Esteroides e Derivados
Os esteroides são compostos orgânicos que possuem uma estrutura de quatro anéis fundidos, conhecida como núcleo esteroide. Esse núcleo pode estar ligado a vários grupos funcionais que modificam suas propriedades e funções biológicas. Os esteroides desempenham um papel fundamental na regulação dos processos metabólicos e hormonais. São utilizados na medicina para tratar distúrbios inflamatórios, doenças autoimunes e desequilíbrios hormonais. Além disso, alguns derivados de esteroides possuem potentes propriedades anti-inflamatórias, como os corticosteroides. Em terapias específicas, são utilizados para reduzir a inflamação e controlar a dor em diversas doenças.
Na CymitQuimica, oferecemos uma variedade de esteroides e seus derivados para pesquisa e desenvolvimento farmacêutico.
Foram encontrados 4949 produtos de "Esteroides e Derivados"
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2-Hydroxy-estrone-6-N3-adenine (90%)
CAS:Produto Controlado<p>Applications 2-Hydroxy-estrone-6-N3-adenine is a depurinating adduct that is created by the interaction of specific metabolites of estrogens in the body with DNA. Unfortunately, these adducts are endogenous initiators of various human cancers, such as breast & prostate.<br>References Yang, L., et al.: Prostate, 69, 41 (2009); Zahid, M., et al.: Chem. Res. Toxicol., 19, 164 (2006); Zhang, Y., et al.: Metabol. Clin. Exp., 56, 887 (2007)<br></p>Fórmula:C23H25N5O3Pureza:90%Cor e Forma:NeatPeso molecular:419.48(11β)-9-Fluoro-11,21-dihydroxy-16-methyl-pregna-1,4,16-triene-3,20-dione
CAS:Produto Controlado<p>Applications (11β)-9-Fluoro-11,21-dihydroxy-16-methyl-pregna-1,4,16-triene-3,20-dione is a derivative of Dexamethasone (D298800), an anti-inflammatory glucocorticoid.<br>References Kodelja, V., et al.: J. Immunol., 160, 1411 (1998), Metselaar, J., et al.: Arthritis Rheum., 48, 2059 (2003), Buttgereit, F., et al.: Arthritis Rheum., 50, 3408 (2004), Martinez, F., et al.: Front Biosci., 13, 453 (2008),<br></p>Fórmula:C22H27FO4Cor e Forma:WhitePeso molecular:374.456a-9-Difluoroprednisolone-17-Carboxylate
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications 6α-9-Difluoroprednisolone-17-Carboxylate is an impurity of 6α,9α-Difluoroprednisolone (D446290), shown to increase metastases and increase glucocorticoid activity in C57/BL6 mice.<br>References Albert, D., Zeidman, I.: Cancer Res., 22, 1297 (1962)<br></p>Fórmula:C20H24F2O5Cor e Forma:NeatPeso molecular:382.4a-Epoxyabiraterone Acetate
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications α-Epoxyabiraterone Acetate is an impurity of Abiraterone (A108490), a steroidal cytochrome P 450 17α-hydroxylase-17,20-lyase inhibitor (CYP17), is currently undergoing phase II clinical trials as a potential drug for the treatment of androgen-dependent prostate cancer.<br>References Denis, L., et al.: Cancer, 72, 3888 (1993); Potter, G.A., et al.: J. Med. Chem., 38, 2463 (1995); Denmeade, S., et al.: Nat. Rev., 2, 389(2002); Scher, H., et al.: J. Clin. Oncol., 23, 8253 (2005)<br></p>Fórmula:C26H33NO3Cor e Forma:NeatPeso molecular:407.55(6α,9β,11β,16α)-21-(Acetyloxy)-9,11-epoxy-6-fluoro-17-hydroxy-16-methylpregna-1,4-diene-3,20-dione
