Derivados de Quinazolina e Quinolina
As quinazolinas e quinolinas são compostos heterocíclicos contendo nitrogénio, com estruturas aromáticas que desempenham um papel fundamental na síntese de fármacos com atividade anticancerígena, antimicrobiana e anti-inflamatória. Os seus derivados apresentam modificações estruturais que otimizam a biodisponibilidade e a seletividade, permitindo o desenvolvimento de novos princípios ativos para diversas aplicações terapêuticas. Estes compostos são utilizados na fabricação de APIs para o tratamento do câncer, infeções, doenças neurodegenerativas e cardiovasculares. Além disso, os derivados de quinazolina e quinolina são essenciais na investigação de inibidores enzimáticos e no desenvolvimento de moléculas bioativas inovadoras.
Na CymitQuimica, oferecemos derivados de quinazolina e quinolina de alta pureza para aplicações em síntese química, desenvolvimento farmacêutico e biotecnologia.
Foram encontrados 65924 produtos de "Derivados de Quinazolina e Quinolina"
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7,7'-[1,4-Piperazinediylbis(4,1-butanediyloxy)]bis-2(1H)-quinolinone
CAS:Produto ControladoFórmula:C30H36N4O4Cor e Forma:NeatPeso molecular:516.631-Bromo-2-(bromomethyl)-4,5-dimethoxybenzene
CAS:Produto Controlado<p>Applications 1-Bromo-2-(bromomethyl)-4,5-dimethoxybenzene is used in the synthesis of novel histone deacetylase 1 inhibitors (HDAC 1). Also used in the synthesis of antibacterial gemifloxacin derivatives.<br>References Sun, Q. et al.L: Bioorg. Med. Chem. Lett., 23, 3295 (2013); Feng, L. et al. Eur. J. Med. Chem., 55, 125 (2012);<br></p>Fórmula:C9H10Br2O2Cor e Forma:NeatPeso molecular:309.98N-Ethylcarbamic Acid 3-[(1S)-1-(Dimethylamino)ethyl]phenyl Ester
CAS:Produto ControladoFórmula:C13H20N2O2Cor e Forma:NeatPeso molecular:236.31Deacetyl Racecadotril Disulfide
CAS:Produto Controlado<p>Applications Deacetyl Racecadotril Disulfide is an impurity of Racecadotril (R070600); an antidiarrheal and enkephalinase inhibitor that reduces the amount of water and electrolytes into the intestine.<br>References Cezard, J., et al.: Gastroenterol., 120, 799 (2001); Sato, T., et al.: J. Med. Chem., 51, 7705 (2008); Lakshmana, P., et al.: J. Pharm. Res., 8, 39 (2009); Fournie-Zaluski, Marie Claude., et al.: J. Med. Chem., 35(13), 2473-81 (1992)<br></p>Fórmula:C38H40N2O6S2Cor e Forma:NeatPeso molecular:684.86rac N-Desmethyl Mephenytoin-D5 (Major)
CAS:Produto Controlado<p>Applications An anticonvulsant, hypnotic. A labelled metabolite of Mephentoin.A representative lot was 85% d5; 15% d4 1% d3 with no detectable d0.<br>References Karlaganis, G., et al.: Drug Metab. Dispos., 8, 173 (1980), Knabe, J., et al.: Arch. Phar., 313, 538 (1980),<br></p>Fórmula:C112H5H7N2O2Cor e Forma:NeatPeso molecular:209.261-(2,4-Bis(benzyloxy)phenyl)ethanone
CAS:Produto Controlado<p>Applications 1-(2,4-Bis(benzyloxy)phenyl)ethanone is a useful research chemical for organic synthesis and other chemical processes.<br>References Chen, D., et al.: Eur. J. Med. Chem., 87, 765 (2014); Malik, N., et al.: Tetrahedron Lett., 54, 4121 (2013)<br></p>Fórmula:C22H20O3Cor e Forma:NeatPeso molecular:332.394-Chlorophenothiazine
CAS:Produto Controlado<p>Applications Intermediate in the preparation of Prochlorperazine (P755800) and related compound.<br></p>Fórmula:C12H8ClNSCor e Forma:NeatPeso molecular:233.725-Chloro-N-methylthiophene-2-carboxamide
CAS:Produto Controlado<p>Applications 5-Chloro-N-methylthiophene-2-carboxamide is an impurity of Rivaroxaban (R538000), which is a novel antithrombotic agent. A highly potent and selective, direct FXa inhibitor.<br>References Ansell, J., et al.: Drugs, 64, 1 (2004), Eriksson, B., et al.: J. Thromb. Haemost., 3, 103 (2005), Kubitza, D., et al.: Clin. Pharmacol. Ther., 78, 412 (2005),<br></p>Fórmula:C6H6ClNOSCor e Forma:NeatPeso molecular:175.64XL518
