Derivados de Quinazolina e Quinolina
As quinazolinas e quinolinas são compostos heterocíclicos contendo nitrogénio, com estruturas aromáticas que desempenham um papel fundamental na síntese de fármacos com atividade anticancerígena, antimicrobiana e anti-inflamatória. Os seus derivados apresentam modificações estruturais que otimizam a biodisponibilidade e a seletividade, permitindo o desenvolvimento de novos princípios ativos para diversas aplicações terapêuticas. Estes compostos são utilizados na fabricação de APIs para o tratamento do câncer, infeções, doenças neurodegenerativas e cardiovasculares. Além disso, os derivados de quinazolina e quinolina são essenciais na investigação de inibidores enzimáticos e no desenvolvimento de moléculas bioativas inovadoras.
Na CymitQuimica, oferecemos derivados de quinazolina e quinolina de alta pureza para aplicações em síntese química, desenvolvimento farmacêutico e biotecnologia.
Foram encontrados 65630 produtos de "Derivados de Quinazolina e Quinolina"
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4-{[5-(Trifluoromethyl)pyridin-2-yl]oxy}benzaldehyde
CAS:Pureza:97.0%Cor e Forma:SolidPeso molecular:267.20700073242192-[[[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl ]methyl]thio]-1H-benzimidazole
CAS:Pureza:95.0%Cor e Forma:SolidPeso molecular:343.45001220703125Zuclopenthixol
CAS:Produto ControladoFórmula:C22H25ClN2OSCor e Forma:White To Light YellowPeso molecular:400.96N-(3-pyridinylmethyl)-1,2,3,4-tetrahydro-1-naphthalenamine hydrobromide
CAS:Pureza:95.0%Peso molecular:319.2460021972656rac Efavirenz-d5 (major)
CAS:Produto Controlado<p>Applications Labelled Efavirenz (E42500). A nonnucleoside HIV-1 reverse transcriptase inhibitor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995),<br></p>Fórmula:C14H4D5ClF3NO2Cor e Forma:White To BeigePeso molecular:320.71Dacarbazine-d6
CAS:Produto Controlado<p>Applications Labelled Dacarbazine (D101400). Dacarbazine is used as an antineoplastic for treatment of malignant melanoma and sarcomas.<br>References Shealy, et al.: Biochem. Pharmacol., 11, 674 (1962), Carter, et al.: Eur. J. Cancer, 8, 85 (1972),<br></p>Fórmula:C62H6H4N6OCor e Forma:Light Yellow SolidPeso molecular:188.22Rivastigmine-d4 Tartrate Salt
CAS:Produto Controlado<p>Applications Rivastigmine-d4 Tartrate Salt, is the labeled analogue of Rivastigmine Tartrate Salt (R541000), a brain selective acetylcholinesterase inhibitor. Nootropic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rosler, M., et al.: Brit. Med. J., 318, 633 (1999), Enz, A., et al.: Prog. Brain Res., 98, 431 (1993),<br></p>Fórmula:C18H24D4N2O8Cor e Forma:NeatPeso molecular:404.45Didesmethyl Cariprazine
CAS:Produto Controlado<p>Applications Didesmethyl Cariprazine, s a derivative of Cariprazine (C183490) which is an orally active D2/D3 dopamine receptor antagonist (1,2,3). Cariprazine is an antipsychotic drug candidate for the potential treatment of schizophrenia, bipolar mania and depression.<br>References Gruender, G.: Curr. Opin. Invest. Drugs, 11, 823 (2010); Seneca, N. et al.: Psychopharmacology, 218, 579 (2011); Kiss, B. et al.: J. Pharmacol. Exp. Therap., 333, 328 (2010)<br></p>Fórmula:C19H28Cl2N4OCor e Forma:NeatPeso molecular:399.36Naproxen-d3
CAS:Produto Controlado<p>Applications Naproxen-d3 is an isotopic compound of Naproxen (N377520). Naproxen is a a nonsteroidal anti-inflammatory compound with analgesic and antipyretic properties.<br>References Harrison, I.T., et al.: J. Med. Chem., 13, 203 (1970)<br></p>Fórmula:C14H11D3O3Cor e Forma:Off-White To BeigePeso molecular:233.2810α-Hydroxy Naloxone
