Derivados de Quinazolina e Quinolina
As quinazolinas e quinolinas são compostos heterocíclicos contendo nitrogénio, com estruturas aromáticas que desempenham um papel fundamental na síntese de fármacos com atividade anticancerígena, antimicrobiana e anti-inflamatória. Os seus derivados apresentam modificações estruturais que otimizam a biodisponibilidade e a seletividade, permitindo o desenvolvimento de novos princípios ativos para diversas aplicações terapêuticas. Estes compostos são utilizados na fabricação de APIs para o tratamento do câncer, infeções, doenças neurodegenerativas e cardiovasculares. Além disso, os derivados de quinazolina e quinolina são essenciais na investigação de inibidores enzimáticos e no desenvolvimento de moléculas bioativas inovadoras.
Na CymitQuimica, oferecemos derivados de quinazolina e quinolina de alta pureza para aplicações em síntese química, desenvolvimento farmacêutico e biotecnologia.
Foram encontrados 65630 produtos de "Derivados de Quinazolina e Quinolina"
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N,O-Dibenzoyl-L-tyrosine (>90%)
CAS:Produto Controlado<p>Applications N,O-Dibenzoyl-L-tyrosine is an impurity of Tiropramide (T446900). Tiropramide impurity A.<br>References Fox, S.W., et al.: Arch. Biochem., 25, 13 (1950),<br></p>Fórmula:C23H19NO5Pureza:>90%Cor e Forma:White To Off-WhitePeso molecular:389.4Rebamipide 3-Chloro Impurity
CAS:Fórmula:C19H15ClN2O4Cor e Forma:White To Off-WhitePeso molecular:370.7864Flumethrin
CAS:Produto Controlado<p>Applications Flumethrin is a synthetic pyrethroid insecticide used in the control of parasites, particularly ticks, on cattle, sheep, goats, horses, and dogs. Flumethrin is also used for control of mites in beehives.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Stendel, W. et al.: VMR Vet. Med. Rev., 2, 115 (1982); Ahrens, E.H. et al.: J. Econ. Entomol., 91, 1133 (1988); Roy, S. et al.: Ind. Vet. J., 82, 778 (2005);<br></p>Fórmula:C28H22Cl2FNO3Cor e Forma:Light YellowPeso molecular:510.38Saccharin N-(2-Acetic Acid Isopropyl Ester)(Piroxicam Impurity F)
CAS:Produto Controlado<p>Impurity Piroxicam EP Impurity F<br>Applications Piroxicam impurity F.<br>References Lombardino, J., et al.: J. Med. Chem., 14, 1171 (1971), Turck, D., et al.: Clin. Drug Invest., 9, 270 (1995),<br></p>Fórmula:C12H13NO5SCor e Forma:NeatPeso molecular:283.30cis-ent-Tadalafil
CAS:Produto Controlado<p>Impurity Tadalafil EP Impurity C<br>Applications The (6S)-cis-enantiomer of Tadalafil (T004500). Tadalafil Impurity (6S,12aR)<br>References Aldridge, J., et al.: Br. Med. J., 318, 669 (1999), Daugan, A., et al.: J. Med. Chem., 46, 4533 (2003), Vredenbregt, M., et al.: J. Pharm. Biomed. Anal., 40, 840 (2006),<br></p>Fórmula:C22H19N3O4Cor e Forma:White To Off-WhitePeso molecular:389.402-Methylindazole-3-carboxylic Acid
CAS:Produto Controlado<p>Applications A reagent used to synthesize 5-HT2A and 5-HT3 receptor ligands for use in treating CNS-related disorders.<br>References Bermudez, J., et al.: J. Med. Chem., 33, 1924 (1990),<br></p>Fórmula:C9H8N2O2Cor e Forma:NeatPeso molecular:176.17(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine (2R)-Hydroxy(phenyl)ethanoate
