Sistema complementar
O sistema complemento é uma parte crucial da resposta imunológica, consistindo em uma série de pequenas proteínas que melhoram a capacidade dos anticorpos e das células fagocíticas de eliminar patógenos de um organismo. Essas proteínas trabalham juntas para opsonizar patógenos, induzir respostas inflamatórias e lisar diretamente as membranas dos patógenos, desempenhando um papel vital na imunidade inata e na função imunológica geral. Na CymitQuimica, fornecemos proteínas de alta qualidade do sistema complemento para apoiar seus estudos imunológicos e pesquisas clínicas.
Foram encontrados 156 produtos de "Sistema complementar"
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Complement factor D-IN-2
CAS:<p>Complement factor D-IN-2 is an inhibitor of Complement factor D and reduces the excessive activation of complement factor D.</p>Fórmula:C27H24BrN7O3Pureza:99.53%Cor e Forma:SolidPeso molecular:574.43Complement C5a Protein, Human, Recombinant
<p>Complement C5 Protein, Human, Recombinant (Complement C5a) is expressed in E.</p>Pureza:SDS-PAGE: 94.9%; SEC-HPLC: 93.5%Cor e Forma:Lyophilized PowderPeso molecular:8.3 kDa (predicted); 8.3 kDa (reducing conditions)AMY-101 acetate
<p>AMY-101 acetate (Cp40 acetate) is a peptide, an inhibitor of C3 Complement in gingivitis and periodontitis, reduces inflammation and lowers MMP-8 and MMP-9.</p>Fórmula:C85H121N23O20S2Pureza:98.80% - 99.98%Cor e Forma:SolidPeso molecular:1849.14Complement factor I Protein, Rat, Recombinant (His & Myc)
<p>Complement factor I Protein, Rat, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag.</p>Cor e Forma:Lyophilized PowderPeso molecular:69.2 kDa (predicted)Complement C5 Protein, Rat, Recombinant (His & Myc)
<p>Complement C5 Protein, Rat, Recombinant (His & Myc) is expressed in E.</p>Cor e Forma:Lyophilized PowderPeso molecular:14.0 kDa (predicted)C1QA Protein, Mouse, Recombinant (E. coli, His)
<p>C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system.</p>Pureza:98%Cor e Forma:Lyophilized PowderPeso molecular:29.1 kDa (predicted)Complement factor B Protein, Mouse, Recombinant (His)
<p>Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb.</p>Cor e Forma:Lyophilized PowderPeso molecular:87.0 kDa (predicted)Complement C8a Protein, Human, Recombinant (His)
<p>Complement C8a Protein, Human, Recombinant (His) is expressed in E. coli.</p>Cor e Forma:Lyophilized PowderPeso molecular:65.8 kDa (predicted)Complement C5a Protein, Pig, Recombinant (His)
<p>Derived from proteolytic degradation of complement C5, C5a anaphylatoxin is a mediator of local inflammatory process.</p>Cor e Forma:Lyophilized PowderPeso molecular:10.6 kDa (predicted)Complement C8b Protein, Human, Recombinant (His)
<p>Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of</p>Cor e Forma:Lyophilized PowderPeso molecular:67.0 kDa (predicted)Properdin Protein, Mouse, Recombinant (His & Myc)
<p>A positive regulator of the alternate pathway of complement.</p>Cor e Forma:Lyophilized PowderPeso molecular:53 kDa (predicted)C1QL3 Protein, Mouse, Recombinant (His & Myc)
<p>May regulate the number of excitatory synapses that are formed on hippocampus neurons.</p>Cor e Forma:Lyophilized PowderPeso molecular:28.6 kDa (predicted)Complement C4-B Protein, Human, Recombinant (His & SUMO)
<p>Complement C4-B Protein, Human, Recombinant (His & SUMO) is expressed in E. coli.</p>Cor e Forma:Lyophilized PowderPeso molecular:49.1 kDa (predicted)C1QL1 Protein, Mouse, Recombinant (His)
<p>May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses.</p>Cor e Forma:Lyophilized PowderPeso molecular:26.9 kDa (predicted)C5AR1 Protein, Mouse, Recombinant (His & KSI)