CAS:Produto Controlado<p>Impurity Naloxone EP Impurity C<br>Applications 10α-Hydroxy Naloxone is a hydroxylated analog of the opioid antagonist Naloxone (N285000(P)), which is a specific opioid antagonist; narcotic antagonist.<br>References Jasinski, D.R., et al.: J. Pharmacol. Exp. Ther., 157, 420 (1967), McNicholas, L.F., et al.: Drugs, 27, 81 (1984), Hasson, M.M.A., et al.: Anal. Profiles Drug Subs., 14, 453 (1985), Stowe, C., et al.: Ann. Pharmacother., 27, 447 (1993)<br></p>Fórmula:C19H21NO5Cor e Forma:NeatPeso molecular:343.372-(2-(Pyridin-2-yl)-1H-indol-3-yl)ethanamine hydrochloride
CAS:Pureza:95.0%Peso molecular:273.76000976562510-(2-(1-Methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine
CAS:Pureza:95.0%Peso molecular:370.570007324218754-Methylbenzenesulfonic Acid Monohydrate
CAS:Produto Controlado<p>Impurity Lisinopril EP Impurity B/ Anastrozole EP Impurity F<br>Applications 4-Methylbenzenesulfonic Acid Monohydrate (Lisinopril EP Impurity B) is used in the synthesis of resveratrol. Also used in the synthesis of oxane derivatives as antimalarial agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Davis, M. et al.: Org. Prep. Proc. Int., 45, 304 (2013); Wang, X. et al.: J. Med. Chem., 56, 2547 (2013);<br></p>Fórmula:C7H8O3S·H2OCor e Forma:WhitePeso molecular:190.22(S)-2-Aminobutyramide Hydrochloride
CAS:Produto Controlado<p>Impurity Levetiracetam USP Related Compound B<br>Applications Levetiracetam USP Related Compound B<br></p>Fórmula:C4H10N2O·ClHCor e Forma:White To Off-WhitePeso molecular:138.60Ref: 10-F530491
1gA consultar2gA consultar5gA consultar100mgA consultar250mgA consultar500mgA consultar1-[5-(Hydroxymethyl)-2-furyl]-2-methyl-1,2,3,4-tetrahydroisochinolin-4,8-diol
CAS:Produto Controlado<p>Applications 1-[5-(Hydroxymethyl)-2-furyl]-2-methyl-1,2,3,4-tetrahydroisochinolin-4,8-diol is a degradation product of phenylephrine during the synthesis of the anti-cold medicine.<br>References Dousa, M. et al.: J. Pharm. Biomed. Anal., 55, 949 (2011);<br></p>Fórmula:C15H17NO4Cor e Forma:NeatPeso molecular:275.37-Amino-5-chloro-2(3H)-benzoxazolone
CAS:Produto ControladoFórmula:C7H5ClN2O2Cor e Forma:NeatPeso molecular:184.581,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 3-Methyl Ester
CAS:<p>Impurity Nicardipine USP Related Compound A<br>Applications 1,4-Dihydropyridine derivative used in the prevention and therapy of atherosclerotic degradation of arterial walls. Nicardipine USP Related Compound A.<br>References Henry, P.D., et al.: Clin. Invest. Med., 10, 601 (1987), Weinstein, D.B., et al.: Am. J. Med., 86, 27 (1989), Gaviraghi, G., et al.: Pharmacol. Res., 31, 251 (1995),<br></p>Fórmula:C16H16N2O6Cor e Forma:Light YellowPeso molecular:332.31Riluzole-13C,15N2
CAS:Produto ControladoFórmula:C713CH5F315N2OSCor e Forma:Light Beige To Light YellowPeso molecular:237.18Omeprazole Sulfide Hydrochloride
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications Omeprazole Sulfide Hydrochloride is a metabolite of Omeprazole (O635000), which binds covalently to proton pump. It inhibits gastric secretion. Used as an anttiulcerative.<br>References Muller, P., et al.: Arzneimittel-Forsch., 33, 1685 (1983); Wallmark, B., et al.: Biochim. Biophys. Acta., 778, 549 (1984); Morii, M., et al.: J. Biol. chem., 268, 21553 (1993); Ritter, M., et al.: Br. J. Pharmacol., 124, 627 (1998)<br></p>Fórmula:C17H19N3O2S·HClCor e Forma:NeatPeso molecular:329.42 + 36.46ent-Ezetimibe
CAS:<p>Applications An enantiomeric impurity of Ezetimibe (E975005).<br></p>Fórmula:C24H21F2NO3Cor e Forma:White To Off-WhitePeso molecular:409.43Sulindac Sulfone Acyl-β-D-Glucuronide
