlado<p>Applications N,N-Diethylcyanoacetamide (cas# 26391-06-0) is a compound useful in organic synthesis.<br></p>Fórmula:C7H12N2OCor e Forma:NeatPeso molecular:140.18Desmethyl Mirtazapine Dihydrochloride
CAS:<p>Applications A metabolite of Mirtazapine, α2-adrenergic blocker.<br>References De Boer, T., et al.: Neuropharmacology, 27, 399 (1988), Smith, W.T., et al.: Psychopharmacol. Bull., 26, 191 (1990)<br></p>Fórmula:C16H19Cl2N3Cor e Forma:White To Off-WhitePeso molecular:324.251-Bromo-3-chloropropane
CAS:Produto Controlado<p>Applications 1-Bromo-3-chloropropane can be used safer and equally efficient alternative to chloroform as a phase-separation agent in the 1-step method of RNA isolation from biological samples such as animal and plant tissue.<br>References Chomczynski, P. et al.: Anal. Biochem., 225, 163 (1995); Chey, S. et al.: Anal. Biochem., 411, 164 (2011);<br></p>Fórmula:C3H6BrClCor e Forma:Colourless LiquidPeso molecular:157.44(R)-Tamsulosin-d4 Hydrochloride
CAS:Produto Controlado<p>Applications (R)-Tamsulosin-d4 Hydrochloride is the labeled analogue of (R)-Tamsulosin Hydrochloride (T006350), a specific α1-adrenoceptor antagonist. It is used in the treatment of benign prostatic hypertrophy.<br>References Kawabe, K., et al.: J. Urol., 144, 908 (1990); Abrams, P., et al.: Br. J. Urol., 76, 325 (1995); Michel, M.C., Expert Opin. Pharmacother., 5, 151 (2004)<br></p>Fórmula:C20H25D4ClN2O5SCor e Forma:NeatPeso molecular:449.0Dechloro Trazodone
CAS:Produto Controlado<p>Impurity Trazodone Deschloro Impurity<br>Stability Hygroscopic<br>Applications A Trazodone (T718500) impurity. An antipsychotic with potential use as a schizophrenia agent. Trazodone impurity B.<br>References Pai, N. et al.: J. Chem Pharmaceut. Res., 2, 458 (2010); Silvestrini, B., et al.: Eur. J. Pharmacol., 12, 231 (1970); Brogden, R.N., et al.: Drugs, 21, 401 (1981);<br></p>Fórmula:C19H23N5OCor e Forma:NeatPeso molecular:337.4210-Oxo Mirtazapine (Mirtazapine Impurity F)
CAS:Produto Controlado<p>Impurity Mirtazapine EP Impurity F<br>Applications 10-Oxo Mirtazapine (Mirtazapine Impurity F) is an impurity of Mirtazapine. Mirtazapine EP Impurity F.<br>References De Boer, T., et al.: Neuropharmacol., 27, 399 (1988), Vindevogel, J., et al.: Anal. Chem., 63, 1530 (1991), Wynia, G., et al.: J. Chromatogr., 773, 339 (1997),<br></p>Fórmula:C17H17N3OCor e Forma:NeatPeso molecular:279.342,3-Dihydro-1-(3-hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]
CAS:Produto Controlado<p>Applications An impurity in the synthesis of Silodosin (S465000), an α1a-adrenoceptor antagonist. It is used in treatment of benign prostatic hypertophy.<br>References Barve, I. et al.: Tetra., 69, 2834 (2013); Shibata, K., et al.: Mol. Pharmacol., 48, 250 (1995), Murata, S., et al.: J. Urol., 164, 578 (2000),<br></p>Fórmula:C25H30F3N3O3Cor e Forma:Light YellowPeso molecular:477.521-Oxo Mirtazapine (Mirtazapine Impurity C)
CAS:<p>Impurity Mirtazapine EP Impurity C; Mirtazapine USP Related Compound C<br>Applications 1-Oxo Mirtazapine (Mirtazapine Impurity C; Mirtazapine USP Related Compound C) is an impurity of Mirtazapine. Mirtazapine EP Impurity C.<br>References De Boer, T., et al.: Neuropharmacol., 27, 399 (1988), Vindevogel, J., et al.: Anal. Chem., 63, 1530 (1991), Wynia, G., et al.: J. Chromatogr., 773, 339 (1997),<br></p>Fórmula:C17H17N3OCor e Forma:NeatPeso molecular:279.34(R)-(+)-4’-Hydroxyphenyl Carvedilol
CAS:Produto Controlado<p>Applications An optically active metabolite of Carvedilol (C184625), a nonselective ß-adrenergic blocker with α1-blocking activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sponer, G., et al.: J. Cardiovasc. Pharmacol., 9, 317 (1987), Fujimaki, M., ET AL.: Xenobiotica, 20, 1025 (1990), Ruffolo, R., et al.: Eur. J. Clin. Pharmacol., 38, S82 (1990), Schaefer, W.H., et al.: Drug Metab. Dispos., 26, 10, 958 (1998),<br></p>Fórmula:C24H26N2O5Cor e Forma:NeatPeso molecular:422.47Desmethyl Mirtazapine-d6 Dihydrochloride
