Derivados de Quinazolina e Quinolina
As quinazolinas e quinolinas são compostos heterocíclicos contendo nitrogénio, com estruturas aromáticas que desempenham um papel fundamental na síntese de fármacos com atividade anticancerígena, antimicrobiana e anti-inflamatória. Os seus derivados apresentam modificações estruturais que otimizam a biodisponibilidade e a seletividade, permitindo o desenvolvimento de novos princípios ativos para diversas aplicações terapêuticas. Estes compostos são utilizados na fabricação de APIs para o tratamento do câncer, infeções, doenças neurodegenerativas e cardiovasculares. Além disso, os derivados de quinazolina e quinolina são essenciais na investigação de inibidores enzimáticos e no desenvolvimento de moléculas bioativas inovadoras.
Na CymitQuimica, oferecemos derivados de quinazolina e quinolina de alta pureza para aplicações em síntese química, desenvolvimento farmacêutico e biotecnologia.
Foram encontrados 65541 produtos de "Derivados de Quinazolina e Quinolina"
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Afatinib
CAS:<p>Applications An aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder.<br>References Nakao, K., et al.: Sci. Rep., 9, 18202 92019); Ebert, K, PLoS One, 14, 0223225 (2019)<br></p>Fórmula:C24H25ClFN5O3Cor e Forma:NeatPeso molecular:485.941,1'-[(5E)-5-Methyl-7-oxo-5-undecene-1,11-diyl] Bis[Theobromine]
CAS:Fórmula:C26H34N8O5Cor e Forma:NeatPeso molecular:538.60N-Dehydroxyzileuton
CAS:Produto Controlado<p>Applications N-Dehydroxyzileuton is a pharmacologically inactive metabolite of Zileuton (Z420000), an inhibitor of 5-lipoxygenase that is used to treat patients with asthma.<br>References Awni, W., et al.: Clin. Pharm., 29, 62 (1995); Machinist, J., et al.: Clin. Pharm., 29, 34 (1995); Remko, M., et al.: Phys. Chem. Chem. Phys., 2, 2511 (2000);<br></p>Fórmula:C11H12N2OSCor e Forma:NeatPeso molecular:220.29Roflumilast-d4
CAS:Produto Controlado<p>Applications Labelled selective phosphodiesterase 4(PDE4) inhibitor. Antiasthmatic; in treatment of chronic obstructive pulmonary disease.<br>References Hatzelmann, A., et al.: J. Pharmacol. Exp. Ther., 297, 267 (2001), Schmidt, B.M.W., et al.: J. Allergy Clin. Immunol., 108, 530 (2001), Timmer, W., et al.: J. Clin. Pharmacol., 42, 297 (2002), Rabe, K.F., et al.: Lancet, 366, 563 (2005),<br></p>Fórmula:C17D4H10Cl2F2N2O3Cor e Forma:NeatPeso molecular:407.234-Bromo Riluzole
CAS:Produto Controlado<p>Applications 4-Bromo Riluzole is an impurity of Riluzole (R510000); a benzothiazole derivative that is used to treat amyotrophic lateral sclerosis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ahamed, A., et al.: J. Pharm. Res., 3, 1028 (2010); Satyanarayana, B., et al.: ARKIVOC, no vol., 109 (2008)<br></p>Fórmula:C8H4BrF3N2OSCor e Forma:NeatPeso molecular:313.09N,O-Bis(trimethylsilyl)trifluoroacetamide (~90%)
CAS:Produto Controlado<p>Applications Used as a reactant in the preparation of pyrimidinone ribosides and analogs that show anti-tumor properties.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Driscoll, J.S. et al.: J. Med. Chem., 34, 3280 (1991); Pan, L. et al.: J. Pharm. Biomed. Anal., 52, 589 (2010);<br></p>Fórmula:C8H18F3NOSi2Pureza:~90%Cor e Forma:Colourless To Light YellowPeso molecular:257.40Bisnortilidine
