
Derivados de Quinazolina e Quinolina
As quinazolinas e quinolinas são compostos heterocíclicos contendo nitrogénio, com estruturas aromáticas que desempenham um papel fundamental na síntese de fármacos com atividade anticancerígena, antimicrobiana e anti-inflamatória. Os seus derivados apresentam modificações estruturais que otimizam a biodisponibilidade e a seletividade, permitindo o desenvolvimento de novos princípios ativos para diversas aplicações terapêuticas. Estes compostos são utilizados na fabricação de APIs para o tratamento do câncer, infeções, doenças neurodegenerativas e cardiovasculares. Além disso, os derivados de quinazolina e quinolina são essenciais na investigação de inibidores enzimáticos e no desenvolvimento de moléculas bioativas inovadoras.
Na CymitQuimica, oferecemos derivados de quinazolina e quinolina de alta pureza para aplicações em síntese química, desenvolvimento farmacêutico e biotecnologia.
Foram encontrados 65630 produtos de "Derivados de Quinazolina e Quinolina"
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1-(6-Methylpyridin-3-yl)-2-((4-(2-(6-methylpyridin-3-yl)-2-oxoethyl)phenyl)sulfonyl)ethanone
CAS:Produto ControladoFórmula:C22H20N2O4SCor e Forma:NeatPeso molecular:408.47Gabapentin Ethyl Ester Hydrochloride
CAS:Produto Controlado<p>Applications Protected Gabapentin (G117250). Amino acid structurally related to γ-Aminobutyric Acid (GABA), designed to cross the blood brain barrier. Used as an anticonvulsant.<br>References Vollmer, K.-O. et al.: Arzneimittel-Forshc., 36, 830 (1986), Saletu, B., et al.: Int. J. Clin. Pharmacol. Ther. Toxicol., 24, 362 (1986)<br></p>Fórmula:C11H21NO2·ClHCor e Forma:NeatPeso molecular:235.752-epi-Darunavir
CAS:<p>Applications 2-epi-Darunavir is a stereoisomer to Darunavir (D193500), a second generation HIV-1-protease inhibitor; structurally similar to amprenavir. Antiviral. It is a COVID19-related research product.<br>References Rao, R.N., et. al.: J. Sep. Sci., 35, 2671 (2012); Koh, Y., et al.: Antimicrob. Agents Chemother., 47, 3123 (2003); Arasteh, K., et al.: AIDS, 19, 943 (2005); Surleraux, D.L.N.G., et al.: J. Med. Chem., 48, 1813 (2005)<br></p>Fórmula:C27H37N3O7SCor e Forma:NeatPeso molecular:547.661-Nitroso-4-phenylpiperazine
CAS:Produto Controlado<p>Applications Metabolite of N-Phenylpiperazine (P336040) found in wastewater treatment facilities.<br>References Jung, C. et al., Appl. Environ. Microb., 74, 6147 (2008)<br></p>Fórmula:C10H13N3OCor e Forma:NeatPeso molecular:191.234-(5-Chloro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-formylpiperidine
CAS:Produto Controlado<p>Impurity Buspirone EP Impurity B<br>Applications An impurity of the gastrokinetic and antinauseant drug Domperidone (D531100).<br></p>Fórmula:C13H14ClN3O2Cor e Forma:BeigePeso molecular:279.72Hydroxynorketamine Hydrochloride
CAS:Produto Controlado<p>Applications Hydroxynorketamine is a metabolite of Ketamine (K165300, HCl salt) which is a medication used mainly for starting and maintaining anesthesia.<br>References Adams, J., et al.: Biomed. Mass Spec., 11, 527 (1981); Sass, W.C., et al.: Anal. Profiles Drug Subs., 6, 297 (1977); Reich, D.L., et al.: Can. J. Anaesth., 36, 186 (1989)<br></p>Fórmula:C12H15Cl2NO2Cor e Forma:White To Off-WhitePeso molecular:276.16Ibrutinib Addition Adduct with (R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)
CAS:Fórmula:C47H46N12O3Cor e Forma:Off-WhitePeso molecular:826.952-Butyl-1,3-diazaspiro[4.4]non-1-en-4-one Hydrochloride
CAS:Produto Controlado<p>Impurity Irbesartan Lactam Impurity<br>Applications 2-Butyl-1,3-diazaspiro[4.4]non-1-en-4-one is an intermediate of Irbesartan (Avapro) (I751000).<br>References Gillis, J., et al.: Drugs, 54, 885 (1997), Chando, T., et al.: Drug Metab. Disps., 26, 408 (1998), Hines, J., et al.: Eur. J. Pharmacol., 384, 81 (1999),<br></p>Fórmula:C11H18N2O·ClHCor e Forma:NeatPeso molecular:230.732-Bromomethyl-6-nitrobenzoic Acid Methyl Ester
CAS:Produto ControladoFórmula:C9H8BrNO4Cor e Forma:Light YellowPeso molecular:274.071,3-Bis(bromomethyl)-5-methylbenzene
CAS:Produto Controlado<p>Impurity Anastrozole 1,3-Dibromomethyl Impurity<br>Applications 1,3-Bis(bromomethyl)-5-methylbenzene is a reagent used in the synthesis of sphingosine kinase 2 inhibitors. Anastrozole 1,3-Dibromomethyl Impurity<br>References Congdon, M. et al.: Bioorg. Med. Chem. Lett., 25, 4956 (2015);<br></p>Fórmula:C9H10Br2Cor e Forma:NeatPeso molecular:277.98Lornoxicam-d4