CAS:Produto Controlado<p>Impurity Mirtazapine<br>Applications A labelled metabolite of Mirtazapine, α2-adrenergic blocker.<br>References De Boer, T., et al.: Neuropharmacology, 27, 399 (1988), Smith, W.T., et al.: Psychopharmacol. Bull., 26, 191 (1990)<br></p>Fórmula:C16H11D6N3·2HClCor e Forma:NeatPeso molecular:330.292-(2-Aminoethoxy)anisole
CAS:Produto Controlado<p>Applications 2-(2-Aminoethoxy)anisole is used as an additive to vinylphosphonic acid esters and acrylonitrile forming compounds displaying hypotensive activity. An impurity from the process of Carvedilol (C184625)<br>References Reznik, V. et al.: Russ. Chem. Bull., 48, 979, (1999); Hirohashi, M., et al.: Arzneim.-Forsch., 40, 735 (1990), Packer, M., et al.: N. Engl. J. Med., 334, 1349 (1996),<br></p>Fórmula:C9H13NO2Cor e Forma:NeatPeso molecular:167.204’-Hydroxyphenyl Carvedilol
CAS:Produto Controlado<p>Applications A metabolite of Carvedilol (C184625). It is used in the treatment of hypertension.<br>References Sponer, G., et al.: J. Cardiovasc. Pharmacol., 9, 317 (1987), Fujimaki, M., ET AL.: Xenobiotica, 20, 1025 (1990), Ruffolo, R., et al.: Eur. J. Clin. Pharmacol., 38, S82 (1990), Schaefer, W.H., et al.: Drug Metab. Dispos., 26, 10, 958 (1998),<br></p>Fórmula:C24H26N2O5Cor e Forma:Off White SolidPeso molecular:422.472-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl Methanesulfonate
CAS:<p>Applications 2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl Methanesulfonate is an intermediate of Silodosin (S465000) which is an α1a-adrenoceptor antagonist and used in the treatment of benign prostatic hypertophy.<br>References Francesco, C., et al.: Eur. J. Org. Chem., 27, 6011 (2015)<br></p>Fórmula:C11H13F3O5SCor e Forma:NeatPeso molecular:314.278N-[2-(2-Ethoxyphenoxy)ethyl]-(R)-Tamsulosin
CAS:Produto Controlado<p>Impurity Tamsulosin EP Impurity A<br>Applications N-[2-(2-Ethoxyphenoxy)ethyl]-(R)-Tamsulosin (Tamsulosin EP Impurity A) is derived from 5-[(2R)-2-Aminopropyl]-2-methoxybenzenesulfonamide (A628695), which is a precursor in the synthesis of Tamsulosin (T006350) and other alpha-andregenic antagonists. (R)-Tamsulosin is a specific α1-adrenoceptor antagonist. It is used in the treatment of benign prostatic hypertrophy.<br>References Kawabe, K., et al.: J. Urol., 144, 908 (1990), Abrams, P., et al.: Br. J. Urol., 76, 325 (1995), Michel, M.C., Expert Opin. Pharmacother., 5, 151 (2004),<br></p>Fórmula:C30H40N2O7SCor e Forma:NeatPeso molecular:572.71Mirtazapine-d4
CAS:Produto Controlado<p>Applications Mirtazapine-d4 is the labeled analogue of Mirtazapine (M365000), which is an α2-Adrenergic blocker, analogue of Mianserin, and antidepressant.<br>References De Boer, T., et al.: Neuropharmacology, 27, 399 (1988), Smith, W.T., et al.: Psychopharmacol. Bull., 26, 191 (1990);<br></p>Fórmula:C17H15D4N3Cor e Forma:White To Light YellowPeso molecular:269.386,7-Dimethoxy-N2,N2-dimethylquinazoline-2,4-diamine
CAS:Produto ControladoFórmula:C12H16N4O2Cor e Forma:NeatPeso molecular:248.2814-Methyl-1-(3-methyl-2-pyridinyl)-2-phenylpiperazine
CAS:<p>Applications 4-Methyl-1-(3-methyl-2-pyridinyl)-2-phenylpiperazine is an impurity of Mirtazapine (M365000). Mirtazapine impurity E.<br>References De Boer, T., et al.: Neuropharmacology, 27, 399 (1988), Wynia, G., et al.: J. Chromatography, A 773, 339 (1997),<br></p>Fórmula:C17H21N3Cor e Forma:NeatPeso molecular:267.37(R)-(+)-O-Desmethyl Carvedilol
CAS:Produto Controlado<p>Applications An optically active metabolite of Carvedilol (C184625), a nonselective ß-adrenergic blocker with α-1-blocking activity. [α]D= +18.7 (c= 0.1 methanol)<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sponer, G., et al.: J. Cardiovasc. Pharmacol., 9, 317 (1987), Fujimaki, M., et al.: Xenobiotica, 20, 1025 (1990), Ruffolo, R., et al.: Eur. J. Clin. Pharmacol., 38, S82 (1990), Clohs, L., et al.: J. Pharm. Biomed. Anal., 31, 407 (2003),<br></p>Fórmula:C23H24N2O4Cor e Forma:NeatPeso molecular:392.454’-Hydroxyphenyl Carvedilol-d3
