Derivados de Purinas e Pirimidinas
As purinas possuem uma estrutura bicíclica, formada por um anel de seis membros fundido a um anel de cinco membros, ambos contendo átomos de nitrogênio em posições-chave. Os derivados das purinas, como a adenina e a guanina, são essenciais para a formação do DNA e RNA. Estes compostos possuem aplicações terapêuticas no tratamento do câncer e de doenças virais, pois inibem a replicação celular. As pirimidinas, por outro lado, possuem uma estrutura monocíclica de seis membros com dois átomos de nitrogênio. Seus derivados, como citosina, timina e uracila, também são componentes essenciais do DNA e RNA e são utilizados na quimioterapia e em tratamentos antivirais.
Na CymitQuimica, oferecemos derivados de purinas e pirimidinas para pesquisa em biologia molecular, genômica e desenvolvimento de terapias inovadoras.
Foram encontrados 8902 produtos de "Derivados de Purinas e Pirimidinas"
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4-([1,1'-Biphenyl]-4-yl)-6-chloro-2-phenylpyrimidine
CAS:Pureza:95.0%Peso molecular:342.8299865722656N-Desmethoxypropyl Prucalopride
CAS:Produto Controlado<p>Applications N-Desmethoxypropyl Prucalopride is an impurity of Prucalopride (P838950), a selective 5-HT4 receptor agonist used effective for chronic constipation, but is not currently approved in the U.S. Prucalopride is approved for the treatment of chronic constipation in Europe.<br>References Shah, N., et al.: Am. J. Gastroenterol., 103, 1746 (2008), McKinnell, R., et al.: J. Med. Chem., 52, 5330 (2009), Shah, N., et al.: Am. J. Gastroenterol., 103, 1746 (2008),<br></p>Fórmula:C14H18ClN3O2Cor e Forma:NeatPeso molecular:132.201Ref: 10-F527886
1gA consultar5gA consultar10gA consultar25gA consultar100mgA consultar250mgA consultar3-Methyluric Acid
CAS:<p>Applications 3-Methyluric Acid is a methylated derivative of uric acid that inhibits peroxynitrite-mediated oxidation, which has potential therapeutic application in the treatment of multiple sclerosis. 3-Methyluric Acid is also a known metabolite of Caffeine (C080100).<br>References Kean, R.B. et al.: J. Immunol., 165, 6511 (2000); Caubet, M.-S. et al.: J. Pharm. Biomed. Anal., 27, 261 (2002);<br></p>Fórmula:C6H6N4O3Cor e Forma:Light YellowPeso molecular:182.14Xanthine
CAS:<p>Applications Found in animal organs, yeast, patatoes, coffee beans, tea. This drug can be used to relax and widen certain breathing passages of the lungs. It is also found that a large number of derivatives have adenoside receptor antagonist properties.<br>References Mueller, C. et. al: Handbook Exp. Pharmacol. 200,151(2011)<br></p>Fórmula:C5H4N4O2Cor e Forma:White SolidPeso molecular:152.11Methotrexate-Cadaverine-Biotin Conjugate
Produto Controlado<p>Applications Methotrexate-Cadaverine-Biotin Conjugate is biotin labelled Methotrexate. Methotrexate (M260675) is a folic acid antagonist and it is used as a antineoplastic and antirheumatic.<br>References Freeman, M.V., J. Pharmacol. Exp. Ther., 122, 154 (1958), Weinblass, M.E., et al.: N. Engl. J. Med., 312, 818 (1985),<br></p>Fórmula:C35H48N12O6SPureza:>85%Cor e Forma:NeatPeso molecular:764.9Methotrexate