CAS:Produto Controlado<p>Applications Labelled Lornoxicam. Cyclooxygenase inhibitor; structurally similar to tenoxicam. Anti-inflammatory; analgesic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ankier, S.I., et al.: Postgrad. Med. J., 64, 752 (1988), Tricerri, M., et al.: Chem. Phys. Lipids, 71, 61 (1994), Santos, N., et al.: Biochemistry, 37, 8674 (1998), Pellicano, A., et al.: Infect. Immun., 75, 1738 (2007),<br></p>Fórmula:C132H4H6ClN3O4S2Cor e Forma:NeatPeso molecular:375.844-Desmethoxypropoxyl-4-chloro Rabeprazole Sulfide
CAS:Produto Controlado<p>Applications A process impurity of Rabeprazole (R070500).<br>References Pingili, R.R., et al.: Pharmazie, 60, 814 (2005),<br></p>Fórmula:C14H12ClN3SCor e Forma:NeatPeso molecular:289.78Leflunomide EP Impurity F
CAS:Produto ControladoFórmula:C12H9F3N2O2Cor e Forma:WhitePeso molecular:270.21Tilidine-d6 Hydrochloride (100μg/ml in Methanol)
CAS:Produto ControladoFórmula:C172H6H17NO2·ClHCor e Forma:ColourlessPeso molecular:315.87Riociguat Nitroso Impurity 1
Produto ControladoFórmula:C18H16FN9OCor e Forma:NeatPeso molecular:393.15β-Tetralone
CAS:Produto Controlado<p>Applications β-Tetralone is the 2-keto derivative of Tetralin. β-Tetralone was initially reported to be a metabolite of Tetralin but was later found to be just an artifact in the metabolism process. β-Tetralone is known to be biological marker in fossil fuels.<br>References Elliott, T.H. et al.: Biochem. J., 108, 551 (1968); Armstrong, D. et al.: Microchem. J., 57, 149 (1997);<br></p>Fórmula:C10H10OCor e Forma:NeatPeso molecular:146.19(R)-(+)-Tolvaptan
CAS:Produto Controlado<p>Applications An enantiomer of Tolvaptan. It is a selective, competitive arginine vasopressin V2 receptor antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH).<br>References Paterna, S., et al.: Eur. J. Heart Fail, 2, 305 (2000), Udelson, J., et al.: Circulation, 104, 2417 (2001), Goldsmith, S., et al.: J. Am. Coll Cardiol., 46, 1785 (2005), Schrier, R., et al.: N. Engl. J. Med., 355, 2099 (2006),<br></p>Fórmula:C26H25ClN2O3Cor e Forma:Off White SolidPeso molecular:448.944-Hydroxy Phenylbutazone
CAS:<p>Applications Impurity in the production of Phenylbutazone (P319570)<br>References Fricoteaux, R., et al.: J. Pharm. Biomed. Anal., 7, 1585 (1989), Segrestaa, J., et al.: Chem. Pharm. Bull., 50, 744 (2002),<br></p>Fórmula:C19H20N2O3Cor e Forma:White To Off-WhitePeso molecular:324.37Isoproturon-d3
CAS:Produto Controlado<p>Applications Labelled Isoproturon. Pre-and post-emergence herbicide for control of annual grasses and broad-leaved weeds. Herbicide.<br>References Fournier, J.-C., et al.: Chemosphere, 4, 207 (1975), Gonzales, P., et al.: Weed Res., 23, 39 (1983),<br></p>Fórmula:C122H3H15N2OCor e Forma:White To Off-WhitePeso molecular:209.302-(2,4-Difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)-1,2-propanediol
CAS:Produto Controlado<p>Impurity Fluconazole EP Impurity F<br>Stability Hygroscopic<br>Applications 2-(2,4-Difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)-1,2-propanediol (Fluconazole EP Impurity F) is a diol impurity of the antifungal agent Fluconazole (F421000).<br>References Dongre, V.G. et al.: J. Pharmac. Biomed. Anal., 42, 334 (2006):<br></p>Fórmula:C11H11F2N3O2Cor e Forma:Light YellowPeso molecular:255.22rac FTY720-d4 Phosphate
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications Labelled rac FTY720 (F805010). rac FTY720 is a sphingosine 1-phosphate receptor modular, ameliorates experimental autoimmune encephalomyelitis by inhibition of T cell infiltration.<br>References Igarashi, J., et al.: J. Biol. Chem., 275, 32363 (2000), Bandhuvula, P., et al.: J. Biol. Chem., 280, 33697 (2005),<br></p>Fórmula:C19H30D4NO5PCor e Forma:NeatPeso molecular:391.48Indomethacin Ethyl Ester
CAS:Produto ControladoFórmula:C21H20ClNO4Cor e Forma:Off-WhitePeso molecular:385.84(3S)-1-[2-(3-Ethenyl-4-hydroxyphenyl)ethyl]-α,α-diphenyl-3-pyrrolidineacetamide
CAS:Produto ControladoFórmula:C28H30N2O2Cor e Forma:NeatPeso molecular:426.557,7’-[(1,4-Butanediyl)bis(oxy)]bis-2(1H)quinolinone
CAS:<p>Applications 7,7’-[(1,4-Butanediyl)bis(oxy)]bis-2(1H)quinolinone is an impurity of Brexpiprazole (B677385), which is a drug candidate useful in treatment and prevention of mental disorders including CNS disorders.<br>References Yamashita, H., et al.: PCT Int. Appl., WO 2006112464 A1 20061026 (2006)<br></p>Fórmula:C22H20N2O4Cor e Forma:NeatPeso molecular:376.4053-(3-Chloropropyl)-7,8-dimethoxy-1H-3-benzazepin-2(3H)-one
