Fosfatos e Fosfonatos Orgânicos
Os fosfatos orgânicos são compostos que contêm um grupo fosfato (-PO₄) ligado a um átomo de carbono numa estrutura orgânica, geralmente em combinação com álcoois, ácidos ou aminas. Estes compostos são utilizados na formulação de APIs para melhorar a solubilidade, estabilidade e biodisponibilidade dos princípios ativos. Os fosfatos orgânicos também desempenham um papel na liberação controlada de fármacos e na melhoria da absorção de certos medicamentos.
Os fosfonatos orgânicos contêm um grupo fosfonato (-PO₃H₂), no qual o átomo de fósforo está ligado a um átomo de carbono e a dois grupos oxigênio. Estes compostos possuem propriedades farmacológicas importantes, especialmente na inibição de enzimas e na modulação de processos bioquímicos. Os fosfonatos orgânicos são utilizados na produção de APIs que atuam no metabolismo ósseo, no tratamento de infecções bacterianas ou como antivirais, devido aos seus efeitos biológicos específicos.
Na CymitQuimica, oferecemos fosfatos e fosfonatos orgânicos para pesquisa em química médica, bioquímica e desenvolvimento de formulações avançadas.
Foram encontrados 1201 produtos de "Fosfatos e Fosfonatos Orgânicos"
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Captopril
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications Orally active angiotensin-converting enzyme (ACE) inhibitor. Neuroprotective & Neuroresearch Product.<br>References Rubin, B., et al.: Eur. J Pharmacol., 51, 377 (1978),<br></p>Fórmula:C9H15NO3SCor e Forma:NeatPeso molecular:217.29Zoledronic Acid-15N2,13C2
CAS:Produto ControladoFórmula:C313C2H1015N2O7P2Cor e Forma:NeatPeso molecular:276.06Ethylenediamine-N,N,N’,N’-tetraacetic Acid-13C4
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications Labelled Ethylenediaminetetraacetic Acid (E917745). EDTA is a powerful chelating agent; EDTA forms stable complexes with most metal ions. EDTA is used in treatment of lead and heavy metal poisoning of farm animals.<br>References Heindorff, K., et al.: Mutat. Res., 115, 149 (1983), Grier, M.T., et al.: Ann. Pharmacother., 27, 1504 (1993), Krokidis, A.A., et al.: Anal. Chim. Acta, 535, 57 (2005),<br></p>Fórmula:C4C6H16N2O8Cor e Forma:NeatPeso molecular:296.2133Triethyl Phosphonoacetate
CAS:Produto Controlado<p>Applications Reagent used for Horner-Emmons modification.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hediger, M., et al.: Bioorg. Med. Chem., 12, 4995 (2004), Kim, J., et al.: Nat., 452, 239 (2008),<br></p>Fórmula:C8H17O5PCor e Forma:ColourlessPeso molecular:224.19N-Nitroso Delapril
CAS:Produto ControladoFórmula:C26H31N3O6Cor e Forma:Light YellowPeso molecular:481.541N,N-Bis(2-chloroethyl)phosphorodiamidic Acid Cyclohexylamine Salt
CAS:Produto Controlado<p>Stability Moisture Sensitive<br>Applications N,N-Bis(2-chloroethyl)phosphorodiamidic Acid Cyclohexylamine Salt is a cytotoxic metabolite of Cyclophosphamide (C988580).<br>References Driven, H.A.A.M. et al.: Chem. BIol. Inter., 93, 185 (1994); Fenselau, C. et al.: Xenobiotica, 22, 1207 (1992);<br></p>Fórmula:C10H24Cl2N3O2PCor e Forma:NeatPeso molecular:320.2Cilazaprilat