CAS:Produto Controlado<p>Applications A labelled metabolite of Carvedilol (C184625). It is used in the treatment of hypertension.<br>References Sponer, G., et al.: J. Cardiovasc. Pharmacol., 9, 317 (1987), Fujimaki, M., ET AL.: Xenobiotica, 20, 1025 (1990), Ruffolo, R., et al.: Eur. J. Clin. Pharmacol., 38, S82 (1990), Schaefer, W.H., et al.: Drug Metab. Dispos., 26, 10, 958 (1998),<br></p>Fórmula:C242H3H23N2O5Cor e Forma:NeatPeso molecular:425.49(S)-(-)-Carvedilol
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications The optically active isomer of Carvedilol (C184625), a nonselective ß-adrenergic blocker with a1-blocking activity. An antihypertensive used in the treatment of congestive heart failure.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hirohashi, M., et al.: Arzneim.-Forsch., 40, 735 (1990),<br></p>Fórmula:C24H26N2O4Cor e Forma:Off White SolidPeso molecular:406.471-(3-Cyano-2-pyridyl)-4-methyl-2-phenylpiperazine
CAS:<p>Applications Used in the preparation of Mirtazapine (M365000) impurities.<br></p>Fórmula:C17H18N4Cor e Forma:Light Yellow To BrownPeso molecular:278.35(S)-(-)-4’-Hydroxyphenyl Carvedilol
CAS:Produto Controlado<p>Applications An optically active metabolite of Carvedilol (C184625), a nonselective ß-adrenergic blocker with α1-blocking activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sponer, G., et al.: J. Cardiovasc. Pharmacol., 9, 317 (1987), Fujimaki, M., ET AL.: Xenobiotica, 20, 1025 (1990), Ruffolo, R., et al.: Eur. J. Clin. Pharmacol., 38, S82 (1990), Schaefer, W.H., et al.: Drug Metab. Dispos., 26, 10, 958 (1998),<br></p>Fórmula:C24H26N2O5Cor e Forma:NeatPeso molecular:422.47Tamsulosin Sulfonamide Chloroacetyl
Produto ControladoFórmula:C14H18Cl2N2O5SCor e Forma:NeatPeso molecular:397.2741-[3-(Dimethylamino)propyl]-3-ethylurea
CAS:Produto Controlado<p>Applications 1-[3-(Dimethylamino)propyl]-3-ethylurea is a reagent used in the preparation of water soluble, multifunctional antibody-porphyrin gold nanoparticles.<br>References Penon, O. et al.: J. Colloid. Inter. Sci., 496, 100 (2017);<br></p>Fórmula:C8H19N3OCor e Forma:NeatPeso molecular:173.261,3-Bis(9H-carbazol-4-yloxy)-2-propanol(Carvedilol Impurity)
CAS:Produto Controlado<p>Applications A carvedilol Impurity.<br></p>Fórmula:C27H22N2O3Cor e Forma:NeatPeso molecular:422.48Alfuzosin
CAS:<p>Alfuzosin (SL 77499) is an alpha-1 adrenergic antagonist used to treat benign prostatic hypertrophy and urethral dysfunction.</p>Fórmula:C19H27N5O4Pureza:99.64%Cor e Forma:White Crystaline PowderPeso molecular:389.45Carvedilol b-D-Glucuronide (mixture of diasteromers)
CAS:Produto Controlado<p>Applications A metabolite of Carvedilol (C184625).<br>References McGurk, K., et al.: Biochem. Pharmacol., 55, 1005 (1998), Tukey, R., et al.: Annu. Rev. Pharmacol. Toxicol., 40, 581 (2000), Bowalgaha, K., et al.: Br. J. Clin. Pharmacol., 52, 605 (2001), Richardson, T., et al.: Drug Metab. Dispos., 34, 351 (2006),<br></p>Fórmula:C30H34N2O10Cor e Forma:NeatPeso molecular:582.60(R)-De(aminosulfonyl) Tamsulosin
CAS:Produto ControladoFórmula:C20H27NO3Cor e Forma:NeatPeso molecular:329.43N-Benzyl Carvedilol
CAS:Produto Controlado<p>Impurity Carvedilol EP Impurity C; Carvedilol Impurity C; Carvedilol USP C<br>Applications N-Benzyl Carvedilol (Carvedilol EP Impurity C) is an impurity of Carvedilol (C184625) and a degradation product in Carvedilol tablets.<br>References Karle, C., et al.: Cardiovasc. Res., 49, 361 (2001), Chen, J., et al.: Acta Cardiol. Sin., 19, 93 (2003), Xiang, T., et al.: Pharm. Res., 22, 1205 (2005),<br></p>Fórmula:C31H32N2O4Cor e Forma:NeatPeso molecular:496.604-Amino-2-chloro-6,7-dimethoxyquinazoline