CAS:Produto Controlado<p>Applications 3-(3-Chloropropyl)-7,8-dimethoxy-1H-3-benzazepin-2(3H)-one is a reactant used in the synthesis of Zatebradine analogues as potential blockers od hyperpolarization-activated current.<br>References Romanelli, M. et al.: Bioorg. med. CHem., 13, 1211 (2005);<br></p>Fórmula:C15H18ClNO3Cor e Forma:NeatPeso molecular:295.762-(Trifluoroacetyl)-4-chloroaniline, Hydrochloride Hydrate
CAS:Produto Controlado<p>Applications HIV reverse transcriptase inhibitor.<br></p>Fórmula:C8H5ClF3NO·ClHCor e Forma:NeatPeso molecular:260.042-Chloromethyl-4-methoxy-3-methylpyridine Hydrochloride
CAS:Produto Controlado<p>Applications A pyridine derivative used in the preparation of anti-ulcerative agents and other pharmaceutical compounds.<br>References Kuehler, T.C. et al.: J. Med. Chem., 38, 4906 (1995);<br></p>Fórmula:C8H10ClNO·ClHCor e Forma:NeatPeso molecular:208.08rac Cinacalcet-d3 Hydrochloride
CAS:Produto Controlado<p>Applications Clinical trial in secondary hyperparathyroidism.<br>References Franceschini N., et al.: Expert Opin. Invest. Drugs, 12, 1413 (2003), Block, G.A., et al.: N. Engl. J. Med. 350, 1516 (2004),<br></p>Fórmula:C222H3H19F3N·ClHCor e Forma:NeatPeso molecular:396.89Moxonidine
CAS:Produto Controlado<p>Applications Moxonidine is an antihypertensive agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rayment, S., et al.: Brit. J. Pharmacol., 160, 1727 (2010), Taksande, B., et al.: Eur. J. Pharmacol., 637, 89 (2010), Nasr, M., et al.: Vas. Pharmacol., 53, 53 (2010),<br></p>Fórmula:C9H12ClN5OCor e Forma:NeatPeso molecular:241.68Diclazuril 6-Carboxylic Acid Butyl Ester
CAS:Produto Controlado<p>Applications Diclazuril 6-carboxylic acid butyl ester is an impurity of Diclazuril (D436200), a nucleotide analog with broad-spectrum anticoccidial activity. Coccidiostat.<br>References Maes, L., et al.: J. Parasitol., 74, 931 (1988),<br></p>Fórmula:C22H17Cl3N4O4Cor e Forma:NeatPeso molecular:507.75cis-Hydroxy Solifenacin N-Oxide(Mixture of Diastereomers)
Produto Controlado<p>Applications Solifenacin (S676700) metabolite.<br></p>Fórmula:C23H26N2O4Cor e Forma:NeatPeso molecular:394.46Efavirenz 1-Desamine-1-oxy
Produto Controlado<p>Applications Efavirenz 1-Desamine-1-oxy is an analog of Efavirenz (E425000), a nonnucleoside HIV-1 reverse transcriptase inhibitor. Antiviral.<br>References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995)<br></p>Fórmula:C14H8ClF3O3Cor e Forma:NeatPeso molecular:316.66Ticagrelor Acetate
CAS:Produto Controlado<p>Applications Ticagrelor Acetoxide is an acetoxy impurity of Ticagrelor (T437700). Ticagrelor (T437700), the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Used in the treatment of acute coronary syndromes (ACS).<br>References Matetzky, S., et al.: Circulation, 109, 3171 (2004), Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007), Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007)<br></p>Fórmula:C25H30F2N6O5SCor e Forma:White To Off-WhitePeso molecular:564.6Methylphenidate Carboxylic Acid Hydrochloride
CAS:Produto Controlado<p>Applications O-Desmethyl Methylphenidate Carboxylic Acid is a derivative of Methylphenidate Hydrochloride (M325880), controlled substance (stimulant). CNS stimulant. Methylphenidate Carboxylic Acid Hydrochloride is a 4:1 Mixture of R533105 (DL-erythro Ritalinic Acid Hydrochloride) and R533110 (DL-threo-Ritalinic Acid Hydrochloride)<br>References Greenblatt, E.N., et al.: J. Pharmacol. Exp. Ther., 131, 115 (1961), Padmanabhan, G.R., Anal. Profiles Drug Subs., 10, 473 (1981), Srinivas, N.R., et al.: Pharm. Res., 10, 14 (1993),<br></p>Fórmula:C13H17NO2·HClCor e Forma:Off-WhitePeso molecular:255.74Ibrutinib Dimer (~90%)
CAS:<p>Applications Ibrutinib Dimer is a dimer impurity of Ibrutinib (I124970), a highly selective Bruton’s tyrosine kinase (Btk) irreversible inhibitor.<br>References MacGlashan, D., et. al.: Int. Immunol., 11, 475 (2011)<br></p>Fórmula:C50H48N12O4Pureza:~90%Cor e Forma:NeatPeso molecular:880.993-Amino-4-(2,4,5-trifluorophenyl)butanyl Sitagliptin
CAS:Produto Controlado<p>Applications 3-Amino-4-(2,4,5-trifluorophenyl)butanyl Sitagliptin is an impurity of Sitagliptin (S490990). Sitagliptin is a trizolopyrazine dipeptidyl peptidase IV inhibitor. It has recently been approved for the therapy of type II diabetes.<br>References Kim, D., et al.: J. Med. Chem., 48, 141 (2005), Ahren, B., et al.: Eur. J. Pharmacol., 521 164 (2005), Bergman, A., et al: Clin. Ther., 28, 55 (2006)<br></p>Fórmula:C26H23F9N6O2Cor e Forma:NeatPeso molecular:622.4854Ezetimibe Hydroxy β-D-Glucuronide