CAS:Produto Controlado<p>Applications The active metabolite of Cilazapril. An ACE inhibitor. Antihypertensive.<br>References Natoff, I.L., et al.: J. Cardiovasc. Pharmacol., 7, 569 (1985), Szucs, T., et al.: Drugs, 41, Suppl.1, 18 (1991), Pordy, R.C., et al.: Cardiology, 86, 41 (1995),<br></p>Fórmula:C20H27N3O5Cor e Forma:Off-WhitePeso molecular:389.455-Descyano Milrinone 5-Carboxyamide
CAS:<p>Impurity Milrinone USP Related Compound A<br>Stability Hygroscopic<br>Applications 5-Descyano Milrinone 5-Carboxyamide (Milrinone USP Related Compound A) is an impurity of Milrinone (M344680), a selective phosphodiesterase inhibitor with vasodilating and positive inotropic activity. Cardiotonic.<br>References Alousi, A.A., et al.: J. Cardiovasc Pharmacol., 5, 792 (1983), Maskin, C.S., et al.: Circulation, 67, 1065 (1983), Sinoway, L.S., et al.: J. Am. Coll. Cardiol., 2, 327 (1983), Baim, D.S., et al.: N. Engl. J. Med., 309, 748 (1983),<br></p>Fórmula:C12H11N3O2Cor e Forma:Light YellowPeso molecular:229.23Bis(2-chloroethyl)amine Hydrochloride
CAS:Produto Controlado<p>Impurity Cyclophosphamide Impurity A<br>Applications A cytotoxic metabolite of Cyclophosphamide; a deuterated analog of Nor-nitrogen mustard. Cyclophosphamide Impurity A<br>References Colvin, M. et al.: Cancer Res., 36, 1121 (1976); Ludeman, S. et al.: Drug Metab Dispos., 20, 337 (1992); Ludeman, S.M. et al.: J. Pharmaceut. Sci., 84, 393 (1995); Yu, L. et al.: Drug Metab. Dispos., 24, 1254 (1996);<br></p>Fórmula:C4H9Cl2N·ClHCor e Forma:White To Light YellowPeso molecular:178.49Fenthion Sulfoxide
CAS:Produto Controlado<p>Applications Fenthion Sulfoxide is the sulfoxide anlogue and metabolite of the organothiophosphate insecticide Fenthion (F278000).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wallnoefer, P. et al.: Pflanzensch.-Nach., 29, 236 (1976); Minelli, E.V. et al.: J. Agric. Food. Chem., 44, 936 (1996);<br></p>Fórmula:C10H15O4PS2Cor e Forma:NeatPeso molecular:294.33D-Captopril
CAS:Produto Controlado<p>Applications D-Captopril and Captopril analogues are New Delhi metallo-β-lactamase-1 (NDM-1) inhibitors which are used clinically as antidotes for metal poisoning and bacterial infection.<br>References Ningning; X., et al.: Bioorg. Med. Chem. Lett., 24, 386 (2014); Guo, Y., et al.: Protein Cell, 2, 384 (2011)<br></p>Fórmula:C9H15NO3SCor e Forma:NeatPeso molecular:217.2854-(1,2,2-Tris(4-(phosphonooxy)phenyl)vinyl)phenyl dihydrogen phosphate
CAS:Pureza:98%Peso molecular:716.3569946289062(S)-TETRAHYDROFURAN-3-YL ((2S,3R)-4-(4-AMINO-N-ISOBUTYLPHENYLSULFONAMIDO)-1-PHENYL-3-(PHOSPHONOOXY)BUTAN-2-YL)CARBAMATE
CAS:Pureza:99%Peso molecular:585.6099853515625Ref: 10-F824417
1mgA consultar5mgA consultar10mgA consultar25mgA consultar50mgA consultar100mgA consultarCyclophosphamide Monohydrate
CAS:Produto Controlado<p>Applications It is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity. This substance is listed as a known human carcinogen.This compound is suitable for aldehyde dehydrogenase (ALDH) related research.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wheeler, A.G., et al.: Toxicol. Appl. Pharmacol., 4, 324 (1962), Fraiser, L.H., et al.: Drugs, 42, 781 (1991), Colvin, O.M., et al.: Curr. Pharmaceut. Design, 5, 555 (1999),<br></p>Fórmula:C7H15Cl2N2O2P·H2OCor e Forma:NeatPeso molecular:279.10Uridine-3'-monophosphate disodium salt