CAS:Produto Controlado<p>Applications A potent, selective, orally bioavailable inhibitor of MEK1, a component of the RAS/RAF/MEK/ERK pathway. It inhibits proliferation and stimulates apoptosis in a variety of human tumor cell lines. In preclinical xenograft models, oral administration of XL518 results in sustained inhibition of pERK in tumor tissue, but not brain tissue, leading to tumor growth inhibition and regression at well tolerated doses.<br>References Rosen, L.S. et al.: J. Clin. Oncol., 26, 14585 (2008);<br></p>Fórmula:C21H21F3IN3O2Cor e Forma:White To Off-WhitePeso molecular:531.317-Hydroxyquinoline-(1H)-2-one
CAS:Produto ControladoFórmula:C9H7NO2Cor e Forma:NeatPeso molecular:161.16Ketoconazole N-Oxide
CAS:Produto Controlado<p>Applications Ketoconazole N-Oxide is an impure analogue of Ketoconazole (K186000) which inhibits cytochrome P-450 dependent steps in the biosynthesis of steroid hormones in vivo. Antimetastatic and antineoplastic activity. Orally active 5-lipoxygenase and thromboxane synthase inhibitor.<br>References Lambert, A., et al.: Biochem. Pharmacol., 35, 3999 (1986), Van Wauwe, J.P. and Janssen, P.A.J., J. Med. Chem., 32, 2231 (1989), Nardone, P.A., et al.: . Surg. Res., 44, 425 (1988), Tucker, W.F.G., et al.: Br. Med. J., 293, 882 (1986)<br></p>Fórmula:C26H28Cl2N4O5Cor e Forma:Off-WhitePeso molecular:547.43OPC 14714
CAS:Produto Controlado<p>Impurity Aripiprazole Impurity<br>Applications A novel antipsychotic agents with dopamine autoreceptor agonist properties. Aripiprazole Impurity<br>References Simpson, G., et al.: Drugs, 1981, 21, 138 (1981), Banno, K., et al.: Chem. Pharm. Bull., 36, 4377 (1988), Momiyama, T., et al.: Life Sci., 47, 761 (1990), Caprathe, B., et al.: J. Med. Chem., 34, 2736 (1991),<br></p>Fórmula:C23H28BrN3O2Cor e Forma:White To Off-WhitePeso molecular:458.393,4-Dichloro Trazodone Dihydrochloride
CAS:Produto Controlado<p>Applications 3,4-Dichloro Trazodone is the dichlorinated analogue and impurity of the antidepressant agent Trazodone (T718500).<br>References Pai, N.R. et al.: J. Chem. Pharmac. Res., 2, 458 (2010); Pai, N. et al.: Int. J. Pharmac. Sci. Rev. Res., 4, 180 (2010);<br></p>Fórmula:C19H21Cl2N5O•2HCiCor e Forma:NeatPeso molecular:406.31236462-Fluoro-4-desfluoro Bicalutamide
CAS:Produto Controlado<p>Impurity Bicalutamide EP Impurity B<br>Applications Bicalutamide impurity. Bicalutamide derivative.<br>References Tucker, H., et al.: J. Med. Chem., 31, 954 (1988),<br></p>Fórmula:C18H14F4N2O4SCor e Forma:NeatPeso molecular:430.3734Quetiapine Dimer Impurity-d8
CAS:Produto Controlado<p>Applications An impurity of labelled Quetiapine.<br>References Xu, H., et al.: J. Pharm. Biomed. Anal., 47, 658 (2008), Stolarczyk, E., et al.: Pharm. Develop. Technol., 14, 27 (2009),<br></p>Fórmula:C30H16D8N4S2Cor e Forma:NeatPeso molecular:512.724-Hydroxy Ramelteon
CAS:<p>Applications A metabolite of Ramelteon (R110051)<br></p>Fórmula:C16H21NO3Cor e Forma:Off White SolidPeso molecular:275.345-Sulfosalicylic Acid Dihydrate
CAS:Produto Controlado<p>Applications 5-Sulfosalicylic Acid Dihydrate is for reducing and fixation of proteins in agarose and polyacrylamide gels.<br></p>Fórmula:C7H6O6S·2H2OCor e Forma:WhitePeso molecular:254.21Efavirenz 1-Desamine-1-oxy
Produto Controlado<p>Applications Efavirenz 1-Desamine-1-oxy is an analog of Efavirenz (E425000), a nonnucleoside HIV-1 reverse transcriptase inhibitor. Antiviral.<br>References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995)<br></p>Fórmula:C14H8ClF3O3Cor e Forma:NeatPeso molecular:316.66rac Dropropizine
CAS:Produto Controlado<p>Applications Dropropizine is a cough suppressant and central sedative therapeutic agent.<br>References Bakken, G., et al.: J. Med. Chem., 43, 4534 (2000), Salunkhe, M., et al.: Enz. Microb. Technol., 28, 333 (2001), Atul, B., et al.: J. Pharm. Sci., 91, 2067 (2002),<br></p>Fórmula:C13H20N2O2Cor e Forma:WhitePeso molecular:236.315’-Oxo Amisulpride
CAS:Produto Controlado<p>Applications 5’-Oxo Amisulpride is an impurity of the dopamine receptor antagonist Amisulpride (A633250).<br></p>Fórmula:C17H25N3O5SCor e Forma:Off-WhitePeso molecular:383.46Nilotinib 3-Imidazolyl N-oxide