CAS:Produto Controlado<p>Applications Sulindac Sulfone Acyl-β-D-Glucuronide is the major metabolite of the non-steroidal anti-inflammatory drug Sulindac (S699215) in plasma and urine.<br>References Hucker, H.B., et al.: Drug Metab. Dispos., 1, 721 (1973),<br></p>Fórmula:C26H25FO10SCor e Forma:NeatPeso molecular:548.53Medetomidine-13C,d3 Hydrochloride
CAS:Produto Controlado<p>Applications Labelled α2-adrenergic agonist. Sedative; analgesic.<br>References Scheinin, M., et al.: Br. J. Clin. Pharmacol., 24, 443 (1987), Stenberg, D., et al.: J. Vet. Pharmacol. Ther., 10, 319 (1987), Virtanen, R., et al.: Eur. J. Pharmacol., 150, 9 (1988), Cullen, L.K., et al.: Br. Vet. J., 152, 519 (1996),<br></p>Fórmula:CC122H3H13N2·ClHCor e Forma:White To Light YellowPeso molecular:240.75Desmethyl Doxylamine
CAS:<p>Impurity Doxylamine EP Impurity C<br>Applications Desmethyl Doxylamine is an impurity of Doxylamine (D562000), an H1 Histamine receptor antagonist used as a antihistaminic and sedative agent.<br>References Pande, S.S., et al.: Int. J. Pharmtech. Res., 3, 209 (2011); Tiford, C.H., et al.: J. Am. Chem. Soc., 70, 4001 (1948);<br></p>Fórmula:C16H20N2OCor e Forma:NeatPeso molecular:256.342,3,5-Trimethylpyridine N-Oxide
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications Intermediate in the preparation of Omeprazole metabolites<br></p>Fórmula:C8H11NOCor e Forma:Off-White To Light BrownPeso molecular:137.182-((6-Chloropyridin-3-yl)methyl)isoindoline-1,3-dione
CAS:Pureza:95.0%Peso molecular:272.69000244140625Demethyl Benzydamine Hydrochloride
CAS:Produto Controlado<p>Applications A metabolite of Benzydamine (B209950).<br>References Kataoka, S., et al.: Chem. Pharma. Bull., 21, 358 (1973),<br></p>Fórmula:C18H22ClN3OCor e Forma:Off White SolidPeso molecular:331.84N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide
CAS:Fórmula:C14H22N4OCor e Forma:Off-White To BeigePeso molecular:262.354-tert-Butylaminoethyl-2-methylphenol
CAS:Produto Controlado<p>Impurity Salbutamol EP Impurity H<br>Applications 4-tert-Butylaminoethyl-2-methylphenol (Salbutamol EP Impurity H) is an impurity of Albuterol Sulfate (Salbutamol Sulfate) (A514500). Albuterol impurity H.<br>References Epshtein, N., et al.: Pharm. Chem. J., 38, 212 (2004), Erram, S., et al.: J. Pharm. Biomed. Anal., 40, 864 (2006),<br></p>Fórmula:C13H21NOCor e Forma:NeatPeso molecular:207.31S-(-)-Etomidate
CAS:Produto Controlado<p>Applications Etomidate (E933300) is a hypnotic. This is a stereoisomer.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Goetz, E., et al.: Anaesthesist, 23, 331 (1974), Chang, Z. L., et al.: Anal. Profiles Drug Subs., 12, 191 (1983),<br></p>Fórmula:C14H16N2O2Cor e Forma:NeatPeso molecular:244.29Saquinavir-d9
CAS:Produto Controlado<p>Applications Labelled Saquinavir (S135000). A selective HIV protease inhibitor. Antiviral.<br>References Roberts, N.A., et al.: Science, 248, 358 (1990), Craig, J.C., et al.: Antiviral Res., 16, 295 (1991),<br></p>Fórmula:C38H41D9N6O5Cor e Forma:NeatPeso molecular:679.90N-Nitrosocinacalcet
Produto ControladoFórmula:C22H21F3N2OCor e Forma:Colourless To Light YellowPeso molecular:386.41Suprofen
CAS:<p>Applications Prostaglandin biosynthesis inhibitor. Analgesic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Niemegeers, C.J.E., et al.: Arzneim.-Forsch., 25, 1537 (1975),<br></p>Fórmula:C14H12O3SCor e Forma:BeigePeso molecular:260.316-chloro-2-(3-methylphenyl)quinoline-4-carboxylic acid
CAS:Pureza:95.0%Peso molecular:297.7399902343752,3-Di-furan-2-yl-quinoxaline-6-carboxylic acid
CAS:Cor e Forma:SolidPeso molecular:306.27700805664062-(piperazin-1-yl)quinazolin-4(3H)-one dihydrochloride
CAS:Pureza:95.0%Peso molecular:303.19000244140625Toltrazuril