CAS:Pureza:99.0%Cor e Forma:SolidPeso molecular:368.1449890136719Ethyl Dihydrogen Phosphate
CAS:Produto ControladoFórmula:C2H7O4PCor e Forma:White To BeigePeso molecular:126.048Sodium (2R,3R,4S)-2,3,4,6-tetrahydroxy-5-oxohexyl phosphate
CAS:Pureza:95.0%Peso molecular:322.004171806Fenthoxon
CAS:Produto Controlado<p>Applications A major metabolite of Fenthion (FEN). It is used as organophosphorus pesticides.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Buratti, F., et al.: Toxicol. Lett., 167, 245 (2006), Buratti, F., et al.: Drug Metab. Dispos., 33, 295 (2005), Buratti, F., et al.: Toxicology, 241, 33 (2007),<br></p>Fórmula:C10H15O4PSCor e Forma:ColourlessPeso molecular:262.26Fenthoxon Sulfoxide
CAS:Produto Controlado<p>Applications A metabolite of Fenthion (FEN).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Buratti, F., et al.: Toxicol. Lett., 167, 245 (2006), Buratti, F., et al.: Drug Metab. Dispos., 33, 295 (2005), Buratti, F., et al.: Toxicology, 241, 33 (2007),<br></p>Fórmula:C10H15O5PSCor e Forma:ColourlessPeso molecular:278.2619Dichlorvos-d6
CAS:Produto Controlado<p>Applications Dichlorvos-d6 is a deuterated analogue of Dichlorvos a Cholinesterase inhibitor. Anthelmintic, insecticide. Used as a standard for Pesticide detection. Also used in Cannabis testing.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gaines, T.B., et al.: Toxicol. Appl. Pharmacol., 14, 515 (1969), Reuber, M.D., et al.: Clin. Toxicol., 18, 47 (1981),<br></p>Fórmula:C42H6HCl2O4PCor e Forma:Clear Colourless To BrownPeso molecular:227.01(4-Amino-1-hydroxybutane-1,1-diyl)diphosphonic acid
CAS:Pureza:95.0%Cor e Forma:Solid, White to slightly pale yellow powderPeso molecular:249.0959930419922Cyclophosphamide-d8 H2O [bis(2-chloroethyl-d4)]
CAS:Produto Controlado<p>Applications Cyclophosphamide-d8 H2O [bis(2-chloroethyl-d4)] is a useful isotopically labeled compound of Cyclophosphamide Monohydrate (C988580)<br></p>Fórmula:C7H9D8Cl2N2O3PCor e Forma:White To Off-WhitePeso molecular:287.15Diazinon
CAS:Produto Controlado<p>Stability Moisture Sensitive<br>Applications A cholinesterase inhibitor; a nonsystemic organophosphate insecticide. This compound is a contaminant of emerging concern (CECs). Used as a standard for Pesticide detection.Diazinon is useful in cannabis testing kits as a component of pesticide mixes (P698230).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gaines, T.B., et al.: Toxicol. Appl. Pharmacol., 14, 515 (1969);<br></p>Fórmula:C12H21N2O3PSCor e Forma:ColourlessPeso molecular:304.35Cyclophosphamide-d4
CAS:Produto Controlado<p>Applications It is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity. This substance is listed as a known human carcinogen.This compound is suitable for aldehyde dehydrogenase (ALDH) related research.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wheeler, A.G., et al.: Toxicol. Appl. Pharmacol., 4, 324 (1962), Fraiser, L.H., et al.: Drugs, 42, 781 (1991), Colvin, O.M., et al.: Curr. Pharmaceut. Design, 5, 555 (1999),<br></p>Fórmula:C72H4H11Cl2N2O2PCor e Forma:Off-WhitePeso molecular:265.11Amifostine Thiol Dihydrochloride >90%
