Nitrosaminas e Derivados

Applications A deuterated metabolite of NNK (Cat. #M325750), a tobacco-specific nitrosamine.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Hecht, S.S., et al.: Cancer Res., 40, 4144 (1980); Kutzer, C., et al.: J. Chromatog. Sci., 35, 1 (1997)

Applications 4-Methylmorpholine is used in the synthesis of novel and selective TYK2 inhibitors, used in the treatment of inflammatory diseases. Also used in the preparation of cathespin K inhibitors which are highly selective.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Liang, J. et al.: Eur. J. Med. Chem., 67, 175 (2013); Yuan, X. et al.: Org. Biomol. Chem., 11, 5847 (2013);

Applications Molsidomine is an antianginal agent. Molsidomine is an effective therapeutic agents in the treatment of angina pectoris. Molsidomine is a sydnonimine derivative that acts as a heterocyclic direct nitric oxide donor.
References Tanayama, S. et al.: Xenobiotica, 4, 175 (1974); Yamada, M. et al.: Chem. Pharmac. Bull., 35, 3390 (1987); Messin, R. et al.: Adv. Ther., 23, 107 (2006);

Applications N'-Nitrosonornicotine (NNN) is a tobacco alkaloid known as esophageal carcinogen. NNN is the cause of esophageal and oral cavity cancer in smokers and snuff dippers. The studies showed that the carcinogenicity of (S)-NNN, the predominant enantiomer in tobacco products, may be greater than that of (R)-NNN or racemic NNN.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Anto, R., et al.: Carcinogenesis, 23, 1511 (2002), Pfeifer, G., et al.: Oncogene, 21, 7435 (2002), Shishodia, S., et al.: Cancer Res., 64, 5004 (2004), Jin, Z., et al.: J. Biol. Chem., 279, 23837 (2004),

Applications Morpholine, is used as selective inhibitors of cytochrome p450 2a13 in treatment of cancer. Morpholine is a building block in the preparation of the antibiotic Linezolid (L466500), the anticancer agent Gefitinib (G304000) and the analgetic Dextromoramide (M630190).
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References Hall, H. K., et al.: J. Am. Chem. Soc., 79 (20), 5441 (1957); Paladini, D., et al.: Biochem., 48, 5760 (2009); Bard, B., et al.: J. Med. Chem., 52, 3416 (2009);

Applications A metabolite of NNK (Cat. #M325750), a tobacco-specific nitrosamine.
References Hecht, S.S., et al.: Cancer Res., 40, 4144 (1980), Kutzer, C., et al.: J. Chromatog. Sci., 35, 1 (1997)