CAS:Produto Controlado<p>Applications A metabolite of Ezetimibe. Antilipemic.<br>References Shah, V., et al.: J. Pharm. Sci., 17, 1551 (2000), Van Heek, M., et al.: Br. J. Pharmacol., 134, 409 (2001), Patrick, J., et al.: Drug Metab. Dispos., 30, 430 (2002),<br></p>Fórmula:C30H29F2NO9Cor e Forma:NeatPeso molecular:585.55N-Desmethyl-4'-hydroxy Tamoxifen-d3 (E/Z Mixture)
CAS:Produto Controlado<p>Applications A labelled metabolite of the anti-cancer drug Tamoxifen (T006000).<br>References Heiman, D., et al.: J. Med. Chem., 23, 994 (1980), Kier, L., et al.: Pharm. Res., 7, 801 (1990),<br></p>Fórmula:C25H24D3NO2Cor e Forma:NeatPeso molecular:376.51Bis(thiazol-5-yl-methyl)[carbonylbis[imino[(2S,3S,5S)-3-hydroxy-1,6-diphenylhexane-5,2-diyl]]]dicarbamate
Produto ControladoFórmula:C47H52N6O7S2Cor e Forma:NeatPeso molecular:877.08Brivaracetam-d7 (Mixture of Diastereomers)
Produto Controlado<p>Applications Brivaracetam-d7 (Mixture of Diastereomers), is a mixture of 2 diastereomers of Brivaracetam-d7 (B677647), and a labeled analogue of Brivaracetam (B677645), 4-n-propyl analog of levetiracetam (L331500), and a racetam derivative with anticonvulsant properties.<br>References Rosenstiel, P., et al.:Neurotherapeutics, 4 (1), 84 (2007); Malawska, B., et al.:, Curr. Opin. Investig. Drugs, 6(7), 740 (2005);<br></p>Fórmula:C11H13D7N2O2Cor e Forma:NeatPeso molecular:219.33Carboxyamidotriazole
CAS:Produto Controlado<p>Applications Carboxyamidotriazole is an orally active calcium channel blocker. Carboxyamidotriazole also exhibits inhibition of pro-inflammatory cytokines in tumor associated macrophages as potential anti-cancer mechanism.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ju, R., et al.: Euro. J. Cancer., 48, 1085 (2012); Corrado, C., et al.: Cancer. lett., 300, 205 (2011);<br></p>Fórmula:C17H12Cl3N5O2Cor e Forma:NeatPeso molecular:424.673-(5-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzenamine
CAS:Produto Controlado<p>Stability Air Sensitive<br>Applications 3-(5-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzenamine is used in the preparation of c-Src and Abl inhibitors based on the scaffold present in Imatinib (G407000), used in the treatment of myelogenic leukemia. It is a COVID19-related research product.<br>References Seeliger, M. et al.: Canc. Res., 69, 2384 (2009); Schindler, T., et al.: Science, 289, 1938 (2000); Drucker, B.J., et al.: N. Engl. J. Med., 344, 1031 (2001)<br></p>Fórmula:C11H10N3F3Cor e Forma:NeatPeso molecular:241.21DL-threo-Droxidopa-d3 Hydrochloride Salt Hydrate
CAS:Produto Controlado<p>Applications DL-threo-Droxidopa-d3 Hydrochloride Salt Hydrate is an isotope labeled compound of DL-threo-Droxidopa (D689950), a synthetic amino acid precursor of Norepinephrine. An Antiparkinson.<br>References Bartholini, J., et al.: J. Pharmacol. Exp. Ther ., 193, 523 (1975), Kato, T., et al.: Biochem. Pharmacol., 36, 3051 (1987), Kawabata, A., et al.: Br J. Pharmacol., 111, 503 (1994)<br></p>Fórmula:C9H8D3NO5•HCl•x(H2O)Cor e Forma:NeatPeso molecular:216.2136461802N-trifluoroacetyl Varenicline
CAS:Produto Controlado<p>Applications 7,8,9,10-Tetrahydro-8-(trifluoroacetyl)-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine is used to prepare varenicline, which is a smoking cessation. It is a Varenicline protected impurity.<br>References Coe, J., et al.: J. Med. Chem., 48, 3474 (2005) ;<br></p>Fórmula:C15H12F3N3OCor e Forma:NeatPeso molecular:307.2705(Z)-4-(2,4-Difluorobenzoyl)piperidine Oxime
CAS:Produto Controlado<p>Applications Intermediate in the preparation of Risperidone (R525000) and it’s derivatives.<br></p>Fórmula:C12H14F2N2OCor e Forma:NeatPeso molecular:240.2492Deschloro-4’-chloro Clomiphene Hydrochloride
CAS:Produto Controlado<p>Applications An impurity of Clomiphene (C587025).<br></p>Fórmula:C26H29Cl2NOCor e Forma:NeatPeso molecular:442.42Nitrofurantoin Monohydrate
CAS:Produto Controlado<p>Applications 1-(((5-Nitrofuran-2-yl)methylene)amino)-imidazolidine-2,4-dione hydrate (CAS# 17140-81-7) is a useful research chemical compound.<br></p>Fórmula:C8H8N4O6Cor e Forma:YellowPeso molecular:256.18Hydroxy Varenicline N-Trifluoroacetic Acid Salt
CAS:Produto Controlado<p>Applications Protected Varenicline metabolite.<br></p>Fórmula:C15H12F3N3O2Cor e Forma:NeatPeso molecular:323.27Indomethacin 1-Menthol ester
CAS:Produto Controlado<p>Applications Indomethacin terpenoids' esters were synthesized and assessed both in vitro and in vivo as indomethacin dermal prodrugs.<br>References Bonina,, Francesco. , et al.: European Journal of Pharmaceutical Sciences, 14, 123 (2001),<br></p>Fórmula:C29H34ClNO4Cor e Forma:NeatPeso molecular:496.038Resiquimod