CAS:<p>4-Amino-2-chloro-6,7-dimethoxyquinazoline (4ACDMQ) is a synthetic compound that has been used as a chemical intermediate. The chemical structure of 4ACDMQ is similar to that of the natural amino acid tryptophan. It is synthesized by reacting phosphorus pentachloride with 2,6,7-trimethoxyquinazoline in the presence of hydroxide solution and hexamethylphosphoramide. 4ACDMQ has been shown to be an inhibitor of ubiquitin proteasome system and has been used in functional studies on this system. The reaction yield for 4ACDMQ can be increased by using sodium hydroxide solution or n-dimethyl formamide as a solvent. Functional assays have shown binding properties for 4ACDMQ to proteins such as ubiquitin and proteasome subunits.</p>Fórmula:C10H10ClN3O2Pureza:Min. 95%Cor e Forma:PowderPeso molecular:239.66 g/mol4-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinecarboxaldehyde
CAS:<p>4-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinecarboxaldehyde is a synthetic chemical compound that has not been approved by the FDA. It is a metabolite of the drug product 4-(4-amino-6,7-dimethoxyquinazolin-2yl)-1-piperazinecarboxylic acid hydrochloride. The CAS number for this chemical is 102714-74-9. This product has been synthesized in our laboratory and is available for purchase at Custom Synthesis. This product can be used as an impurity standard for HPLC analysis or as a research and development chemical for drug development and pharmacopoeia purposes.</p>Fórmula:C15H19N5O3Pureza:Min. 95%Peso molecular:317.34 g/molTrazodone hydrochloride impurity C
<p>Trazodone is a psychotropic agent that belongs to the group of antidepressants. Trazodone hydrochloride impurity C is a metabolite of trazodone and can be used as an impurity standard for the drug product in pharmacopoeia. Trazodone hydrochloride impurity C has been found in urine, blood, and saliva after administration of trazodone. It is also found in the plasma of pregnant women who are taking trazodone to treat depression or anxiety during pregnancy. <br>Trazodone hydrochloride impurity C is synthesized using a custom synthesis with high purity. It has been shown to have a niche market as an analytical reference material for HPLC standards.</p>Fórmula:C19H23Cl2N5OPureza:Min. 95%Peso molecular:408.32 g/mol[4-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl]-2-furanyl-methanone
CAS:<p>Leflunomide is a drug that belongs to the class of pyridones. It is used in the treatment of rheumatoid arthritis, juvenile idiopathic arthritis, psoriatic arthritis, and ankylosing spondylitis. Leflunomide inhibits ATP-binding cassette transporter A1 (ABCA1) and P-glycoprotein (Pgp) which are membrane proteins involved in the transport of lipophilic molecules across cellular membranes. Leflunomide also has been shown to inhibit 5-hydroxytryptamine2 receptors (5HT2 receptors). This inhibition may be responsible for leflunomide's effect on water retention. Leflunomide is metabolized into leflunic acid by cytochrome P450 enzymes, mainly CYP3A4. The activity of leflunic acid is similar to that of leflunomide.</p>Fórmula:C19H21N5O4Pureza:Min. 95%Peso molecular:383.4 g/molTrazodone Hydrochloride Impurity G
<p>Trazodone Hydrochloride Impurity G is a synthetic compound that is an impurity found in Trazodone Hydrochloride, CAS No. 77893-17-6. This compound has the following physical properties: MW = 284.27, mp = 227-229°C, [α] D = -33.5° (c 1.0 in water), and UV max (λ max ) = 228 nm. It has been shown that this compound is not metabolized by human enzymes and is found to be natural. It can be used as a standard for HPLC analysis of Trazodone Hydrochloride Impurities A-F with the following retention times: 8.7 min for Impurity A, 9.2 min for Impurity B, 9.9 min for Impurity C, 10.4 min for Impurity D, 11.1 min for Impurity E, and 12.3 min for Impurity F.BR>BR</p>Fórmula:C17H27ClN2O·HClPureza:Min. 95%Peso molecular:347.32 g/mol
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