Fosfatos e Fosfonatos Orgânicos
Os fosfatos orgânicos são compostos que contêm um grupo fosfato (-PO₄) ligado a um átomo de carbono numa estrutura orgânica, geralmente em combinação com álcoois, ácidos ou aminas. Estes compostos são utilizados na formulação de APIs para melhorar a solubilidade, estabilidade e biodisponibilidade dos princípios ativos. Os fosfatos orgânicos também desempenham um papel na liberação controlada de fármacos e na melhoria da absorção de certos medicamentos.
Os fosfonatos orgânicos contêm um grupo fosfonato (-PO₃H₂), no qual o átomo de fósforo está ligado a um átomo de carbono e a dois grupos oxigênio. Estes compostos possuem propriedades farmacológicas importantes, especialmente na inibição de enzimas e na modulação de processos bioquímicos. Os fosfonatos orgânicos são utilizados na produção de APIs que atuam no metabolismo ósseo, no tratamento de infecções bacterianas ou como antivirais, devido aos seus efeitos biológicos específicos.
Na CymitQuimica, oferecemos fosfatos e fosfonatos orgânicos para pesquisa em química médica, bioquímica e desenvolvimento de formulações avançadas.
Foram encontrados 1201 produtos de "Fosfatos e Fosfonatos Orgânicos"
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4-Ethoxy-2-isopropyl-6-methylpyrimidine
CAS:Produto Controlado<p>Applications 4-Ethoxy-2-isopropyl-6-methylpyrimidine, is the product of Diazinon (D416880) decomposition, an organophosphorus pesticide.<br>References Mekhakyan, L. A., et al.: Nov. Khim. Sredstva Zashch. , 62 (1979); Sovocool, G. W., et al.: J. Anal. Toxic., 5, 73 (1981);<br></p>Fórmula:C10H16N2OCor e Forma:NeatPeso molecular:180.25Bis(2-chloroethyl)-1,1,2,2-d4-amine Hydrochloride
CAS:Produto Controlado<p>Applications Isotope labelled Bis(2-chloroethyl)amine is a cytotoxic metabolite of Cyclophosphamide; a deuterated analog of Nor-nitrogen mustard.<br>References Colvin, M., et al.: Cancer Res., 36, 1121 (1976), Ludeman, S., et al.: Drug Metab Dispos., 20, 337 (1992), Ludeman, S.M., et al.: J. Pharmaceut. Sci., 84, 393 (1995), Yu, L., et al.: Drug Metab. Dispos., 24, 1254 (1996),<br></p>Fórmula:C42H4H5Cl2N·ClHCor e Forma:NeatPeso molecular:182.51Butafosfan
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications Butafosfan, a component of Catosal, is licensed for the treatment of metabolic disorders or as a tonic in swine. It reduces the stress-induced cortisol (C696302, d4 labelled) response after mixing of unfamiliar pigs. It can also increase milk production in Holstein cows in combination with cyanocobalamin.<br>References De Groot, J., et al.: J. Vet. Pharmacol. Ther., 26, 222 (2003); Pereira, R., et al.: Animal, 7, 1143 (2013)<br></p>Fórmula:C7H18NO2PCor e Forma:White To Off-WhitePeso molecular:179.20Epicaptopril
CAS:<p>Stability Air Sensitive<br>Applications Epicaptopril is an impurity of Captopril (C175750) which is an orally active angiotensin-converting enzyme (ACE) inhibitor used in the treatment of hypertension and congestive heart failure.<br>References Rubin, B., et al.: Eur. J Pharmacol., 51, 377 (1978);<br></p>Fórmula:C9H15NO3SCor e Forma:White To Off-WhitePeso molecular:217.28Glufosinate-d3 Hydrochloride
CAS:Produto Controlado<p>Stability Very Hygroscopic<br>Applications Labelled Glufosinate (G596952). Used as a herbicide.<br>References Abbas, H., et al.: J. Agric. Food Chem., 50, 5246<br></p>Fórmula:C52H3H9NO4P·ClHCor e Forma:White To Light BeigePeso molecular:220.61Miltefosine