CAS:<p>Stability Hygroscopic<br>Applications A Folic acid antagonist. Used as a antineoplastic and antirheumatic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Freeman, M.V., J. Pharmacol. Exp. Ther., 122, 154 (1958), Weinblass, M.E., et al.: N. Engl. J. Med., 312, 818 (1985),<br></p>Fórmula:C20H22N8O5Cor e Forma:Yellow To Dark YellowPeso molecular:454.44Tetrabenazine-d6
CAS:Produto Controlado<p>Applications Labelled Tetrabenazine. Dopamine depleting agent. An antidyskinetic; antipsychotic.<br>References Schwartz, et al.: Biochem. Pharmacol., 15, 645 (1966), Janovic, J., et al.: Ann. Neurol., 11, 41 (1982), Janovic, J., et al.: Neurology, 38, 391 (1988),<br></p>Fórmula:C19H21D6NO3Cor e Forma:NeatPeso molecular:323.465-Cyclopropyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one
CAS:Fórmula:C7H8N2OSPureza:95.0%Cor e Forma:SolidPeso molecular:168.21(6-Benzhydryloxycarbonylamino-purin-9-yl)-acetic acid
CAS:Pureza:97.0%Cor e Forma:SolidPeso molecular:403.398010253906253-(Formylamino)-1H-pyrazole-4-carboxamide
CAS:Produto Controlado<p>Impurity Allopurinol EP Impurity B / Allopurinol USP Related Compound B<br>Stability Hygroscopic<br>Applications 3-(Formylamino)-1H-pyrazole-4-carboxamide (Allopurinol EP Impurity B) is an impurity of Allopurinol (A547300) with inhibitory effects on human hypoxanthine phosphoribosyltransferase.<br>References Krenitzky, T.A. et al.: J. Biol. Chem., 244, 1263 (1969);<br></p>Fórmula:C5H6N4O2Cor e Forma:White To Off-WhitePeso molecular:154.1274-(4-Fluoronaphthalen-1-yl)-6-isopropylpyrimidin-2-amine
CAS:Pureza:95.0%Peso molecular:281.33401489257811,2,3,9-Tetrahydro-3-(1H-imidazol-1-ylmethyl)-9-methyl-4H-carbazol-4-one (Ondansetron Impurity G)
CAS:Produto Controlado<p>Applications 1,2,3,9-Tetrahydro-3-(1H-imidazol-1-ylmethyl)-9-methyl-4H-carbazol-4-one is an metabolite of Ondansetron (O655000), is a selective 5-hydroxytryptamine3 (5-HT3) receptor antagonist that has been introduced to clinical practice as an antiemetic for cancer treatment-induced and anesthesia-related nausea and vomiting.<br>References Kris, M.G., et al.: J. Clin. Oncol., 6, 659 (1988), Faris, P..L., et al.: Lances, 355, 792 (2000), Ye, J.H., et al.: CNS Drug Reviews., 7, 199 (2001);<br></p>Fórmula:C17H17N3OCor e Forma:White To Off-WhitePeso molecular:279.34Iopamidol
CAS:<p>Applications Nonionic radiocontrast medium. Diagnostic aid (radiopaque medium).<br>References Drayer, B., et al.: Am. J. Neuroradiol., 3, 59 (1982), Molyneux, A.J., et al.: Br. J. Radiol., 55, 117 (1982), Sovak, M., et al.: Radiology, 142, 115 (1982), Felder, E., et al.: Anal. Profiles Drug Subs., 17, 115 (1988),<br></p>Fórmula:C17H22I3N3O8Cor e Forma:WhitePeso molecular:777.096-Amino-1,3-dipropyl-5-nitrosouracil
CAS:Produto Controlado<p>Stability Stable at RT<br>Applications An intermediate used for the sythesis of xanthine derivatives.<br>References Daly, J.W., et al.: J. Med. Chem., 28, 487 (1985), Erickson, R.H., et al.: J. Med. Chem., 34, 3405 (1991),<br></p>Fórmula:C10H16N4O3Cor e Forma:NeatPeso molecular:240.264-Hydroxy-3,5-diiodobenzyl Alcohol
CAS:Produto Controlado<p>Applications Intermediate in the production of Thyroxine<br></p>Fórmula:C7H6I2O2Cor e Forma:NeatPeso molecular:375.93Sumatriptan-d6
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications A serotonin 5HT1-receptor agonist. Antimigraine.<br>References Humphrey, P.P.A., et al.: Br. J. Pharmacol., 94, 1123 (1988),<br></p>Fórmula:C14H15D6N3O2SCor e Forma:NeatPeso molecular:301.44N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine
