Derivados de Purinas e Pirimidinas
As purinas possuem uma estrutura bicíclica, formada por um anel de seis membros fundido a um anel de cinco membros, ambos contendo átomos de nitrogênio em posições-chave. Os derivados das purinas, como a adenina e a guanina, são essenciais para a formação do DNA e RNA. Estes compostos possuem aplicações terapêuticas no tratamento do câncer e de doenças virais, pois inibem a replicação celular. As pirimidinas, por outro lado, possuem uma estrutura monocíclica de seis membros com dois átomos de nitrogênio. Seus derivados, como citosina, timina e uracila, também são componentes essenciais do DNA e RNA e são utilizados na quimioterapia e em tratamentos antivirais.
Na CymitQuimica, oferecemos derivados de purinas e pirimidinas para pesquisa em biologia molecular, genômica e desenvolvimento de terapias inovadoras.
Foram encontrados 8901 produtos de "Derivados de Purinas e Pirimidinas"
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3-Nitro-L-tyrosine-d3
CAS:Produto Controlado<p>Applications A labelled marker for peroxynitrite. Oxidant and cytotoxic agent.<br>References Sekiguchi, M., et al.: Brain Res., 978, 228 (2003), van den Tweel, E., et al.: J. Neurobiol., 167, 64 (2005), Shirakura, T., et al.: Biol. Pharm. Bull., 28, 1658 (2005),<br></p>Fórmula:C9D3H7N2O5Cor e Forma:NeatPeso molecular:229.24-(3-bromophenyl)-6-(3,4-dimethylphenyl)pyrimidin-2-amine
CAS:Pureza:95.0%Peso molecular:354.2510070800781Ethyl-S-(+)-Clopidogrel Sulfate
CAS:Produto Controlado<p>Stability Very Hygroscopic<br>Applications Ethyl-(S)-(+)-Clopidogrel Sulfate is an analogue of S-(+)-Clopidogrel Hydrogen Sulfate (C587250) which is used as an antithrombotic.<br>References Mills, D.C.B., et al.: Arterioscler. Thromb., 12, 430 (1992), Feuerstein, G., et al.: Exp. Opin. Invest. Drugs, 4, 425 (1995)<br></p>Fórmula:C17H20ClNO6S2Cor e Forma:White To Off-WhitePeso molecular:433.93(S)-4-(4-Aminobenzyl)-2-(1H)-oxazolidinone
CAS:Produto Controlado<p>Impurity Zolmitriptan USP Related Compound G<br>Applications An intermediate of Zolmitriptan, as a novel inhibitor of the cytochrome P-450 enzyme aromatase. Zolmitriptan USP Related Compound G.<br>References Ahmed, S., et al.: Bioorg. Med. Chem. Lett., 5, 2789(1995), Ahmed, S., et al.: Drug. Des. Discov., 15, 239 (1998), Brodie, A., et al.: Steroids, 65, 171 (2000),<br></p>Fórmula:C10H12N2O2Cor e Forma:NeatPeso molecular:192.212-(5-amino-3-cyclopropyl-1H-pyrazol-1-yl)-5,6-dimethylpyrimidin-4(3H)-one
CAS:Pureza:95.0%Peso molecular:245.285995483398445-Amino-N1-methyl-1H-imidazole-1,4-dicarboxamide
CAS:Produto Controlado<p>Applications 5-Amino-N1-methyl-1H-imidazole-1,4-dicarboxamide is a metabolite of Temozolomide (T017775); an imidazotetrazine alkylating agent and antineoplastic.<br>References Newlands, E.S., et al.: Cancer Treat. Rev., 23, 35 (1997); Kim, C., et al.: J. Biol. Chem., 274, 1233 (1999); Hait, W., et al.: Cancer Res., 69, 1263 (2009); Wang, Y., et al.: J. Org. Chem., 62, 7288 (1997)<br></p>Fórmula:C6H9N5O2Cor e Forma:Off-WhitePeso molecular:183.177-Methyl Memantine Hydrochloride
CAS:<p>Stability Hygroscopic<br>Applications 7-Methyl Memantine is an impurity of Memantine (HCl salt, M218000) which is used as an antiparkinsonian and antispasmodic.<br>References Rohde, H., et al.: Fortschr. Med., 100, 2023 (1982), Kornhuber, J., et al.: Eur. J. Pharmacol., 166, 589 (1989), Gortelmeyer, R. and Erbler, H.: Arzneimittel-Forsch., 42, 904 (1992)<br></p>Fórmula:C13H23N·ClHCor e Forma:White SolidPeso molecular:229.79Tenofovir Phosphate Diammonia Salt, >90%