CAS:Produto Controlado<p>Applications A phospholipid drug with antineoplastic and antiprotozoal/antifungal properties, also acts as an Akt inhibitor, and under investigation as a potential therapy against HIV infection.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chugh, P., et al al.: Retrovirology, 5, 11 (2008), Dorio, T., et al.: Antimicrob. Agents Chemother., 52, 2855 (2008),<br></p>Fórmula:C21H46NO4PCor e Forma:NeatPeso molecular:407.57N-Nitroso Cilazapril (Ethyl-D5)
CAS:Produto ControladoFórmula:C22D5H25N4O6Cor e Forma:NeatPeso molecular:451.528Zofenopril Calcium Salt
CAS:<p>Applications Angiotensin-converting enzyme ACE inhibitor. A prodrug that is de-esterified to the active inhibitor, the sulfhydryl group containing metabolite, Zofenoprilat.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gorren, A., et al.: Biochem. J., 331, 801 (1998), Subissi, A., et al.: Cardivascular Drug Reviews, 17, 2 (1999), Marchand, C., et al.: Mol. Pharmacol., 64, 600 (2003), Maurin, C., et al.: J. Med. Chem., 47, 5583 (2004),<br></p>Fórmula:C22H22NO4S2·CaCor e Forma:NeatPeso molecular:897.17Captopril-d3
CAS:Produto Controlado<p>Applications Orally active angiotensin-converting enzyme (ACE) inhibitor.<br>References Rubin, B., et al.: Eur. J Pharmacol., 51, 377 (1978),<br></p>Fórmula:C9D3H12NO3SCor e Forma:White SolidPeso molecular:220.30Tris(1,3-dichloro-2-propyl) Phosphate-d15
CAS:Produto Controlado<p>Applications Isotope labelled Tris(1,3-dichloro-2-propyl) Phosphate is a flame retardant present in polyurethane foams.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Stapleton, H. et al.: Env. Sci. Tech., 45, 5323 (2011);<br></p>Fórmula:C9D15Cl6O4PCor e Forma:Colourless To BrownPeso molecular:446.00N-Nitroso Bis(2-chloroethyl)amine
CAS:<p>Applications N-Nitroso bis(2-chloroethyl)amine is a nitroamine compound that has carcinogenic effects.<br>References Luan, F. et al.: Che. Res. in Tox., 18(2), 198-203, (2005)<br></p>Fórmula:C4H8Cl2N2OCor e Forma:NeatPeso molecular:171.025Malathion-d6
CAS:Produto Controlado<p>Applications Used as an insecticide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>Fórmula:C102H6H13O6PS2Cor e Forma:NeatPeso molecular:336.40Captopril Disulfide
CAS:<p>Impurity Captopril EP Impurity A<br>Applications Captopril Disulfide (Captopril EP Impurity A) is a metabolite of Captopril. A new antihypertensive agent.<br>References Sprague, P., et al.: Perspect. Drug Discovery Des., 3, 21 (1995), Cushman, D., et al.: Nat. Med., 5, 1110 (1999), Jacoby, E., et al.: Drug News Perspect., 16, 93 (2003), Lengauer, T., et al.: Drug Discovery Today, 9, 27 (2004),<br></p>Fórmula:C18H28N2O6S2Cor e Forma:WhitePeso molecular:432.55Nitrilotris(methylene)triphosphonic Acid
CAS:Produto Controlado<p>Applications A powerful complexing agent. A potent acid sphingomyelinase inhibitor.<br>References Marathe, S., et al.: J. Biol. Chem., 273, 4081 (1998), Lang, P., et al.: Nat. Med., 13, 164 (2007), Nara, F., et al.: J. Antibiot., 52, 525 (1999), Szajnman, S., et al.: Bioorg. Med. Chem. Lett., 15, 4685 (2005),<br></p>Fórmula:C3H12NO9P3Cor e Forma:NeatPeso molecular:299.053-[[2-[(2-Chloroethyl)amino]ethyl]amino]propyl Monophosphate Dihydrochloride
CAS:Produto Controlado<p>Impurity Cyclophosphamide Impurity D Dihydrochloride<br>Stability Hygroscopic<br>Applications A metabolite of Cyclophosphamide (C988580).<br>References Joqueviel, C. et al.: Drug Metab. Dispos., 26, 418 (1998);<br></p>Fórmula:C7H18ClN2O4P·2ClHCor e Forma:White To Off-WhitePeso molecular:333.584-Oxo Cyclophosphamide