CAS:Produto Controlado<p>Applications 4-Methyl-3-(4-pyridin-3-yl)pyrimidin-2-yl]amino-N-(5-(3-oxo-4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)phenyl)benzamine is an impurity compound of Nilotinib (N465300), useful in the treatment of chronic myelogenous leukemia. It is a COVID19-related research product.<br>References Wei-Sheng H., et al.: Synthesis, 14, 2121 (2007); Corbin, A., et al.: J. Biol. Chem., 277, 32214(2002), Golemovic, M., et al.: Clin. Cancer Res., 11, 4941 (2005), Gleixner, K., et al.: Blood, 107, 752 (2006), Nicolini, F., et al.: Leukemia, 20, 1061 (2006),<br></p>Fórmula:C28H22F3N7O2Cor e Forma:NeatPeso molecular:545.52Efavirenz Amino Alcohol Ethyl Carbamate
CAS:Produto Controlado<p>Applications Efavirenz Amino Alcohol Ethyl Carbamate is used in the synthesis of Efavirenz (E425000), a potent non-nucleoside HIV-1 reverse transcriptase inhibitor. Antiviral<br>References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995)<br></p>Fórmula:C16H15ClF3NO3Cor e Forma:NeatPeso molecular:361.74O-Desethyl Resiquimod-d6
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications O-Desethyl Resiquimod-d6 is the labelled analogue of O-Desethyl Resiquimod (D228575), which is derived from its parent compound Resiquimod (R144680), which is an imidazoquinoline derivative that acts as an immune response modifier. Resiquimod shows antitumor and antiviral activity and is used in the treatment of skin lesions such as herpes simplex virus. Resiquimod is a toll-like receptor 9 (TLR7) agonist.<br>References Wu, J.J. et al.: Antivir. Res., 64, 79 (2004); Fife, K.H. et al.: Antimicrob. Agents Chemother., 52, 477 (2008); Szeimies, R.M. et al.: Brit. J. Dermatol., 159, 205 (2008);<br></p>Fórmula:C15H12D6N4O2Cor e Forma:NeatPeso molecular:292.374-Fluoro-2-(hydroxymethyl)phenol
CAS:Produto Controlado<p>Applications 4-Fluoro-2-(hydroxymethyl)phenol can be used in preparation of naphthyridine derivatives as chemokine receptor antagonists useful in the treatment of pain.<br>References Wang, X., et al.: PCT Int. Appl., WO 2013010453 A1 20130124 (2013)<br></p>Fórmula:C7H7FO2Cor e Forma:NeatPeso molecular:142.128Ambroxol Cycloimine Impurity
CAS:Produto Controlado<p>Applications 4-(6,8-Dibromo-3(4H)-quinazolinyl)-cyclohexanol is an impurity of Ambroxol (A575900), a bronchosecretolytic drug.<br>References Jauch, R., et al.: Arzneim-Forsch., 13, 474 (1963)<br></p>Fórmula:C14H16Br2N2OCor e Forma:NeatPeso molecular:388.0976Palbociclib
CAS:<p>Applications Palbociclib (also known as compound number PD-0332991) is an experimental drug for the treatment of breast cancer being developed by Pfizer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6.<br>References Finn, R., et al.: Breast Cancer Res., 11, 5 (2009);<br></p>Fórmula:C24H29N7O2Cor e Forma:NeatPeso molecular:447.531-Nitroso-4-phenylpiperazine
CAS:Produto Controlado<p>Applications Metabolite of N-Phenylpiperazine (P336040) found in wastewater treatment facilities.<br>References Jung, C. et al., Appl. Environ. Microb., 74, 6147 (2008)<br></p>Fórmula:C10H13N3OCor e Forma:NeatPeso molecular:191.232-Amino Edoxaban Methanesulfonate
CAS:Produto ControladoFórmula:C16H22ClN5O3•(CH4O3S)Cor e Forma:NeatPeso molecular:463.93Valsartan Decarboxylic Acid
CAS:Produto ControladoFórmula:C23H29N5OCor e Forma:NeatPeso molecular:391.5093Cilostazol-d4
CAS:Produto Controlado<p>Applications Cilostazol-d4 is the labeled analogue of Cilostazol (C441500), a potent phosphodiesterase III A (PDE3A) inhibitor (IC50=0.2uM) and inhibitor of adenosine uptake. Has antimitogeni, antithrombotic, vasodilatory and cardiotonic properties in vivo. Also affects lipid levels in vivo.<br>References Suri, A., et al.: J. Clin. Pharmacol., 38, 144 (1998); Park, S.-W., et al.: Am. J. Cardiol., 84, 511 (1999); Tsuchikane, E., et al.: Circulation, 100, 21 (1999)<br></p>Fórmula:C20H23D4N5O2Cor e Forma:NeatPeso molecular:373.49N-Nitroso-desethyl-Hydroxychloroquine
Produto ControladoFórmula:C16H21ClN4O3Cor e Forma:NeatPeso molecular:336.8175-(4'-Methyl-2-biphenyl)tetrazole-d4
CAS:Produto Controlado<p>Applications Labelled Valsartan (V095750) impurity.<br>References Thai, H., et al.: J. Cardiovasc. Pharmacol., 50, 703 (2007), Lukas, J., et al.: Science, 313, 662 (2006),<br></p>Fórmula:C14H8D4N4Cor e Forma:Off-WhitePeso molecular:240.3011-(4-(4-(tert-Butyl)phenyl)-4-hydroxybutyl)-4-piperidinecarboxylic Acid Ethyl Ester