CAS:Produto Controlado<p>Applications (6α,9β,11β,16α)-21-(Acetyloxy)-9,11-epoxy-6-fluoro-17-hydroxy-16-methylpregna-1,4-diene-3,20-dione is an intermediate in the synthesis of Paramethasone Acetate (P191845), a derivative of Dexamethasone (D298800), a potent synthetic member of the glucocorticoid class of steroid drugs that has anti-inflammatory and immunosuppressant properties.<br>References Wershil, B.K., et al.: Int. Arch. Allergy Immunol., 107, 323 (1995), Riccardi, C., et al.: Cell Death Diff., 6, 1182 (1999), Llanos, S.L. and Roldan, A.: Bio Cell, 23, 29 (1999)<br></p>Fórmula:C24H29FO6Cor e Forma:Off-WhitePeso molecular:432.48Mexrenone
CAS:Produto Controlado<p>Applications Mexrenone is an impurity of eplerenon (E588775). Eplerenone is a selective aldosterone receptor antagonist (SARA), structurally similar to Spiranolactone. Eplerenone is used alone or in combination with other medications to treat high blood pressure. Eplerenone is in a class of medications called mineralocorticoid receptor antagonists. It works by blocking the action of aldosterone, a natural substance in the body that raises blood pressure.<br>References de Gasparo, M., et al.: J. Pharmacol. Exp. Ther., 240, 650 (1987), Delyani, J.A., et al.: Cardiovasc. Drug Rev., 19, 185 (2001), Burgess, E., et al.: Expert. Opin. Pharmacother., 5, 2573 (2004), Ravis, W.R., et al.: J. Clin. Pharmacol., 45, 810 (2005),<br></p>Fórmula:C24H32O5Cor e Forma:Off-WhitePeso molecular:400.507925-Hydroxy Vitamin D3 3,3'-Biotinylaminopropyl Ether
CAS:<p>Applications Vitamin D3 (V676045) analog.<br>References Roy, A., et al.: Steroids, 60, 530 (1995);<br></p>Fórmula:C40H65N3O4SCor e Forma:NeatPeso molecular:684.0313β-Ethyl-11-methylenegon-4-en-17-one
CAS:Produto Controlado<p>Applications Desogestrel intermediate.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bergink, E., et al.: J. Steroid Biochem., 14, 175 (1981), Phillips, A., et al.: Contraception, 36, 181 (1987)<br></p>Fórmula:C20H28OCor e Forma:NeatPeso molecular:284.44Des[[N-(1,1-Dimethylethyl)amino]carbonyl] 17-(Propionyl) Finasteride
CAS:Produto Controlado<p>Applications An impurity of Finasteride (F342000).<br></p>Fórmula:C21H31NO2Cor e Forma:NeatPeso molecular:329.4817β-Dihydro Equilin-16,16,17-d3
CAS:Produto Controlado<p>Applications A labelled metabolite of Equilin (E592800).<br>References Enmark, E., et al.: J. Clin. Endocrinol. Metab., 82, 4258 (1997), Wang, Z., et al.: J. Med. Chem., 43, 2419 (2000), Jiang, X., et al.: Steroids, 71, 334 (2006),<br></p>Fórmula:C182H3H17O2Cor e Forma:NeatPeso molecular:271.37δ6-Fulvestrant
CAS:Produto Controlado<p>Impurity Fulvestrant Impurity E;<br>Applications Fulvestrant (F862500) impurity E.<br></p>Fórmula:C32H45F5O3SCor e Forma:NeatPeso molecular:604.75Betamethasone 21-Acetate
CAS:Produto Controlado<p>Applications Betamethasone acetate (BA) is a glucocorticoid steroid with anti-inflammatory and immunosuppressive properties which can be used in treatment of asthma and itching.<br>References Kerns, E., et al.: J. Pharm. Sci., 90, 1838 (2001), Seidler, J., et al.: J. Med. Chem., 46, 4477 (2003), Alsenz, J., et al.: J. Pharm. Sci., 96, 1748 (2007),<br></p>Fórmula:C24H31FO6Cor e Forma:WhitePeso molecular:434.50Finasteride Carboxaldehyde
CAS:Produto Controlado<p>Applications A metabolite of Finasteride (F342000) in human bile (M2 metabolite).<br>References Faller, B., et al.: Biochemistry, 32, 5705 (1993), Carlin, J.R., Drug Metab. Dispos., 25, 100 (1997), Bergman, E., et al.: Eur. J. Pharm. Sci., 29, 205 (2006),<br></p>Fórmula:C23H34N2O3Cor e Forma:NeatPeso molecular:386.53Bexarotene-13C4
