Outros

<p>Applications Palbociclib (also known as compound number PD-0332991) is an experimental drug for the treatment of breast cancer being developed by Pfizer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6.<br>References Finn, R., et al.: Breast Cancer Res., 11, 5 (2009);<br></p>

<p>Stability Hygroscopic<br>Applications (S)-4-Oxo-homophenylalanine Hydrochloride is a derivative of L-Homophenylalanine (H600500); an antitumor agent.<br>References Brunner, Henri., et al.: Eur. J. Med. Chem., 25, 35 (1990)<br></p>

<p>Stability Moisture Sensitive<br>Applications 4-​Amino-​2-​fluoro-​N-​methylbenzamide acts as a reagent in the design, synthesis and biological evaluation of novel 5-oxo-2-thioxoimidazolidine derivatives as potent androgen receptor antagonists. Also, in the preparation and structure-activity relationship of chiral benzyloxypyridinone derivatives as c-Met kinase inhibitors<br>References Ivachtchenko, A. V., et al.: Eur. J. Med. Chem., 99, 51 (2015); Zhang, D., et al.: Bioorg. Med. Chem. Lett., 23, 2408 (2013)<br></p>

<p>Applications: Labelled Almotriptan (A575200). Almotriptan is a serotonin 5HT1B /1D-receptor agonist used for treatment of migraine.<br>References Fleishaker, J.C., et al.: Clin. Pharmacol. Ther., 67, 498 (2000), Kamali, F., et al.: Curr. Opin. Cent. Peripher. Nerv. Syst. Invest. Drugs, 2, 197 (2000), Dodick, D.W., et al.: Expert Opin.Pharmacother., 4, 1157 (2003)<br></p>

<p>Applications Deschloro-Zopiclone is a metabolite of Zopiclone (Z700500) which is a cyclopyrrolone member of a family of non-benzodiazepine GABAA receptor agonists.<br>References Noble, S., et al.: Drugs, 55, 277 (1998), Musch, B., et al.: Int. J. Clin. Psychopharmacol., 5, 147 (1990),<br></p>

<p>5-Bromo-4-chloro-3-indolyl β-D-glucuronide (BCIG) is an chromogenic enzyme substrate used to detect the presence of glucuronidase enzyme activity. The reaction occurs when BCIG reacts with the enzyme beta-glucuronidase yielding an intense blue color. It is used in a variety of biochemical and biomedical applications, such as the detection of pathogenic bacteria, the diagnosis of genetic disorders, and the isolation of recombinant proteins.</p>

<p>2-Nitrophenyl 6-O-trityl-b-D-galactopyranoside is a chromogenic enzyme substrate used in assays to detect galactosidase activity. It is a derivative of galactose that can be hydrolyzed by galactosidase to release the yellow-colored 2-nitrophenyl group, which can be detected spectrophotometrically. The trityl group helps to stabilize the molecule and prevent undesired hydrolysis during storage. This substrate is commonly used in the study of carbohydrate metabolism and in the detection of galactosidase activity in microorganisms.</p>

<p>4-Nitrophenyl 2-acetamido-2-deoxy-6-O-trityl-b-D-glucopyranoside offers unmatched versatility as a chromogenic pNP substrate for detecting b-D-glucopyranosidase activity. The substrate is specifically designed to produce a yellow 4-nitrophenol product upon enzyme hydrolysis, which can be measured using absorbance spectroscopy. The unique tritylated glucopyranoside group ensures improved compound stability and selectivity while providing ease of handling. This versatile substrate is ideal for a broad range of biochemical, research, and diagnostic applications.</p>

<p>2-Nitrophenyl-2,3,4-tri-O-acetyl-b-D-glucuronide methyl ester is a tri-O-acetylated glucuronide substrate commonly used in chromogenic assays to detect the activity of beta-glucuronidase. Upon hydrolysis by the enzyme, the substrate releases 2-nitrophenol, which can be spectrophotometrically. The substrate is widely used in diagnostic tests to assess bacterial and fungal infections, as well as in drug metabolism studies.</p>

<p>2-Nitrophenyl-b-D-glucuronide is a chromogenic substrate used to detect the activity of beta-glucuronidase in various biological samples. Upon hydrolysis by the enzyme, the substrate releases 2-nitrophenol, which can be spectrophotometrically measured at 405 nm. The substrate is commonly used in clinical assays to evaluate liver and kidney function, as well as in drug metabolism studies. It is also used in environmental monitoring to assess the presence of microbial activity in soil and water samples. Overall, 2-Nitrophenyl-b-D-glucuronide is a widely used substrate with excellent sensitivity and specificity, making it a valuable tool in enzymology research and diagnostic testing.</p>

<p>2-Chloro-4-nitrophenyl 2,3,4,6-tetra-O-acetyl-a-D-glucopyranoside is a chromogenic substrate used to characterize enzymes in biochemical assays. The substrate is cleaved by enzymes, such as esterases and glycosidases, releasing the chromogenic group, which can be detected by its yellow color.</p>

<p>4-Nitrophenyl 4,6-O-benzylidene-3-O-(2,3,4,6-tetra-O-acetyl-b-D-glucopyranosyl)-b-D-glucopyranoside is a high purity fluorescent reagent that can be used as a substrate for many enzymes. It is also used in environmental testing and to detect the presence of nitrophenols in food. This product has CAS number 545414.</p>

<p>4-Nitrophenyl 4-O-(2,3,4,6-tetra-O-acetyl-b-D-galactopyranosyl)-2,3,6-tri-O-acetyl-b-D-thioglucopyranoside is a superior chromogenic substrate for the detection of enzymes. Specifically designed for optimal performance, it provides exquisite sensitivity and definitive results in enzyme assays. Its exceptional properties make it a top choice among researchers and professionals in biochemistry, enabling accurate analysis and quantification of enzymatic activities.</p>

<p>Aldol® 515 propionate is a chromogenic substrate that is used as a reagent in food testing, diagnostics, and environmental testing. It reacts with an enzyme to form a fluorescent product that can be detected with a spectrophotometer. The substrate has been shown to have high purity and high quality.</p>