Derivados de Quinazolina e Quinolina
As quinazolinas e quinolinas são compostos heterocíclicos contendo nitrogénio, com estruturas aromáticas que desempenham um papel fundamental na síntese de fármacos com atividade anticancerígena, antimicrobiana e anti-inflamatória. Os seus derivados apresentam modificações estruturais que otimizam a biodisponibilidade e a seletividade, permitindo o desenvolvimento de novos princípios ativos para diversas aplicações terapêuticas. Estes compostos são utilizados na fabricação de APIs para o tratamento do câncer, infeções, doenças neurodegenerativas e cardiovasculares. Além disso, os derivados de quinazolina e quinolina são essenciais na investigação de inibidores enzimáticos e no desenvolvimento de moléculas bioativas inovadoras.
Na CymitQuimica, oferecemos derivados de quinazolina e quinolina de alta pureza para aplicações em síntese química, desenvolvimento farmacêutico e biotecnologia.
Foram encontrados 65630 produtos de "Derivados de Quinazolina e Quinolina"
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Lumateperone
CAS:<p>Lumateperone (ITI 722) is a 5HT2A receptor antagonist and a dopamine receptor phosphoprotein modulator (DPPM).</p>Fórmula:C24H28FN3OPureza:99.68% - 99.91%Cor e Forma:SolidPeso molecular:393.511,11'-(1,4-Piperazinediyl)bis-dibenzo[b,f][1,4]thiazepine
CAS:<p>11,11'-(1,4-Piperazinediyl)bis-dibenzo[b,f][1,4]thiazepine is a molecule that inhibits the replication of DNA and RNA in viruses. The structure of 11,11'-(1,4-Piperazinediyl)bis-dibenzo[b,f][1,4]thiazepine has been determined by X-ray crystallography. Hepatocyte cells were used for this study because they are important for the metabolism of drugs. This molecule binds to serine proteases and prevents them from functioning properly. It also inhibits the replication of hepatitis C virus and human immunodeficiency virus type 1 (HIV-1). 11,11'-(1,4-Piperazinediyl)bis-dibenzo[b,f][1,4]thiazepine can be used as a template for designing other molecules with antiviral</p>Fórmula:C30H24N4S2Pureza:Min. 95%Cor e Forma:Yellow SolidPeso molecular:504.67 g/mol2-Amino-5,6-dichloro-3(4H)-quinazoline acetic acid
CAS:<p>This is a synthetic, impurity standard for 2-Amino-5,6-dichloro-3-(4H)-quinazoline acetic acid (CAS No. 1159977-03-3) that can be used in the drug product development process. This product is available as a custom synthesis and as an analytical standard for HPLC. It is also available as a pharmacopoeia grade material. The compound has been shown to have niche applications in metabolism studies and natural products research.</p>Fórmula:C10H9Cl2N3O2Pureza:Min. 95%Peso molecular:274.1 g/molLisuride
CAS:<p>Lisuride: an oral D2 dopamine agonist, ergot derivative, used in Parkinson's, migraine, and high prolactin research.</p>Fórmula:C20H26N4OCor e Forma:SolidPeso molecular:338.45Finafloxacin
CAS:<p>Finafloxacin is a pH-activated fluoroquinolone, most effective at pH 5.0-6.0, targeting bacterial topoisomerases, used for UTIs and H. pylori infections.</p>Fórmula:C20H19FN4O4Cor e Forma:SolidPeso molecular:398.39Tezosentan
CAS:<p>Tezosentan is an antagonist of the endothelin receptor (pA2s: 9.5, 7.7 for ETA and ETB receptors, respectively).</p>Fórmula:C27H27N9O6SPureza:98%Cor e Forma:SolidPeso molecular:605.63Thioquinapiperifil dihydrochloride
CAS:<p>Thioquinapiperifil dihydrochloride is a potent, selective PDE-5 inhibitor (IC50: 0.074 nM) for research.</p>Fórmula:C24H29ClN6OSPureza:98.73%Cor e Forma:SolidPeso molecular:485.05SD-2590 HCl
CAS:<p>SD-2590 HCl is an MMP-2,-3, -9, -8, 13, and -14 inhibitor.</p>Fórmula:C22H26ClF3N2O7SPureza:98%Cor e Forma:SolidPeso molecular:554.96Beloranib