CAS:Pureza:95.0%Cor e Forma:SolidPeso molecular:277.33099365234375(2R,3R,4R,5R)-2-(2-AMINO-9H-PURIN-9-YL)-5-(HYDROXYMETHYL)-3-METHYLTETRAHYDROFURAN-3,4-DIOL
CAS:Pureza:95.0%Peso molecular:281.2720031738281(3aS,4S,6R,6aR)-6-(6-Amino-2-chloro-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole-4-carboxylic acid
CAS:Pureza:97.0%Peso molecular:355.7399902343752-(5-amino-3-cyclopropyl-1H-pyrazol-1-yl)-5-ethyl-6-methylpyrimidin-4(3H)-one
CAS:Pureza:95.0%Peso molecular:259.312988281251,3-Dimethyluric Acid
CAS:Produto Controlado<p>Applications 1,3-Dimethyluric Acid, is a metabolite of Caffeine (C080100), that is shown to have some of Its similar effects.<br>References Kalow, W., et al.: Clin. Pharmacol. Ther., 53, 503 (1993), Sharma, S., et al.: Cancer Res., 54, 5848 (1994), Sugawara, M., et al.: J. Biol. Chem., 275, 16473 (2000), Takeda, M., et al.: J. Pharmacol. Exp. Ther., 302, 666 (2002),<br></p>Fórmula:C7H8N4O3Cor e Forma:NeatPeso molecular:196.169-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6,9-dihydro-3H-purin-6-one
CAS:Pureza:97%Peso molecular:270.22000122070313,5,3',5'-Tetraiodo Thyrolactic Acid (~90%)
CAS:Produto Controlado<p>Stability Hygroscopic, Temperature sensitive<br>Applications 3,5,3',5'-Tetraiodo Thyrolactic Acid is a thyroid hormone analogue. A Thyroxine (T425600) analogue.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Horst, C., et al.: Biochem. J., 261, 945 (1989); Kvetny, J., et al.: Horm. Metab. Res., 24, 322 (1992); Yamauchi, K., et al.: J. Biol. Chem., 274, 8460 (1999); Davis, P., et al.: J. Endocrinol. Invest., 25, 377 (2002);<br></p>Fórmula:C15H10I4O5Pureza:~90%Cor e Forma:BeigePeso molecular:777.85Chloromethyl Propyl Carbonate
CAS:Produto Controlado<p>Applications Chloromethyl Propyl Carbonate (cas# 35273-90-6) is a compound useful in organic synthesis.<br></p>Fórmula:C5H9ClO3Cor e Forma:Colourless OilyPeso molecular:152.58N'-Methyl-N,N-diphenylurea
CAS:<p>Impurity Temozolomide USP Related Compound B<br>Applications N'-Methyl-N,N-diphenylurea is used in the stabilization of thermal propellants. Temozolomide USP Related Compound B.<br>References Bohn, M. et al.: Prop. Exp. Pyro.,et al.: 19, 266 (1994); Muthurajan, H. et al.: J. Hazard. Mat., 133, 30 (2006);<br></p>Fórmula:C14H14N2OCor e Forma:NeatPeso molecular:226.272-[5-amino-3-(2-furyl)-1H-pyrazol-1-yl]-6-isopropylpyrimidin-4(3H)-one
CAS:Pureza:95.0%Peso molecular:285.3070068359375(2R,3R,4S,5R)-2-(6-((2-Hydroxyethyl)amino)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
CAS:Pureza:95.0%Cor e Forma:SolidPeso molecular:311.29800415039062-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
CAS:Pureza:98.0%Cor e Forma:SolidPeso molecular:349.31698608398444-(6-BROMOIMIDAZO[1,2-A]PYRIDIN-3-YL)PYRIMIDIN-2-AMINE
CAS:Pureza:95.0%Peso molecular:290.1239929199219Ref: 10-F531136
1gA consultar2gA consultar5gA consultar100mgA consultar250mgA consultar500mgA consultarL-Monapterin
CAS:Produto Controlado<p>Applications L-Monapterin is the major pterin compound extracted from Escherichia coli (E.coli) and is used in its detection and identification.<br>References Sugimoto, T. et al.: Hetero., 54, 283 (2001); Ikawa, M. et al.: Phytochem., 38, 1229 (1995);<br></p>Fórmula:C9H11N5O4Cor e Forma:Light OrangePeso molecular:253.21(6R)-5,6,7,8-Tetrahydrobiopterin Dihydrochloride
