Derivados de Purinas e Pirimidinas
As purinas possuem uma estrutura bicíclica, formada por um anel de seis membros fundido a um anel de cinco membros, ambos contendo átomos de nitrogênio em posições-chave. Os derivados das purinas, como a adenina e a guanina, são essenciais para a formação do DNA e RNA. Estes compostos possuem aplicações terapêuticas no tratamento do câncer e de doenças virais, pois inibem a replicação celular. As pirimidinas, por outro lado, possuem uma estrutura monocíclica de seis membros com dois átomos de nitrogênio. Seus derivados, como citosina, timina e uracila, também são componentes essenciais do DNA e RNA e são utilizados na quimioterapia e em tratamentos antivirais.
Na CymitQuimica, oferecemos derivados de purinas e pirimidinas para pesquisa em biologia molecular, genômica e desenvolvimento de terapias inovadoras.
Foram encontrados 8888 produtos de "Derivados de Purinas e Pirimidinas"
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3-(4H-1,2,4-Triazol-4-yl)-1H-pyrazole-4-carboxamide
CAS:Produto Controlado<p>Impurity Allopurinol EP Impurity C / Allopurinol USP Related Compound C<br>Applications 3-(4H-1,2,4-Triazol-4-yl)-1H-pyrazole-4-carboxamide (Allopurinol EP Impurity C) is an impurity of Allopurinol (A547300).<br></p>Fórmula:C6H6N6OCor e Forma:Off-WhitePeso molecular:178.15MOC-POC Tenofovir Fumarate Salt (Mixture of Diastereomers)
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications Tenofovir (T018500) impurity.<br></p>Fórmula:C17H26N5O10P·C4H4O4Cor e Forma:White To Off-WhitePeso molecular:607.46N6-(2-Isopentenyl)adenine
CAS:Produto Controlado<p>Applications N6-(2-Isopentenyl)adenine can be used in biological study for cytokinins stimulated expression of stress-related proteins and transcripts in Arabidopsis thaliana with isopentenyltransferase overexpression.<br>References Skalak, J., et al.: J. Exp. Bot., 67, 2861-2873 (2016)<br></p>Fórmula:C10H13N5Cor e Forma:White To Off-WhitePeso molecular:203.244,6-Dihydroxypyrazolo[3,4-d]pyrimidine
CAS:Produto Controlado<p>Stability Hygroscoipic<br>Applications 4,6-Dihydroxypyrazolo[3,4-d]pyrimidine is a major metabolite of Allopurinol (A547300). It is a xanthine oxidase inhibitor.<br>References Pacher, P., et al.: Pharmacol. Rev., 58, 87 (2006); Marro, P., et al.: Brain Res., 650, 9 (1994); Abramov, A., et al.: J. Neurosci., 27, 1129 (2007); Day, R., et al.: Clin. Pharmacokinet., 46, 623 (2007);<br></p>Fórmula:C5H4N4O2Cor e Forma:Off White SolidPeso molecular:152.11Nicotinic Acid-d3 (major)
CAS:Produto Controlado<p>Applications Labelled Nicotinic acid. It is a precursor of the coenzymes NAD and NADP. Widely distributed in nature; appreciable amounts are found in liver , fish, yeast and cereal grains. Dietary deficiency is associated with pellagra. The term “niacin” has also been applied to nicotinamide or to other derivatives exhibiting the biological activity of nicotinic acid. Vitamin (enzyme cofactor).A representative lot contains >20% d4.<br>References Darby, W.J., et al.: Nutr. Rev., 33, 289 (1975), Black, A., et al.: Eur. J. Clin. Nutr., 54, 395 (2000), Cole, T., et al.: Br. Med. J., 320, 1240 (2000), Forshee, R., et al.: J. Nutr., 134, 2733 (2004),<br></p>Fórmula:C6H2D3NO2Cor e Forma:NeatPeso molecular:126.13Theophylline-d6
CAS:Produto Controlado<p>Applications Xanthine derivative with diuretic, cardiac stimulant and smooth muscle relaxant activities; isomeric with theobromine. Small amounts occur in tea. Bronchodilator.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cohen, J.L., et al.: Anal. Profiles Drug Subs., 4, 466 (1975), Svedmyr, K., et al.: Allergy, 37, 111 (1982),<br></p>Fórmula:C72H6H2N4O2Cor e Forma:White To Off-WhitePeso molecular:186.201-Bromo-3,5-dimethyladamantane
CAS:Produto Controlado<p>Applications 1-Bromo-3,5-dimethyladamantane (cas# 941-37-7) is a compound useful in organic synthesis.<br></p>Fórmula:C12H19BrCor e Forma:ColourlessPeso molecular:243.18Orotic Acid-15N2 Monohydrate
CAS:<p>Applications Orotic Acid-15N2 Monohydrate is a labelled analogue of Orotic Acid Monohydrate (O691500(P)), which is used in the preparation of therapeutic agents for chronic obstructive pulmonary disease (COPD) treatment.<br>References Furukawa, S.: PCT Int. Appl. (2009), WO 2009069291 A1<br></p>Fórmula:C5H415N2O4·H2OCor e Forma:NeatPeso molecular:177.09Methotrexate a-Methyl Ester (>90%)