CAS:Produto Controlado<p>Applications A triazinetrione anticoccidial. Coccidiostat.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Eberts, T., et al.: Clin. Chem., 25, 1440 (1979), Goodwin, M., et al.: Avian Dis., 29, 630 (1985), Sorensen, S., et al.: Clin. Chim. Acta, 264, 103 (1997), Conway, D., et al.: Poult. Sci., 280, 426 (2001),<br></p>Fórmula:C18H14F3N3O4SCor e Forma:Off WhitePeso molecular:425.382-(chloromethyl)-5-(5-methylthiophen-2-yl)-1H,4H-thieno[2,3-d]pyrimidin-4-one
CAS:Pureza:95%Peso molecular:296.7900085449219Selexipag
CAS:Produto Controlado<p>Applications Selexipag is an orally available, highly selective, long-acting prostacyclin (IP) receptor agonist prodrug. It is a potential drug for the treatment of various vascular disorders such as pulmonary arterial hypertension and arteriosclerosis obliterans.<br>References Kuwano, K., et al.: J. Pharm. Exp. Ther., 322, 1181 (2007);<br></p>Fórmula:C26H32N4O4SCor e Forma:Light YellowPeso molecular:496.623-[(5S)-(4-Fluorophenyl)-5-hydroxypentanoyl]-(4S)-phenyl-1,3-oxazolidin-2-one
CAS:Produto Controlado<p>Applications 3-[(5S)-(4-Fluorophenyl)-5-hydroxypentanoyl]-(4S)-phenyl-1,3-oxazolidin-2-one is an intermediate of Ezetimibe (E975000, E975002), an antihyperlipoproteinemic. A cholesterol absorption inhibitor.<br>References Singh, A., et. al.: J. Molecular Catal. B., 85, 99 (2013); van Heek, M., at al.: J. Pharmacol. Exp. Ther., 283, 157 (1997); van Heek, M., at al.: Brit. J. Pharmacol., 129, 1748 (2000)<br></p>Fórmula:C20H20FNO4Cor e Forma:NeatPeso molecular:357.38Clozapine N-Oxide-d8
CAS:Produto ControladoFórmula:C18H11D8ClN4OCor e Forma:Yellow To Dark YellowPeso molecular:350.87Benzocaine
CAS:Produto Controlado<p>Applications Benzocaine is used as an anesthetic (local).<br>References Kholod, Y., et al.: Environ. Sci. Technol., 43, 9208 (2009), Fliri, A., et al.: J. Med. Chem., 52, 8038 (2009), Perez-Garrido, Alfonso; Helguera, A., et al.: J. Pharm. Sci., 98, 4557 (2009), Onoue, S., et al.: J. Pharm. Sci., 98, 3647 (2009),<br></p>Fórmula:C9H11NO2Cor e Forma:NeatPeso molecular:165.194-(2,3-Epoxypropoxy)carbazole
CAS:Produto Controlado<p>Impurity Carvedilol EP Impurity D; Carvedilol USP-D<br>Applications 4-(2,3-Epoxypropoxy)carbazole (Carvedilol EP Impurity D; Carvedilol USP-D) is an intermediate in the synthesis of Carvedilol (C184625).<br></p>Fórmula:C15H13NO2Cor e Forma:Beige SolidPeso molecular:239.27Granisetron Hydrochloride
CAS:Produto Controlado<p>Applications A specific serotonin (5HT3) receptor antagonist. Used as an antiemetic. Granisetron HCl is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy. Its main effect is to reduce the activity of the vagus nerve. It does not have much effect on vomiting due to motion sickness. This drug does not have any effect on dopamine receptors or muscarinic receptor<br>References Kilpatrick, G.J., et al.: Nature, 330, 746 (1987), Durig, T., et al.: J. Pharm. Sci., 86, 1092 (1997), Yuasa, H., et al.: Chem. Pharm. Bull., 44, 1361 (1996),<br></p>Fórmula:C18H24N4O·ClHCor e Forma:NeatPeso molecular:348.87Metomidate Hydrochloride
CAS:Produto Controlado<p>Applications Metomidate Hydrochloride is used as an anesthetic for veterinary use.<br>References Harvey, B., et al.: Vet. Rec. 122(8), 174-7 (1988); Green, C. J., et al.: Lab. Anim., 15(2), 171-5 (1981); Cadle, D. R., et al.: Vet. Rec., 98(5), 91-2 1976); Massee, K. C., et al.: Aquaculture, 134(3-4), 351-359 (1995)<br></p>Fórmula:C13H14N2O2·ClHCor e Forma:White To Off-WhitePeso molecular:266.72Riluzole 4-Trifluoromethoxy Isomer
CAS:Produto Controlado<p>Applications Riluzole 4-Trifluoromethoxy Isomer is an impurity of Riluzole (R510000), a neuroprotective agent. Modulates glutamatergic transmission. A glutamate release inhibitor. An anticonvulsant.<br>References Satyanarayana, B., et. al.: ARKIVOC, 14, 109 (2008); Mizoule, J., et al.: Neuropharmacology, 24, 767 (1985), Wahl, F., et al.: Eur. J. Pharmacol., 230, 209 (1993) Bensimon, G., et al.: N. Engl. J. Med., 330, 585 (1994)<br></p>Fórmula:C8H5F3N2OSCor e Forma:NeatPeso molecular:234.20Benzophenone-2,3,4,5,6-d5