CAS:<p>Applications (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine is an intermediate in the preparation of orally active reversible P2Y12 receptor antagonists such as Ticagrelor (T437700)for the prevention of thrombosis.<br>References Springthorpe, B. et al.: Bioorg. Med. Chem. Lett., 17, 6013 (2007);<br></p>Fórmula:C9H9F2N·C8H8O3Cor e Forma:NeatPeso molecular:321.322-((2R,3R)-3-(tert-butyl)-4(2,6-dimethoxyphenyl)-2,3dihydrobenzo[d][1,3]oxaphosphol-2-yl)pyridine
CAS:Pureza:97%Peso molecular:407.45001220703125a-Desmethyl Anastrozole(>90%)
CAS:Produto Controlado<p>Impurity Anastrozole EP Impurity A<br>Applications α-Desmethyl Anastrozole (Anastrozole EP Impurity A) is an impurity of Anastrozole (A637425) (impurity B).<br></p>Fórmula:C16H17N5Pureza:>90%Cor e Forma:ColourlessPeso molecular:279.34Benzophenone
CAS:Produto Controlado<p>Impurity Diphenhydramine EP Impurity E<br>Applications It is used in the manufacturing of antihistamines, hypnotics, insecticides.This compound is a contaminant of emerging concern (CECs)<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wallace, W., et al.: Environ. Toxicol. Chem., 19, 962 (2000), Hayashi, T., et al.: Toxicol. Lett., 167, 1 (2006), Bechard, K., et al.: Aquat. Toxicol., 90, 310 (2008),<br></p>Fórmula:C13H10OCor e Forma:ColourlessPeso molecular:182.22(R)-3-Chloro-1-phenyl-1-(2-methylphenoxy)propane
CAS:Produto ControladoFórmula:C16H17ClOCor e Forma:NeatPeso molecular:260.76[1,1'-Biphenyl]-4-yl(phenyl)methanol
CAS:Produto Controlado<p>Impurity Bifonazole EP Impurity A<br>Applications [1,1'-Biphenyl]-4-yl(phenyl)methanol (Bifonazole EP Impurity A) is a Bifonazole (B383400), an anti-fungal agent used in the treatment of skin diseases. Causes an increase in Ca2+ concentration and triggers cell death in PC3 human prostate cancer cells.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cheng, J. et al.: J. Recep. Sign. Transduct., 34, 493 (2014); Chen, Z. et al.: Mol. Pharm., 12, 590 (2015);<br></p>Fórmula:C19H16OCor e Forma:NeatPeso molecular:260.335-(Benzyloxy)-1-(2,2-dimethoxyethyl)-6-(methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid
CAS:Pureza:97.0%Peso molecular:391.3760070800781Celiprolol-d9 Hydrochloride
CAS:Produto Controlado<p>Applications Labelled Celiprolol. Cardioselective β1-adrenergic blocker. Antihypertensive, antianginal.<br>References Mazzo, D.J., et al.: Anal. Profiles Drug Subs., 20, 237 (1991), Meininger, C., et al.: Biochem. J., 349, 353 (2000), Ruan, H., et al.: Diabetes, 51, 1319 (2002), Liao, Y., et al.: Circulation, 110, 692 (2004),<br></p>Fórmula:C20H25D9ClN3O4Cor e Forma:NeatPeso molecular:425.012,5-Dimethyl Celecoxib
CAS:Produto Controlado<p>Applications A non-cyclooxygenase-2 inhibitor analog of Celecoxib (C251000). The celecoxib analog, 2,5-di-Me celecoxib (DMC), lacks COX-2 inhibitory activity but exhibits cytotoxic properties comparable to the COX-2 inhibitor Celecoxib.<br>References Deckmann, K. et al.: Biochem. Pharmacol., 80, 1365 (2010); Virrey, J.J. et al.: Mol. Cancer. Therap., 9, 631 (2010); Chen, S. et al.: Leukemia Res., 34, 250 (2010);<br></p>Fórmula:C18H16F3N3O2SCor e Forma:NeatPeso molecular:395.3987Desmethyl Mirtazapine-d6 Dihydrochloride