CAS:<p>Applications Resiquimod is an imidazoquinoline derivative that acts as an immune response modifier. Resiquimod shows antitumor and antiviral activity and is used in the treatment of skin lesions such as herpes simplex virus. Resiquimod is a toll-like receptor 9 (TLR7) agonist.<br>References Wu, J.J. et al.: Antivir. Res., 64, 79 (2004); Fife, K.H. et al.: Antimicrob. Agents Chemother., 52, 477 (2008); Szeimies, R.M. et al.: Brit. J. Dermatol., 159, 205 (2008);<br></p>Fórmula:C17H22N4O2Cor e Forma:White SolidPeso molecular:314.382,2'-(4,4'-(Oxybis(butane-4,1-diyl))bis(piperazine-4,1-diyl))dipyrimidine Dihydrochloride
Produto Controlado<p>Impurity Buspirone<br>Applications 2,2'-(4,4'-(Oxybis(butane-4,1-diyl))bis(piperazine-4,1-diyl))dipyrimidine is an impurity of anxiolytic drug Buspirone (B689855) that acts as 5-hydroxytryptamine (5-HT1) receptor agonist.<br>References Wu, Y.H., et al.: J. Med. Chem., 15, 477 (1972); Allen, L.E., et al.: Arzneim.-Forsch., 24, 917 (1974); Goa, K.L., et al.: Drugs, 32, 114 (1986);<br></p>Fórmula:C24H38N8O·2(HCl)Cor e Forma:White To Off-WhitePeso molecular:527.54Vilazodone Carboxylic Acid
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications Vilazodone Carboxylic Acid is the carboxylic acid impurity and an intermediate in the preparation of the antidepressant Vilazodone (V265000).<br>References Heinrich, T. et al.: J. Med. Chem., 47, 4684 (2004); Hu, B. et al.: Org. Proc. Res. Dev., 16, 1552 (2012);<br></p>Fórmula:C26H26N4O3Cor e Forma:NeatPeso molecular:442.51Apatinib-d8 25-N-Oxide Dihydrochloride
CAS:Produto Controlado<p>Applications Labelled Apatinib 25-N-Oxide (A726160). Apatinib 25-N-Oxide is a metabolite of the antiangiogenic agent and selective VEGFR2 inhibitor Apatinib (A726150).<br>References Ding, J, et al.: J. Chrom B Anal. Technol. Biomed. Life Sci., 895, 108 (2012);<br></p>Fórmula:C24H15D8N5O2•2HClCor e Forma:NeatPeso molecular:421.5223646S-Desethylpiperidino S-[2-Carboxyl-2-oxo-ethyl-(2-aminoethyl)amino] Vardenafil
CAS:Produto Controlado<p>Applications S-Desethylpiperidino S-[2-Carboxyl-2-oxo-ethyl-(2-aminoethyl)amino] Vardenafil is an impurity of Vardenafil (V098001, 2HCl); a selective phosphodiesterase type 5 (PDE5) inhibitor.<br>References Bischoff, E., et al.: J. Urol., 165, 1316 (2001); Kim, N.N., et al.: Life Sci., 69, 2249 (2001); Kendirci, M., et al.: Expert Opin. Pharmacother., 5, 923 (2004)<br></p>Fórmula:C21H26N6O7SCor e Forma:Off White SolidPeso molecular:506.53Cibenzoline
CAS:Produto Controlado<p>Applications Cibenzoline acts as a highly active class I antiarrhythmic agent.<br>References Xie, C. et al.: Handbook. Metab. Pathway. Xenobio., 3, 1110 (2014);<br></p>Fórmula:C18H18N2Cor e Forma:NeatPeso molecular:262.35Efavirenz Amino Alcohol Ethyl Carbamate
CAS:Produto Controlado<p>Applications Efavirenz Amino Alcohol Ethyl Carbamate is used in the synthesis of Efavirenz (E425000), a potent non-nucleoside HIV-1 reverse transcriptase inhibitor. Antiviral<br>References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995)<br></p>Fórmula:C16H15ClF3NO3Cor e Forma:NeatPeso molecular:361.74(Z)-4-Hydroxy Tamoxifen O-β-D-Glucuronide (~90%)
CAS:Produto Controlado<p>Applications (Z)-4-Hydroxy Tamoxifen O-β-D-Glucuronide is an active metabolite of Tamoxifen (T006000).<br>References Ogura, K. et al.: Biochem. Pharmacol., 71, 1358 (2006); Nishiyama, T. et al.: Biochem. Pharmacol., 63, 1817 (2002); McCague, R. et al.: Biochem. Pharmacol., 39, 1459 (1990);<br></p>Fórmula:C32H37NO8Pureza:~90%Cor e Forma:NeatPeso molecular:563.64(±)-2'-Methylpropranolol Hydrochloride
CAS:Produto Controlado<p>Applications (±)-2'-Methylpropranolol Hydrochloride, is an impurity of Nadolol (N201050), a β-Adrenergic blocker. Antihypertensive; antianginal.<br>References Dreyfuss, J., et al.: J. Clin. Pharmacol., 17, 300 (1977); Sibley, P.L., et al.: Toxicol. Appl. Pharmacol., 44, 379 (1978); Slusarek, L., et al.: Anal. Profiles Drug Subs., 9, 455 (1980)<br></p>Fórmula:C17H23NO2·ClHCor e Forma:NeatPeso molecular:309.83rac erythro-Dihydro Bupropion-d9
CAS:Produto Controlado<p>Applications A labelled metabolite of the drug Bupropion (B689625).<br>References Hsyu, P-H., et al.: J. Clin. Pharmacol., 37, 737 (1997)<br></p>Fórmula:C13H11D9ClNOCor e Forma:NeatPeso molecular:250.81N-(4-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine
