Esteroides e Derivados
Os esteroides são compostos orgânicos que possuem uma estrutura de quatro anéis fundidos, conhecida como núcleo esteroide. Esse núcleo pode estar ligado a vários grupos funcionais que modificam suas propriedades e funções biológicas. Os esteroides desempenham um papel fundamental na regulação dos processos metabólicos e hormonais. São utilizados na medicina para tratar distúrbios inflamatórios, doenças autoimunes e desequilíbrios hormonais. Além disso, alguns derivados de esteroides possuem potentes propriedades anti-inflamatórias, como os corticosteroides. Em terapias específicas, são utilizados para reduzir a inflamação e controlar a dor em diversas doenças.
Na CymitQuimica, oferecemos uma variedade de esteroides e seus derivados para pesquisa e desenvolvimento farmacêutico.
Foram encontrados 4962 produtos de "Esteroides e Derivados"
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Digoxigenin Bisdigitoxoside
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications A metabolite of Digoxin (Dx) (D446575).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Fujii, Y., et al.: Clin. Chem., 37, 476 (1991), Salphati, L., et al.: Xenobiotica, 29, 171 (1999), Song, S., et al.: Drug Metab. Dispos., 27, 689 (1999),<br></p>Fórmula:C35H54O11Cor e Forma:NeatPeso molecular:650.80trans-Latanoprost
CAS:<p>Impurity Latanoprost USP Related Compound A<br>Stability Temperature Sensitive<br>Applications Prostaglandin analog; prodrug of active acid metabolite. It is a synthetic derivative of the natural prostaglandin PGF2α, used as an anti-glaucoma agent that is effective in various types of glaucoma and ocular hypertension. Latanoprost USP Related Compound A.<br>References Resul, B., et al.: J. Med. Chem., 36, 2242 (1993), Toris, C., et al.: Ophthalmology, 100, 1297 (1993), Holmstrom, S., et al.: Curr. Med. Res. Op., 21, 1875 (2005),<br></p>Fórmula:C26H40O5Cor e Forma:ColourlessPeso molecular:432.59Promestriene
CAS:Produto Controlado<p>Applications A synthetic diethyl-ether of Estradiol with no distal hormonal effects, in patients undergoing surgical correction for stress urinary incontinence (SUI).<br>References Kelleher, C., et al.: Br. J. Obstet. Gynaecol., 104, 1374 (1997), Deffieux, X., et al.: J. Gynecol. Obstet. Biol. Reprod., 35, 678 (2006),<br></p>Fórmula:C22H32O2Cor e Forma:NeatPeso molecular:328.49trans-Doxercalciferol
CAS:Produto Controlado<p>Applications A Vitamin D derivative.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Koeffler, M.R., et al.: Blood, 74, 82 (1989),<br></p>Fórmula:C28H44O2Cor e Forma:NeatPeso molecular:412.6517,21-Dihydroxy-16a-methylpregna-1,4,9(11)-triene-3,20-dione 21-Acetate
CAS:Produto Controlado<p>Applications 17,21-Dihydroxy-16α-methylpregna-1,4,9(11)-triene-3,20-dione 21-Acetate is an intermediate in the synthesis of Mometasone Furoate (M490000), a tropical corticosteroid used as an anti-inflammatory agent.<br>References Spangler, M., et al.: Chromatograph., 54, 329 (2001); Reeves, E.K., et al.: Bioorg. Med. Chem., 21, 2241 (2013);<br></p>Fórmula:C24H30O5Cor e Forma:White To Light YellowPeso molecular:398.4921-Deoxy Cortisone
