Flavonoides e Polifenóis

<p>3',4',7-Trimethoxyquercetin (3,5-Dihydroxy-7,3',4'-trimethoxyflavone) is a polymethoxyquercetin isolated from Scutellaria baicalensis with antioxidant activity.</p>

<p>Punicalin: anti-inflammatory, antioxidative, anti-hepatotoxic, inhibits HIV-1 reverse transcriptase with an IC50 of 0.14 µM.</p>

<p>Lutein (Xantofyl) fights tumors, mutations, microbes, and may treat macular degeneration.</p>

<p>Eriodictyol: anti-inflammatory, antioxidant, may improve diabetes and atopic dermatitis symptoms.</p>

<p>Cinnamyl alcohol (Styryl Carbinol) readily autoxidizes upon air exposure, and forms strong sensitizers as determined by the local lymph node assay.</p>

<p>Swertisin: an herbal molecule with antihyperglycemic, antidiabetic, anti-inflammatory, and antioxidant properties; blocks adenosine A1 receptor.</p>

<p>Bifendate (Bifendatatum) is commonly used to treat the transaminase elevation that caused by viral hepatitis and drug-induced liver injury.</p>

<p>Osthenol: Natural, selective hMAO-A inhibitor with antitumor, antifungal, and antibacterial properties. Ki=0.26 μM.</p>

<p>Kumatakenin can suppress &gt;80% of the SOS-inducing activity of Trp-P-1 at &lt;0.06 micromol/mL.</p>

<p>Narirutin combats cell growth, oxidation, allergies, and inflammation.</p>

<p>Isoastragaloside I is a natural product,has the enhancement adiponectin quantity activity.</p>

<p>Cinnamic acid may combat cancer; IC50 in glioblastoma, melanoma, prostate, and lung cells is 1-4.5 mM.</p>

<p>Chlorogenic acid is a natural phenol. Chlorogenic acid has anti-inflammatory, antitumor, and antimicrobial effects. Cost-effective and quality-assured.</p>

<p>Silibinin, main component in milk thistle, offers liver protection and shows anti-cancer potential in various human cells.</p>

<p>Aloesin, a C-glycosylated chromone from aloe, blocks tyrosinase (IC50=0.9mM) in melanin production.</p>

<p>Kahweol has anticarcinogenic, anti-angiogenic,and anti-inflammatory activities, it can block the LPS-induced activation of NF-kappaB by preventing IkappaB</p>

<p>Applications Probucol is an antilipemic.<br>References Shakir, D., et al.: J. Clin. Med. Res., 1, 8 (2009), Kubo, Y., et al.: Biol. Pharm. Bull., 32, 1880 (2009), Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2010),<br></p>

<p>Stability Hygroscopic<br>Applications Quercetin 3-O-β-D-Glucuronide is a metabolite of Quercetin (Q509500).<br>References Ajay, M., et al.: Life Sci., 74, 603 (2003), Shen, S., et al.: Toxicol. Appl. Pharmacol., 197, 84 (2004), Amira, S., et al.: Eur. J. Pharmacol. 599, 126 (2008),<br></p>

<p>Impurity Probucol USP Related Compound A<br>Applications Tetra-tert-butyldiphenoquinone is an antioxident used in the prevention of aging/rusting in dyes, rubber and textiles. Metabolite of Probucol (P755100) an antilipemic. Probucol USP Related Compound A.<br>References Bukharov, S.et al.: Russ J. Green Chem., 72, 1805 (2002); Shanina, E. et al.: Aging Polym. Polym. Blends Polym. Compos., 2, 189 (2002); Shakir, D., et al.: J. Clin. Med. Res., 1, 8 (2009), Kubo, Y., et al.: Biol. Pharm. Bull., 32, 1880 (2009), Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2010),<br></p>

<p>Applications 2,4,5-Trichlorophenol is used as a broad range pesticide against insects, fungi, vegetation and bacteria. It has become a common environmental contaminant and probable human carcinogen.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Amer, S. et al.: Cytologia, 39, 633 (1974); Xu, X. wt l.: Occup. Environ. Med., 68, 557 (2011); Sinclair, C.J. et al.: Environ. Sci. Technol., 37, 4617 (2003);<br></p>

<p>Applications A metabolite of trans Resveratrol (150000).<br>References Schroder, H., et al.: Clin. Nutr., 20, 429 (2001), Yu, C., et al.: Pharm. Res., 19, 1907 (2002), Rimando, A., et al.: J. Agric. Food Chem., 52, 4713 (2004), Walle, T., et al.: Drug Metab. Dispos., 32, 1377 (2004), Ito, H., et al.: Br. J. Nutr., 94, 500 (2005),<br></p>

<p>M01481 - Capsaicin, natural extract (mixture of Capsaicinoids)</p>

<p>Applications Hesperetin 3тАЩ-O-b-D-Glucuronide is one of the most abundant metabolite of Hesperetin (H289500) in vivo.<br>References van Zanden, J., et al.: Biochem. Pharmacol., 74, 345 (2007), Yanez, J., et al.: Biopharm. Drug Dispos., 29, 63 (2008), Brand, W., et al.: Drug Metab. Dispos., 38, 617 (2010),<br></p>

<p>Stability Light Sensitive<br>Applications Chlorophyll A is a photosynthetic pigment that is essential for photosynthesis of eukaryotes and cyanobacteria, acting as a primary donor in the electron transport chain. Dyes and metabolites.<br>References Prasad, K., et al.: Curr. Res. Chem., 3, 98 (2011); Shanab, S.M., et al.: Int. J. Electrochem. Sci., 6, 3017 (2011); Ajayan, K.V., et al.: Biores. Techol., 102, 7591 (2011); Felming, I.: Nature, 216, 151 (1967); Woodward, R.B. et al.: Tetrahedron, 46, 7599 1990); Chen, M. et al.: Sciemce, 319, 1318 (2010); Gitelson, A.A. et al.: Rem. Sens. Environ., 69, 296 (1999);<br></p>

<p>Stability Light Sensitive<br>Applications Exhibits specific inhibitory activity against tyrosine kinases,including autophosphorylation of epidermal growth factor receptor kinase (IC50 - 2.6uM). Also inhibits other protein kinases through competitive inhibition of ATP. Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell-cycle arrest and apoptosis in Jurat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Genistein also inhibits topoisomerase II activity in vitro. Genistein has also been shown to inhibit the action of GABA on recombinant GABAA receptors 2. uv(max)ethanol: 262.5 nm (e= 138). moderately sol. in hot alcohol<br>References Akiyama, T., et al.: J. Biol. Chem., 262, 5592 (1987), O'Dell, T.J., et al.: Nature, 353, 588 (1991), Aharonovits, O., et al.: Biochim Biophys. Acta, 1112, 181 (1992), Platanias, L.C., et al.: J. Biol. Chem., 267, 24053 (1992), Yoshida, H., et al.: Biochim. Biophys. Acta, 1137, 321 (1992), Uckun, F.M., et al.: Science, 267, 886 (1995), Merck Index 12th ed. 4395, Huang, R.Q.; Fang, M.J.; Dillon, G.H., Mol. Brain Res. 67: 177-183 (1999)<br></p>