CAS:<p>Beloranib is a fumagillin anticancer drug. Beloranib belongs to an angiogenesis inhibitor.</p>Fórmula:C29H41NO6Pureza:98%Cor e Forma:SolidPeso molecular:499.64Arterolane
CAS:<p>Arterolane is an antimalarial compound. For against P. falciparum Ro73 and W2, the IC50s are both 1.1 nM.</p>Fórmula:C22H36N2O4Cor e Forma:SolidPeso molecular:392.53RJF02215
CAS:<p>RJF02215, an MMP-9 inhibitor, exhibits growth inhibitory activity against the ovarian cancer cell line SKOV3. It is utilized in tumor research.</p>Fórmula:C17H12ClN3OS3Cor e Forma:SolidPeso molecular:405.95COTI-219
CAS:<p>COTI-219 is an oral inhibitor of KRAS with antitumor properties [1].</p>Fórmula:C17H18N6SCor e Forma:SolidPeso molecular:338.43BAY-7598
CAS:<p>BAY-7598 is a potent, selective, and orally bioavailable MMP12 inhibitor (IC50s: 0.085, 0.67, and 1.1 nM for human/murine/rat MMP12).</p>Fórmula:C28H31N3O6Pureza:98%Cor e Forma:SolidPeso molecular:505.56Rodatristat
CAS:<p>Rodatristat is an effective tryptophan hydroxylase 1 and TPH2 inhibitor (IC50s: 33 nM and 7 nM, respectively).</p>Fórmula:C27H27ClF3N5O3Pureza:98%Cor e Forma:SolidPeso molecular:561.98Tipelukast
CAS:<p>Tipelukast (KCA 757), an oral drug for asthma research, blocks leukotrienes and fights inflammation and fibrosis.</p>Fórmula:C29H38O7SPureza:>99.99%Cor e Forma:SolidPeso molecular:530.67UK-370106
CAS:<p>UK-370106 is a potent and highly selective inhibitor of MMP-3 with IC50 of 23 nM and MMP-12 with IC50 of 42 nM, and potently inhibits cleavage of [3H]-</p>Fórmula:C35H44N2O5Pureza:98%Cor e Forma:SolidPeso molecular:572.73RuDiOBn
CAS:<p>RuDiOBn exhibits low antioxidant activity by scavenging DPPH and ABTS free radicals with scavenging rates of 13.2% and 5.9% at a concentration of 100 μg/mL. It inhibits collagen glycation and reduces the formation of advanced glycation end-products (AGE) with an IC50 of 2.45 μg/mL. RuDiOBn also enhances fibroblast proliferation and migration, stimulates collagen synthesis, and aids in skin repair and regeneration while inhibiting collagenase.</p>Fórmula:C29H22O7Cor e Forma:SolidPeso molecular:482.4813-Aminobenzene-1,2-diol
CAS:<p>3-Aminobenzene-1,2-diol (compound C8) is an inhibitor of matrix metalloproteinases (MMP), with IC50 values of 20, 26, 16, and 16.3 μM against MMP-2, MMP-8, MMP-9, and MMP-14, respectively.</p>Fórmula:C6H7NO2Cor e Forma:SolidPeso molecular:125.13OncoFAP
CAS:<p>OncoFAP is an ultra-high affinity fibroblast activating protein (FAP) ligand with potential tumour targeting.</p>Fórmula:C21H19F2N5O5Pureza:99.77%Cor e Forma:SolidPeso molecular:459.40Neptinib
CAS:<p>Neptinib (NEP010), a derivative of Afatinib, exhibits enhanced antitumor properties and improved pharmacokinetics when administered orally. It demonstrates a notable suppression of tumor expansion in mouse models of non-small cell lung cancer harboring various EGFR mutations. Furthermore, Neptinib effectively inhibits the EGFR kinase family, exhibiting IC 50 values of 0.24 nM for EGFR wt, 7.25 nM for EGFR L858R/T790M, 0.46 nM for EGFR L858R, and 1.79 nM for EGFR T790M.</p>Fórmula:C22H23ClFN5O2Cor e Forma:SolidPeso molecular:443.90CM-352
CAS:<p>CM-352 is a metalloproteinase inhibitor that reduces brain damage and improves functional recovery in rat models of cerebral hemorrhage.</p>Fórmula:C24H29N3O6SPureza:99.36%Cor e Forma:SolidPeso molecular:487.57Faldaprevir
CAS:<p>Faldaprevir is an orally effective, selective, non-covalent HCV NS3/4A protease inhibitor with high inhibitory activity against HCV 1a and 1b genotype.</p>Fórmula:C40H49BrN6O9SPureza:99.04% - 99.19%Cor e Forma:SolidPeso molecular:869.82Indinavir monohydrate