CAS:Produto Controlado<p>Applications A Cortisone derivative, a glucocorticoid.<br>References Mickelson, K., et al.: Biochemistry, 20, 6211 (1981), Westphal, U., et al.: J. Steroid Biochem., 19, 1 (1983),<br></p>Fórmula:C21H28O4Cor e Forma:NeatPeso molecular:344.44Estriol Methyl Ether
CAS:<p>Impurity Estriol EP Impurity C<br>Applications Estriol Methyl Ether (Estriol EP Impurity C) is a metabolite (1,2) of Estriol (E888960), which is a produced naturally and also a metabolite of Estradiol (E888000). Estriol is a GPR3 antagonist in estrogen receptor-negative breast cancer cells displaying anti-proliferative effects (3).<br>References 1. Marrian, G. et al.: Biochem. J. 1929;23(5):1090-8.2. Rogerson, B. et al.: Arch. Biochem. Biophys. 1986 Oct;250(1):70-85.3. Lappano, R. et al.: Mol Cell Endocrinol. 2010 May 14;320(1-2):162-70.<br></p>Fórmula:C19H26O3Cor e Forma:NeatPeso molecular:302.41Fulvestrant 9-Sulfone
CAS:Produto Controlado<p>Impurity Fulvestrant EP Impurity B<br>Applications A metabolite of Fulvestrant (F862500).<br>References Rao, P., et al.: J. Steroid Biochem., 25, 417 (1986), Wakeling, A., et al.: J. Steroid Biochem. Mol. Biol., 43, 173 (1992), DeFriend, D., et al.: Cancer Res., 54, 408 (1994),<br></p>Fórmula:C32H47F5O4SCor e Forma:NeatPeso molecular:622.77Ospemifene
CAS:Produto Controlado<p>Applications Ospemifene is used to treat dyspareunia. It is a selective estrogen receptor modulator (SERM) acting similarly to an estrogen.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rutanen, E., et al.: Menopause, 10, 433 (2003);<br></p>Fórmula:C24H23ClO2Cor e Forma:White To Off-WhitePeso molecular:378.891,2-Dihydro Desoxymetasone
CAS:Produto Controlado<p>Applications A metabolite of Desoxymetasone (D296970).<br>References Schriks, M., et al.: Environ. Sci. Technol., 44, 4766 (2010), Baeck, M., et al.: Eur. J. Dermatol., 20, 102 (2010), Lee, P., et al.: Bioorg. Med. Chem. Lett., 20, 69 (2010),<br></p>Fórmula:C22H31FO4Cor e Forma:NeatPeso molecular:378.484-Methoxy Estrone
CAS:Produto Controlado<p>Applications An endogenous estrogen metabolite, risk-factor for development of breast cancer.<br>References Beral, V., et al.: Lancet, 362, 419 (2003), Nelson, R., et al.: Clin. Chem., 50, 373 (2004), Malekinejad, H., et al.: J. Agric. Food Chem., 54, 9785 (2006),<br></p>Fórmula:C19H24O3Cor e Forma:Off White SolidPeso molecular:300.39Dexamethasone Sodium Phosphate Impurity C
<p>Applications Dexamethasone Sodium Phosphate Impurity C is a derivative of Dexamethasone Sodium Phospahte, which is an impurity compound of Dexamethasone (D298800). Dexamethasone regulates T cell survival, growth, and differentiation. it also inhibits the induction of nitric oxide synthase.<br>References Wershil, B.K., et al.: Int. Arch. Allergy Immunol., 107, 323 (1995), Riccardi, C., et al.: Cell Death Diff., 6, 1182 (1999), Llanos, S.L. and Roldan, A.: Bio Cell, 23, 29 (1999)<br></p>Fórmula:C22H29FO5Cor e Forma:NeatPeso molecular:392.461Dexamethasone 21-Mesylate
CAS:Produto Controlado<p>Stability Moisture Sensitive<br>Applications Dexamethasone 21-Mesylate is a derivative of Dexamethasone (D298800), a glucocorticoid used as an anti-inflammatory agent.<br>References Kim, T.H., et al.: J. Nanosci. Nanotech., 13, 7325 (2013); Joshi, T., et al.: Brit. J. Pharmacol., 172, 1360 (2015);<br></p>Fórmula:C23H31FO7SCor e Forma:NeatPeso molecular:470.55Z,Z-Dienestrol