CAS:Produto ControladoFórmula:C22H35NO3Cor e Forma:NeatPeso molecular:361.52Selexipag D-Mannitol Ester (>80%)
Produto ControladoFórmula:C31H41N3O8Pureza:>80%Cor e Forma:NeatPeso molecular:583.68(4S3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(S)-[(4-fluorophenyl)amino][4-[(trimethylsilyl)oxy]phenyl]methyl]-1-oxo-5-[(trimethylsilyl)oxy]pentyl]-4-phenyl-2-oxazolidinone
CAS:Produto Controlado<p>Applications (4S3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(S)-[(4-fluorophenyl)amino][4-[(trimethylsilyl)oxy]phenyl]methyl]-1-oxo-5-[(trimethylsilyl)oxy]pentyl]-4-phenyl-2-oxazolidinone is used in the synthesis of Ezetimibe (E975000), an antihyperlipoproteinemic; a cholesterol absorption inhibitor.<br>References Bankowski, K., et. al.: Przemysl Chemiczny, 91, 289 (2012); van Heek, M., at al.: J. Pharmacol. Exp. Ther., 283, 157 (1997); van Heek, M., at al.: Brit. J. Pharmacol., 129, 1748 (2000)<br></p>Fórmula:C39H46F2N2O5Si2Cor e Forma:NeatPeso molecular:716.961(±)-Epinephrine-2,5,6,α,β,β-d6
CAS:Produto Controlado<p>Applications (±)-Epinephrine-2,5,6,alpha,beta,beta-d6 (CAS# 1219803-77-6) is a useful isotopically labeled research compound.<br></p>Fórmula:C92H6H7NO3Cor e Forma:NeatPeso molecular:189.24rac trans-2-Phenylcyclopropylamine Hydrochloride
CAS:Produto Controlado<p>Applications Non-selective MAO-A/B inhibitor.<br>References Stout, S.C., et al.: J. Pharmacol. Exp. Ther., 300, 1085 (2002),<br></p>Fórmula:C9H11N·ClHCor e Forma:NeatPeso molecular:169.65L-Valinol
CAS:Produto Controlado<p>Applications L-Valinol is used as a reagent in the synthesis of simple 1,3-thiazolidine-2-thione derivatives which can exhibit fungicidal activity. L-Valinol is also used as a reagent in the synthesis of small-molecule inhibitors of MDM2-p53 protein-protein interaction (MDM2 inhibitors) in clinical trials for the treatment of cancer.<br>References Chen, N., et al.: Phosphorus Sulfur, 190, 112 (2015); Zhao, Y., et al.: J. Med. Chem., 58, 1038 (2015)<br></p>Fórmula:C5H13NOCor e Forma:WhitePeso molecular:103.1634-Hydroxy Propranolol β-D-Glucuronide (Mixture of Diastereomers)
CAS:Produto Controlado<p>Applications A metabolite of 4-Hydroxy propranolol. Antihypertensive; antianginal; antiarrhythmic (class II).<br>References Walle, T., et al.: Clin. Pharmacol. Ther., 46, 257 (1989), Christ, D.D., et al.: Drug Metab. Dispos., 18, 1 (1990),<br></p>Fórmula:C22H29NO9Cor e Forma:NeatPeso molecular:451.47Olanzapine-d3 (1 mg/ml in Acetonitrile)
CAS:Produto ControladoFórmula:C172H3H17N4SCor e Forma:ColourlessPeso molecular:315.45Thiorphan Disulfide
CAS:Produto Controlado<p>Applications Thiorphan Disulfide is an impurity of Racecadotril (R070600); an antidiarrheal and enkephalinase inhibitor that reduces the amount of water and electrolytes into the intestine.<br>References Cezard, J., et al.: Gastroenterol., 120, 799 (2001); Sato, T., et al.: J. Med. Chem., 51, 7705 (2008); Lakshmana, P., et al.: J. Pharm. Res., 8, 39 (2009); Fournie-Zaluski<br></p>Fórmula:C24H28N2O6S2Cor e Forma:NeatPeso molecular:504.62Desmethyl-N-propyl Imiquimod
CAS:Produto Controlado<p>Applications Desmethyl-N-propyl Imiquimod is a pharmacologically active compound related to Imiquimod (I475000), an immune response modifier. It stimulates the production of Interferon-a.<br>References Megyeri, K., et al.: Mol. Cell Biol., 15, 2207, (1995), Witt, P.L., et al.: Cancer Res., 53, 5176 (1993), Edwards, L., et al.: Arch. Dermatol., 134, 25 (1998); Gerster, J. et al.: J. Med. Chem., 48, 3481 (2005);<br></p>Fórmula:C13H14N4Cor e Forma:NeatPeso molecular:226.28Tipelukast
CAS:Produto Controlado<p>Applications Tipelukast a novel oral anti-inflammatory agent, suppresses bladder hyperactivity in a rat model.<br>References Rajasekaran, M., et. al.: BJU Int., 98, 430 (2006)<br></p>Fórmula:C29H38O7SCor e Forma:NeatPeso molecular:530.67(S)-Rivastigmine
CAS:<p>Applications S-Rivastigmine is an isomer of Rivastigmine ( an acetylcholinesterase inhibitor used in the treatment of neurological disorders such as Alzheimer’s disease.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Howes, L et al.: Drug. Safe., 37, 391 (2014); Shahar, O. et al.: Nucl. Acids Res., 42, 5869 (2014);<br></p>Fórmula:C14H22N2O2Cor e Forma:ColourlessPeso molecular:250.343-[(1E)-2-[4-[[(2-Carboxyethyl)amino]carbonyl]phenyl]diazenyl] Balsalazide Sodium Salt (>90%)
