Esteroides e Derivados

<p>Soluble in Chloroform &amp; in Methanol Confirmed<br>Insoluble in Wate</p>

<p>Fluticasone Propionate EP Impurity F is an impurity of Fluticasone Propionate. Fluticasone Propionate is a synthetic glucocorticoid used in the treatment of asthma and other allergic disorders. Impurity F is a metabolite of Fluticasone Propionate and has been detected in human plasma at low levels (5% of total fluticasone propionate). The metabolism of Fluticasone Propionate to Impurity F has been studied in rat, mouse, dog and man.<br>br&gt;br&gt;<br>The following table summarizes the metabolic pathways that have been identified for this impurity:<br>br&gt;br&gt;<br>Metabolism studies indicate that Impurity F is mainly metabolized by CYP3A4 to form conjugates with glucuronic acid or sulfates. It may also be hydrolyzed to form 5α-flurostan-3β,17β-d</p>

<p>Atorvastatin epoxy tetrahydrofuran impurity is a byproduct of the synthesis process. It is a white crystalline powder that is soluble in organic solvents and sparingly soluble in water. Atorvastatin epoxy tetrahydrofuran impurity has been shown to be an impurity of atorvastatin. It is not known to have any biological activity, but it may pose a health risk if present in large quantities.</p>

<p>Atorvastatin impurity F is an impurity that can be found in atorvastatin. It is a white to off-white crystalline solid with a melting point of 142°C. It has a molecular weight of 273.5 and chemical formula of C14H13N3O2. This impurity can be found in atorvastatin as an API impurity, which may have an effect on the efficacy or toxicity of the drug product. Impurities are present in all pharmaceutical products and should be identified, characterized, and quantified for quality control purposes. Impurities are often unavoidable byproducts of the manufacturing process and can lead to potential safety concerns if they are not detected early on during drug development. The presence of impurities may also affect the pharmacological effects or therapeutic efficacy of the drug product.</p>

<p>Fluoxetine is a selective serotonin reuptake inhibitor that is used to treat major depressive disorder, obsessive-compulsive disorder (OCD), bulimia nervosa, panic disorder, premenstrual dysphoric disorder (PMDD), and social anxiety disorder. It is also used as an appetite suppressant in some countries. Fluoxetine inhibits the neuronal uptake of serotonin by blocking the presynaptic transporter protein. The most common adverse effects are nausea, diarrhea, drowsiness, dry mouth, blurred vision and sexual dysfunction.</p>

<p>(betaS,deltaS)-2-(4-Fluorophenyl)-beta,delta-dihydroxy-5- (1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole- 1-heptanoic acid calcium salt (2:1) is a fluorinated derivative of the natural metabolite 2-(4-fluorophenyl)-beta,delta-dihydroxy -5-(1 methylethyl)-3 phenyl 4-[(phenylamino)carbonyl]-1H pyrrole 1 heptanoic acid. It is an enantiomer of the racemate with optical purity &gt; 98%. The compound has been used as a pharmacological and supramolecular chemistry probe for assays and chemosensors.</p>

<p>Dutasteride impurity D is a natural impurity found in dutasteride and has been reported to be an analytical marker for dutasteride. It is also used as an impurity standard, HPLC standard, and custom synthesis for drug development. Metabolism studies have shown that the major route of elimination for Dutasteride impurity D is through glucuronidation with minor amounts being excreted in urine unchanged.</p>

<p>Calcipotriol EP Impurity E is a synthetic impurity that is found in the calcipotriol EP API. Calcipotriol EP Impurity E is an impurity standard for HPLC and can be used in drug development, research and development, and pharmacopoeia. It has been shown to have no significant effect on the pharmacological activity of calcipotriol EP.</p>