CAS:Produto Controlado<p>Stability Light Sensitive<br>Applications A metabolite of Diethylstilbestrol.<br>References Liehr, J.G., et al.: Steroids, 40, 713 (1982),<br></p>Fórmula:C18H18O2Cor e Forma:NeatPeso molecular:266.33(2α)-Methyl Megestrol Acetate
CAS:Produto Controlado<p>Impurity Megestrol Acetate EP Impurity H<br>Applications (2α)-Methyl Megestrol Acetate (Megestrol Acetate EP Impurity H) is a related impurity in Megestrol acetate (M208050).<br>References Schneider, F., et al.: Helv. Chim. Acta, 56, 2396 (1973), Aisner, J., et al.: Semin. Oncol., 15, 68 (1988), Krischenowski, D., et al.: Steroids, 58, 278 (1993), Bratoeff, E., et al.: Chem. Pharm. Bull., 51, 1132 (2003),<br></p>Fórmula:C25H34O4Cor e Forma:NeatPeso molecular:398.54Dexamethasone Sodium Sulfobenzoate
CAS:Produto Controlado<p>Applications Dexamethasone Sodium Sulfobenzoate is related to Dexamethasone (D298800) a steroid that regulates T cell survival, growth, and differentiation.<br>References Wershil, B.K., et al.: Int. Arch. Allergy Immunol., 107, 323 (1995); Riccardi, C., et al.: Cell Death Diff., 6, 1182 (1999); Llanos, S.L. and Roldan, A.: Bio Cell, 23, 29 (1999);<br></p>Fórmula:C29H32FO9S·NaCor e Forma:NeatPeso molecular:598.616(7)-Dehydro Norgestrel
CAS:<p>Impurity Levonorgestrel EP Impurity M<br>Applications 6(7)-Dehydro Norgestrel (Levonorgestrel EP Impurity M) is a Norgestrel (N689500) impurity.<br>References Gorog, S., et al.: J. Chromatogr., 400 177 (1987),<br></p>Fórmula:C21H26O2Cor e Forma:NeatPeso molecular:310.4317α-Progesterone
CAS:<p>Applications 17α-Progesterone is a testosterone precursror generated from cholesterol. Also used as a diagnostic agent in the identification and study of ovarian Leydig cell tumor disease.<br>References Vesely, D. et al.: Proc. Natl. Acad. Sci. USA., 76, 3491 (1979); Arhan, E. et al.: J. Pediatric Endocrinol. Metab., 21, 181 (2008);<br></p>Fórmula:C21H30O2Cor e Forma:NeatPeso molecular:314.46δ7-Avenasterol (E/Z mixture)
CAS:<p>Applications Δ7-Avenasterol is an analog of Stigmasterol (S686750); a plant sterol that is used as a precursor in the synthesis of progesterone.<br>References Han, P., et al.: Biotechnol. App. Biochem., 54, 105 (2009); Matsunaga, I., et al.: Anal. Biochem., 393, 222 (2009); Huang, C., et al.: Plant Physiol., 150, 1192 (2009)<br></p>Fórmula:C29H48OCor e Forma:White To Off-WhitePeso molecular:412.6924(R/S)-Hydroxycholesterol-d7
CAS:Produto Controlado<p>Applications 24(R/S)-Hydroxycholesterol-d7 is used in the study of biochemical methods for quantitative detection of steroids containing quantitative charge tags and oxidizing agents and using mass spectroscopy for detection.<br>References Groffoths, Williams., US 20150233953, (2015)<br></p>Fórmula:C272H7H39O2Cor e Forma:NeatPeso molecular:409.70Digitoxin
CAS:<p>Stability Hygroscopic<br>Applications Cardiotonic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Foerster, et al.: Arch. Int. Pharmacodyn. Ther., 159, 1 (1966), Jakovljevic, I.M., Anal. Profiles Drug Subs., 3, 149 (1974)<br></p>Fórmula:C41H64O13Cor e Forma:White To Off-WhitePeso molecular:764.9417-Hydroxy-3,11-dioxo-androsta-1,4-diene-17β-carboxylic Acid