CAS:Produto Controlado<p>Applications An impurity of the anti-inflammatory drug Balsalazide (B116300).<br></p>Fórmula:C27H24N6O9xNaPureza:>90%Cor e Forma:NeatPeso molecular:576.51(free acid)N-Desethyl N-Methyl rac-Rivastigmine
CAS:<p>Impurity Rivastigmin USP Related Compound B<br>Applications N-Desethyl N-Methyl rac-Rivastigmine (Rivastigmin USP Related Compound B) is an impurity in the synthesis of Rivastigmine (R541000) a brain selective acetylcholinesterase inhibitor. Nootropic.<br>References Rosler, M., et al.: Brit. Med. J., 318, 633 (1999), Enz, A., et al.: Prog. Brain Res., 98, 431 (1993),<br></p>Fórmula:C13H20N2O2Cor e Forma:Clear ColourlessPeso molecular:236.31Clonidine
CAS:Produto Controlado<p>Applications Clonidine is an α2-Adrenergic agonist. Antihypertensive; analgesic for neuropathic pain.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Roach, A.G., et al.: J. Pharmacol. Exp. Ther., 227, 421 (1983); Glassman, A.H., et al.: Science, 226, 864 (1984); Abounassif, A.M., et al.: Anal. Profiles Drug Subs. Excip., 21, 109 (1992);<br></p>Fórmula:C9H9Cl2N3Cor e Forma:NeatPeso molecular:230.092-[[(3aR,4S,6R,6aS)-6-[[5-Amino-6-chloro-2-(propylthio)-4-pyrimidinyl]amino]tetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol
CAS:Produto Controlado<p>Applications 2-[[(3aR,4S,6R,6aS)-6-[[5-Amino-6-chloro-2-(propylthio)-4-pyrimidinyl]amino]tetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol is used as a reagent in the synthesis of Ticagrelor (T437700) derivatives as antiplatelet agents.<br>References Zhang, H., et al.: Bioorg. Med. Chem. Lett., 22, 3598 (2012)<br></p>Fórmula:C17H27ClN4O4SCor e Forma:NeatPeso molecular:418.94Dacomitinib
CAS:Produto Controlado<p>Applications Dacomitinib is an Erb-inhibitor, or an inhibitor of the members of the epidermal growth factor receptor family. Used as an ant-cancer agent due to observation of over-expressed epidermal growth factor receptor in nearly all cases of squamous cell carcinoma in the head and neck.<br>References Williams, J. et al.: PLoS., 9, e98557 (2014); Peters, S. et al.: Canc. Treatment Rev., 40, 917 (2014);<br></p>Fórmula:C24H25ClFN5O2Cor e Forma:NeatPeso molecular:469.944-Desisopropyl-4-ethyl Nateglinide
CAS:Produto Controlado<p>Applications D-phenylanaline derivative and an analog Nateglinide (N379375) with similar hypoglycemic activity.<br>References Shinkai, H. et al.: J. Med. Chem., 32, 1436 (1989);<br></p>Fórmula:C18H25NO3Cor e Forma:NeatPeso molecular:303.40(E)-Naftifine
CAS:<p>Applications (E)-Naftifine is an intermediate in synthesizing Naftifine N-Oxide (N213110), which is an impurity or metabolite of Naftifine Hydrochloride (N213100), an allylamine antifungal agent.<br>References Georgopoulos, A., et al.: Antimicrob. Ag. Chemother., 19, 386 (1981); Meingassner, J.C., et al.: J. Invest. Dermatol., 77, 444 (1981); Paltauf, F., et al.: Biochim Biophys. Acta, 712, 268 (1982); Aggarwal, D., et al.: J. Pharm. Pharmacol., 56, 1509 (2004)<br></p>Fórmula:C21H21NCor e Forma:NeatPeso molecular:287.404-(4-Amino-1-oxoisoindolin-2-yl)-4-carbamoyl Butyric Acid
CAS:Produto ControladoFórmula:C13H15N3O4Cor e Forma:Off WhitePeso molecular:277.28Safinamide-d4
CAS:Produto Controlado<p>Applications Safinamide-d4 is a labelled analogue of Safinamide. Safinamide is a potent and selective MAO-B inhibitor, and is used as an add-on treatment to treat Parkinson’s disease.<br>References Finberg, J.P.M., et al.: Front Pharmacol., 7, 340-54 (2016);<br></p>Fórmula:C17D4H15FN2O2Cor e Forma:NeatPeso molecular:306.368α-Phenyl-2-pyridineacetamide
CAS:Produto Controlado<p>Applications α-Phenyl-2-pyridineacetamide (cas# 7251-52-7) is a compound useful in organic synthesis.<br></p>Fórmula:C13H12N2OCor e Forma:NeatPeso molecular:212.25N-Desmethyl-4'-hydroxy Tamoxifen-d3 (E/Z Mixture)
CAS:Produto Controlado<p>Applications A labelled metabolite of the anti-cancer drug Tamoxifen (T006000).<br>References Heiman, D., et al.: J. Med. Chem., 23, 994 (1980), Kier, L., et al.: Pharm. Res., 7, 801 (1990),<br></p>Fórmula:C25H24D3NO2Cor e Forma:NeatPeso molecular:376.513-O-Benzyl-4,5-O-(1-methylethyldiene)-β-D-fructopyranose