CAS:Produto Controlado<p>Impurity Mirtazapine<br>Applications A labelled metabolite of Mirtazapine, α2-adrenergic blocker.<br>References De Boer, T., et al.: Neuropharmacology, 27, 399 (1988), Smith, W.T., et al.: Psychopharmacol. Bull., 26, 191 (1990)<br></p>Fórmula:C16H11D6N3·2HClCor e Forma:NeatPeso molecular:330.292-Hydroxy Imiquimod
CAS:Produto Controlado<p>Applications 1-(4-Amino-1H-imidazo[4,5-c]quinolin-1-yl)-2-methylpropan-2-ol, has been shown to activate a toll-like receptor 7/8 Independent Cytokine, which can be used in the design of immunomodulating agents for use as vaccine adjuvants and anticancer treatments.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Shi, C., et al.: ACS Med. Chem. Lett., 3, 501 (2012);<br></p>Fórmula:C14H16N4OCor e Forma:NeatPeso molecular:256.3Prochlorperazine Edisylate
CAS:Produto ControladoFórmula:C20H24ClN3S·C2H6O6S2Cor e Forma:NeatPeso molecular:564.141-Benzyl-3-(2,4-dimethylphenyl)-1H-pyrazole-5-carboxylic acid
Pureza:95.0%Peso molecular:306.364990234375Tert-Butyl-4-(isoquinolin-5-yl)piperazine-1-carboxylate
CAS:Pureza:97%Peso molecular:313.40100097656252-(5-cyclopropyl-3-(thiophen-2-yl)-1H-pyrazol-1-yl)acetonitrile
CAS:Pureza:95.0%Peso molecular:229.3000030517578Furazolidone
CAS:<p>Applications Antimicrobial.Environmental contaminants; Food contaminants; Heat processing contaminants<br>References Yurchenco, J.A., et al.: Antimicrob. Chemother., 3, 1035 (1953), Sharma, C., et al.: J. Clin. Microbiol., 36, 756 (1998),<br></p>Fórmula:C8H7N3O5Cor e Forma:YellowPeso molecular:225.162-(Acetylamino)-6-[[[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]amino]carbonyl]-benzoic Acid
CAS:Produto ControladoFórmula:C22H26N2O8SCor e Forma:NeatPeso molecular:478.52Relcovaptan
CAS:<p>Stability Hygroscopic<br>Applications Relcovaptan is a selective vasopressin-1a receptor antagonist that prevents cellular swelling and provides treatment for post-traumatic brain edema.<br>References Marmarou, C.R., et. al.: Brain Res., 1581, 89 (2014)<br></p>Fórmula:C28H27Cl2N3O7SCor e Forma:NeatPeso molecular:620.50N-Acetyl-(+)-Pseudoephedrine
CAS:Produto Controlado<p>Applications N-Acetyl-(+)-Pseudoephedrine is the N-acetylated analogue of the non-selective adrenergic agonist (+)-Pseudoephedrine (P839350).<br>References Tanaka, K.: Yakug. Zas., 70, 220 (1950); Rodriguez, M. et al.: Org. Biomol. Chem., 3, 2026 (2005);<br></p>Fórmula:C12H17NO2Cor e Forma:WhitePeso molecular:207.277-Chloro-1-ethyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic Acid, 90%
CAS:Produto Controlado<p>Impurity Norfloxacin EP Impurity A; Norfloxacin USP Related Compound A (7-Chloro-1-ethyl-6-fluoro-4-oxo-1,4-d<br>Applications 7-Chloro-1-ethyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic Acid (Norfloxacin EP Impurity A) is a Norfloxacin intermediate. Norfloxacin EP Impurity A; Norfloxacin USP Related Compound A (7-Chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid).<br>References Piganeau, N., et al.: J. Mol. Biol., 312, 1177 (2001), Rameshkumar, N., et al.: Eur. J. Med. Chem., 38, 1001 (2003), You, Q., et al.: J. Med. Chem., 52, 5649 (2009),<br></p>Fórmula:C12H9ClFNO3Pureza:90%Cor e Forma:NeatPeso molecular:269.663-[5-(1,5-Dioxo-5-(p-fluophenylpentyl]-4(S)-phenyl-2-oxazolidinone