Produto Controlado<p>Applications 17-Hydroxy-3,11-dioxo-androsta-1,4-diene-17β-carboxylic Acid is an intermediate used to prepare (11β,17α)-17-[(Ethoxycarbonyl)oxy]-11-hydroxy-3-oxo-androsta-1,4-diene-17-carboxylic acid (E890570) which is a derivative of Loteprednol Etabonate (L471400), an ophthalmic corticosteroid.<br>References Alberth, M., et al.: J. Biopharm.Sci., 2, 115 (1991), Bodor, N., et al.: Pharm. Res., 9, 1275 (1992), Bartlett, J.D., et al.: J. Ocul. Pharmacol., 9, 157 (1993)<br></p>Fórmula:C20H24O5Cor e Forma:NeatPeso molecular:344.4020(α)-Dihydro Pregnenolone
CAS:<p>Applications 20α-Dihydro Pregnenolone is a metabolite of Pregnenolone (P712200).<br>References Purdy, R., et al.: J. Med. Chem., 33, 1572 (1990), Bixo, M., et al.: Brain Res., 764, 173 (1997), Huang, X., et al.: J. Biol. Chem., 275, 29452 (2000),<br></p>Fórmula:C21H34O2Cor e Forma:NeatPeso molecular:318.4913-Ethyl-17-hydroxy-18,19-dinor-17α-pregn-5(10)-en-20-yn-3-one(Levo Norgestrel Impurity)
CAS:Produto Controlado<p>Impurity Levonorgestrel EP Impurity B<br>Applications 13-Ethyl-17-hydroxy-18,19-dinor-17α-pregn-5(10)-en-20-yn-3-one (Levonorgestrel EP Impurity B) is an impurity of Levonorgestrel.<br>References McGinty, D., et al.: Endocrinology, 24, 829 (1939), Belanger, A., et al.: Steroids, 37, 361 (1981), Nieman, L., et al.: J. Clin. Endocrinol. Metab., 61, 536 (1985), Klebe, G., et al.: J. Med. Chem., 37, 4130 (1994),<br></p>Fórmula:C21H28O2Cor e Forma:NeatPeso molecular:312.45Exemestane-19-d3
CAS:Produto Controlado<p>Stability Light Sensitive<br>Applications An antineoplastic (hormonal).<br>References Giudici, D., et al.: J. Steroid Biochem., 30, 391 (1988), Evans, T.R.J., et al.: Cancer Res., 52, 5933 (1992), Zilembo, N., et al.: Brit. J. Cancer, 72, 1007 (1995)<br></p>Fórmula:C20H21D3O2Cor e Forma:NeatPeso molecular:299.42Betamethasone 17-Propionate
CAS:Produto Controlado<p>Impurity Clobetasol Propionate EP Impurity A / Betamethasone Dipropionate EP Impurity B<br>Applications Betamethasone 17-Propionate (Clobetasol Propionate EP Impurity A) is a degradation product of Betamethasone. Glucocorticoid.<br>References Andersson, P., et al.: J. Pharm. Pharmacol., 36, 763 (1984), Wurthwein, G., et al.: Biopharm. Drug Dispos., 11, 381 (1990), Samtani, M., et al.: J. Pharm. Sci., 93, 726 (2004), Samtani, M., et al.: Drug Metab. Dispos., 33, 1124 (2005),<br></p>Fórmula:C25H33FO6Cor e Forma:Off-WhitePeso molecular:448.52Tachysterol3 (80%)
CAS:Produto Controlado<p>Impurity Cholecalciferol EP Impurity E<br>Stability Light Sensitive, Temperature Sensitive, Unstable in DMSO<br>Applications Tachysterol3 (Cholecalciferol EP Impurity E) is a bioactive, synthetic vitamin D3 analog.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bouillon, R., et al.: Endocr. Rev., 16, 200 (1995), Ettinger, R., et al.: Adv. Drug Res., 28, 269 (1996), Doi, T., et al.: Tetrahedr. Lett., 45, 5727 (2004),<br></p>Fórmula:C27H44OPureza:80%Cor e Forma:Colourless To YellowPeso molecular:384.64Finasteride Carboxylic Acid Methyl Ester
CAS:Produto Controlado<p>Applications Finasteride Carboxylic Acid Methyl Ester is an metabolite of Finasteride (F342000), an inhibitor of 5α-reductase, the enzyme which converts testosterone to the more potent androgen, 5α-dihydrotestosterone.<br>References Koronkowski, M.J., et al.: Pharmacotherapy, 13, 309 (1993), Tenover, J.L., et al.: Clin. Ther., 19, 243 (1997), McConnell, J.D., et al.: N. Engl. J. Med., 338, 557 (1998),<br></p>Fórmula:C24H36N2O4Cor e Forma:NeatPeso molecular:416.55417β-Hydroxy Exemestane-d3