<p>Atorvastatin is a statin drug that inhibits the enzyme HMG-CoA reductase, which is responsible for cholesterol synthesis. Atorvastatin is used to lower LDL cholesterol and total cholesterol levels in the blood. It also lowers triglyceride levels and raises HDL cholesterol levels. Atorvastatin has been shown to inhibit fibrinogen production, reduce TNF-α production, and improve body mass index (BMI) in obese patients. This drug has been shown to be effective in reducing the size of atherosclerotic lesions by decreasing the amount of cholesteryl esters transferred from high-density lipoprotein (HDL) to low-density lipoprotein (LDL). It has also been shown to inhibit collagen production and stimulate muscle cell proliferation.</p>

<p>Defluoro atorvastatin calcium is a bulk drug that has been approved to be used as an adjunct to diet to reduce elevated cholesterol levels in adults. Defluoro atorvastatin calcium is the desfluoro-enantiomer of atorvastatin, which is a statin that inhibits the enzyme HMG-CoA reductase. This enzyme catalyzes the conversion of HMG-CoA to mevalonic acid, which is an early step in the synthesis of cholesterol. The fluoro group on defluoro atorvastatin calcium is not expected to have any significant effect on its potency or metabolic pathways and any impurities are not expected to have any therapeutic effect.</p>

<p>Beta-Epoxyabiraterone acetate is a synthetic and natural metabolite of abiraterone that is used as an API impurity in the synthesis of abiraterone acetate. The drug product is a niche compound with CAS No. 52464-96-6. The Metabolite is an impurity found in the synthesis of beta-epoxyabiraterone acetate. Drug development research and development, analytical methods, and pharmacopoeia are all involved in the production of this compound.</p>

<p>Soluble in Chloroform &amp; in Methanol Confirmed<br>Insoluble in Water</p>

<p>7α-Hydroxyhydrocortisone</p>

<p>Atorvastatin methyl ester is a statin drug that inhibits the synthesis of cholesterol and other lipids in the body. It is used to reduce high levels of low-density lipoprotein (LDL) cholesterol, which may lead to heart disease or stroke. Atorvastatin methyl ester has been shown to be effective in reducing the uptake of LDL cholesterol into cells by preventing the formation of LDL particles. This drug also decreases the production of biphosphate-containing phospholipids, which are essential for dendritic cell maturation. The crystalline polymorphs have been characterized by X-ray diffraction and microscopy. Impurities can be detected using ultraviolet spectroscopy, infrared spectroscopy, or nuclear magnetic resonance spectroscopy.</p>

<p>Calcipotriol EP Impurity B is a drug product that is an impurity in Calcipotriol EP. It is produced during the synthesis of calcipotriol and may be present in the natural product. It has been shown to have anti-inflammatory properties, and can be used as a research tool to study calcipotriol metabolism.</p>

<p>Calcipotriol EP Impurity H is an impurity found in calcipotriol EP. It is a metabolite of calcipotriol EP, which is the active ingredient in Dovonex. Calcipotriol EP Impurity H can be detected by HPLC with a retention time of 11.5 minutes and its purity can be determined by UV spectroscopy at 254 nm with a purity of &gt;98%. Calcipotriol EP Impurity H can also be synthesized from natural or synthetic sources.</p>

<p>Atorvastatin lactone is a prodrug for atorvastatin. It is an inhibitor of the enzyme HMG-CoA reductase, which is involved in cholesterol synthesis and reduces LDL cholesterol levels. Atorvastatin lactone is absorbed from the gut into the bloodstream and then converted to atorvastatin, which has a higher potency than atorvastatin lactone. This conversion occurs in the liver by cytochrome P450 enzymes, including cytochrome CYP3A4. The pharmacokinetics of atorvastatin lactone are influenced by drugs that inhibit these enzymes. Atorvastatin and its metabolites are excreted in human serum as glucuronide or sulfate conjugates.</p>

<p>(5α)-17-(3-Pyridinyl)androst-16-en-3-one is a natural metabolite of testosterone that is produced in the liver. It has been identified as an impurity in API, which can be found in drugs used for the treatment of high blood pressure and prostate cancer. (5α)-17-(3-Pyridinyl)androst-16-en-3-one is not active as a drug itself, but it can be used as a standard to study the metabolism of testosterone and other steroids.</p>