Derivados de Purinas e Pirimidinas
As purinas possuem uma estrutura bicíclica, formada por um anel de seis membros fundido a um anel de cinco membros, ambos contendo átomos de nitrogênio em posições-chave. Os derivados das purinas, como a adenina e a guanina, são essenciais para a formação do DNA e RNA. Estes compostos possuem aplicações terapêuticas no tratamento do câncer e de doenças virais, pois inibem a replicação celular. As pirimidinas, por outro lado, possuem uma estrutura monocíclica de seis membros com dois átomos de nitrogênio. Seus derivados, como citosina, timina e uracila, também são componentes essenciais do DNA e RNA e são utilizados na quimioterapia e em tratamentos antivirais.
Na CymitQuimica, oferecemos derivados de purinas e pirimidinas para pesquisa em biologia molecular, genômica e desenvolvimento de terapias inovadoras.
Foram encontrados 8888 produtos de "Derivados de Purinas e Pirimidinas"
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Caffeine-d3 (1-methyl-d3)
CAS:Produto Controlado<p>Applications Caffeine-d3 (1-methyl-d3) (CAS# 26351-03-1) is a useful isotopically labeled research compound.<br></p>Fórmula:C8H7D3N4O2Cor e Forma:NeatPeso molecular:197.204-Amino-1,3-dimethyl-5-nitrosouracil x-H2O
CAS:Produto Controlado<p>Applications 4-Amino-1,3-dimethyl-5-nitrosouracil is a useful building block for organic synthesis.<br></p>Fórmula:C6H8N4O3Cor e Forma:NeatPeso molecular:184.15Methotrexate (1 mg/mL in Methanol with 0.1N NaOH)
CAS:Fórmula:C20H22N8O5Cor e Forma:Single SolutionPeso molecular:454.44N-(9-((2R,3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide
CAS:Pureza:98%Peso molecular:373.343994140625MTIC
CAS:<p>Applications A metabolite of Temozolomide, an antineoplastic.<br></p>Fórmula:C5H8N6OCor e Forma:Off-WhitePeso molecular:168.16L-Phenylalanine-13C6
CAS:Produto Controlado<p>Applications Labelled analogue of L-Phenylalanine, an essential amino acid. L-Phenylalanine is biologically converted into L-tyrosine, another one of the DNA-encoded amino acids, which in turn is converted to L-DOPA and further converted into dopamine, norepinephrine, and epinephrine. L-Phenylalanine is produced for medical, feed, and nutritional applications such as in the preparation of Aspartame.<br>References Hollunger, G. et al.: Acta Pharmacol. Toxicol., 34, 391 (1974); Bagchi, S.P. et al.: Biochem. Pharmacol., 26, 900 (1977);<br></p>Fórmula:C313C6H11NO2Cor e Forma:White To Off-WhitePeso molecular:171.15Isonicotinic Acid
CAS:<p>Applications Used in the biological study of differentiation induced by nicotinic acid, nicotinamide and isonicotinic acid in human leukemia cell lines.<br>References Zeilinger, S., et al.: J. Biol. Chem., 271, 25624 (1996), Panagiotou, G., et al.: J. Biotechnol., 118, 304 (2005),<br></p>Fórmula:C6H5NO2Cor e Forma:Light BrownPeso molecular:123.11Tenofovir Disoproxil Fumarate
CAS:<p>Applications Acyclic phosphonate nucleotide analogue; reverse transcriptase inhibitor. Used as an anti-HIV agent. Antiviral.<br>References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997), Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007),<br></p>Fórmula:C19H30N5O10P·C4H4O4Cor e Forma:White To Off-WhitePeso molecular:635.51Ondansetron-d3 Hydrochloride Salt
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications A labelled specific serotonin (5-HT3) receptor antagonist. Antiemetic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kris, M.G., et al.: J. Clin. Oncol., 6, 659 (1988), Faris, P..L., et al.: Lances, 355, 792 (2000),<br></p>Fórmula:C18H16D3N3O•HClCor e Forma:NeatPeso molecular:296.3936462-[3-Carboxy-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic Acid