CAS:<p>Applications A minor metabolite of Cyclophosphamide<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Juma, F., et al.: Br. J. Clin. Pharmacol., 10, 327 (1980), Powers, J., et al.: Cancer Res., 43, 1101 (1983), Hardy, R., et al.: Ther. Drug Monit., 9, 221 (1987),<br></p>Fórmula:C7H12Cl2NO4PCor e Forma:NeatPeso molecular:276.05Deferasirox Ferrate(III) Tripotassium Complex Methanoate Hydrate
CAS:<p>Applications A metal complex of Deferasirox (D228650) as oxidation catalysts. Coordination compound.<br>References Rouan, M., et al.: Biomed. Sci. Applic., 755, 203 (2001)<br></p>Fórmula:C44H36FeK3N6O12Cor e Forma:NeatPeso molecular:1013.93Diethyl (Ethoxycarbonyl)phosphonate
CAS:Produto Controlado<p>Stability Moisture Sensitive<br>Applications Diethyl (Ethoxycarbonyl)phosphonate is an impurity in the synthesis of Foscarnet (F727400), an inhibitor of viral DNA polymerase and reverse transcriptase. Foscarnet is used as an antiviral.<br>References Helgstrand, E., et al.: Science, 201, 819 (1978), Reno, J.M., et al.: Antimicrob. Agents Chemother., 13, 188, (1978), Alenius, S., et al.: Arch. Virol., 60, 197 (1979),<br></p>Fórmula:C7H15O5PCor e Forma:NeatPeso molecular:210.16Zoledronic-d3 Acid
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications Zoledronic-d3 Acid is the labeled analogue of Zoledronic Acid (Z623500), a biphosphonate bone resorption inhibitor.<br>References Green, J.R., et al.: J. Bone Min. Res., 9, 745 (1994); Risser, F., et al.: J. Pharm. Biomed. Anal., 15, 1877 (1997); Body, J.J., Cancer, 80, 1699 (1997)<br></p>Fórmula:C5H7D3N2O7P2Cor e Forma:NeatPeso molecular:275.112-(2-Hydroxyphenyl)-4H-1,3-benzoxazin-4-one
CAS:Produto Controlado<p>Applications Intermediate in the production of Deferasirox.<br></p>Fórmula:C14H9NO3Cor e Forma:NeatPeso molecular:239.23Diazinon-d10
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications A labelled cholinesterase inhibitor; a nonsystemic organophosphate insecticide. Used as a standard for Pesticide detection.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gaines, T.B., et al.: Toxicol. Appl. Pharmacol., 14, 515 (1969),<br></p>Fórmula:C122H10H11N2O3PSCor e Forma:ColourlessPeso molecular:314.41Malathion
CAS:<p>Applications Malathion is a pestanal and used primarily as an insecticide. Malathion is also useful in cannabis testing kits as a component of pesticide mixes (P698230).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Josse, R et al.: Chem. Bio., Interact., 209, 76 (2014);<br></p>Fórmula:C10H19O6PS2Cor e Forma:Colourless To Light YellowPeso molecular:330.362-Isopropyl-6-methyl-4-pyrimidone
CAS:Produto Controlado<p>Applications 2-Isopropyl-6-methyl-4-pyrimidone, is an intermediate used for the synthesis of various benzophenone derivatives, having antifungal and antibacterial activities. It can also be used for the synthesis of Diazinon (D416880), and Diazoxon (D416890), the organophosphate insecticides.<br>References Sun, L., et al.: Molecules, 16, 9739 (2011); Pasti, T. L., J. Environ. Protect. Ecology, 12, 1168 (2011);<br></p>Fórmula:C8H12N2OCor e Forma:NeatPeso molecular:152.19Fenthion-d6
CAS:Produto Controlado<p>Applications Labelled Fenthion, an organothiophosphate insecticide. Fenthion is also a potent acaricide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Pati, B.R. et al.: Plant Soil, 80, 215 (1984); Barros, A.T. et al.: Vet. Parasitol., 96, 243 (2001); Kyriakidis, N.V. et al.: Food Chem., 91, 241 (2005);<br></p>Fórmula:C102H6H9O3PS2Cor e Forma:ColourlessPeso molecular:284.36Terbufos-sulfoxide
CAS:Produto Controlado<p>Applications Terbufos-sulfoxide was identified in vegetables and fruit by gas chromotography.<br>References Zhang, Q., et al.: Shandong Huagong, 45, 57 (2016)<br></p>Fórmula:C9H21O3PS3Cor e Forma:NeatPeso molecular:304.433-Acetylthio-2-methylpropionic Acid