CAS:Produto Controlado<p>Applications Intermediate in the preparation of Imatinib impurities. It is a COVID19-related research product.<br></p>Fórmula:C16H15N5Cor e Forma:NeatPeso molecular:277.323-[2-[4-(6-Fluoro-2-benzoxazolyl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one (Risperidone Impurity)
CAS:Produto ControladoFórmula:C23H27FN4O2Cor e Forma:NeatPeso molecular:410.48Desmethyl Nintedanib Carboxylic Acid (Nintedanib Impurity A)
Produto Controlado<p>Applications Desmethyl Nintedanib Carboxylic Acid is an impurity of Intedanib (I666650), which is an indolinone derivative potently blocking VEGF-, PDGF-, and FGF-receptor kinases. it is an indolinone as triple angiokinase inhibitors and an antitumor agent.<br>References Sun, L., et al.: J. Med. Chem., 41, 2588 (1998); Xie, H., et al.: J. Med. Chem., 50, 4898 (2007); Hilberg, F., et al.: Cancer Res., 68, 4774 (2008); Roth, G., et al.: J. Med. Chem., 58, 1053 (2015)<br></p>Fórmula:C29H29N5O5Cor e Forma:NeatPeso molecular:527.57N-Desethyl N-Methyl Rivastigmine
CAS:Produto Controlado<p>Impurity Rivastigmine EP Impurity B<br>Applications N-Desethyl N-Methyl Rivastigmine (Rivastigmine EP Impurity B) is an impurity of Rivastigmine (R541000), a brain selective acetylcholinesterase inhibitor. Nootropic.<br>References Rosler, M., et al.: Brit. Med. J., 318, 633 (1999), Enz, A., et al.: Prog. Brain Res., 98, 431 (1993),<br></p>Fórmula:C13H20N2O2Cor e Forma:NeatPeso molecular:236.321H-1-Ethyl-d5 Candesartan
CAS:Produto Controlado<p>Applications Labelled Candesartan (C175575) impurity.<br></p>Fórmula:C26H19D5N6O3Cor e Forma:Off-White To Light YellowPeso molecular:473.54N,O-Diacetyl Pseudoephedrine
CAS:Produto Controlado<p>Applications N,O-Diacetyl Pseudoephedrine is the diacetylated analogue of the non-selective adrenergic agonist Pseudoephedrine (P839350).<br></p>Fórmula:C14H19NO3Cor e Forma:NeatPeso molecular:249.31N’-[2-[2,4-(Dimethylphenyl)thio]phenyl] Vortioxetine
Produto Controlado<p>Applications N’-[2-[2,4-Dimethylphenyl)thio]phenyl] Vortioxetine is an impurity of Vortioxetine (V766000, HBr salt) which is a multimodal serotonergic agent, inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT.<br>References Bang-Andersen, B., et al.: J. Med. Chem., 54, 3206 (2011); Mørk, A., et al.: J. Pharmacol. Exp. Ther., 340, 666 (2012); Mørk, A., et al.: Pharmacol. Biochem. Behav. 105C, 41 (2013)<br></p>Fórmula:C32H34N2S2Cor e Forma:NeatPeso molecular:510.761,4,8,11-Tetraazacyclotetradecane
CAS:Produto Controlado<p>Applications 1,4,8,11-Tetraazacyclotetradecane is macrocyclic ligand that is used as an antioxidant in rubber and has been shown to suppress oxidation catalyzed by some metal ions.<br>References Goh, S.H.: Poly, Degrad, Stab., 8, 123 (1984);<br></p>Fórmula:C10H24N4Cor e Forma:NeatPeso molecular:200.32N-Nitrososotalol-d6
CAS:Produto ControladoFórmula:C12D6H13N3O4SCor e Forma:Off-WhitePeso molecular:307.3992-Nitrodeamino Fingolimod
CAS:Produto Controlado<p>Applications An impurity of Fingolimod (F805000, HCl salt), a novel immune modulator that prolongs allograft transplant survival in numberour models by inhibiting lymphocyte emigration from lymphoid organs.<br>References Brinkmann, V., et al.: Transplantation, 72, 764 (2001), Brinkmann, et al.: J. Biol. Chem., 277, 24, 21453 (2002), Mtaloubian, M., et al.: Nature, 427, 355 (2004),<br></p>Fórmula:C19H31NO4Cor e Forma:NeatPeso molecular:337.45Bicalutamide Sulfoxide
CAS:Produto Controlado<p>Impurity Bicalutamide USP Related Compound A<br>Applications Bicalutamide Sulfoxide is a derivative of Bicalutamide (B382000), non-steroidal peripherally active antiandrogen. Used as an antiandrogen, antineoplastic (hormonal).<br>References Tucker, H., et al.: J. Med. Chem., 31, 954 (1988), Cockshott, I.D., et al.: Eur. Urol., 18, Suppl. 3, 10 (1990), Cockshott, I., et al.: Br. J. Clin. Pharm., 36, 339 (1993), McKillop, D., et al.: Xenobiotica, 25, 623 (1995),<br></p>Fórmula:C18H14F4N2O3SCor e Forma:NeatPeso molecular:414.37Loratadine-d5 (ethyl-d5)
CAS:Produto Controlado<p>Applications Loratadine-d5 (ethyl-d5) (CAS# 1398065-63-8) is a useful isotopically labeled research compound.<br></p>Fórmula:C22D5H18ClN2O2Cor e Forma:NeatPeso molecular:387.92Tadalafil Hydroxypiperidone
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications Tadalafil Hydroxypiperidone, is an impurity of Tadalafil (T004500), a phosphodiesterase 5-inhibitor used for the treatment of erectile dysfunction.<br>References Carrier, S., et al.: Can. J. Urol., 10(1), 12 (2003), Doggrell, S.A., et al.: Expert Opin. Pharmacother., 6, 75 (2005), Forgue, S.T., et al.: Br. J. Clin. Pharmacol., 61, 280 (2005),<br></p>Fórmula:C22H19N3O6Cor e Forma:NeatPeso molecular:421.4Paliperidone N-Oxide