CAS:Produto Controlado<p>Applications Benzophenone-2,3,4,5,6-d5 is derived from Benzene-d6 (B185282), which is an isotope labelled benzene, an organic compound that is a natural constituent of crude oil and one of the most basic petrochemicals.<br>References Feng, Z.X.. et al.: J. Phys. Chem. Lett. 4, 285 (2013); Pilling. M., et al.: Chem. Eng. Prog., 108, 32 (2012);<br></p>Fórmula:C13D5H5OCor e Forma:NeatPeso molecular:187.253-Deschloro-4-desfluoro-4-chloro-3-fluoro Gefitinib
CAS:Produto Controlado<p>Applications 3-Deschloro-4-desfluoro-4-chloro-3-fluoro Gefitinib is an impurity of Gefitinib (G304000); a tyrosine kinase inhibitor that targets the epidermal growth factor receptor (EGFR).<br>References Lynch, T.J., et al.: N. Engl. J. Med., 350, 2129 (2004); Engelman, J.A., et al.: Science, 316, 1039 (2007); Kris, M.G., et al.: J. Am. Med. Assoc., 290, 2149 (2003)<br></p>Fórmula:C22H24ClFN4O3Cor e Forma:NeatPeso molecular:446.90(R)-(+)-Carvedilol
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications The optically active isomer of Carvedilol (C184625), a nonselective ß-adrenergic blocker with a1-blocking activity. An antihypertensive used in the treatment of congestive heart failure.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hirohashi, M., et al.: Arzneim.-Forsch., 40, 735 (1990),<br></p>Fórmula:C24H26N2O4Cor e Forma:Off White SolidPeso molecular:406.473-Amino-5-methylpyridin-2(1H)-one
CAS:Fórmula:C6H8N2OPureza:95.0%Cor e Forma:SolidPeso molecular:124.143Telmisartan-d7
CAS:Produto Controlado<p>Applications Labelled Telmisartan (T017000). Telmisartan is an angiotensin II receptor antagonist.<br>References Wienen, W. et al.: Br. J. Pharmacol., 110, 245 (1993); Neutel, J.M. et al: Adv. Therap., 15, 206 (1998);<br></p>Fórmula:C33H23D7N4O2Cor e Forma:NeatPeso molecular:521.6631-Benzhydrylpiperazine
CAS:Produto ControladoFórmula:C17H20N2Cor e Forma:White To BeigePeso molecular:252.352,4-Diamino-6-piperidinopyrimidine (Desoxyminoxidil)
CAS:<p>Impurity Minoxidil EP Impurity E<br>Applications 2,4-Diamino-6-piperidinopyrimidine (Desoxyminoxidil) (Minoxidil EP Impurity E) is an analogue of Minoxidil (M345000).<br>References Cox, J., et al.: Adv. Drug Res., 5, 115 (1970), Watanabe., et al.: Microbiol. Immunol., 23, 1009 (1979), Nakai, H., et al.: J. Med. Chem., 31, 84 (1988), Shiraishi, M., et al.: J. Med. Chem., 32, 2214 (1989),<br></p>Fórmula:C9H15N5Cor e Forma:Off-White To BeigePeso molecular:193.254,6-Dimethyl-2-(methylsulfonyl)pyrimidine
CAS:Produto Controlado<p>Applications 4,6-Dimethyl-2-(methylsulfonyl)pyrimidine is a reactant used in the preparation of [(dimethylpyrimidinyl)oxy]diphenyl butyric acid derivatives as endothelin receptor antagonists.<br>References Xia, J., et. al.: Bioorg. Med. Chem. Lett., 21, 3894 (2011)<br></p>Fórmula:C7H10N2O2SCor e Forma:Off WhitePeso molecular:186.235-(1-Methyl-4-piperidinyl)-5H-dibenzo[a,d]cyclohepten-5-ol
CAS:Produto Controlado<p>Applications 5-(1-Methyl-4-piperidinyl)-5H-dibenzo[a,d]cyclohepten-5-ol is a derivative of Cyproheptadine (C989200) which is a first-generation antihistamine with additional anticholinergic, antiserotonergic, and local anesthetic properties. Cyproheptadine is a 5-HT2/5-HT1C serotonin receptor antagonist; H1 histamine receptor antagonist; antipruritic.<br>References Marchei, E., et al.: J. Pharm. Biomed. Anal., 41, 1633 (2006); de-Benedictis, F., et al.: Allergy, 63, 1395 (2008); Feas, X., et al.: J. Pharm. Biomed. Anal., 50, 1044 (2009); Yu, C., et al.: Talanta, 2011, 83, 1376 (2011);<br></p>Fórmula:C21H23NOCor e Forma:NeatPeso molecular:305.41Zaltoprofen