CAS:Produto Controlado<p>Applications Labelled Bexarotene (B336750). Used as an antineoplastic. A selective retinoid X receptor (RXR) agonist.<br>References Boehm, M.F., et al.: J. Med. Che., 37,2930 (1994), Gottardis, M.M., et al.: Cancer Res., 56, 5566 (1996), Mukherjee, R., et al.: Nature, 386, 407 (1997), Miller, V.A., et al.: J. Clin. Oncol., 15, 790 (1997)<br></p>Fórmula:C4C20H28O2Cor e Forma:NeatPeso molecular:352.456b-Methyl Fluorometholone
CAS:Produto Controlado<p>Stability Not stable in Acidic or basic condition<br>Applications 6β-Methyl Fluorometholone is an impurity in the synthesis of Fluorometholone (F593145), a glucocorticoid; anti-inflammatory.<br>References Kupferman, A., et al.: Arch. Ophthlmol., 640, 100 (1982), Tokunaga H., et al.: Chem. Pharm. Bull., 32, 4012 (1984),<br></p>Fórmula:C22H29FO4Cor e Forma:NeatPeso molecular:376.46Atorvastatin Lactone Diepoxide(Mixture of Diastereomers)
CAS:Produto Controlado<p>Stability Light Sensitive, Temperature Sensitive<br>Applications An Atorvastatin (A791750) derivative which have improved stability.<br></p>Fórmula:C33H33FN2O6Cor e Forma:NeatPeso molecular:572.62Dexamethasone Acetate Impurity E
CAS:<p>Applications Dexamethasone Acetate Impurity E is a pregn-4-ene derivative used in the preparation of antiallergic and antiinflammatory drugs.<br>References Nedelec, L., et al.: Ger. Offen. (1978)<br></p>Fórmula:C24H33FO6Cor e Forma:NeatPeso molecular:436.51Atorvastatin-d5 tert-Butyl Ester
CAS:Produto Controlado<p>Applications Atorvastatin-d5 tert-Butyl Ester is the labeled analogue of Atorvastatin tert-Butyl Ester (A791740), an impurity arising in the synthesis of Atorvastatin (A791750), a selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia.<br>References Kearney, A.S., et al.: Pharm. Res., 10, 1461 (1993); Heinonen, T.M., et al.: Clin. Ther., 18, 853 (1996); Whitfield, L.R., et al.: Eur. J. Drug Metab. Pharmacokinet., 25, 97 (2000)<br></p>Fórmula:C37H38D5FN2O5Cor e Forma:NeatPeso molecular:619.78Deflazacort-d3 (Major)
CAS:Produto ControladoFórmula:C25H28D3NO6Cor e Forma:NeatPeso molecular:444.543-epi-25-Hydroxy Vitamin D3
CAS:<p>Stability Light Sensitive, Temperature Sensitive<br>Applications The epimer metabolite of Calcifediol or 25-hydroxyvitamin D3 (C125700).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sakaki, T., et al.: Eur. J. Biochem., 267, 6158 (2000), Kamao, M., et al.: J. Biol. Chem., 278, 1463 (2003),<br></p>Fórmula:C27H44O2Cor e Forma:NeatPeso molecular:400.646β-Hydroxymethylandrosta-1,4-diene-3,17-dione
CAS:Produto ControladoFórmula:C20H26O3Cor e Forma:White To Off-WhitePeso molecular:314.42Cholesterol 5α,6α-Epoxide
CAS:Produto Controlado<p>Applications Cholesterol 5alpha,6alpha-epoxide is used in the generation of oxysterols and in the studies of the biological significance of oxysterols.<br>References Lizard, G., et al.: Eur. J. Lipid Sci. Technol., 118, 135 (2016); Sabolova, M., et al.: J. Sci. Food Agric., 97, 5092 (2017); Bezine, M., et al.: Biochimie (2018)<br></p>Fórmula:C27H46O2Cor e Forma:NeatPeso molecular:402.65Cortisol-D4 21-Sulfate Potassium Salt
CAS:Produto Controlado<p>Applications Labelled Cortisol-d4 21-Sulfate (C696320). Cortisol 21-Sulfate is a phase II metabolite of Cortisol (H714615).<br>References Spielgelhalder, B., et al.: J. Steroid Biochem., 7, 749 (1976), Vanluchene, E., et al.: J. Chromatogr., 456, 175 (1988), Choi, M., et al.: Steroids, 65, 54 (2000),<br></p>Fórmula:C21H25D4KO8SCor e Forma:NeatPeso molecular:484.64D-Homoanalog of Triamcinolone