CAS:Produto Controlado<p>Applications A labelled metabolite of Exemestane; exerts biological effects as an androgen.<br>References Howell, A., et al.: Lancet, 365, 60 (2005), Goss, P., et al.: Clin. Cancer Res., 10, 5717 (2004), Buzdar, A., et al.: Lancet Oncol., 7, 633 (2006), Coates, A., et al.: J. Clin. Oncol., 25, 486 (2007), Jordan, V., et al.: Steroids, 72, 7 (2007),<br></p>Fórmula:C20H23D3O2Cor e Forma:NeatPeso molecular:301.44Dexamethasone Acid Ethyl Ester
CAS:<p>Applications Dexamethasone Acid Ethyl Ester is a derivative of Dexamethasone (D298800), a glucocorticoid used as an anti-inflammatory agent. Dexamethasone regulates T cell survival, growth, and differentiation. Dexamethasone inhibits the induction of nitric oxide synthase.<br>References Wershil, B.K., et al.: Int. Arch. Allergy Immunol., 107, 323 (1995), Riccardi, C., et al.: Cell Death Diff., 6, 1182 (1999), Llanos, S.L. and Roldan, A.: Bio Cell, 23, 29 (1999)<br></p>Fórmula:C23H31FO5Cor e Forma:Off-WhitePeso molecular:406.49BGP 15
CAS:Produto Controlado<p>Applications BGP 15 is a calcipotriene-based vitamin D3 analog that inhibits poly(ADP-ribose) polymerasesis (PARP), a class of enzymes that regulate DNA repair and apoptosis (1). BGP 15 is also a cardioprotective agent (2). Also, BPG 15 improves mitochondrial function, protects neurons from dying in vitro and in vivo, and promotes cardiac innervation in vivo.<br>References (1) Berkovich, L., et al.: Anticancer Drugs. 21, 609 (2010) (2) Szabados, E., et al. Biochem Pharmacol. 59, 937 (2000)<br></p>Fórmula:C14H22N4O2·2HClCor e Forma:NeatPeso molecular:351.2717β-Estradiol-d3 3-β-D-Glucuronide
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications A labelled metabolite of Estradiol (E888000).<br>References Agasan, A., et al.: J. Immunol. Methods., 177, 251 (1994), Stone, R., et al.: Science, 265, 308 (1994), Tacey, R., et al.: J. Pharm. Biomed. Anal., 2, 1303 (1994),<br></p>Fórmula:C24H29D3O8Cor e Forma:NeatPeso molecular:451.52D-Digitoxose
CAS:Produto Controlado<p>Applications D-Digitoxose is a derivative of D-ribo-Hexonic acid that is metabolized in the liver. It inhibits glucose-stimulated insulin release.<br>References Domschke, W. et al.: Naun.-Schmied. Arch. Pharmacol., 265, 149 (1969); Brown, D.F. et al.: Experientia, 39, 979 (1983); Hussain, M. et al.: Biochem. Biophys. Res. Comm., 129, 358 (1985);<br></p>Fórmula:C6H12O4Pureza:>85%Cor e Forma:White SolidPeso molecular:148.16Prednisolone Tebutate
CAS:Produto Controlado<p>Applications Prednisolone Tebutate is an anaesthetic corticosteroid.<br>References Lewis, A. et al.: Agents and Actions, 10, 258 (1980); Myers, S. et al.: Arthris. Rheum., 28, 1275 (1985);<br></p>Fórmula:C27H38O6Cor e Forma:NeatPeso molecular:458.59Bisnorcholenaldehyde
CAS:Produto Controlado<p>Applications Bisnorcholenaldehyde can be used to prepare 27-Nor-Δ4-dafachronic acid as a synthetic ligand of Caenorhabditis elegans DAF-12 receptor. It is also used to synthesize 3β,6α-dihydroxy-5α-cholan-23-one.<br>References Samaja, G., et al.: Bioorg. Med. Chem. Lett., 23, 2893 (2013); Nahar, L., et al.: Tetrahedron, 59, 8623 (2003)<br></p>Fórmula:C22H32O2Cor e Forma:NeatPeso molecular:328.49Digitoxigenin