CAS:Produto Controlado<p>Applications A metabolite of Tilidine (T440300(M)), which is a controlled substance (opiate) and a analgesic. Tilidine is used in clinical trial in comparison with Nefopam. Tilidine is one of the most widely used narcotics in Germany and Belgium.<br>References Hengy, H., et al.: J. Pharm. Sci., 67, 1765 (1978); Cordonnier, J., et al.: J. Anal. Toxicol., 11, 144 (1987); Hajda, J., et al.: J. Clin. Pharmacol., 42, 1257 (2002); Vollmer, K.-O., et al.: Arzneim.-Forsch., 20, 990 (1970); Abeloos, J., et al.: Acta Anaesthesiol. Belg., 34, 283 (1983); Van Cauwenberge, H., et al.: Int. J. Clin. Pharmacol. Res., 12, 1 (1992)<br></p>Fórmula:C15H19NO2Cor e Forma:NeatPeso molecular:245.32(S)-(-)-Carvedilol
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications The optically active isomer of Carvedilol (C184625), a nonselective ß-adrenergic blocker with a1-blocking activity. An antihypertensive used in the treatment of congestive heart failure.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hirohashi, M., et al.: Arzneim.-Forsch., 40, 735 (1990),<br></p>Fórmula:C24H26N2O4Cor e Forma:Off White SolidPeso molecular:406.47Decoquinate
CAS:Produto Controlado<p>Applications Decoquinate is a quinolone coccidiostat used in veterinary medicine, in particular as animal feed for poultry.<br>References Del Cacho, E. et al.: Int. J. Parasitol., 36, 1515 (2006); Guo, F.C. et al.: Vet. Parasitol., 147, 239 (2007); Davis, J.L. et al.: Vet. Pharmacol. Therap., 9, 1145 (2009);<br></p>Fórmula:C24H35NO5Cor e Forma:Off-WhitePeso molecular:417.54Mavoglurant
CAS:Produto Controlado<p>Applications Mavoglurant is a non-competitive metabotropic glutamate receptor 5 (mGlu5) receptor antagonist.<br>References Vranesic, I., et al.; Bioorg. Med. Chem., 22, 5790 (2014); Kubas, H., et al.: Bioorg. Med. Chem. Lett., 23, 6370 (2013)<br></p>Fórmula:C19H23NO3Cor e Forma:NeatPeso molecular:313.39Ebastine
CAS:<p>Applications A nonsedating type histamine H1-receptor antagonist. Antihistaminic.<br>References Fliri, A., et al.: J. Med. Chem., 52, 8038 (2009), Inomata, N., et al.: J. Dermatol., 36, 224 (2009), Carvajal, A., et al.: Clin. Pharmacol. Ther., 85, 481 (2009), Yamashita, S., et al.: Mol. Pharm., 6, 48 (2009),<br></p>Fórmula:C32H39NO2Cor e Forma:White To Off-WhitePeso molecular:469.6642-O-tert-Butyldimethylsilyloxyethyl Rapamycin
CAS:<p>Stability Hygroscopic<br>Applications 42-O-tert-Butyldimethylsilyloxyethyl Rapamycin is a useful synthetic intermediate in the synthesis of Everolimus (E945400); an immunosuppressant macrolide and analog of the parent drug Rapamycin (R124000). Everolimus inhibits cytokine-mediated lymphocyte proliferation.<br>References Dumont, F.J., et al.: Curr. Opin. Invest. Drugs, 2, 1220 (2001); Kovarik, J. M., et al.: Clin. Pharmacol. Ther., 69, 48 (2001); Nashan, B., et al.: Ther. Drug Monit., 24, 53 (2002); Venkata, S.P., et al.: PCT Int. Appl. WO 2012066502 A1 20120524. May 24, 2012<br></p>Fórmula:C59H97NO14SiCor e Forma:NeatPeso molecular:1072.48Hydroxydehydro Nifedipine Carboxylate
CAS:Produto ControladoFórmula:C16H14N2O7Cor e Forma:NeatPeso molecular:346.29Desfluoro Risperidone
CAS:Produto Controlado<p>Impurity Risperidone EP Impurity K<br>Applications Desfluoro Risperidone (Risperidone EP Impurity K) is a Risperidone (R525000) impurity, as antipsychotics.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>Fórmula:C23H28N4O2Cor e Forma:NeatPeso molecular:392.49(Z,Z)-5-(2-Methyl-3-phenyl-propenylidene)-4-oxo-2-thioxo-3-thiazolidineacetic Acid