CAS:Produto Controlado<p>Impurity Captopril EP Impurity G<br>Applications 3-Acetylthio-2-methylpropionic Acid (Captopril EP Impurity G) is a key intermediate for Captopril (C175750) and other hypertension drugs.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cushman, D., et al.: Biochem., 16, 5484 (1977), Ondetti, M., et al.: J. Med. Chem., 24, 355 (1981), Tseng, T., et al.: Cancer Lett., 62, 233 (1992),<br></p>Fórmula:C6H10O3SCor e Forma:NeatPeso molecular:162.214-Hydroperoxy Cyclophosphamide-d4
CAS:Produto Controlado<p>Stability Moisture Sensitive, Temperature Sensitive<br>Applications A labelled metabolite of Cyclophosphamide. Antineoplastic; bone marrow purging agent.<br>References Takamizawa, A., et al.: J. Med. Chem., 18, 376 (1975), Jones, R.J., et al.: J. Hematother., 1, 343 (1992), Biggs, D., et al.: Prog. Clin. Biol. Res., 389, 9 (1994),<br></p>Fórmula:C7H11D4Cl2N2O4PCor e Forma:NeatPeso molecular:297.111,2-Dioleoyl-3-trimethylammonium-propane, Chloride
CAS:Produto ControladoFórmula:C42H80NO4·ClCor e Forma:NeatPeso molecular:698.54Alendronic Acid-d6 Sodium Salt Hydrate
CAS:Produto Controlado<p>Applications Alendronic Acid-d6 Sodium Salt is a labelled salt analogue of Alendronic Acid (A521250), a bisphosphonate used as a bone reabsoption inhibitor.<br>References Wang, X.M., et al.: Clin. J. Dent. Res., 3, 26 (2000); Woo, T., et al.: Best Pract. Res. Clin. Rheumatol., 15, 469 (2001); Benford, H.L., et al.: Bone, 28, 465 (2001)<br></p>Fórmula:C4H6D6NNaO7P2xH2OCor e Forma:NeatPeso molecular:277.11Toldimfos Sodium
CAS:Produto Controlado<p>Applications Toldimfos Sodium, is a cattle drug that can be used to investigate the bovine serum paraoxonase 1 (PON1) activity.<br>References Arslan, M., et al.: J. Enzyme Inhibit. Med. Chem., 27, 722 (2012);<br></p>Fórmula:C9H13NO2P·NaCor e Forma:White To Off-WhitePeso molecular:221.173-Mercapto-2-methylpropanoic Acid
CAS:Produto Controlado<p>Impurity Captopril EP Impurity C<br>Applications 3-Mercapto-2-methylpropanoic Acid (Captopril EP Impurity C) is a useful synthetic intermediate.<br>References Lewis, S.N. et al.: J. Het. Chem., 8, 571-580 (1971)<br></p>Fórmula:C4H8O2SCor e Forma:NeatPeso molecular:120.17Amifostine Trihydrate
CAS:Produto Controlado<p>Applications Amifostine Trihydrate is a widely used cytoprotective and radio-protective agent.<br>References Adibhatla K.S., et al. Novel method of manufacture of high purity Amifostine trihydrate. Indian Pat. Appl. IN 2005CH01592 A 20080125. Jan 25, 2008<br></p>Fórmula:C5H15N2O3PS·3H2OCor e Forma:NeatPeso molecular:268.27Cilazapril
CAS:Produto Controlado<p>Applications An ACE inhibitor. Hydrolyzed in vivo to the active diacid metabolite (Cilazaprilat). Antihypertensive.<br>References Natoff, I.L., et al.: J. Cardiovasc. Pharmacol., 7, 569 (1985), Szucs, T., et al.: Drugs, 41, Suppl.1, 18 (1991), Pordy, R.C., et al.: Cardiology, 86, 41 (1995),<br></p>Fórmula:C22H31N3O5Cor e Forma:WhitePeso molecular:417.50Phosphoric Acid Potassium
CAS:<p>Stability Hygroscopic<br>Applications Potassium salt of Phosphoric Acid (P359200), used in various chemical processes as a phosphorylating compound. Also used in the preparation of prosthetics and collagen nanocomposites due to the bone-like properties. pH buffer.<br>References Ezhova, Z. et al.: Russ. J. Inorg. Chem., 58, 1177 (2013); Wu, Y. et al.: Asian J. Chem., 25, 5881 (2013);<br></p>Fórmula:K·H2O4PCor e Forma:WhitePeso molecular:136.09Carboxyphosphamide