CAS:Produto Controlado<p>Impurity Paliperidone USP Related Compound D<br>Applications One of the major degradation product of Risperidone in bulk drug and pharmaceutical dosage forms. Paliperidone USP Related Compound D.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Leysen, J., et al.: J. Pharmacol. Exp. Ther., 247, 661 (1988), Huang, M., et al.: Pharm. Drug Dispos., 54, 257 (1993), Smyth, W., et al.: Anal. Bioanal. Chem., 378, 1305 (2004),<br></p>Fórmula:C23H27FN4O4Cor e Forma:NeatPeso molecular:442.48N-Ethylcarbamic Acid 3-[(1S)-1-(Dimethylamino)ethyl]phenyl Ester
CAS:Produto ControladoFórmula:C13H20N2O2Cor e Forma:NeatPeso molecular:236.31N-[3-Methyl-1-(1-phenylcyclobutyl)butyl]-N,N-dimethylamine Hydrochloride
CAS:Produto Controlado<p>Applications N-[3-Methyl-1-(phenylcyclobutyl)butyl]-N,N-dimethylamine Hydrochloride is an impurity of Sibutramine Hydrochloride (S422500), a serotonin and noradrenaline reuptake inhibitor.<br>References Hanotin, C., et al.: Int. J. Obesity, 22, 32 (1998)<br></p>Fórmula:C17H27N·ClHCor e Forma:NeatPeso molecular:281.862-Amino Edoxaban Methanesulfonate
CAS:Produto ControladoFórmula:C16H22ClN5O3•(CH4O3S)Cor e Forma:NeatPeso molecular:463.932-Hydroxy Nevirapine-d3
CAS:Produto Controlado<p>Applications A labelled metabolite of Nevirapine (N391275).<br>References Rettie, A., et al.: J. Biol. Chem., 263, 13733 (1988), Lamson, M., et al.: Biopharm. Drug Dispos., 20, 285 (1999), Guengerich, F., et al.: Chem. Res. Toxicol., 14, 611 (2001), Lu, W., et al.: Drug Metab. Dispos., 36, 1624 (2008),<br></p>Fórmula:C15H11D3N4O2Cor e Forma:NeatPeso molecular:285.32Quetiapine Carboxylate Impurity
CAS:Produto Controlado<p>Applications Quetiapine Carboxylate is an impurity of Quetiapine Hemifumarate (Q510000), an atypical antipsychotic agent used for the treatment of patients with schizophrenia, biopolar disorder and to treat major depressive disorder.<br>References Wetzel, H., et al.: Psychopharmacol., 119, 231 (1995); Bharathi, C., et al.: Pharmazie., 63, 14 (2008);<br></p>Fórmula:C22H25N3O4SCor e Forma:Light Orange ColourPeso molecular:427.522-(1-aminocyclohexyl)acetic acid
CAS:Produto ControladoFórmula:C8H15NO2Cor e Forma:NeatPeso molecular:157.219-Acridinecarboxylic acid
CAS:Produto Controlado<p>Applications 9-Acridinecarboxylic acid is used in the synthesis of short DNA-binding peptides.<br></p>Fórmula:C14H9NO2Cor e Forma:YellowPeso molecular:223.23N-Desmethyl-4-hydroxy Tamoxifen β-D-Glucuronide (E/Z Mixture)
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications A novel active metabolite of the anti-cancer drug Tamoxifen (T006000).<br>References Furr, B., et al.: Pharmacol. Ther., 25, 127 (1984), Leonessa, F., et al.: Cancer Res., 54, 441 (1994), Stearns, V., et al.: Lancet, 360, 1851 (2002), Rae, J., et al.: Pharmacogenetics, 13, 501 (2003), Zheng, Y., et al.: Drug Metab. Dispos., 35, 1942 (2007),<br></p>Fórmula:C31H35NO8Cor e Forma:NeatPeso molecular:549.61(S)-Carisbamate
CAS:<p>Applications Carisbamate is being developed for adjuvant treatment of partial onset epilepsy. Carisbamate produces anticonvulsant effects in primary generalized, complex partial and absence-type seizure models, and exhibits neuroprotective and antiepileptogenic properties in rodent epilepsy models.<br>References Novak GP, et al. 2007. Neurotherapeutics. Jan;4(1):106-9Nau C, 2004. J Membr Biol. Sep 1;201(1):1-8Codd EE, 2008. Pain. Feb;134(3):254-62. Epub 2007 May 25<br></p>Fórmula:C9H10ClNO3Cor e Forma:NeatPeso molecular:215.63Benzo[b]thien-2-yl Ketone (Zileuton Impurity)
CAS:Produto Controlado<p>Applications Benzo[b]thien-2-yl ketone is an impurity of Zileuton (Z420000), an inhibitor of 5-lipoxygenase that is used to treat patients with asthma. Benzo[b]thien-2-yl ketone is used as a reagent to synthesize Bis(1H-2-indolyl)methanone, compounds that inhibit the activity of growth factor receptor kinase. Benzo[b]thien-2-yl ketone is also used as a reagent to prepare annulated oligothiophenes, compounds that are used in organic light-emitting devides (OLEDs).<br>References Israel, E., et al.: JAMA, 275, 931 (1996); Mahboobi, S., et al.: J. Med. Chem., 45, 1002 (2002); Mitschke, U. & Bäuerle, P.: J. Chem. Soc. Perk. Trans., 1, 740 (2001); Nenajdenko, V., et al.: Russ. Chem. Bull., 61, 1456 (2012)<br></p>Fórmula:C17H10OS2Cor e Forma:NeatPeso molecular:294.39N10-Monodesmethyl Rizatriptan