CAS:Produto Controlado<p>Stability Light Sensitive<br>Applications (Z,Z)-5-(2-Methyl-3-phenyl-propenylidene)-4-oxo-2-thioxo-3-thiazolidineacetic Acid is a stereoisomer of Epalrestat (E565300), an aldose reductase inhibitor. Used in the treatment of diabetic neuropathy.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Terashima, H., et al.: J. Pharmacol. Exp. Ther., 229, 226 (1983), Kikkawa, R., et al.: Diabetologia, 24, 290 (1983), Kojima, K., et al.: Jpn. J. Ophthalmol., 29, 99 (1985), Qi, M. et al.: J. Beij, Inst. Tech., 13, 445 (2004);<br></p>Fórmula:C15H13NO3S2Cor e Forma:Yellow-Red SolidPeso molecular:319.4Carboxymefloquine-d3
CAS:Produto Controlado<p>Applications Labelled Carboxymefloquine (C178700). Carboxymefloquine is a metabolite of Mefloquine (M207050).<br>References Crevoisier, C., et al.: Eur. J. Clin. Pharmacol., 53, 135 (1997), Ridtitid, W., et al.: J. Pharm. Pharmacol., 52, 1265 (2000),<br></p>Fórmula:C12H2D3F6NO2Cor e Forma:NeatPeso molecular:312.18N-Nitroso Desmethyl Olopatadine
Produto ControladoFórmula:C20H20N2O4Cor e Forma:NeatPeso molecular:352.384N,N'-Methylene Ambroxol Hydrochloride
CAS:Produto Controlado<p>Impurity Ambroxol EP Impurity B Hydrochloride<br>Stability Hygroscopic<br>Applications Ambroxol Cyclic Impurity is a metabolite as well as an impurity of the bronchosecretolytic drug, Ambroxol (A575900).<br>References Hammer, R. et al.: Arzneim.-Forsch., 28, 899 (1978); Nieder, M. et al.: HRC & CC, 9, 561 (1986); Huq, F. et al.: J. Pharmacol. Toxicol., 3, 147 (2008);<br></p>Fórmula:C14H18Br2N2O·ClHCor e Forma:White To Off-WhitePeso molecular:426.57N-Benzyl Hydroxymedetomidine
CAS:Produto Controlado<p>Applications N-Benzyl Hydroxymedetomidine is an impurity of Medetomidine (M203250, HCl); an α2-adrenergic agonist, sedative, and analgesic.<br>References Scheinin, M., et al.: Br. J. Clin. Pharmacol., 24, 443 (1987); Stenberg, D., et al.: J. Vet. Pharmacol. Ther., 10, 319 (1987); Virtanen, R., et al.: Eur. J. Pharmacol., 150, 9 (1988); Cullen, L.K., et al.: Br. Vet. J., 152, 519 (1996)<br></p>Fórmula:C20H22N2OCor e Forma:NeatPeso molecular:306.41-(3-Cyano-2-pyridyl)-4-methyl-2-phenylpiperazine
CAS:<p>Applications Used in the preparation of Mirtazapine (M365000) impurities.<br></p>Fórmula:C17H18N4Cor e Forma:Light Yellow To BrownPeso molecular:278.35(2S)-1-(2-Chloroacetyl)-2-9-pyrrolidinecarbonitrile
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications (2S)-1-(2-Chloroacetyl)-2-9-pyrrolidinecarbonitrile is a key intermediate for dipeptidyl peptidase IV inhibitor Vildagliptin (V305000).<br>References Singh, S.K., et al.: Beil. J. Org. Chem., 4, 20 (2008);<br></p>Fórmula:C7H9ClN2OCor e Forma:NeatPeso molecular:172.614-Amino-2,6-dichloro-α-(4-chlorophenyl)benzeneacetonitrile
CAS:Produto Controlado<p>Applications This compound is used in the synthesis of Diclazuril (D436200) and diclazuril derivatives.<br></p>Fórmula:C14H9Cl3N2Cor e Forma:NeatPeso molecular:311.59(R)-2-((4-Aminophenethyl)amino)-1-phenylethanol
CAS:Produto ControladoFórmula:C16H20N2OCor e Forma:NeatPeso molecular:256.34N-Nitroso-N-methyl-4-aminobutyric Acid (200 μg/mL in Methanol)
CAS:Fórmula:C5H10N2O3Cor e Forma:ColourlessPeso molecular:146.146-Chloro-2-cyclopropyl-4-(trifluoromethyl)-quinoline