CAS:Produto Controlado<p>Applications Intermediate in the preparation of 2,3-Desisopropylidene Topiramate, a metabolite of Topiramate<br></p>Fórmula:C16H22O6Cor e Forma:NeatPeso molecular:310.34Diclazuril 6-Carboxylic Acid Butyl Ester
CAS:Produto Controlado<p>Applications Diclazuril 6-carboxylic acid butyl ester is an impurity of Diclazuril (D436200), a nucleotide analog with broad-spectrum anticoccidial activity. Coccidiostat.<br>References Maes, L., et al.: J. Parasitol., 74, 931 (1988),<br></p>Fórmula:C22H17Cl3N4O4Cor e Forma:NeatPeso molecular:507.753-(3-Chloropropyl)-7,8-dimethoxy-1H-3-benzazepin-2(3H)-one
CAS:Produto Controlado<p>Applications 3-(3-Chloropropyl)-7,8-dimethoxy-1H-3-benzazepin-2(3H)-one is a reactant used in the synthesis of Zatebradine analogues as potential blockers od hyperpolarization-activated current.<br>References Romanelli, M. et al.: Bioorg. med. CHem., 13, 1211 (2005);<br></p>Fórmula:C15H18ClNO3Cor e Forma:NeatPeso molecular:295.76Plerixafor Hydrochloride (1:8)
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications Plerixafor Hydrochloride (1:8), is an immunostimulant used to mobilize hematopoietic stem cells in cancer patients. It is a hematopoietic stem cell (HSC) mobilizer that inhibits the CXCR4 chemokine receptor and blocks binding of its ligand, stromal cell-derived factor-1-α (SDF-1-α).<br>References Xie, T., et al.: Science, 290, 328 (2000), Leone, D., et al.: J. Pharmacol. Exp. Ther., 305, 1150 (2003), Chigaev, A., et al.: J. Immunol. 178, 6828 (2007), Kiel, M., et al.: Cell Stem Cell, 1, 204 (2007),<br></p>Fórmula:C28H54N8·8ClHCor e Forma:NeatPeso molecular:794.473-Hexyl Chloroformate (>80%)
CAS:<p>Stability Air Sensitive, Moisture Sensitive<br>Applications 3-Hexyl Chloroformate is a potential impurity in the synthesis of Dabigatran Etexilate Mesylate (D100150); a nonpeptide and direct thrombin inhibitor. Antithrombotic.<br>References Zheng, Y., et al.: Org. Process Res. Dev., 18, 744 (2014); Hauel, N., et al.: J. Med. Chem., 45, 1757 (2002); Mungall, D., et al.: Curr. Opin. Invest. Drugs, 3, 095 (2002); Stangier, J., et al.: J. Clin. Pharmacol., 45, 555 (2005)<br></p>Fórmula:C7H13ClO2Pureza:>80%Cor e Forma:NeatPeso molecular:164.63N-Des(4-Fluorophenyl)-N-(3-chlorophenyl)-ezetimibe
CAS:Produto ControladoFórmula:C24H21ClFNO3Cor e Forma:NeatPeso molecular:425.88Ticagrelor Acetate
CAS:Produto Controlado<p>Applications Ticagrelor Acetoxide is an acetoxy impurity of Ticagrelor (T437700). Ticagrelor (T437700), the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Used in the treatment of acute coronary syndromes (ACS).<br>References Matetzky, S., et al.: Circulation, 109, 3171 (2004), Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007), Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007)<br></p>Fórmula:C25H30F2N6O5SCor e Forma:White To Off-WhitePeso molecular:564.610-Acetyloxy Oxcarbazepine
CAS:Produto Controlado<p>Applications An intermediate in the preparation of Carbamazepine metabolites.<br>References Heckendorn, R., et al.: Helv. Chimica Acta, 70, 1955 (1987),<br></p>Fórmula:C17H14N2O4Cor e Forma:NeatPeso molecular:310.30rac Methyl Efavirenz (Mixture of Diastereomers)
CAS:Produto Controlado<p>Applications Efavirenz (E425000) potential synthetic impurity and degradation product.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Phelan, P., et al.: J. Chromatogr. Sci., 19, 13 (1981), Mangia, A., et al.: Anal. Chim. Acta., 149, 349 (1983), Careri, M., et al.: J. Chromatogr., 647, 79 (1993), van Beek, T., et al.: Phytochem. Anal., 6, 1 (1995),<br></p>Fórmula:C15H11ClF3NO2Cor e Forma:NeatPeso molecular:329.70Anastrozole EP Impurity E (2-[3-(Cyanodimethylmethyl)-5-hydroxymethylphenyl]-2-methylpropionitrile)
CAS:Produto Controlado<p>Impurity Anastrozole EP Impurity E<br>Applications 2-[3-(Cyanodimethylmethyl)-5-hydroxymethylphenyl]-2-methylpropionitrile (Anastrozole EP Impurity E ) is an impurity of Anastrozole (A637425), an aromatase inhibitor which functions as an antineoplastic (1,2). Anastrozole is used in post-menopausal women with advanced breast cancer.<br>References 1. Plourde, P. et al.: Breast Cancer Res Treat. 1994;30(1):103-112. Buzdar, A. et al.: Cancer. 1997 Feb 15;79(4):730-9.<br></p>Fórmula:C15H18N2OCor e Forma:NeatPeso molecular:242.322-(Trifluoroacetyl)-4-chloroaniline, Hydrochloride Hydrate