CAS:<p>Stability Hygroscopic<br>Applications Amifostine Thiol is a metabolite of Amifostine (A576810) which provides normal cells with selective protection against the toxic effects of cancer chemotherapy and radiation treatment.<br>References Satge, J., et al.: Eur. J. Med. Chem., 24, 48 (1989); Geary, R.S., et al.: Biopharm. Drug Dispos., 12, 261 (1991); Brown, D.Q., et al. Pharmacol. Ther., 39, 159 (1988); Capizzi, R.L., et al.: Cancer, 72, 3495 (1993); Treskes, M., et al.: Cancer Chemother. Pharmacol., 33, 93 (1993)<br></p>Fórmula:C5H14N2S·2ClHPureza:>90%Cor e Forma:NeatPeso molecular:207.16Carboxyphosphamide-d4
CAS:Produto Controlado<p>Applications A labelled metabolite of Cyclophosphamide (CPA) (C988580).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Takamizawa, A., et al.: J. Med. Chem., 18, 376 (1975), Jones, R.J., et al.: J. Hematother., 1, 343 (1992), Biggs, D., et al.: Prog. Clin. Biol. Res., 389, 9 (1994),<br></p>Fórmula:C7H11D4Cl2N2O4PCor e Forma:NeatPeso molecular:297.11(R,S)-4-Hydroxy Cyclophosphamide Preparation Kit
CAS:<p>Stability Unstable in Solution<br>Applications A metabolite of Cyclophosphamide.This Kit consists of a vial of the precursor, 4-hydroperoxycyclophosphamide (H714675), and a vial of sodium thiosulfate (S673640). Simply add water to the reducing agent until it is completely dissolved and add this solution to the precursor. This solution has a half-life of approximately 200 minutes at room temperature. Detailed instructions are enclosed.<br>References Peter, G., et al.: Cancer. Chemother. Pharmacol., 3, 181 (1979), Fenselau, C., et al.: Drug Metab. Dispos., 10, 636 (1982), Gamcsik, M., et al.: J. Med. Chem., 33, 1009 (1990), Habib, A., et al.: Biochem. Pharmacol., 50, 429 (1995),<br></p>Fórmula:C7H15Cl2N2O3PCor e Forma:Off White CrystallinePeso molecular:277.09(2-(3,6-Dimethoxy-9H-carbazol-9-yl)ethyl)phosphonic acid
CAS:Pureza:98%Peso molecular:335.2959899902344Malathion α-Monoacid
CAS:Produto Controlado<p>Stability Moisture Sensitive<br>Applications A major biodegradation product of Malathion (M111000).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kim, Y. et al.: Chemosphere, 60, 1349 (2005); Yoshii, K. et al.: J. Health Sci., 54, 535 (2008); Hayasaka, M. et al.: Jap. J. Forensic Toxicol., 12, 15 (1994);<br></p>Fórmula:C8H15O6PS2Cor e Forma:NeatPeso molecular:302.3Malathion Diacid Dipotassium Salt
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications A biodegradation product of Malathion (M111000).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kim, Y. et al.: Chemosphere, 60, 1349 (2005); Yoshii, K. et al.: J. Health Sci., 54, 535 (2008); Hayasaka, M. et al.: Jap. J. Forensic Toxicol., 12, 15 (1994);<br></p>Fórmula:C6H9K2O6PS2Cor e Forma:NeatPeso molecular:350.43Zoledronic Acid Disodium Salt Tetrahydrate
CAS:Produto Controlado<p>Applications A biphosphonate bone resorption inhibitor.<br>References Green, J.R., et al.: J. Bone Min. Res., 9, 745 (1994), Risser, F., et al.: J. Pharm. Biomed. Anal., 15, 1877 (1997), Body, J.J., Cancer, 80, 1699 (1997),<br></p>Fórmula:C5H8N2O7P2·2Na·4H2OCor e Forma:NeatPeso molecular:388.11Imidazol-1-yl-acetic Acid
CAS:Produto Controlado<p>Applications An impurity arising in the synthesis of zoledronic acid (Z623500).<br></p>Fórmula:C5H6N2O2Cor e Forma:BeigePeso molecular:126.115-Decyano 5-Carboxymilrinone