<p>Expression system: E. coli<br>Length: 306-351, Partial<br>Activity: Not Tested</p>Cor e Forma:Lyophilized PowderPeso molecular:20.4 kDa (Predicted)Complement factor D Protein, Rat, Recombinant (His & Myc)
<p>Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate</p>Cor e Forma:Lyophilized PowderPeso molecular:29.8 kDa (predicted)C5AR1 Protein, Human, Recombinant (Cell-Free, His)
<p>Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a.</p>Pureza:90%Cor e Forma:Lyophilized PowderPeso molecular:40.7 kDa (predicted)Complement C4-B Protein, Mouse, Recombinant (His)
<p>Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway.</p>Cor e Forma:Lyophilized PowderPeso molecular:39.0 kDa (predicted)C1RA Protein, Mouse, Recombinant (His & Myc)
<p>C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system.</p>Cor e Forma:Lyophilized PowderPeso molecular:85.7 kDa (predicted)Complement C3 Protein, Mouse, Recombinant (His & SUMO)
<p>Complement C3 Protein, Mouse, Recombinant (His & SUMO) is expressed in E.</p>Cor e Forma:Lyophilized PowderPeso molecular:55.3 kDa (predicted)C1QA Protein, Human, Recombinant (His & Myc)
<p>C1QA Protein, Human, Recombinant (His & Myc) is expressed in E. coli.</p>Cor e Forma:Lyophilized PowderPeso molecular:30.7 kDa (predicted)C5AR1 Protein-VLP, Human, Recombinant (His)
<p>Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a.</p>Cor e Forma:Lyophilized PowderPeso molecular:41.1 kDa (predicted)Properdin Protein, Mouse, Recombinant (His)
<p>A positive regulator of the alternate pathway of complement.</p>Cor e Forma:Lyophilized PowderPeso molecular:51.9 kDa (predicted)C5AR1 Protein, Mouse, Recombinant (MBP & His-Avi), Biotinylated
<p>Expression system: E. coli<br>Length: 306-351, Partial<br>Activity: Not Tested</p>Cor e Forma:Lyophilized PowderPeso molecular:52.8 kDa (Predicted)Complement C8g Protein, Human, Recombinant (His)
<p>C8 is a constituent of the membrane attack complex.</p>Pureza:95%Cor e Forma:Lyophilized PowderPeso molecular:26.4 kDa (predicted)CR1 Protein, Human, Recombinant
<p>Expression system: E. coli<br>Length: 41-234, Partial<br>Activity: Not Tested</p>Cor e Forma:Lyophilized PowderPeso molecular:21.6 kDa (Predicted)C1SB Protein, Mouse, Recombinant (His & Myc)
<p>C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system.</p>Cor e Forma:Lyophilized PowderPeso molecular:82.4 kDa (predicted)C1QA Protein, Mouse, Recombinant (His)
<p>C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system.</p>Pureza:90% - 92%Cor e Forma:Lyophilized PowderPeso molecular:25.6 kDa (predicted)Complement C3 Protein, Bovine, Recombinant (His & SUMO)
<p>Complement C3 Protein, Bovine, Recombinant (His & SUMO) is expressed in E.</p>Cor e Forma:Lyophilized PowderPeso molecular:39.5 kDa (predicted)Complement factor D Protein, Rat, Recombinant (His)
<p>Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate</p>Cor e Forma:Lyophilized PowderPeso molecular:27.8 kDa (predicted)Empasiprubart
CAS:<p>Empasiprubart (anti-C2 mAb) inhibits classical & lectin complement pathways upstream of C3, showing efficacy in autoimmune models.</p>Pureza:95%Cor e Forma:LiquidCrovalimab
CAS:<p>Crovalimab (SKY59; RO7112689) is an humanised monoclonal antibody that binds to complement C5 , paroxysmal nocturnal haemoglobinuria (PNH).</p>Pureza:95%Cor e Forma:LiquidGefurulimab
CAS:<p>Gefurulimab (ALXN-1720) is a bispecific antibody derived from humans, targeting complement C5 and albumin.</p>Cor e Forma:LiquidRiliprubart
CAS:<p>Riliprubart (SAR445088) is a humanized monoclonal antibody that acts as an anti-C1s inhibitor in the proximal part of the classical complement system. It selectively targets activated C1s, inhibiting its enzymatic activity on substrates C4 and C2, thereby preventing the formation of the classical pathway C3 convertase, C4b2a [1].</p>Pureza:95% - 95%Cor e Forma:LiquidIsocyclosporin A