CAS:Produto Controlado<p>Applications Zaltoprofen is a non-steroidal anti-inflammatory drug. It inhibits bradykinin-induced pain responses without blocking bradykinin receptors.<br>References Hirate, K., et al.: Nerosci. Res., 54, 288 (2006); Yamamoto, M., et al.: Chirality, 2, 280 (1990); Inoue, M., et al.: J Pharmacol. Exp. Ther., 293, 662 (2000); Graven-Nielsen, T., et al.: Clin. J. Pain, 17, 2 (2001)<br></p>Fórmula:C17H14O3SCor e Forma:NeatPeso molecular:298.36Celiprolol-d9 Hydrochloride
CAS:Produto Controlado<p>Applications Labelled Celiprolol. Cardioselective β1-adrenergic blocker. Antihypertensive, antianginal.<br>References Mazzo, D.J., et al.: Anal. Profiles Drug Subs., 20, 237 (1991), Meininger, C., et al.: Biochem. J., 349, 353 (2000), Ruan, H., et al.: Diabetes, 51, 1319 (2002), Liao, Y., et al.: Circulation, 110, 692 (2004),<br></p>Fórmula:C20H25D9ClN3O4Cor e Forma:NeatPeso molecular:425.015-[[4-[3-(Aminocarbonyl)-1,4,5,7-tetrahydro-1-(4-methoxyphenyl)-7-oxo-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl]amino]pentanoic Acid
CAS:<p>Applications Apixaban Open chain Acid Is an open ring impurity of Apixaban (A726700). Apixaben is a potent, direct, selective, and orally active inhibitor of coagulation factor Xa. It is a potential new oral coagulant that may be useful prevention of venous thromboembolism in total hip, knee replacement orthopedic surgery and stroke in treatment of patient with venous thromboembolic disorder or with atrial fibrillation.<br>References Luettgen, J.M. et al.: J. Enz. Inhib. Med. Chem., 26, 514 (2011); Glanis, T. et al.: J. Thromb. Thrombol., 31, 310 (2011); barrett, Y.C. et al.: Thromb. Haemos., 105, 181 (2011);<br></p>Fórmula:C25H27N5O5Cor e Forma:Light YellowPeso molecular:477.515,6-Dihydro-3-(methylamino)-2H-1,4-thiazin-2-one Oxime Hydrochloride
CAS:Produto Controlado<p>Impurity Ranitidine EP Impurity G<br>Stability Hygroscopic<br>Applications 5,6-Dihydro-3-(methylamino)-2H-1,4-thiazin-2-one Oxime Hydrochloride (Ranitidine EP Impurity G) is a Ranitidine HCl (R120000) impurity.<br>References Wu, V., et al.: Pharmazie, 55, 508 (2000), Salameh, A., et al.: J. Food Sci., 71, E10 (2006),<br></p>Fórmula:C5H9N3OS·ClHCor e Forma:NeatPeso molecular:195.67Domperidone-d6
CAS:Produto Controlado<p>Applications A novel peripheral dopamine receptor antagonist that does not cross the blood-brain barrier; anti-emetic.<br>References Baudry, M., et al.: Arch. Pharmacol., 308, 231 (1979), Ennis, C., et al.: J. Pharm. Pharmacol., 31, 14 (1979), Brogden, R.N., Drugs, 24, 360 (1982),<br></p>Fórmula:C22H18D6ClN5O2Cor e Forma:NeatPeso molecular:431.951-[[3-[(1R)-3-[Bis(1-methylethyl)amino]-1-phenylpropyl]4-hydroxyphenyl]methyl 2-Butanedioic Acid Ester (>90%)
<p>Impurity Fesoterodine Impurity 6;<br>Applications 1-[[3-[(1R)-3-[Bis(1-methylethyl)amino]-1-phenylpropyl]4-hydroxyphenyl]methyl 2-Butanedioic Acid Ester is derived from (R)-Fesoterodine Fumarate (F321300), which is a muscarinic receptor antagonist for the treatment of Lower Urininary Tract Symptoms (LUTS). It is very similar to Tolterodine (T535800).<br>References Rogers, D., et al.: Pharmacotherapy, 20, 1092 (2000), Praharaj, S., et al.: J. Psychopharmacology, 19, 426 (2005),<br></p>Fórmula:C26H35NO5Pureza:>90%Cor e Forma:NeatPeso molecular:441.56Phthalic Hydrazide
CAS:<p>Applications Phthalic Hydrazide is a reagent in the synthesis in various pyrazolophthalazine derivatives.<br>References Rezaei, S.et al.: Tetra. Lett., 53, 5123 (2012);<br></p>Fórmula:C8H6N2O2Cor e Forma:NeatPeso molecular:162.15Dechloro Trazodone