CAS:Produto Controlado<p>Applications Tenofovir Phosphate Diammonia Salt is a metabolite of Tenofovir (T018500), an acyclic phosphonate nucleotide analogue; reverse transcriptase inhibitor. Used as an anti-HIV agent. Antiviral.<br>References Michelson, A.M., et al.: Biochim. Biophys. Acta, 91, 1 (1964); Rosenberg, I., et al.: Collect. Czeck. Chem. Commun., 50, 1507 (1985); Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997); Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005),; Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006); Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007)<br></p>Fórmula:C9H21N7O7P2Pureza:>90%Cor e Forma:NeatPeso molecular:401.253-((3-(N-Cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-(3,5-difluorophenoxy)benzoic acid
CAS:Pureza:98%Peso molecular:649.630004882813Ref: 10-F867169
5mgA consultar10mgA consultar25mgA consultar50mgA consultar100mgA consultar250mgA consultarUrea-urethane Compound (~85%)
CAS:Produto Controlado<p>Applications Urea-urethane Compound is a reaction product of 4,4'-sulfonylbis[benzenamine] and 2,4-TDI.<br></p>Fórmula:C42H36N6O8SPureza:~80%Cor e Forma:NeatPeso molecular:784.84N-(6-Amino-3-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)acetamide
CAS:<p>Applications N-(6-Amino-3-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)acetamide is an intermediate in synthesizing 5-Acetylamino-6-formylamino-3-methyluracil (A168210), which is a metabolite of Caffeine (C080100).<br>References Grant, D.M., et al.: Clin. Pharm. and Ther., 33, 591 (1983),<br></p>Fórmula:C7H10N4O3Cor e Forma:Off White SolidPeso molecular:198.18Lifitegrast
CAS:Produto Controlado<p>Applications Lifitegrast is used for the treatment of signs and symptons of dry eye diseases. It also Inhibites corneal inflammation that is capable of causing pains, blurred vision and ocular discomfort in sufferer.<br>References Holland, E. J., et al.: Curr. Med. Res. Opin., 32, 1759 (2016); Sun, Y., et al.: J. Ocul. Pharmacol. Ther., 29, 395 (2013);<br></p>Fórmula:C29H24Cl2N2O7SCor e Forma:White To Off-WhitePeso molecular:615.4811-((2R,3R,4S,5S)-3,5-DIFLUORO-4-HYDROXY-5-(HYDROXYMETHYL)TETRAHYDROFURAN-2-YL)PYRIMIDINE-2,4(1H,3H)-DIONE
Pureza:90.0%Peso molecular:264.18499755859375D-Neopterin
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications Precursor in the biosynthesis of Biopterin. First isolated from the pupae of bees.<br>References Kobashi, I., et al.: Agric. Biol. Chem., 35, 47 (1971), Fukushima, S., et al.: J. Biol. Chem., 247, 4549 (1972),<br></p>Fórmula:C9H11N5O4Cor e Forma:NeatPeso molecular:253.214-(3-fluorophenyl)-6-(5-methylfuran-2-yl)pyrimidin-2-amine
CAS:Pureza:95.0%Peso molecular:269.27899169921875Methyl 2-[3-Cyano-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylate
CAS:Produto ControladoFórmula:C17H18N2O3SCor e Forma:NeatPeso molecular:330.42-[(2-Amino-6-chloro-4-pyrimidinyl)amino]ethanol
CAS:Pureza:95.0%Cor e Forma:Solid, Yellow powderPeso molecular:188.6199951171875Ref: 10-F863238
1g33,00€5g99,00€10g156,00€25g293,00€100g751,00€10mg17,00€50mg17,00€100mg17,00€250mgA consultar2-(5-amino-3-phenyl-1H-pyrazol-1-yl)-6-methylpyrimidin-4(3H)-one
CAS:Pureza:95.0%Peso molecular:267.29199218752-CHLOROPYRIMIDINE-4-CARBALDEHYDE
CAS:Fórmula:C5H3ClN2OPureza:95.0%Cor e Forma:Liquid, No data available.Peso molecular:142.544-(5-methylfuran-2-yl)-6-(3,4,5-trimethoxyphenyl)pyrimidin-2-amine