CAS:<p>Isocyclosporin A is a rearranged degradation product. It is formed by acid treatment of cyclosporin A under aqueous and non-aqueous conditions.</p>Fórmula:C62H111N11O12Cor e Forma:SolidPeso molecular:1202.61C5aR-IN-2
CAS:<p>C5aR-IN-2, a potent C5aR inhibitor, shows promise for researching inflammatory diseases.</p>Fórmula:C36H40FN5O2Cor e Forma:SolidPeso molecular:593.73BCX 1470
CAS:<p>BCX 1470 inhibits the esterolytic activity of factor D and C1s (IC50: 96 nM and 1.6 nM), 3.4- and 200-fold better than that of trypsin, respectively.</p>Fórmula:C14H10N2O2S2Pureza:98%Cor e Forma:SolidPeso molecular:302.37NRP1 antagonist 2
CAS:<p>NRP1 antagonist 2 (Compound 1) is an NRP1 antagonist.</p>Fórmula:C20H17ClN6OS2Cor e Forma:SolidPeso molecular:456.97FD-IN-1
CAS:<p>FD-IN-1: Factor D inhibitor, IC50=12 nM; blocks FXIa, Tryptase β2 (IC50s: 7.7 μM, 6.5 μM); key in innate immunity.</p>Fórmula:C23H23NO4Cor e Forma:SolidPeso molecular:377.43EG00229
CAS:<p>EG00229 blocks VEGF-A/NRP1 binding, IC50 of 3 μM; doesn't affect VEGFR-1/2. It's an NRP1 antagonist.</p>Fórmula:C19H20F3N7O7S3Pureza:98.23%Cor e Forma:SolidPeso molecular:611.6C3a Receptor Agonist
CAS:<p>C3a Receptor Agonist activates C3aRs, inhibits neutrophil mobilization in ischemia, and promotes neural progenitor differentiation.</p>Fórmula:C27H35N3O2Pureza:99.76%Cor e Forma:SolidPeso molecular:433.59NDT 9513727
CAS:<p>NDT 9513727 is a potent, selective and competitive C5aR1 inverse agonist for the study of inflammatory and immune disorders.</p>Fórmula:C36H35N3O4Pureza:99.21%Cor e Forma:SolidPeso molecular:573.68Complement C5-IN-1
CAS:<p>Complement C5-IN-1 is a small-molecule inhibitor of complement component 5 protein (C5).</p>Fórmula:C24H32N2O6Pureza:98.27%Cor e Forma:SolidPeso molecular:444.52Factor D inhibitor 6
CAS:<p>Factor D inhibitor 6 is a potent, highly selective, and orally active compound that specifically inhibits the activity of factor D (FD) with an IC50 of 30 nM and a Kd of 6 nM. It does not exhibit inhibitory effects against factor B, classical and lectin complement-pathway activation, or a broad array of receptors, ion channels, kinases, and proteases.</p>Fórmula:C23H22ClFN6O3Cor e Forma:SolidPeso molecular:484.92W-54011
CAS:<p>W-54011: potent non-peptide C5a receptor blocker; binds 125I-C5a (Ki=2.2nM); stops Ca2+ movement, chemotaxis, ROS in neutrophils (IC50=1.6-3.1nM).</p>Fórmula:C30H37ClN2O2Pureza:96.8%Cor e Forma:SolidPeso molecular:493.08Factor B-IN-2
CAS:<p>Factor B-IN-2 is a potent inhibitor (IC50: 1.5 μM) of complement factor B. Factor B-IN-2 can be used to study inflammatory and immune-related diseases.</p>Fórmula:C25H32N2O4Cor e Forma:SolidPeso molecular:424.53EG01377
CAS:<p>EG01377 is a NRP1 antagonist with antiangiogenic, antimigratory, and antitumor activity, Kd 1.32 μM, IC50s 609 nM for NRP1-a1/b1, inactive on NRP2.</p>Fórmula:C26H30N6O6S2Pureza:98%Cor e Forma:SolidPeso molecular:586.68C5aR-IN-1
CAS:<p>C5aR-IN-1, a potent C5aR inhibitor, may aid in researching autoimmune and inflammatory diseases.</p>Fórmula:C36H39F4N3O2Cor e Forma:SolidPeso molecular:621.71Iptacopan
CAS:<p>Iptacopan (LNP023) is an inhibitor with high affinity to factor B, with a KD value of 7.9 nM and an IC50 value of 10 nM. Cost-effective and quality-assured.</p>Fórmula:C25H30N2O4Pureza:99.07% - >99.99%Cor e Forma:SolidPeso molecular:422.52C5aR-IN-3
CAS:<p>C5aR-IN-3, a potent C5aR inhibitor, may treat autoimmune and inflammatory diseases.</p>Fórmula:C36H40FN5O3Cor e Forma:SolidPeso molecular:609.73