CAS:Produto Controlado<p>Impurity Milrinone Impurity 12<br>Applications 5-Decyano 5-Carboxymilrinone (Milrinone Impurity 12) is an impurity of Milrinone (M344680), a selective phosphodiesterase inhibitor with vasodilating and positive inotropic activity.<br>References Alousi, A.A., et al.: J. Cardiovasc Pharmacol., 5, 792 (1983); Maskin, C.S., et al.: Circulation, 67, 1065 (1983); Sinoway, L.S., et al.: J. Am. Coll. Cardiol., 2, 327 (1983); Baim, D.S., et al.: N. Engl. J. Med., 309, 748 (1983)<br></p>Fórmula:C12H10N2O3Cor e Forma:Off-WhitePeso molecular:230.22Deferasirox Methyl Ester
CAS:Produto Controlado<p>Applications Deferasirox Methyl Ester is a derivative of Deferasirox (D228650); an orally active tridentate iron chelator.<br>References Hershko, C., et al.: Blood, 97, 1115 (2001); Galanello, R., et al.: J. Clin. Pharmacol., 43, 565 (2003); Nick, H., et al.: Curr. Med. Chem., 10, 1065 (2003)<br></p>Fórmula:C22H17N3O4Cor e Forma:White To BeigePeso molecular:387.39Parathion
CAS:Produto Controlado<p>Stability Hygroscopic, Moisture Sensitive<br>Applications Parathion is an organophosphate insecticide used on cotton, rice and fruit trees.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Seifert, J., et al.: Environ. Toxicol. Pharmacol., 35, 200 (2013); Ciffroy, P., et al.: Environ. Toxicol. Chem., 32, 602 (2013);<br></p>Fórmula:C10H14NO5PSCor e Forma:YellowPeso molecular:291.26N-Dechloroethyl Cyclophosphamide
CAS:<p>Stability Reacts with DMSO<br>Applications A metabolite of Cyclophosphamide (C988580).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bohnenstengel, F., et al.: Eur. J. Clin. Pharmacol., 51, 297 (1996), Busse, D., et al.: J. Clin. Oncol., 15, 188 (1997), Roy, P., et al.: Drug Metab. Dispos., 27, 655 (1999),<br></p>Fórmula:C5H12ClN2O2PCor e Forma:NeatPeso molecular:198.593-Aminopropyl Monophosphate
CAS:Produto Controlado<p>Applications A metabolite of the anti-tumor drug Ifosfamide (I265000). An impurity of Cyclophosphamide (C988580).<br>References Gilard, V. et al.: J. Med. Chem., 42, 2542 (1999); Seligman, A.M. et al.: Cancer Chemother. Rep., 59, 233 (1975);<br></p>Fórmula:C3H10NO4PCor e Forma:White To Off-WhitePeso molecular:155.09(R,S)-4-Hydroxy Cyclophosphamide-d4 Preparation Kit
CAS:Produto ControladoFórmula:C7H11D4Cl2N2O3PCor e Forma:White To Off-WhitePeso molecular:281.11(S)-(-)-3-Acetylthio-2-methylpropionic Acid
CAS:Produto Controlado<p>Applications S-Acetylthio-2-methylpropionic Acid (S-AMPA) is a key chiral intermediate for Captopril (C175750) and other hypertension drugs.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cushman, D., et al.: Biochem., 16, 5484 (1977), Ondetti, M., et al.: J. Med. Chem., 24, 355 (1981), Tseng, T., et al.: Cancer Lett., 62, 233 (1992),<br></p>Fórmula:C6H10O3SCor e Forma:ColourlessPeso molecular:162.21(4S)-4-(Phenylthio)-L-proline Hydrochloride
CAS:<p>Applications (4S)-4-(Phenylthio)-L-proline is an impurity of Zofenopril (Z587000).<br>References Krapcho, J., et al.: J. Med. Chem., 31, 1148 (1988),<br></p>Fórmula:C11H14ClNO2SCor e Forma:NeatPeso molecular:259.75
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