CAS:Produto Controlado<p>Applications 2-[3-Carboxy-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic Acid is an impurity of Febuxostat (F229000), an xanthine oxidase/ xanthine dehydrogenase inhibitor used for the treatment of hyperuricemia and chronic gout.<br>References Kadivar, M.H.,e t al.: J. Pharm. Biomed. Anal., 56, 749 (2011);<br></p>Fórmula:C16H17NO5SCor e Forma:White SolidPeso molecular:335.37Porphobilinogen
CAS:Produto Controlado<p>Applications An intermediate in the biosynthesis of Heme, found in the urine of patients with acute porphyria.<br>References Westall, et al.: Nature, 170, 614 (1952), Cookson, R., et al.: Biochem, J., 57, 476 (1954), MacDonald, J., Can. J. Chem., 35, 715 (1957),<br></p>Fórmula:C10H14N2O4Cor e Forma:NeatPeso molecular:226.23Allopurinol
CAS:<p>Applications Allopurinol is a xanthine oxidase inhibitor; decreases uric acid production. Used in treatment of hyperuricemia and chronic gout. Antiurolithic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Benezra, S.A., et al.: Anal. Profiles Drug Subs., 7, 1, (1978); Dalbeth, N., et al.: Rheumatology, 44, 1090 (2005); Dinarello, C., et al.: J. Exp. Med., 201, 1355 (2005);<br></p>Fórmula:C5H4N4OCor e Forma:Off-WhitePeso molecular:136.116-Methylmercaptopurine-d3
CAS:Produto Controlado<p>Applications Metabolite of 6-Mercaptopurine, an immunosuppressive drug used to treat leukemia.<br>References Chou, C., et al.: Biochem. Pharmacol., 75, 1601 (2008), Conejo-Garcia, A., et al.: Eur. J. Med. Chem., 43, 1742 (2008), Hawwa, A., et al.: Brit. J. Clin. Pharmacol., 66, 826 (2008), Askanase, A., et al.: J. Rheumatol., 36, 89 (2009),<br></p>Fórmula:C62H3H3N4SCor e Forma:NeatPeso molecular:169.22Tenofovir Alafenamide
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications Tenofovir Alafenamide is a prodrug of Tenofovir (T018500), which is a reverse transcriptase inhibitor used to treat HIV and Hepatitis B. Antiviral.<br>References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997), Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007),<br></p>Fórmula:C21H29N6O5PCor e Forma:NeatPeso molecular:476.47D-Neopterin-13C5
CAS:<p>Applications Labelled precursor in the biosynthesis of Biopterin. First isolated from the pupae of bees.<br>References Kobashi, I., et al.: Agric. Biol. Chem., 35, 47 (1971), Fukushima, S., et al.: J. Biol. Chem., 247, 4549 (1972),<br></p>Fórmula:C413C5H11N5O4Cor e Forma:Light Beige To BrownPeso molecular:258.187-Methyl Xanthine
CAS:Produto Controlado<p>Applications Metabolite of Theophylline and Caffeine.<br>References Yu, Ch. et al.: J. Bacteriol. 191, 4624 (2009); Geraets, L. et al.: Biochem. Pharmacol. 72, 902 (2006).<br></p>Fórmula:C6H6N4O2Cor e Forma:NeatPeso molecular:166.141,7-Dimethyluric Acid-d3
CAS:Produto ControladoFórmula:C7H5D3N4O3Cor e Forma:Off-White To Light GreyPeso molecular:199.18Tryptamine
CAS:<p>Applications Tryptamine is a monoamine alkaloid found in plants. Tryptamine is commonly used in the preparation of biologically active compounds such as neurotransmitters and psychedelics.<br>References Nichols, D. E., et al.: Curr. Top. Behav. Neurosci., 36, 1(2018); Espinoza, S., et al.: Top. Med. Chem., 23, 175 (2017)<br></p>Fórmula:C10H12N2Cor e Forma:YellowPeso molecular:160.22
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