CAS:Produto Controlado<p>Applications D-Homoanalog of Triamcinolone is a rearrangement product of the drug triamcinolone, an anti-inflammatory drug.<br>References Delaney, E. J.; et al.: Steroids, 59, 196 (1994)<br></p>Fórmula:C21H27FO6Cor e Forma:NeatPeso molecular:394.43Testosterone (1 mg/mL in Acetonitrile)
CAS:Produto ControladoFórmula:C19H28O2Cor e Forma:ColourlessPeso molecular:288.42Testosterone-16,16,17-d3 17-Decanoate
CAS:Produto Controlado<p>Applications Testosterone 17-Decanoate-d3, is the labeled analogue of Testosterone 17-Decanoate (T155120), an ester of Testosterone (T155000). Testosterone 17-Decanoate, can be used as a potential long-acting male contraceptive, with the combination of subcutaneous etonogestrel implants.<br>References Brady, B. M., et al.: Human Reproduction, 21 (1), 285 (2006); Themmen, A., et al.: Endocr. Rev. 21, 551 (2000);<br></p>Fórmula:C292H3H43O3Cor e Forma:NeatPeso molecular:445.69a,a,a-Trifluorotoluene
CAS:Produto Controlado<p>Applications α,α,α-Trifluorotoluene, is used as a specialty solvent in organic synthesis and an intermediate in the production of pesticides and pharmaceuticals.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Skelly, P. D., et al.: Handbook for Critical Cleaning, 1, 191 (2011);<br></p>Fórmula:C7H5F3Cor e Forma:ColourlessPeso molecular:146.11E-Ospemifene
CAS:Produto Controlado<p>Applications E-Ospemifene is the E-isomer of Ospemifene (O703000) and is useful for lowering serum cholesterol. It acts as a antiatherosclerotic and is also estrogen-like.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sodervall, M., et al.: PCT Int. Appl. WO 9942427 A1 19990826. Aug 26, 1999<br></p>Fórmula:C24H23ClO2Cor e Forma:NeatPeso molecular:378.8916α-Hydroxypregna-4,9(11)-diene-3,20-dione
Produto Controlado<p>Applications 16α-Hydroxypregna-4,9(11)-diene-3,20-dione is an intermediate in the synthesis of 16-Hydroxycorticosterone 20-Hydroxy-21-Acid (H918430), an oxidized derivative of corticosterone (C695700).<br>References Allen, G.R., et al.: J. Am. Chem. Soc., 81, 4968 (1959);<br></p>Fórmula:C21H28O3Cor e Forma:NeatPeso molecular:328.45Dexamethasone 21-Palmitate
CAS:Produto Controlado<p>Applications A corticosteroid prodrug for the treatment of eye disorders.<br>References Benameur, H., et al.: J. Pharm. Pharmacol., 47, 812 (1995), Tauchi, Y., et al.: Biol. Pharm. Bull., 24, 925 (2001), Chono, S., et al.: J. Drug Targeting, 13, 407 (2005),<br></p>Fórmula:C38H59FO6Cor e Forma:NeatPeso molecular:630.876b-Chloro-7a-hydroxy-6,7-dihydro Cyproterone Acetate
CAS:Produto Controlado<p>(1β,2β,6β-7α)-17-(Acetyloxy)-6-chloro-1,2-dihydro-7-hydroxy<br>-3'H-cyclopropa[1,2]pregna-1,4-diene-3,20-dione; 6β-Chloro<br>-1β,2β-dihydro-7α,17-dihydroxy-3'Hcyclopropa[1,2]pregna-1,4-diene-3,20-dione 17-Acetate;<br>Cyproterone Acetate EP Impurity G</p>Fórmula:C24H31ClO5Cor e Forma:NeatPeso molecular:434.9533-O-Benzyl Estriol
CAS:Produto Controlado<p>Applications Protected Estriol.<br>References Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2010),<br></p>Fórmula:C25H30O3Cor e Forma:NeatPeso molecular:378.50Testosterone-d8