CAS:Pureza:95.0%Peso molecular:341.36700439453125Febuxostat-d7
CAS:Produto Controlado<p>Applications Febuxostat-d7, is the labeled analogue of Febuxostat-d7 (F229000), a Xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout.<br>References Osada, Y., et al.: Eur. J. Pharmacol., 241, 183 (1993), Okamoto, K., et al.: J. Biol. Chem., 278, 1848 (2003), Mayer, M.D., et al.: Am. J. Therap., 12, 22 (2005), Tomlinson, B., et al.: Curr. Opin. Invest. Drugs, 6, 1168 (2005),<br></p>Fórmula:C16H9D7N2O3SCor e Forma:NeatPeso molecular:323.426-Mercaptopurine-13C2,15N (major)
CAS:Produto Controlado<p>Applications An immunosuppressive drug used to treat leukemia. It is also used for pediatric non-Hodgkin’s lymphoma, polycythemia vera, and psoriatic arthritis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Naguib, F., et al.: Biochem. Pharmacol., 50, 1685 (1995), Zeng, H., et al.: Biochem. Pharmacol., 68, 911 (2004).<br></p>Fórmula:C313C2H4N315NSCor e Forma:NeatPeso molecular:155.16Tenofovir
CAS:<p>Applications Tenofovir is an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor. It is used as an anti-HIV agent. Antiviral.<br>References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997); Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007);<br></p>Fórmula:C9H14N5O4PCor e Forma:White To Off-WhitePeso molecular:287.215-METHOXY-4-((4-(1-METHYL-1H-INDOL-3-YL)PYRIMIDIN-2-YL)AMINO)-2-NITROPHENOL
Pureza:95.0%Peso molecular:391.38699340820314-[6-(4-Methoxy-phenyl)-pyridin-3-yl]-pyrimidin-2-ylamine
Pureza:95.0%Peso molecular:278.315002441406254-Acetylamino-3-hydroxybenzoic Acid Ethyl Ester, 100 mg
CAS:<p>Impurity Oseltamivir EP Impurity D<br>Applications 4-Acetylamino-3-hydroxybenzoic Acid Ethyl Ester (Oseltamivir EP Impurity D) is an impurity in the antiviral drug Oseltamivir (O700100).<br></p>Fórmula:C11N13NO4Cor e Forma:NeatPeso molecular:223.234-Chloro Kynurenine-13C2,15N
CAS:Produto Controlado<p>Applications 7-Cl-kynurenic acid (7-Cl-KYNA) is a potent, selective antagonist of the NMDA/glycine receptor but penetrates poorly through the blood-brain barrier. Its prodrug, L-4-Cl-kynurenine (4-Cl-KYN), readily enters the brain from the circulation and provides antiexcitotoxic neuroprotection after systemic application.<br>References Leeson, P., et al.: J. Med. Chem., 37, 4053 (1994), Hilmas, C., et al.: J. Neurosci., 2001, 21, 7463 (2001), Palmer, G., et al.: Curr. Drug Targets, 2, 241 (2001), Wu, H., et al.: Exp. Neurol., 177, 222 (2002),<br></p>Fórmula:C813C2H11ClN15NO3Cor e Forma:NeatPeso molecular:245.64N-Hydroxymethyl Sumatriptan
CAS:Produto Controlado<p>Applications Hydroxymethyl Sumatriptan is an analog of Sumatriptan (S810000), a serotonin 5HT1-receptor agonist.<br>References Humphrey, P.P.A., et al.: Brit. J. Pharmacol., 94, 1123 (1988), Doenicke, A., et al.: Lancet 1, 1309 (1988),<br></p>Fórmula:C15H23N3O3SCor e Forma:NeatPeso molecular:325.435-Cyclopropyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one
CAS:Fórmula:C7H8N2OSPureza:95.0%Cor e Forma:SolidPeso molecular:168.214-(3-fluorophenyl)-6-(thiophen-2-yl)pyrimidin-2-amine
CAS:Pureza:95.0%Peso molecular:271.30999755859375Pemetrexed Sodium Methyl Ester
Produto Controlado<p>Applications Pemetrexed Sodium Methyl Ester is an impurity of Pemetrexed(P219550). Pemetrexed Disodium Heptahydrate is an chemotherapy drug for the treatment of pleural mesothelioma and non-small cell lung cancer. Pemetrexed Disodium Heptahydrate exhibit inhibitory activities towards thymidylate synthase as well as other folate dependent enzymes.<br>References Vogelzang, N.J., et al.: J. Clin. Oncol., 21,2636 (2003); Paz-Ares, L., et al.: Lancet. Oncol., 13, 247 (2012);<br></p>Fórmula:C21H22N5NaO6Cor e Forma:NeatPeso molecular:463.419Zeatin