CAS:Produto Controlado<p>Impurity Trazodone Deschloro Impurity<br>Stability Hygroscopic<br>Applications A Trazodone (T718500) impurity. An antipsychotic with potential use as a schizophrenia agent. Trazodone impurity B.<br>References Pai, N. et al.: J. Chem Pharmaceut. Res., 2, 458 (2010); Silvestrini, B., et al.: Eur. J. Pharmacol., 12, 231 (1970); Brogden, R.N., et al.: Drugs, 21, 401 (1981);<br></p>Fórmula:C19H23N5OCor e Forma:NeatPeso molecular:337.42Depropylamino Chloro Propafenone
CAS:<p>Impurity Propafenone EP Impurity E; Propafenone BP Impurity E; Propafenone USP Impurity E<br>Applications Depropylamino Chloro Propafenone (Propafenone EP Impurity E; Propafenone BP Impurity E; Propafenone USP Impurity E) is an impurity of Propafenone (D288655).<br>References Hollmann, M., et al.: Arzneim.-Forsch., 33, 763 (1983); Bryson, H. M., et al.:Drugs, 45, 85 (1993);<br></p>Fórmula:C18H19ClO3Cor e Forma:NeatPeso molecular:318.792-(4-chlorophenyl)-6-methylquinoline-4-carboxylic acid
CAS:Cor e Forma:SolidPeso molecular:297.739990234375Deferiprone-d3 3-O-β-D-Glucuronide Sodium Salt
CAS:Produto Controlado<p>Stability Very Hygroscopic<br>Applications A labelled metabolite of Deferiprone (D474000).<br>References Choudhury, R., et al.: Drug Metab. Dispos., 23, 314 (1995);<br></p>Fórmula:C13H13D3NNaO8Cor e Forma:Off-White To Light BeigePeso molecular:340.28α,α,α’,α’-Tetramethyl-5-bromomethyl-1,3-benzenediacetonitrile
CAS:Produto Controlado<p>Impurity Anastrozole EP Impurity C / Anastrozole USP Related Compound D<br>Applications α,α,α’,α’-Tetramethyl-5-bromomethyl-1,3-benzenediacetonitrile (Anastrozole EP Impurity C) is an impurity of Anastrozole (A637425) (impurity D).<br>References Ge, Z., et al.: J. Med. Chem., 13, 146 (2003),<br></p>Fórmula:C15H17BrN2Cor e Forma:NeatPeso molecular:305.21Desmethyl Mirtazapine-d6 Dihydrochloride
CAS:Produto Controlado<p>Impurity Mirtazapine<br>Applications A labelled metabolite of Mirtazapine, α2-adrenergic blocker.<br>References De Boer, T., et al.: Neuropharmacology, 27, 399 (1988), Smith, W.T., et al.: Psychopharmacol. Bull., 26, 191 (1990)<br></p>Fórmula:C16H11D6N3·2HClCor e Forma:NeatPeso molecular:330.29Febantel
CAS:Produto Controlado<p>Applications Used as an anthelmintic.<br>References Thomas, H.: Res. Vet. Sci., 25, 290 (1978), Shmidl, J.A.: Vet. Med. Small Anim. Clin., 73, 775 (1978)<br></p>Fórmula:C20H22N4O6SCor e Forma:NeatPeso molecular:446.48Gabapentin-d6 Hydrochloride
CAS:Produto Controlado<p>Applications Gabapentin Hydrochloride is a salt analogue of Gabapentin-d6 (G117253), a labelled amino acid structurally related to γ-Aminobutyric Acid (GABA), designed to cross the blood brain barrier. Used as an anticonvulsant.<br>References Vollmer, K.O. et al.: Arzneim.-Forsch., 36, 830 (1986); Saletu, B., et al.: Int. J. Clin. Pharmacol. Ther. Toxicol., 24, 362 (1986)<br></p>Fórmula:C9H11D6NO2·HClCor e Forma:NeatPeso molecular:213.73Cabozantinib Des-O-fluoroaniline
CAS:Produto Controlado<p>Applications Cabozantinib Des-O-fluoroaniline is a degradation product of Cabozantinib(C051500). Cabozantinib is a small molecule C-Met modulator. Cabozantinib shows dose-dependent inhibition of tumor growth and tumor regression, associated with disruption of the tumor vasculature and extensive tumor cell apoptosis.<br>References Camp, R., et al.: Cancer, 86, 2259 (1999), Morello, S., et al.: J. Cell Physiol., 189, 285 (2001), Zhang, Y., et al.: Oncogene, 21, 217 (2002), Wells, S., et al.: J. Clin. Oncol., 28, 767 (2010); Wu, C., et al.: J. Pharm. Biomed. Anal., 98, 356 (2014)<br></p>Fórmula:C22H20N2O6Cor e Forma:NeatPeso molecular:408.41-Methyl-3-(morpholine-4-carbonyl)-1H-pyrazole-5-carboxylic acid