CAS:Produto Controlado<p>Impurity Methotrexate EP Impurity I<br>Applications Methotrexate α-methyl ester is an impurity of Methotrexate (M260675), a folic acid antagonist. Used as a antineoplastic and antirheumatic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Freeman, M.V., J. Pharmacol. Exp. Ther., 122, 154 (1958), Weinblass, M.E., et al.: N. Engl. J. Med., 312, 818 (1985),<br></p>Fórmula:C21H24N8O5Pureza:>90%Cor e Forma:NeatPeso molecular:468.47Methotrexate-d3
CAS:Produto Controlado<p>Applications Labelled Methotrexate (M260675). A Folic acid antagonist. Used as a antineoplastic and antirheumatic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Freeman, M.V., J. Pharmacol. Exp. Ther., 122, 154 (1958), Weinblass, M.E., et al.: N. Engl. J. Med., 312, 818 (1985),<br></p>Fórmula:C20H19D3N8O5Cor e Forma:NeatPeso molecular:457.461,7-Dimethyluric Acid
CAS:Produto Controlado<p>Applications A metabolite of Caffeine.<br>References Kalow, W., et al.: Clin. Pharmacol. Ther., 53, 503 (1993), Sharma, S., et al.: Cancer Res., 54, 5848 (1994), Sugawara, M., et al.: J. Biol. Chem., 275, 16473 (2000), Takeda, M., et al.: J. Pharmacol. Exp. Ther., 302, 666 (2002),<br></p>Fórmula:C7H8N4O3Cor e Forma:NeatPeso molecular:196.16Methotrexate Heptaglutamate Trifluoroacetate
CAS:Produto ControladoFórmula:C50H64N14O23xC2HF3O2Cor e Forma:NeatPeso molecular:1229.122-Fluoroadenosine
CAS:Produto Controlado<p>Applications 2-Fluoroadenosine is a fluorinated analog of Adenoside (A280400) nucleotide.<br>References Long, X., et al.: J. Pharmacol. Exper. Ther., 335, 781 (2010); Ham, M., et al.: J. Pharmacol. Exper. Ther., 335, 607 (2010);<br></p>Fórmula:C10H12FN5O4Cor e Forma:NeatPeso molecular:285.23Tenofovir Monohydrate
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications Tenofovir Monohydrate is an HIV-1 RT inhibitor and antiretroviral drug.<br>References Zhao, Z., et al.: Method for preparing medical salts and/or derivatives of tenofovir disoproxil, and their application for preventing and/or treating HBV and HIV/AIDS infections, CN 101574356 (2009);<br></p>Fórmula:C9H14N5O4P·H2OCor e Forma:NeatPeso molecular:305.23Paraxanthine-d3
CAS:Produto Controlado<p>Applications Paraxanthine-d3, is the labeled analogue of Paraxanthine (P192500), an adenosine receptor ligand and a major metabolite of caffeine.<br>References Proc. Natl. Acad. Sci. USA 78, 3260 (1981); Cell Mol. Neurobiol., 3, 69 (1983); Eur. J. Pharmacol., 179, 295 (1990)<br></p>Fórmula:C72H3H5N4O2Cor e Forma:NeatPeso molecular:183.18N-Demethyl Ondansetron
CAS:<p>Applications A metabolite of Ondansetron (O655000).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bayliss, M., et al: Xenobiotica, 24, 231 (1994), Atkins, W., et al.: J. Biol. Chem., 277, 33258 (2002), De Graaf, I., et al.: Drug Metab. Dispos., 30, 1129 (2002),<br></p>Fórmula:C17H17N3OCor e Forma:White To BrownPeso molecular:279.343-Descyano Febuxostat
CAS:Produto Controlado<p>Applications 3-Descyano Febuxostat is an impurity of Febuxostat (F229000), a xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout. 40-120 mg/day febuxostat was proven effective in lowering serum urate levels when administered to manage hyperuricemia in patients with gout.<br>References Kadivar, M.H., et. al.: J. Pharmaceut. Biomed. Anal., 56, 749 (2011); Vallu, V., et. al.: Anal. Chem. Indian J., 14, 339 (2014); Osada, Y., et al.: Eur. J. Pharmacol., 241, 183 (1993); Okamoto, K., et al.: J. Biol. Chem., 278, 1848 (2003); Mayer, M.D., et al.: Am. J. Therap., 12, 22 (2005); Tomlinson, B., et al.: Curr. Opin. Invest. Drugs, 6, 1168 (2005)<br></p>Fórmula:C15H17NO3SCor e Forma:NeatPeso molecular:291.37Fmoc N-Hydroxysuccinimide Ester
CAS:<p>Stability Moisture Sensitive<br>Applications Used in conjunction with Isothiocyanate to conduct partial Edman Degradation on biologically active peptides.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Heidenreich, O., et al.: J. Biol. Chem., 269, 2131 (1994), Kothe, U., et al.: Anal. Biochem., 356, 148 (2006), Thakkar, A., et al.: Anal. Chem., 78, 5935 (2006),<br></p>Fórmula:C19H15NO5Cor e Forma:NeatPeso molecular:337.33Tenofovir Diphosphate Triethylamine Salt (Mixture of Diastereomers)
CAS:<p>Stability Very Hygroscopic<br>Applications A metabolite of Tenofovir (T018500).<br>References Hazra, R., et al.: Antimicrob. Agents Chemother., 48, 124 (2004), Piketty, C., et al.: Antivir. Ther., 11, 213 (2006), Molto, J., et al.: Ther. Drug Monit., 29, 648 (2007),<br></p>Fórmula:C9H16N5O10P3·C6H15NCor e Forma:Off-White To Light YellowPeso molecular:447.17
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