CAS:Produto Controlado<p>Impurity Rizatriptan EP Impurity I<br>Applications N10-Monodesmethyl Rizatriptan (Rizatriptan EP Impurity I) is a metabolite of Rizatriptan.<br>References Dechant, K., et al.: Drugs, 43, 776 (1992), Castro, J., et al.: Bioorg. Med. Chem. Lett., 3, 993 (1993), Lee, Y., et al.: Biopharm. Drug Dispos., 19, 577 (1998), Chen, J., et al.: J. Pharm. Biomed. Anal., 35, 639 (2004),<br></p>Fórmula:C14H17N5Cor e Forma:NeatPeso molecular:255.32Raltegravir Potassium Salt
CAS:Produto ControladoFórmula:C20H20FN6O5·KCor e Forma:NeatPeso molecular:482.518-Bromo-3,9-dihydro-3-methyl-1H-purine-2,6-dione
CAS:<p>Applications 8-Bromo-3,9-dihydro-3-methyl-1H-purine-2,6-dione, is a substituted derivative of Xanthine (X499950), found in animal organs, yeast, potatoes, coffee beans, tea. It can also be used for the synthesis of Linagliptin (L465900), which is a novel potent and selective dipeptidyl peptidase-4 (DPP-4) inhibitor with potential use in the treatment of type 2 diabetes.<br>References Mueller, C. et. al: Handbook Exp. Pharmacol. 200,151(2011); Prabavathy, N. et al.: Int. J. Pharm. Bio. Sci., 2, 438 (2011); Deacon, C.F.: Diab. Obes. Metab., 13, 7 (2011); Mtthias E., et. al: J. Med. Chem., 50, 6450 (2007);<br></p>Fórmula:C6H5BrN4O2Cor e Forma:NeatPeso molecular:245.031-(1H-Benzo[d]imidazol-2-yl)-3-methyl-4-oxo-1,4-dihydropyridine-2-carboxylic acid Sodium Salt
CAS:<p>Applications 1-(1H-Benzo[d]imidazol-2-yl)-3-methyl-4-oxo-1,4-dihydropyridine-2-carboxylic acid is an impurity of Rabeprazole. It is also a degradation product formed in stressed tablets of Rabeprazole sodium.<br>References Kommanaboyina, B., et al.: Drug Dev. Ind. Pharm., 25, 857 (1999); Carswel, C., et al.: Drugs, 61, 2327 (2001); Garcia, C., et al.: J. Pharm. Biomed. Anal., 46, 88 (2008)<br></p>Fórmula:C14H10N3NaO3Cor e Forma:NeatPeso molecular:291.24Asenapine-d7 (Major)
CAS:Produto Controlado<p>Applications Labelled Asenapine. Asenapine is a combined serotonin (5HT2) and dopamine (D2) receptor antagonist; structurally related to Mianserin. Antipsychotic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Meltzer, H. et al.: J. Pharmacol. Exp. Ther., 251, 238 (1989); Schotte, A. et al.: Brain Res., 631, 191 (1993); Andree, B. et al.: Psychopharmacology, 131, 339 (1997); Richelson, E. et al.: Life Sci., 68, 29 (2000);<br></p>Fórmula:C17D7H9ClNOCor e Forma:NeatPeso molecular:292.814'-(Bromomethyl)-[1,1'-biphenyl]-2-carboxamide
CAS:Produto Controlado<p>Impurity Telmisartan Bromo Amide Impurity<br>Applications An impurity in the preparation of the angiotensin II receptor antagonist Telmisartan (T017000).<br>References Wienen, W., et al.: Brit. J. Pharmacol., 110, 245 (1993), Neutel, J.M., and Smith, D.H.G.: Adv. Ther., 15, 206 (1998)<br></p>Fórmula:C14H12BrNOCor e Forma:WhitePeso molecular:290.164,5-Dichlorothiophene-2-carboxylic Acid
CAS:Produto Controlado<p>Applications 4,5-Dichlorothiophene-2-carboxylic Acid is used in the preparation of compounds that have therapeutic BACE1 and BACE2 inhibitors which are used for the treatment of Alzheimer’s disease, type 2 diabetes and other metabolic disorders.<br>References Banner, D., et al.: PCT Int. Appl., 2011:1438553 (2013)<br></p>Fórmula:C5H2Cl2O2SCor e Forma:NeatPeso molecular:197.04Ebastine N-Oxide
CAS:<p>Stability -20°C Freezer<br>Applications Ebastine N-Oxide is an impurity of Ebastine (E320000). Ebastine impurity F and G (mixture of cis/trans).<br>References Yardley, J., et al.: J. Med. Chem., 33, 2899 (1990), Johnson, R., et al.: J. Antibiot., 49, 788 (1996), Takekawa, K., et al.: Xenobiotica, 31, 11 (2001), Chen, Z., et al.: Bioorg. Med. Chem. Lett., 14, 5275 (2004),<br></p>Fórmula:C32H39NO3Cor e Forma:NeatPeso molecular:485.66Carisoprodol (1 mg/ml in Methanol)
CAS:Produto ControladoFórmula:C12H24N2O4Cor e Forma:ColourlessPeso molecular:260.33(S)-(-)-Tolvaptan
CAS:Produto Controlado<p>Applications An enantiomer of Tolvaptan. It is a selective, competitive arginine vasopressin V2 receptor antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH).<br>References Paterna, S., et al.: Eur. J. Heart Fail, 2, 305 (2000), Udelson, J., et al.: Circulation, 104, 2417 (2001), Goldsmith, S., et al.: J. Am. Coll Cardiol., 46, 1785 (2005), Schrier, R., et al.: N. Engl. J. Med., 355, 2099 (2006),<br></p>Fórmula:C26H25ClN2O3Cor e Forma:Off White SolidPeso molecular:448.94α-(2,4-Difluorophenyl)-1H-1,2,4-triazole-1-ethanol
CAS:Produto ControladoFórmula:C10H9F2N3OCor e Forma:NeatPeso molecular:225.19