CAS:Produto Controlado<p>Applications HIV reverse transcriptase inhibitor.<br></p>Fórmula:C8H5ClF3NO·ClHCor e Forma:NeatPeso molecular:260.04(R)-Ofloxacin-d3
CAS:Produto Controlado<p>Applications A labelled fluorinated quinolone antibacterial. An enantiomer of Levofloxacin (L360000).<br>References Hwangbo, H.J. et al.: Eur. J. Pharmac. Sci., 18, 197 (203); Gascon, A.R. et al.: J. Clin. Pharmacol, 40, 869 (2000); Monk, J.P., et al.: Drugs, 33, 346 (1987); Drlica, K., Curr. Opin. Microbiol. 2, 504 (1990);<br></p>Fórmula:C182H3H17FN3O4Cor e Forma:NeatPeso molecular:364.396-Hydroxy-7-methoxy-4(1H)-quinazolinone
CAS:Produto Controlado<p>Applications 6-Hydroxy-7-methoxy-4(1H)-quinazolinone is a reactant used in the preparation of 4-anilinoquinazoline derivatives that have shown antitumor activities. 6-Hydroxy-7-methoxy-4(1H)-quinazolinone was also used as a reactant in the synthetic preparation of 2-arylbenzothiazoles as kinase inhibitors.<br>References Chandregowda, V., et al.: Eur. J. Med. Chem., 44, 3046 (2009); Tasler, S., et al.: Bioorg. Med. Chem. Lett., 17, 6728 (2009);<br></p>Fórmula:C9H8N2O3Cor e Forma:BeigePeso molecular:192.17Carvedilol Bisalkylpyrocatechol Impurity
CAS:Produto Controlado<p>Applications A new known impurity of Carvedilol (C184625), published in Carvedilol USP monograph.<br></p>Fórmula:C40H42N4O6Cor e Forma:NeatPeso molecular:674.78Thioridazine 2-Sulfone
CAS:Produto Controlado<p>Impurity Thioridazine EP Impurity E<br>Applications Thioridazine 2-Sulfone (Thioridazine EP Impurity E) is a major metabolite of Thioridazine (THD 2-SO2).<br>References Niedzwiecki, D., et al.: J. Pharmacol. Exp. Ther., 250, 126 (1989), Eap, C., et al.: Ther. Drug Monit., 13, 356 (1991), Shah, P., et al.: J. Pharm. Sci., 81, 309 (1992), Eap, C., et al.: J. Pharm. Biomed. Anal., 11, 451 (1993), Blake, B., et al.: Xenobiotica, 25, 337 (1995),<br></p>Fórmula:C21H26N2O2S2Cor e Forma:NeatPeso molecular:402.57Loratadine Impurity F
CAS:Produto Controlado<p>Impurity Loratadine EP Impurity F; Loratadine USP Related Compound G Impurity<br>Applications Loratadine Impurity F (Loratadine EP Impurity F; Loratadine USP Related Compound G Impurity) is a fluorinated analog of Loratadine (L469575), which is a nonsedating-type histamine H1-receptor.<br>References Bruttmann, G., et al.: J. Allergy Clin. Immunol., 83, 411 (1989), Haria, M., et al.: Drugs, 48, 617 (1994)<br></p>Fórmula:C22H24ClFN2O2Cor e Forma:White To Off-WhitePeso molecular:402.89N-Nitroso-(1S,2R)-ephedrine
CAS:Produto ControladoFórmula:C10H14N2O2Cor e Forma:NeatPeso molecular:194.23R-Mirtazapine
CAS:Produto Controlado<p>Applications R-Mirtazapine is an enantiomer of Mirtazapine (M365000); an antidepressant. R-Mirtazapine showed antinociceptive effects in acute thermal nociception, whereas S-Mirtazapine showed pronociceptive effects.<br>References Muth-Selbach, Uta., et al.: Brain Res. Bull., 79(1), 63-68 (2009); Smith, Donald F., et al.: Psychopharmacology, 200(2), 273-279 (2008); Freynhagen, Rainer., et al.: Brain Res. Bull., 69(2), 168-173 (2006)<br></p>Fórmula:C17H19N3Cor e Forma:NeatPeso molecular:265.35Hydroxy Varenicline N-Trifluoroacetic Acid Salt
CAS:Produto Controlado<p>Applications Protected Varenicline metabolite.<br></p>Fórmula:C15H12F3N3O2Cor e Forma:NeatPeso molecular:323.27Verapamil Ethyl Methanethiosulfonate, Bromide
CAS:Produto Controlado<p>Applications An analog of Verapamil. P Glycoprotein drug binding domain verapamil methanethiosulfonate. Useful for mapping the pore region of L-type calcium channels and Kv1.3 potassium channels.<br>References Loo, T., et al.: J. Biol. Chem., 270, 843 (1995), Sharom, F., et al.: J. Membr. Biol., 160, 161 (1997), Kim, R., et al.: J. Clin. Invest., 101, 289 (1998), Lee, C., et al.: Biochemistry., 37, 3594 (1998),<br></p>Fórmula:C30H45N2O6S2·BrCor e Forma:NeatPeso molecular:673.72Oprozomib