CAS:<p>Indinavir monohydrate is a potent and specific HIV protease inhibitor that appears to have good oral bioavailability.</p>Fórmula:C36H49N5O5Cor e Forma:SolidPeso molecular:631.82Aclidinium
CAS:<p>Aclidinium, a dual-action compound, serves as a long-acting muscarinic antagonist and a β2-adrenoceptor (β2-AR) agonist, exhibiting bronchodilator properties. It effectively reduces lung hyperinflation, enhances lung function, and prolongs exercise endurance time. This compound is commonly utilized in studies focusing on chronic obstructive pulmonary disease (COPD).</p>Fórmula:C26H30NO4S2Cor e Forma:SolidPeso molecular:484.65(3S,4R)-Tofacitinib
CAS:<p>(3S,4R)-Tofacitinib is an less active enantiomer of Tofacitinib. Tofacitinib is a JAK3 inhibitor(IC50 : 1 nM).</p>Fórmula:C16H20N6OPureza:98%Cor e Forma:SolidPeso molecular:312.37Quinagolide Free Base
CAS:<p>Quinagolide Free Base is a non-ergot dopamine D(2)-agonist.</p>Fórmula:C20H33N3O3SCor e Forma:SolidPeso molecular:395.56Macitentan (n-butyl analogue)
CAS:<p>Macitentan n-butyl analogue, an oral ETA/ETB receptor blocker, may treat IPF and PAH.</p>Fórmula:C20H21Br2N5O4SPureza:98%Cor e Forma:SolidPeso molecular:587.29ZK159222
CAS:<p>ZK159222 is an effective 1α,25-(OH)2D3 receptor (VDR) agonist. ZK159222 has a partial agonistic character.</p>Fórmula:C32H48O5Pureza:98%Cor e Forma:SolidPeso molecular:512.72SD-7300
CAS:<p>SD-7300 (SC-81490) functions as an orally active inhibitor targeting MMP-2, MMP-9, and MMP-13, exhibiting potent inhibition with K_i values of 0.03, 0.01, and 0.03 nM, respectively. By inhibiting these metalloproteinases, SD-7300 effectively reduces extracellular matrix degradation by tumor cells, thereby curbing their invasion and metastasis. Additionally, this compound acts as a dose-dependent inhibitor of mouse corneal angiogenesis and prevents interleukin-1-induced degradation of bovine cartilage. SD-7300 is applicable in the study of breast cancer.</p>Fórmula:C21H30F3N3O7SCor e Forma:SolidPeso molecular:525.54PNU-248686A
CAS:<p>PNU-248686A is an inhibitor of matrix metalloproteinase (MMP).</p>Fórmula:C22H18ClNaO5S2Pureza:98%Cor e Forma:SolidPeso molecular:484.95Tofogliflozin
CAS:<p>Tofogliflozin specifically inhibits SGLT2; IC50s are 2.9 nM (human), 14.9 nM (rat), 6.4 nM (mouse).</p>Fórmula:C22H26O6Pureza:98%Cor e Forma:SolidPeso molecular:386.44UK 356618
CAS:<p>UK 356618 is a potent and selective inhibitor of matrix metalloprotease-3 (IC50: 5.9 nM).</p>Fórmula:C34H43N3O4Pureza:98%Cor e Forma:SolidPeso molecular:557.72Vibegron
CAS:<p>Vibegron (MK-4618) is an effective and selective Beta 3 adrenergic receptor agonist, used to treat overactive bladder (OAB).</p>Fórmula:C26H28N4O3Cor e Forma:SolidPeso molecular:444.53Quinapril
CAS:<p>Quinapril is an orally active, non-peptide, and non-thiol angiotensin-converting enzyme (ACE) inhibitor. It primarily blocks the conversion of angiotensin I to angiotensin II in both plasma and tissues. Upon enzymatic hydrolysis, Quinapril is converted into the pharmacologically active Quinaprilat and is effective in hypertension models.</p>Fórmula:C25H30N2O5Cor e Forma:SolidPeso molecular:438.516HU-308
CAS:<p>HU-308, a synthetic cannabinoid analogue, is a highly selective agonist of the CB2 receptor. It demonstrates an affinity for the CB2 receptor that is over 440 times greater than its affinity for the CB1 receptor, which are predominantly found in immune cells. This compound plays a crucial role in modulating the immunosuppressive effects of the endocannabinoid system (ECS). Additionally, HU-308 possesses anti-inflammatory and neuroprotective properties, and it regulates the function of microglia. Its potential applications include research into neuroinflammation and retinal diseases.</p>Fórmula:C27H42O3Cor e Forma:SolidPeso molecular:414.62Vecabrutinib