CAS:Fórmula:C10H13N3O4Cor e Forma:SolidPeso molecular:239.2315,5-Diphenyl Hydantoin Sodium
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications 5,5-Diphenyl Hydantoin Sodium salt reduces incidence of grand mal seizures; appears to stabilize excitable membranes perhaps through effects on Na+, K+, and Ca2+ channels.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Faucette, S., et al.: J. Pharmacol. Exp. Ther., 320, 72 (2007), Guo, D., et al.: J. Biol. Chem., 282, 36766 (2007), Merrell, M., et al.: Drug Metab. Dispos., 36, 1716 (2008),<br></p>Fórmula:C15H11N2O2·NaCor e Forma:NeatPeso molecular:274.25Valsartan Methyl Ester
CAS:Produto Controlado<p>Impurity Valsartan USP Related Compound E<br>Applications Valsartan Methyl Ester (Valsartan USP Related Compound E) is an analog of Valsartan (V095750), is a nonpeptide angiotensin II AT1-receptor antagonist. Antihypertensive.<br>References Criscione, L., et al.: Brit. J. Pharmacol., 110, 761 (1993), Muller, P., et al.: Eur. J. Clin. Pharmacol., 47, 231 (1994)<br></p>Fórmula:C25H31N5O3Cor e Forma:NeatPeso molecular:449.55Plerixafor
CAS:<p>Stability Hygroscopic<br>Applications Plerixafor is a hematopoietic stem cell (HSC) mobilizer that inhibits the CXCR4 chemokine receptor and blocks binding of its ligand, stromal cell-derived factor-1-α (SDF-1-α). This agent was approved on Dec. 15, 2008, as treatment in combination with granulocyte-colony stimulating factor (G-CSF) to mobilize HSCs to the peripheral blood for collection and subsequent autologous transplantation in patients with non-Hodgkin's lymphoma (NHL) and multiple myeloma (MM). Selective CXCR4 antagonist.<br>References Xie, T., et al.: Science, 290, 328 (2000), Leone, D., et al.: J. Pharmacol. Exp. Ther., 305, 1150 (2003), Chigaev, A., et al.: J. Immunol. 178, 6828 (2007), Kiel, M., et al.: Cell Stem Cell, 1, 204 (2007),<br></p>Fórmula:C28H54N8Cor e Forma:Off White PowderPeso molecular:502.784’-Hydroxy Dutasteride
Produto Controlado<p>Applications 4’-Hydroxy Dutasteride is an impurity of Dutasteride (D735000), a dual inhibitor of 5α-reductase isoenzymes type 1 and 2; structurally related to Finasteride (F342000). Dutasteride is used in the treatment of benign prostatic hyperplasia.<br>References Bakshi, R.K., et al.: J. Med. Chem., 38, 3189 (1995), Gisleskog, P.O., et al.: Brit. J. Clin. Pharmacol., 47, 53 (1999), Djavan, B., et al.: Expert Opin. Pharmacother., 6, 311 (2005)<br></p>Fórmula:C27H30F6N2O3Cor e Forma:NeatPeso molecular:544.53rac Normetanephrine-d3 Hydrochloride
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications A labelled metabolite of Epinephrine (E588585). A naturally occurring derivative of Epinephrine, found together with Metanephrine in urine and in certain tissues.<br>References Eisenhofer, G., et al.: J. Clin. Endocrinol. Metab., 82, 3864 (1997), Akiyama, T., et al.: Cardiovasc. Res., 49, 78 (2001), Burke, W., et al.: Brain Res., 891, 218 (2001),<br></p>Fórmula:C92H3H10NO3·ClHCor e Forma:BeigePeso molecular:222.682,6-Dichloroaniline
CAS:<p>Impurity Diclofenac Impurity<br>Applications 2,6-Dichloroaniline (cas# 608-31-1) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>Fórmula:C6H5Cl2NCor e Forma:WhitePeso molecular:162.027-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one
CAS:Produto Controlado<p>Applications Gefitinib intermediate.<br>References Kelly, L., et al.: Cancer Cell., 1, 421 (2002), Pandey, A., et al.: J. Med. Chem., 45, 3772 (2002), Ciardiello, F., et al.: Exp. Opin Emerg. Drugs, 8, 501 (2003), Caponigro, F., et al.: Curr. Opin Oncol., 16, 225 (2004),<br></p>Fórmula:C16H21N3O4Cor e Forma:NeatPeso molecular:319.36
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