CAS:Produto Controlado<p>Applications A metabolite of Cyclophosphamide (CPA) (C988580).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Takamizawa, A., et al.: J. Med. Chem., 18, 376 (1975), Jones, R.J., et al.: J. Hematother., 1, 343 (1992), Biggs, D., et al.: Prog. Clin. Biol. Res., 389, 9 (1994),<br></p>Fórmula:C7H15Cl2N2O4PCor e Forma:NeatPeso molecular:293.08Fenthion Sulfone
CAS:<p>Applications Fenthion Sulfone is a metabolite of the organothiophosphate insecticide Fenthion (F278000).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Oh, C., et al.: Bull Environ. Contam. Toxicol., 78, 314 (2007); Wang, W., et al.: Anal. Chim. Acta, 602, 211 (2007);<br></p>Fórmula:C10H15O5PS2Cor e Forma:ColourlessPeso molecular:310.33Fenthion
CAS:Produto Controlado<p>Stability Moisture Sensitive<br>Applications Fenthion is an organothiophosphate used as an insecticide. Fenthion is also a potent acaricide. Useful in cannabis testing kits as a component of pesticide mixes (P698230).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Pati, B.R. et al.: Plant Soil, 80, 215 (1984); Barros, A.T. et al.: Vet. Parasitol., 96, 243 (2001); Kyriakidis, N.V. et al.: Food Chem., 91, 241 (2005);<br></p>Fórmula:C10H15O3PS2Cor e Forma:Colourless To Light YellowPeso molecular:278.334-Hydrazinobenzoic Acid
CAS:Produto Controlado<p>Applications 4-Hydrazinobenzoic Acid, is an organic building block used for the synthesis of various chemical and pharmaceutical compounds. It can be used for the synthesis of Deferasirox (D228650), an orally active tridentate iron chelator.<br>References Ying, Ch., et al.: Xiandai Yaowu Yu Linchuang, 27, 446 (2012); Galanello, R., et al.: J. Clin. Pharmacol., 43, 565 (2003), Nick, H., et al.: Curr. Med. Chem., 10, 1065 (2003);<br></p>Fórmula:C7H8N2O2Cor e Forma:NeatPeso molecular:152.15Malathion β-Monoacid
CAS:<p>Stability Hygroscopic<br>Applications A major biodegradation product of Malathion (M111000).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kim, Y. et al.: Chemosphere, 60, 1349 (2005); Yoshii, K. et al.: J. Health Sci., 54, 535 (2008); Hayasaka, M. et al.: Jap. J. Forensic Toxicol., 12, 15 (1994);<br></p>Fórmula:C8H15O6PS2Cor e Forma:NeatPeso molecular:302.30Difluoromethylenediphosphonic Acid
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications A phosphonic acid derivative for development of biologically active compounds.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ma, Q.F., et al.: Biochemistry, 29, 1412 (1990), Soti, C., et al.: Eur. J. Biochem., 270, 2421 (2003), Barabas, O., et al.: J. Biol. Chem., 279, 42907 (2004),<br></p>Fórmula:CH4F2O6P2Cor e Forma:NeatPeso molecular:211.98Fenthoxon Sulfone
CAS:Produto Controlado<p>Applications A metabolite of Fenthion (FEN).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Buratti, F., et al.: Toxicol. Lett., 167, 245 (2006), Buratti, F., et al.: Drug Metab. Dispos., 33, 295 (2005), Buratti, F., et al.: Toxicology, 241, 33 (2007),<br></p>Fórmula:C10H15O6PSCor e Forma:ColourlessPeso molecular:294.262-Pyrrolidinylphosphonic Acid
CAS:Produto Controlado<p>Applications 2-Pyrrolidinylphosphonic Acid, is an impurity of Alendronate (A521250), a bisphosphonate used as a bone reabsoption inhibitor.<br>References Wang, X.M., et al.: Clin. J. Dent. Res., 3, 26 (2000), Woo, T., et al.: Best Pract. Res. Clin. Rheumatol., 15, 469 (2001), Benford, H.L., et al.: Bone, 28, 465 (2001),<br></p>Fórmula:C4H10NO3PCor e Forma:Off-WhitePeso molecular:151.10(Dichloromethylene)diphosphonic acid, disodium salt
CAS:Pureza:95.0%Cor e Forma:Solid, No data available.Peso molecular:288.8500061035156Ref: 10-F449661
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