CAS:Produto Controlado<p>Applications Oprozomib is the second class of proteasome inhibitors with higher specificities and reduced toxicities, against head and neck squamous cell carcinoma.<br>References Zang, Y., et al.: Autophagy., 8, 1837 (2012); Zang, Y., et al.: Clin. Cancer. Res., 18, 5639 (2012); Mato, A.R., et al.: Oncologist., 17, 694 (2012); Zhou, H.J., et al.: J. Med. Chem., 52, 3028 (2009);<br></p>Fórmula:C25H32N4O7SCor e Forma:NeatPeso molecular:532.61Sulcotrione-d7
CAS:Produto ControladoFórmula:C14D7H6ClO5SCor e Forma:Light Yellow SolidPeso molecular:335.81Afatinib Impurity AFT-8
CAS:Produto Controlado<p>Applications Afatinib Impurity AFT-8 is an impurity of its parent compound Afatinib (A355300), which is an aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder.<br></p>Fórmula:C24H27ClFN5O4Cor e Forma:NeatPeso molecular:503.954(1S,3S)-1-(1,3-Benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic Acid Methyl
CAS:Produto Controlado<p>Applications Tadalafil (T004500) derivative. Used in the preparation of pyrazinopyridoindole derivatives for their PDE5 inhibitory activity.<br>References Beghyn, T. et al.: Bioorgan. Med. Chem. Lett. 17, 789(2007)<br></p>Fórmula:C20H18N2O4Cor e Forma:Off White SolidPeso molecular:350.37Raltegravir Potassium Salt
CAS:Produto ControladoFórmula:C20H20FN6O5·KCor e Forma:NeatPeso molecular:482.51Hydroxy Iloperidone-d4
CAS:Produto Controlado<p>Applications A hydroxylated labelled metabolite of Iloperidone (I267200).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mutlib, A., et al.: Drug Metab. Dispos., 23, 951 (1995), Westerink, B., et al.: Eur. J. Pharmacol., 412, 127 (2001),<br></p>Fórmula:C24H25D4FN2O4Cor e Forma:Off White SolidPeso molecular:432.52Dronedarone-d6 Hydrochloride
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications A drug used for the treatment of atrial fibrillation and atrial flutter in patients who have suffered cardiac arrhythmias.<br>References Singh, B., et al.: J. Cardiovas. Pharmacol., 52, 300 (2008), Hoy, S., et al.: Drugs, 69, 1647 (2009), Hohnloser, S., et al.: New Eng. J. Med., 360, 668 (2009),<br></p>Fórmula:C31H39D6ClN2O5SCor e Forma:NeatPeso molecular:599.25Moxonidine
CAS:Produto Controlado<p>Applications Moxonidine is an antihypertensive agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rayment, S., et al.: Brit. J. Pharmacol., 160, 1727 (2010), Taksande, B., et al.: Eur. J. Pharmacol., 637, 89 (2010), Nasr, M., et al.: Vas. Pharmacol., 53, 53 (2010),<br></p>Fórmula:C9H12ClN5OCor e Forma:NeatPeso molecular:241.68N-Nitroso Cyamemazine Impurity
Produto ControladoFórmula:C18H18N4OSCor e Forma:NeatPeso molecular:338.427Ofloxacin N-Oxide Hydrochloride
CAS:Produto ControladoFórmula:C18H20FN3O5·ClHCor e Forma:Off-WhitePeso molecular:413.83Ethionamide Sulfoxide-D3
CAS:Produto ControladoFórmula:C8D3H7N2OSCor e Forma:NeatPeso molecular:185.26Ethyl (2R,4S)-4-Methylpipecolate, 90%
CAS:Produto Controlado<p>Applications Ethyl (2R,4S)-4-Methylpipecolate is an intermediate in the preparation of Argatroban (A769000).<br>References Hilpert, K. et al.: J. Med. Chem., 37, 3889 (1994), Kim, K. et al.: Med. Chem. Res., 6, 377 (1996),<br></p>Fórmula:C9H17NO2Pureza:>90%Cor e Forma:NeatPeso molecular:171.246,8-Dioxo Apalutamide
CAS:Produto Controlado<p>Applications 6,8-Dioxo Apalutamide is an impurity of Apalutamide (A726120). Apalutamide is a second-generation antiandrogen used in the treatment of prostate cancer.<br>References Li, Huifang, et al.: J. of Chem. Info. and Model., 53(1), 123-130 (2013);Joseph, James D., et al.: Cancer Disc., 3(9), 1020-1029 (2013)<br></p>Fórmula:C21H15F4N5O3Cor e Forma:NeatPeso molecular:461.385-Amino-4-(4-nitro-1-oxoisoindolin-2-yl)-5-oxopentanoic Acid
CAS:Produto ControladoFórmula:C13H13N3O6Cor e Forma:Off-WhitePeso molecular:307.259m-Salicylic Acid
CAS:Produto Controlado<p>Applications m-Salicylic Acid is widely used in organic synthesis. It is also an important active metabolite of aspirin (A187780).<br>References Haynes, M., et al.: CRC H.b Chem. Phys., 92, 306 (2011)<br></p>Fórmula:C7H6O3Cor e Forma:Off-WhitePeso molecular:138.12
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