CAS:Produto Controlado<p>Impurity Efavirenz USP Related Compound C/ Efavirenz Quinoline Impurity<br>Applications 6-Chloro-2-cyclopropyl-4-(trifluoromethyl)-quinoline is an impurity of Efavirenz (E425000), a nonnucleoside HIV-1 reverse transcriptase inhibitor and antiviral agent.<br>References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995), Jiang, B., et al.: Euro. J. Org. Chem., 16, 2693 (2008); Ribeiro, J.A., et al.: J. Pharma. Biomed. Anal., 43, 298 (2007);<br></p>Fórmula:C13H9ClF3NCor e Forma:NeatPeso molecular:271.67Piperazin-1-yl(quinoxalin-6-yl)methanone hydrochloride
CAS:Pureza:95.0%Cor e Forma:SolidPeso molecular:278.739990234375(R)-3-((tert-Butoxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoic Acid
CAS:Produto Controlado<p>Applications (R)-3-((tert-Butoxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoic Acid has been used as a reactant for the preparation of dipeptidyl peptidase-4 (DPP4) inhibitors for the treatment of type 2 diabetes, such as sitagliptin.<br>References Kim, H.J., et. al.: Bioorg. Med. Chem. Lett., 22, 5545 (2012)<br></p>Fórmula:C15H18F3NO4Cor e Forma:NeatPeso molecular:333.30Aripiprazole N4-Oxide
CAS:Produto Controlado<p>Impurity Aripiprazole Impurity 9<br>Applications Aripiprazole N4-Oxide is a metabolite of anti-psychotic drug, Aripiprazole (A771000). Aripiprazole Impurity 9<br>References Rowley, M., et al.: J. Med. Chem., 44, 477 ( 2001), Ozdemir, V., et al.: Curr. Opin. Invest Drugs 2002, 3, 113,,,4) Jordan, S; European Journal Pharmacol 2002, 441, 137<br></p>Fórmula:C23H27Cl2N3O3Cor e Forma:NeatPeso molecular:464.384-Anilino-4-oxobutanoic Acid
CAS:Produto Controlado<p>Applications The metabolite (MII) of Suberoylanilide Hydroxamic Acid (S688700).<br>References Sun, W.S., et al.: J. Med. Chem., 46, 5619 (2003)<br></p>Fórmula:C10H11NO3Cor e Forma:NeatPeso molecular:193.20Maraviroc
CAS:Produto ControladoFórmula:C29H41F2N5OCor e Forma:White To Off-WhitePeso molecular:513.67Methyl 4’-[[2-n-Propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazol-1-yl]methyl]biphenyl-2-ca
CAS:Fórmula:C34H32N4O2Cor e Forma:YellowPeso molecular:528.64Nifursol (~90%)
CAS:Produto Controlado<p>Applications A medicinal, prophylactic additive in animal feeds, protecting poultry from histomoniasis.Environmental contaminants; Food contaminants; Heat processing contaminants<br>References Kowalski, P., et al.: J. Pharm. Biomed. Anal., 32, 937 (2003), Khlebnikov, A., et al.: Bioorg. Med. Chem., 16, 9302 (2008), Schepetkin, I., et al.: Mol. Pharmacol., 74, 392 (2008),<br></p>Fórmula:C12H7N5O9Pureza:~90%Cor e Forma:NeatPeso molecular:365.21Vildagliptin Amide
CAS:Produto Controlado<p>Impurity Vildagliptin Amide Impurity<br>Applications N-(3-Hydroxytricyclo[3.3.1.13,7]dec-1-yl)glycyl-L-prolinamide is an impurity of Vildagliptin (V305000) which is an oral anti-hyperglycemic agent that inhibit dipeptidyl peptidase 4 (DPP-4).<br>References Ahren, B., et al.: J. Clin. Endocrinol. Metab., 89, 2078 (2004), Ahren, B., et al.: Diabetes Care, 27, 2874 (2004), Barlocco, D., et al.: Curr. Opin. Invest. Drugs, 5, 1094 (2004),<br></p>Fórmula:C17H27N3O3Cor e Forma:Off-WhitePeso molecular:321.41Felbamate-d4
CAS:Produto Controlado<p>Applications Antiepileptic, structurally similar to meprobamate.<br>References Swinyard, E.A., et al.: Epilepsia, 27, 27 (1986), Remmel, R.P., et al.: Ther. Drug Monit., 12, 90 (1990), Sofia, R.D., et al.: Epilepsy Res. Suppl., 3, 103 (1991),<br></p>Fórmula:C11H10D4N2O4Cor e Forma:NeatPeso molecular:242.267Irbesartan-d4