CAS:<p>Vecabrutinib (SNS-062) is a potent and noncovalent BTK and ITK inhibitor (Kd: 0.3 nM and 2.2 nM, respectively). Vecabrutinib displays an IC50 of 24 nM for ITK.</p>Fórmula:C22H24ClF4N7O2Pureza:99.74%Cor e Forma:SolidPeso molecular:529.92Obicetrapib
CAS:<p>Obicetrapib (AMG-899) is an inhibitor of cholesteryl ester transfer protein.</p>Fórmula:C32H31F9N4O5Pureza:99.26% - >99.99%Cor e Forma:SolidPeso molecular:722.6Aleglitazar
CAS:<p>Aleglitazar (R1439) (R1439) is a potent dual PPARα/γ agonist, with IC50s of 38 nM and 19 nM for human PPARa and PPARγ, respectively.</p>Fórmula:C24H23NO5SPureza:99.03%Cor e Forma:SolidPeso molecular:437.51(S)-Rasagiline
CAS:<p>(S)-Rasagiline is rasagiline S-isomer, and is an agent of anti-Parkinson.</p>Fórmula:C12H13NCor e Forma:SolidPeso molecular:171.24(4-Methylbenzoyl)trifluoroacetone (1,1,1-Trifluoro-4-hydroxy-4-(4-methylphenyl)-3-buten-2-one)
CAS:Ketones and quinones, w/not with other oxygen function,and their halogenated,sulfated,nitrated,or nitrosated derivatives, nesoiFórmula:C11H9F3O2Cor e Forma:White SolidPeso molecular:230.05546Dasatinib
CAS:Compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structureFórmula:C22H26ClN7O2S·H2OPeso molecular:505.16629Levetiracetam acid ((S)-2-(2-oxopyrrolidin-1-yl)butanoic acid)
CAS:Lactams, nesoiFórmula:C8H13NO3Cor e Forma:Off-White SolidPeso molecular:171.08954Methylbis(2-pyridylethyl)amine Hydrochloride (N-Methyl-N,N-bis(2-pyridin-2-yl-ethyl)amine trihydrochloride)
CAS:Compounds containing an unfused pyridine ring in the structure, nesoiFórmula:C15H19N3·3HClCor e Forma:Light Brown PowderPeso molecular:241.1579Desmethoxy Omeprazole (2-(((3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-5-methoxy-1H-benzo[d]imidazole; 2-[(RS)-[(3,5-Dimethylpyridin-2-yl)methyl]sulfinyl]-5-methoxy-1H-benzimidazole) (DISCONTINUED)
CAS:Compounds containing an unfused pyridine ring in the structure, nesoiFórmula:C16H17N3O2SCor e Forma:White Off-White SolidPeso molecular:315.10415Ezetimibe Tetrahydropyran Analog ((2R,3R,6S)-N,6-bis(4-fluorophenyl)-2-(4-hydroxyphenyl)tetrahydro-2H-pyran-3-carboxamide)
CAS:Aromatic heterocyclic compounds with oxygen hetero-atom(s) only, nesoiFórmula:C24H21F2NO3Cor e Forma:White Off-White SolidPeso molecular:409.14895Ezetimibe Ketone ((3R,4S)-1-(4-Fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-(4-hydroxyphenyl)azetidin-2-one)
CAS:Lactams, nesoiFórmula:C24H19F2NO3Cor e Forma:White SolidPeso molecular:407.1333Methoxyamiodarone ([2-[(1RS)-1-Methoxybutyl]benzofuran-3-yl][4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl]methanone) (DISCONTINUED)
CAS:Aromatic heterocyclic compounds with oxygen hetero-atom(s) only, nesoiFórmula:C26H31I2NO4Cor e Forma:Colorless GelPeso molecular:675.03425Ezetimibe 2-Fluorobenzene Isomer ((3R,4S)-1-(4-fluorophenyl)-3-((S)-3-(2-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one)
CAS:Lactams, nesoiFórmula:C24H21F2NO3Cor e Forma:White Off-White SolidPeso molecular:409.14895Chlorothiophene carboxylic acid (5-chlorothiophene-2-carboxylic acid)
CAS:Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoiFórmula:C5H3ClO2SCor e Forma:Off-White Pale Yellow SolidPeso molecular:161.95423N-Acetyl-L-Leucine (Acetyl-L-leucine)
CAS:Acyclic amides (including acyclic carbamates) and their derivatives and salts thereof, nesoiFórmula:C8H15NO3Cor e Forma:White PowderPeso molecular:173.10519Dasatinib Related Compound A