CAS:Produto ControladoFórmula:C20H18FNO4Cor e Forma:NeatPeso molecular:355.3596(R)-(+)-Thalidomide
CAS:Produto Controlado<p>Applications Optically active isomer of Thalidomide, which inhibits FGF-induced angiogenesis. Inhibits replication of human immunodeficiency virus type 1. Teratogenic sedative.<br>References D’Amato, r.J., et al.: Proc. Natl. Acad. Sci. USA, 91, 4082 (1994), Makonkawkeyoon, S., et al.: Proc. Natl. Acad. Sci. USA, 90, 5974 (1993), Schumacher, H., et al.: J. Pharmacol. Exp. Therap., 160, 189 (1968)<br></p>Fórmula:C13H10N2O4Cor e Forma:NeatPeso molecular:258.23N-Boc-piperazine
CAS:<p>Applications N-Boc-piperazine (cas# 57260-71-6) is a compound useful in organic synthesis.<br></p>Fórmula:C9H18N2O2Cor e Forma:NeatPeso molecular:186.254-(4-Amino-3-fluorophenoxy)-N-methylpyridine-2-carboxamide
CAS:Produto Controlado<p>Applications 4-(4-Amino-3-fluorophenoxy)-N-methylpyridine-2-carboxamide is a compound used as a reagent to synthesize Regorafenib (R143000), a multikinase inhibitor that is used to treat patients with advanced colorectal cancer.<br>References Mross, K., et al.: Clin. Cancer Res., 18, 2658 (2012); Stiehl, J., et al. Process for Preparation of Regorafenib. PCT Int. Appl. 2011128261. Oct 20, 2011; Van Cutsem, E., et al.: J. Clin. Oncol., 30, 3502 (2012)<br></p>Fórmula:C13H12FN3O2Cor e Forma:Dark Orange To Red BrownPeso molecular:261.25rac Kynurenine
CAS:Produto Controlado<p>Applications A tryptophan metabolite, is a precursor of kynurenic acid, which is an antagonist of N-methyl-aspartate receptor. An amino acid produced in the body from tryptophan.<br>References Swartz, K., et al.: J. Neurosci., 10, 2965 (1990), Hasegawa, H., et al.: Anal. Bioanal. Chem., 377, 886 (2003), Tsai, Y., et al.: Anal. Biochem., 319, 34 (2003), Mitsuhashi, S., et al.: Anal. Chim. Acta, 584, 315 (2007),<br></p>Fórmula:C10H12N2O3Cor e Forma:NeatPeso molecular:208.21Ombitasvir
CAS:Produto Controlado<p>Applications Ombitasvir is a pharmaceutical drug that is used in the treatment of hepatitis C virus in patients with HCV genotype 1 infection. It inhibits an important viral phosphoprotein, NS5A, which is involved in viral replication, assembly, and secretion.<br>References Feld, J.J., et al.: New Eng. J. Med., 370, 1594 (2014); Lawitz, E., et al.: J. Hepatol., 57, 24 (2012); Afdhal, N., et al.: New England J. Med., 370, 1889 (2014)<br></p>Fórmula:C50H67N7O8Cor e Forma:NeatPeso molecular:894.11(S)-N-(1-Amino-1-oxobutan-2-yl)-4-chlorobutanamide
CAS:<p>Impurity Levetiracetam USP Related Compound A<br>Applications (S)-N-(1-Amino-1-oxobutan-2-yl)-4-chlorobutanamide is a related compound of Levetiracetam (L331500). Levetiracetam related compound A. Levetiracetam USP Related Compound A.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>Fórmula:C8H15ClN2O2Cor e Forma:White To Off-WhitePeso molecular:206.67Gimeracil