CAS:<p>Applications Zeatin belongs to the family of plant-growth hormones called cytokinins and it can be used for agricultural use as agrochemicals for increasing crop yields and regulate various aspects of plant growth and development.<br>References Koprna, R., et al.: Bioorgan. Med. Chem., 24, 484-492 (2016)<br></p>Fórmula:C10H13N5OCor e Forma:White To Off-WhitePeso molecular:219.24Methotrexate-d3 Heptaglutamate Trifluoroacetate
CAS:Produto ControladoFórmula:C50H61D3N14O23xC2HF3O2Cor e Forma:NeatPeso molecular:1232.142LY 368962
CAS:Produto Controlado<p>Applications LY 368962 is a metabolite of the antifolate Pemetrexed (P219500).<br>References Woodland, J.M. et al.: Drug Metab. Dispos., 25, 693 (1997);<br></p>Fórmula:C19H21N5O7Cor e Forma:NeatPeso molecular:431.401-Methyl Xanthine-d3
CAS:Produto Controlado<p>Applications A labelled metabolite of Theophylline.<br>References ottrup, A., et al.: Pharmacol. Toxicol., 67, 340 (1990), El-Kadi, A., et al.: Drug Metab. Dispos., 28, 1112 (2000), Kim, S., et al.: J. Med. Chem., 45, 2131 ( 2002), Hansel, T., et al.: Drugs Today, 40, 55 (2004),<br></p>Fórmula:C62H3H3N4O2Cor e Forma:NeatPeso molecular:169.16N-Formyl Memantine
CAS:Produto Controlado<p>Applications N-Formyl Memantine is an impurity of Memantine (M218000). Memantine impurity E per USP.<br>References Gerzon, K., et al.: J. Med. Chem., 6, 760 (1963),<br></p>Fórmula:C13H21NOCor e Forma:WhitePeso molecular:207.315-Diazoimidazole-4-carboxamide
CAS:Produto Controlado<p>Impurity Temozolomide USP Related Compound A<br>Applications Temozolomide USP Related Compound A<br></p>Fórmula:C4H3N5OCor e Forma:NeatPeso molecular:137.106,6'-Binicotinic Acid
CAS:Produto Controlado<p>Applications A Nicotinic acid (N429250) derivative for treatment of hypercholesterolemia and hyperlipidemia and cardiovascular disease.<br>References Hales, N.J., et al.: J. Med. Chem., 36, 3853 (1993),<br></p>Fórmula:C12H8N2O4Cor e Forma:NeatPeso molecular:244.20Iopamidol-d8
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications Labelled Iopamidol, a nonionic radiocontrast medium. Diagnostic aid (radiopaque medium).<br>References Drayer, B., et al.: Am. J. Neuroradiol., 3, 59 (1982); Molyneux, A.J., et al.: Br. J. Radiol., 55, 117 (1982); Sovak, M., et al.: Radiology, 142, 115 (1982); Felder, E., et al.: Anal. Profiles Drug Subs., 17, 115 (1988);<br></p>Fórmula:C17H14D8I3N3O8Cor e Forma:NeatPeso molecular:785.13Sumatriptan Succinate
CAS:Produto Controlado<p>Applications Sumatriptan Succinate is a selective 5-HT1B/1D-receptor agonist with anticonvulsant properties (1,2). Sumatriptan Succinate is used for migraine relief (2).<br>References (1) Razzaque, Z., et al.: Br J Clin Pharmacol. 47, 75 (1999) (2) Cady, R. K., et al.: J Headache Pain. 18, 17 (2017)<br></p>Fórmula:C14H21N3O2S·C4H6O4Cor e Forma:White To Off-WhitePeso molecular:413.492-Hydrazino Adenosine
CAS:Produto Controlado<p>Stability Moisture Sensitive<br>Applications A useful synthetic intermediate for making potent and selective coronary vasodilators.<br>References Niiya, K., et al.: J. Med. Chem., 35, 4557 (1992)<br></p>Fórmula:C10H15N7O4Cor e Forma:NeatPeso molecular:297.27
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