CAS:<p>Stability Hygroscopic<br>Applications Tetrahydrobiopterin is a naturally occurring essential cofactor of the three aromatic amino acid hydroxylase enzymes, used in the degradation of amino acid phenylalanine and in the biosynthesis of the neurotransmitters serotonin, melatonin, dopamine, norepinephrine , epinephrine, and is a cofactor for the production of nitric oxide by the nitric oxide synthases. Chemically, its structure is that of a reduced pteridine derivative.<br>References Levy, Harvey L., et al.: Lancet, 370, 504 (2007); Isojima, Yasushi., et al.: Proc Natl Acad Sci USA .,106, 15744 (2009); Burton, B. K., et al.: J. Inherit. Metab. Dis., 30, 700 (2007)<br></p>Fórmula:C9H15N5O3·2(HCl)Cor e Forma:White To Off-WhitePeso molecular:241.25 + 2(36.46)Ethyl-S-(+)-Clopidogrel Sulfate
CAS:Produto Controlado<p>Stability Very Hygroscopic<br>Applications Ethyl-(S)-(+)-Clopidogrel Sulfate is an analogue of S-(+)-Clopidogrel Hydrogen Sulfate (C587250) which is used as an antithrombotic.<br>References Mills, D.C.B., et al.: Arterioscler. Thromb., 12, 430 (1992), Feuerstein, G., et al.: Exp. Opin. Invest. Drugs, 4, 425 (1995)<br></p>Fórmula:C17H20ClNO6S2Cor e Forma:White To Off-WhitePeso molecular:433.934-Chloro-5,6-dimethyl-2-(trifluoromethyl)-pyrimidine
CAS:Fórmula:C7H6ClF3N2Pureza:97.0%Cor e Forma:LiquidPeso molecular:210.58Pemetrexed Sodium Methyl Ester
Produto Controlado<p>Applications Pemetrexed Sodium Methyl Ester is an impurity of Pemetrexed(P219550). Pemetrexed Disodium Heptahydrate is an chemotherapy drug for the treatment of pleural mesothelioma and non-small cell lung cancer. Pemetrexed Disodium Heptahydrate exhibit inhibitory activities towards thymidylate synthase as well as other folate dependent enzymes.<br>References Vogelzang, N.J., et al.: J. Clin. Oncol., 21,2636 (2003); Paz-Ares, L., et al.: Lancet. Oncol., 13, 247 (2012);<br></p>Fórmula:C21H22N5NaO6Cor e Forma:NeatPeso molecular:463.4192-[4-(3-chlorophenyl)piperazin-1-yl]-6-methyl-3,4-dihydropyrimidin-4-one
CAS:Pureza:98%Peso molecular:304.77999877929695-Amino-N1-methyl-1H-imidazole-1,4-dicarboxamide
CAS:Produto Controlado<p>Applications 5-Amino-N1-methyl-1H-imidazole-1,4-dicarboxamide is a metabolite of Temozolomide (T017775); an imidazotetrazine alkylating agent and antineoplastic.<br>References Newlands, E.S., et al.: Cancer Treat. Rev., 23, 35 (1997); Kim, C., et al.: J. Biol. Chem., 274, 1233 (1999); Hait, W., et al.: Cancer Res., 69, 1263 (2009); Wang, Y., et al.: J. Org. Chem., 62, 7288 (1997)<br></p>Fórmula:C6H9N5O2Cor e Forma:Off-WhitePeso molecular:183.17Ref: 10-F538203
1gA consultar2gA consultar5gA consultar100mgA consultar250mgA consultar500mgA consultar2-Oxo Clopidogrel Hydrochloride(Mixture of Diastereomers)
CAS:Produto Controlado<p>Applications The essential intermediate metabolite from which the active metabolite of Clopidogel is formed.<br>References Feliste, R., et al.: Thromb. Res., 48, 403 (1987), Savi, P., et al.: Biochem. Pharmacol., 44, 527 (1992), Herbert, J., et al.: Cardiovasc Drug. Rev., 11, 180 (1993), Sugidachi, A., et al.: B. J. Pharmacol., 132, 47 (2001)<br></p>Fórmula:C16H17Cl2NO3SCor e Forma:NeatPeso molecular:374.28
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