CAS:Produto Controlado<p>Applications Irbesartan-d4 is the labeled analogue of Irbesartan (I751000), an angiotensin II type 1 (AII1)-receptor antagonist.<br>References Gillis, J.C. and Markham, A.: Drugs, 54, 885 (1997); Chando, T.J., et al.: Drug. Metabol. Dispos., 26, 408 (1998); Massie, B., et al.: New Eng. J. Med., 359, 2456 (2008); Ren, X., et al.: Pharmacol., 83, 80 (2009)Aromatics, Heterocycles, Inhibitors, Isotope Labelled Compounds, Pharmaceuticals, Intermediates & Fine Chemicals<br></p>Fórmula:C25H24D4N6OCor e Forma:NeatPeso molecular:432.55Trametinib
CAS:Produto Controlado<p>Applications Used in the systematic treatment of advanced cutaneous melanoma. An EGFR kinase inhibitor and potent MEK inhibitor.<br>References Ercan, D. et al.: Canc. Disc., 2, 934 (2012); Mackiewicz-Wysocka, M. et al.: Exp. Opin. Investig. Drugs., 22, 181 (2013);<br></p>Fórmula:C26H23FIN5O4Cor e Forma:Off-WhitePeso molecular:615.39Alogliptin-d3
CAS:Produto Controlado<p>Applications Labelled Alogliptin (A575425). It is an oral antihyperglycemic agent that is a selective inhibitor of the enzyme dipeptidyl peptidase-4 (DPP-4). Antidiabetic agent.<br>References Lynn, F., et al.: Diabetes, 50, 1004 (2001), Trumper, A., et al.: J. Endocrinol., 174, 233 (2002), Vollmer, K., et al.: J. Clin. Endocrinol. Metab., 94, 1379 (2009),<br></p>Fórmula:C182H3H18N5O2Cor e Forma:NeatPeso molecular:342.41Vismodegib
CAS:Produto Controlado<p>Applications Vismodegib targets the Hedgehog (Hh) pathway. Inhibition of the Hh signaling may be effective in the treatment and prevention of many types of human cancers. Potent Hedgehog inhibitor.<br>References Gupta, S. et al.: Ther. Advances in Med. Oncology 2,237(2010)<br></p>Fórmula:C19H14Cl2N2O3SCor e Forma:Off-WhitePeso molecular:421.30Nimodipine
CAS:<p>Applications A dihydropyridine calcium channel blocker. It is used as a vasodilator (cerebral). Neuroprotective & Neuroresearch products.<br>References Allen, G.S., et al.: N. Engl. J. Med., 308, 619 (1983), Schluter, H.: Arzneim.-Forsch., 36, 1733 (1986), Deyo, R.A., et al.: Science, 243, 809 (1989),<br></p>Fórmula:C21H26N2O7Cor e Forma:NeatPeso molecular:418.44N-Chloro Ethyl ThioTEPA
CAS:Produto Controlado<p>Stability Hygroscopic, Moisture Sensitive<br>Applications N-Chloro Ethyl ThioTEPA is an impurity of ThioTEPA which is an alkylating agent used to treat cancer.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Maanen, M., et al.: Cancer Treatment Rev., 26, 257 (2000); Sykes, M., et al.: Cancer, 6, 142 (1953)<br></p>Fórmula:C6H13ClN3PSCor e Forma:White To Off-WhitePeso molecular:225.681,1-Cyclohexanediacetic Acid Monoamide
CAS:Produto Controlado<p>Applications 1,1-Cyclohexanediacetic acid monoamide is an impurity of Gabapentin (G117250), an amino acid structurally related to γ-Aminobutyric Acid (GABA), designed to cross the blood brain barrier. Gabapentin is used as an anticonvulsant.<br>References Vollmer, K.-O. et al.: Arzneimittel-Forshc., 36, 830 (1986), Saletu, B., et al.: Int. J. Clin. Pharmacol. Ther. Toxicol., 24, 362 (1986)<br></p>Fórmula:C10H17NO3Cor e Forma:White To Off-WhitePeso molecular:199.247N-Ethoxycarbonyl Norfloxacin
CAS:Fórmula:C19H22FN3O5Cor e Forma:White To Off-WhitePeso molecular:391.39
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