CAS:Produto Controlado<p>Applications Gimeracil is an antitumor agent. Gimeracil is a potent inhibitor of dihydropyrimidine dehydrogenase (DPD).<br>References Shirasaka, T., et al.: Cancer Res., 56, 2602 (1996), Patt, Y., et al.: J. Clin. Oncol., 22, 271 (2004), Shirao, K., et al.: Cancer, 100, 2355 (2004), Kelly, H., et al.: J. Clin. Oncol., 23, 4553 (2005),<br></p>Fórmula:C5H4ClNO2Cor e Forma:NeatPeso molecular:145.542-Amino-5-(trifluoromethoxy)phenyl Thiocyanate
CAS:<p>Applications An impurity of Riluzole (R510000).<br></p>Fórmula:C8H5F3N2OSCor e Forma:NeatPeso molecular:234.20Acetamiprid-d3
CAS:Produto Controlado<p>Applications Acetamiprid-d3 is labelled Acetamiprid (A150800), a novel neonicotinid insecticide against Holotrichia consanguinea in sugarcane. Reports show that when exposed to neonicotinid pesticides honeybees have probelms returnign home after foraging and bumblebee colonies grow poorly and produce fewer queens. Also used in Cannabis testing.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Srivastava, A., et al.: Indian Sugar, 32, 673 (1983), Fleming, R., et al.: J. Econ. Entomol., 78, 1179 (1985), Rao, Ch.V., et al.: Pestology, 35, 47 (2011), Chem. and Eng. News 90: 10 (2012)<br></p>Fórmula:C102H3H8ClN4Cor e Forma:ColourlessPeso molecular:225.69Telmisartan Acyl-β-D-glucuronide
CAS:Produto Controlado<p>Applications Telmisartan Acyl-β-D-glucuronide is a metabolite of Telmisartan (T017000).<br>References Abe, T., et al.: J. Biol. Chem., 274, 17159 (1999), Hirano, M., et al.: Drug Metab. Dispos., 34, 1229 (2006),<br></p>Fórmula:C39H38N4O8Cor e Forma:White To Off-WhitePeso molecular:690.74N-Formyl Apixaban
CAS:Produto Controlado<p>Applications N-Formyl Apixaban is derived from Apixaban (A726700) which is a potent, direct, selective, and orally active inhibitor of coagulation factor Xa. It is a potential new oral coagulant that may be useful prevention of venous thromboembolism in total hip, knee replacement orthopedic surgery and stroke in treatment of patient with venous thromboembolic disorder or with atrial fibrillation.<br>References Luettgen, J.M. et al.: J. Enz. Inhib. Med. Chem., 26, 514 (2011); Glanis, T. et al.: J. Thromb. Thrombol., 31, 310 (2011); barrett, Y.C. et al.: Thromb. Haemos., 105, 181 (2011);<br></p>Fórmula:C26H25N5O5Cor e Forma:NeatPeso molecular:487.51ent-Paroxol
CAS:Produto Controlado<p>Applications An intermediate in the synthesis of Paroxetine (P205750), a selective serotonin reuptake inhibitor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Dechant, K., et al.: Drugs, 41, 225 (1991),<br></p>Fórmula:C13H18FNOCor e Forma:NeatPeso molecular:223.29Ritonavir Ethyl Carbamate
Produto Controlado<p>Applications Ritonavir Ethyl Carbamate is an impurity of the selective HIV protease inhibitor Ritonavir (R535000).<br>References Harrigan, P., et al.: J. Infect. Dis., 191, 339 (2005), Miller, J., et al.: Bioorg. Med. Chem. Lett., 16, 1788 (2006)<br></p>Fórmula:C31H40N4O6SCor e Forma:NeatPeso molecular:596.737
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