CAS:Compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structureFórmula:C22H26ClN7O3SPeso molecular:503.15064Ezetimibe Desfluoroaniline Analog ((3R,4S)-3-[(S)-3-(4-Fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-1-phenylazetidin-2-one)
CAS:Lactams, nesoiFórmula:C24H22FNO3Cor e Forma:White Off-White PowderPeso molecular:391.15837Acetyl Rotigotine Hydrochloride ((S)-6-(propyl(2-(thiophen-2-yl)ethyl)amino)-5,6,7,8-tetrahydronaphthalen-1-yl acetate hydrochloride)
CAS:Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoiFórmula:C21H28ClNO2SCor e Forma:Off-White SolidPeso molecular:393.15293Rivaroxaban Open Ring ((R)-5-chloro-N-(2-hydroxy-3-((4-(3-oxomorpholino)phenyl)amino)propyl)thiophene-2-carboxamide)
CAS:Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoiFórmula:C18H20ClN3O4SCor e Forma:Off-White SolidPeso molecular:409.0863Everolimus System Suitability Mixture (This is a mixture of Everolimus, Everolimus oxepane isomer and 9-O-Hydroxyethyl Sirolimus)
Diagnostic or lab reagents on a backing, prepared diagnostic or lab reagents whether or not on a backing, whether or not in the form of kits, nesoiCor e Forma:White Yellow PowderAtazanavir Benzylidenehydrazine Carbamate (Methyl [(S)-1-{[(2S,3S)-3-hydroxy-1-phenyl-4-{1-[4-(pyridin-2-yl)benzyl]-2-[4-(pyridin-2-yl)benzylidene]hydrazinyl}butan-2-yl]amino}-3,3-dimethyl-1-oxobutan-2-yl]carbamate)
CAS:Compounds containing an unfused pyridine ring in the structure, nesoiFórmula:C42H46N6O4Cor e Forma:Light Yellow SolidPeso molecular:698.35805Ref: 4Z-T-0336
Produto descontinuadoRef: 4Z-V-0543
Produto descontinuadoRef: 4Z-M-191016
Produto descontinuadoRef: 4Z-D-3557
Produto descontinuadoRef: 4Z-V-2243
Produto descontinuado4-[[3-[2-(3-Chlorophenyl)ethyl]-2-pyridinyl]carbonyl]-1-piperidinecarboxylic Acid
Fórmula:C20H21ClN2O3Peso molecular:372.85Ref: 4Z-L-1038
Produto descontinuadoRef: 4Z-C-0345
Produto descontinuadoRef: 4Z-B-432
Produto descontinuadoRef: 4Z-D-5930
Produto descontinuadoRef: 4Z-T-1099
Produto descontinuadoRef: 4Z-N-1788
Produto descontinuadoRef: 4Z-N-0550
Produto descontinuadoSolifenacin Related Compound 17 (Dimethyl Carbonate)
CAS:Fórmula:C3H6O3Cor e Forma:Colorless LiquidPeso molecular:90.08Ref: 4Z-S-1838
Produto descontinuadoRef: 4Z-N-066022
Produto descontinuadoRef: 4Z-P-0192
Produto descontinuadoRef: 4Z-E-1018
Produto descontinuadoRef: 4Z-B-0821
Produto descontinuadoRef: 4Z-P-0197
Produto descontinuadoRef: 4Z-L-44138
Produto descontinuadoRef: 4Z-N-1756
Produto descontinuadoRef: 4Z-Q-0144
Produto descontinuadoRef: 4Z-A-08153
Produto descontinuadoUlifloxacin
CAS:<p>Ulifloxacin is a useful organic compound for research related to life sciences. The catalog number is T65577 and the CAS number is 112984-60-8.</p>Fórmula:C16H16FN3O3SCor e Forma:SolidPeso molecular:349.38Ref: 4Z-A-102139
Produto descontinuadoRef: 4Z-R-080005
Produto descontinuadoRef: 4Z-M-269058
Produto descontinuadoRef: 4Z-A-4910
Produto descontinuadoRef: 4Z-E-068011
Produto descontinuadoRef: 4Z-M-269014
Produto descontinuadoRef: 4Z-V-098
Produto descontinuadoRef: 4Z-A-277033
Produto descontinuadoRef: 4Z-L-1134
Produto descontinuadoRef: 4Z-T-0532
Produto descontinuadoRef: 4Z-S-146012
Produto descontinuadoRef: 4Z-I-134034
Produto descontinuadoRef: 4Z-B-154015
Produto descontinuadoRef: 4Z-L-4237
Produto descontinuadoRef: 4Z-Q-0170
Produto descontinuadoRef: 4Z-A-6062
Produto descontinuadoRef: 4Z-E-1015
Produto descontinuadoRef: 4Z-N-2132
Produto descontinuadoRef: 4Z-N-0528
Produto descontinuado
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