CAS:Produto Controlado<p>Applications Labelled Testosterone (T155000). Principal hormone of the testes, produced by the interstitial cells. Major circulating androgen; converted by 5α-reductase in androgen-dependent target tissues to 5α-dehydrotestosterone which is required for normal male sexual differentiation. Also converted by aromatization to Estradiol.Controlled substance (anabolic steroid). Androgen.<br>References McFarland, K., et al.: Science, 245, 494 (1989), Heckert, L., et al.: Mol. Endocrinol., 12, 1499 (1998), Themmen, A., et al.: Endocr. Rev. 21, 551 (2000), Kumar, R., et al.: Biol. Reprod., 65, 710 (2001),<br></p>Fórmula:C19H20D8O2Cor e Forma:White To Off-WhitePeso molecular:296.473-Oxo-4-aza-5-androstene-17β-carboxylic Acid
CAS:Produto ControladoFórmula:C19H27NO3Cor e Forma:NeatPeso molecular:317.42(3(α))-Allopregnanolone 3-(β)-DGlucuronide
CAS:Produto Controlado<p>Applications (3α)-Allopregnanolone 3-β-D-Glucuronide is the glucuronide conjugate of (3α)-Allopregnanolone (A547100), metabolite of progesterone and potent positive modulator of GABAA receptors.<br>References Martin, F. et al.: LJ Steroid Biochem., 6, 1339 (1975); Lin, M.T. et al.: Steroids, 32, 547 (1978);<br></p>Fórmula:C27H42O8Cor e Forma:NeatPeso molecular:494.6221-Butyryloxy Budesonide
<p>Applications 21-Butyryloxy Budesonide is a derivative of Budesonide (B689490), a non-halogenated glucocorticoid related to triamcinolone hexacetonide.<br>References Ryrfeldt., A., et a.: J. Steroid Biochem., 10, 317 (1979); Roth, G., et al.: J. Pharm. Sci., 69, 766 (1980); Clissold, S.P., et al.: Drugs, 28, 485 (1984)<br></p>Fórmula:C29H40O7Cor e Forma:NeatPeso molecular:500.62Equilenin-d3
CAS:Produto Controlado<p>Applications Isotope labelled Equilenin (E592400), which is a naturally occuring estrogenic steroidal hormone (1,2) isolated from urine of pregnant mares (3). Not found in human urine. Component of conjugated estrogenic hormones. Estrogen. This compound is a contaminant of emerging concern (CECs). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.<br>References 1. Corbellini, A. et L.: Farmaco Sci. 1964 Nov;19:913-22.2. Stein, R. et al.: Tetrahedron 1970 Apr;26(8):1917-33.<br></p>Fórmula:C182H3H15O2Cor e Forma:White To Light BrownPeso molecular:269.3517-Hydroxypregn-5-ene-3,20-dione
CAS:Produto Controlado<p>Applications 17-Hydroxypregn-5-ene-3,20-dione is used in the synthesis of physiologically active steroid esters and spirolactones that functions as potential aldosterone antagonists.<br>References Seletskii, B. M., et al.: Croat. Chem. Acta. , 58, 699 (1986)<br></p>Fórmula:C21H30O3Cor e Forma:NeatPeso molecular:330.46Digitoxigenin Mono-β-D-digitoxoside
CAS:Produto ControladoFórmula:C29H44O7Cor e Forma:White To Off-WhitePeso molecular:504.66Estriol 3,16a,17b-Triacetate
CAS:Produto Controlado<p>Applications Estriol 3,16α,17β-Triacetate is a triacetate derivative of Estriol (E888960) with contraceptive activity.<br>References Wotiz, H.H., et al.: J. Reprod. Fertil., 26, 363 (1971)<br></p>Fórmula:C24H30O6Cor e Forma:NeatPeso molecular:414.4911b-Hydroxy Etiocholanolone
CAS:Produto Controlado<p>Applications A metabolite of Etiocholanolone.<br>References Eriksson, H., et al.: Eur. J. Biochem., 15, 132 (1970), Cook, D., et al.: Endocrinology, 93, 1019 (1973),<br></p>Fórmula:C19H30O3Cor e Forma:White To Off-WhitePeso molecular:306.44Carbenoxolone
CAS:Produto Controlado<p>Applications Carbenoxolone<br></p>Fórmula:C34H50O7Cor e Forma:NeatPeso molecular:570.76
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