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications Digitoxigenin has been used in a study to assess its stereochemical effects in cancer cytotoxicity. It has also been used in a study to investigate the advantage of gold(I)-catalyzed glycosidation of glycosyl o-alkyl benzoates to assemble digitoxin.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hinds, J., et al.: Chemmedchem, 8, 63 (2013); Ma, Y., et al.: J. Org. Chem., 76, 9748 (2011)<br></p>Fórmula:C23H34O4Cor e Forma:NeatPeso molecular:374.51Ruscogenin
CAS:<p>Applications A major steroidal sapogenin from Radix ophiopogon japonicus with robust anti-inflammatory and anti-thrombotic activities. Studies suggest that it inhibits adhesion of leukocytes to a human umbilical vein endothelial cell line (ECV304) injured by tumor necrosis factor-α (TNF-α) in a concentration-dependent manner.<br>References Huang, Y. et al.: Drug Dev. Res., 69, 196 (2008); Huang, Y. et al.: J. Pharmacol. Sci., 108, 198 (2008); Song, J. et al.: J. Pharmacol. Sci., 113, 409 (2010);<br></p>Fórmula:C27H42O4Cor e Forma:NeatPeso molecular:430.622-Hydroxy Estrone
CAS:Produto ControladoFórmula:C18H22O3Cor e Forma:Off-White To Light BrownPeso molecular:286.37(25R)-26-Hydroxycholesterol
CAS:Produto Controlado<p>Applications (25R)-26-Hydroxycholesterol is a desmosterol metabolite that is found in the brain. 26-Hydroxycholesterol has been used as a biomarker for carbon cycling in the northwestern Mediterranean Sea.<br>References Meljon, A., et. al.: J. Lipid Res., 53, 2469 (2012); Christodoulou, S., et. al.: Marine Chem., 113, 25 (2009)<br></p>Fórmula:C27H46O2Cor e Forma:NeatPeso molecular:402.6526-Ethylchenodeoxycholic-d5 Acid
CAS:Produto Controlado<p>Applications 6-Ethylchenodeoxycholic-d5 Acid is an isotope labelled compound of 6-Ethylchenodeoxycholic Acid (E899810), which is used in the investigative treatment of primary biliary cholangitis. Primary biliary cholangitis is an autoimmune disease of the liver that slowly progresses to cirrhosis.<br>References Ali, A. H, et al.: Expert Opin. Orphan Drugs, 4, 1011 (2016)<br></p>Fórmula:C26H39D5O4Cor e Forma:NeatPeso molecular:425.665,6-Dehydro-17a-Dutasteride
Produto Controlado<p>Applications 5,6-Dehydro-17α-dutasteride is an epimer of 5,6-Dehydro-17β-dutasteride (D229560) an impurity in the synthesis of Dutasteride (D735000), a dual inhibitor of 5α-reductase isoenzymes type 1 and 2; structurally related to Finasteride (F342000). Dutasteride is used in the treatment of benign prostatic hyperplasia.<br>References Bakshi, R.K., et al.: J. Med. Chem., 38, 3189 (1995), Gisleskog, P.O., et al.: Brit. J. Clin. Pharmacol., 47, 53 (1999), Djavan, B., et al.: Expert Opin. Pharmacother., 6, 311 (2005),<br></p>Fórmula:C27H28F6N2O2Cor e Forma:NeatPeso molecular:526.51Clobetasol 17-Propionate
CAS:Produto Controlado<p>Applications Topical corticosteroid. Glucocorticoid; anti-inflammatory.<br>References Olsen, E.A., et al.: J. Am. Acad. Dermatol., 15, 246 (1986),<br></p>Fórmula:C25H32ClFO5Cor e Forma:White To Off-WhitePeso molecular:466.97
