Nucleosídeos e Nucleotídeos
Os nucleosídeos são compostos formados por uma base nitrogenada ligada a um açúcar (ribose ou desoxirribose). Quando um grupo fosfato é adicionado ao nucleosídeo, forma-se um nucleotídeo. Esses compostos são essenciais na biologia celular, pois os nucleotídeos são os blocos fundamentais do DNA e RNA, responsáveis pelo armazenamento e transmissão da informação genética. Os nucleosídeos têm aplicações no tratamento de doenças virais, atuando como inibidores da replicação viral. Os nucleotídeos, além do seu papel estrutural nos ácidos nucleicos, participam de processos energéticos, como a síntese de ATP.
Na CymitQuimica, oferecemos uma ampla gama de nucleosídeos e nucleotídeos essenciais para pesquisa em biologia molecular, virologia e farmacologia.
Foram encontrados 3429 produtos de "Nucleosídeos e Nucleotídeos"
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Lobucavir
CAS:Produto Controlado<p>Applications A nucleoside analog used in the treatment of viral infections, including those caused by human immunodeficiency virus, cytomegalovirus, and herpes virus.<br>References Faulds, D., et al.: Drugs, 39, 597 (1990), Greene, J., et al.: Fundam. Appl. Toxicol., 32, 140 (1996), Poirier, M., et al.: Toxicol. Appl. Pharmacol., 199, 151 (2004),<br></p>Fórmula:C11H15N5O3Cor e Forma:NeatPeso molecular:265.27(1S,4R)-4-(2-Amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol Hydrochloride
CAS:Produto ControladoFórmula:C11H12ClN5O·ClHCor e Forma:NeatPeso molecular:302.162,3’-Anhydrothymidine
CAS:Produto Controlado<p>Applications An intermediate in the preparation of thymidine derivatives<br>References el Kouni, M., et al.: Biochem. Pharmacol., 51, 1687 (1996),<br></p>Fórmula:C10H12N2O4Cor e Forma:NeatPeso molecular:224.21Adenosine 5’-Diphosphate-13C5 Ammonium Salt Hydrate
CAS:Produto Controlado<p>Stability Moisture Sensitive<br>Applications Adenosine 5’-Diphosphate-13C5 Ammonium Salt Hydrate is the isotope labelled analog of Adenosine 5’-Diphosphate Ammonium Salt Hydrate (A281700); a nucleoside diphosphate that interacts with a family of ADP receptors found on platelets (P2Y1, P2Y12 and P2X1), to induce platelet activation. ADP in the blood is converted to adenosine by the action of ecto-ADPases, inhibiting further platelet activation via adenosine receptors.<br>References Gamba, G. et al.: Haematologia, 58, 1215 (1973); Dejana, E. et al.: Thromb. Haemost., 39, 135 (1978)<br></p>Fórmula:C513C5H15N5O10P2xNH3xH2OCor e Forma:NeatPeso molecular:432.16O,O'-Dipropanal Ganciclovir
CAS:Produto Controlado<p>Impurity Ganciclovir EP Impurity I<br>Applications O,O'-Dipropanal Ganciclovir (Ganciclovir EP Impurity I) is derived from Ganciclovir (G235000), which is a nucleoside analog structurally related to Acyclovir (A192400). Ganciclovir is an antiviral.<br>References Halloran, P.J. and Fenton, R.G.: Cancer Res., 58, 3855 (1998), Rubsam, L.Z., et al.: Cancer Res., 59, 669 (1999), Yamasaki, H., et al.: C.R. Acad. Sci. III, 322, 151 (1999)<br></p>Fórmula:C15H21N5O6Cor e Forma:NeatPeso molecular:367.36N-[2-(Methylthio)ethyl]-2-[(3,3,3-trifluoropropyl)thio]-adenosine
CAS:Produto Controlado<p>Applications N-[2-(Methylthio)ethyl]-2-[(3,3,3-trifluoropropyl)thio]-adenosine is used for developing platelet P2T receptor antagonists, which have potential applications for antithrombotic therapy.<br>References Ingall, A. H., et al.: J. Med. Chem. 42, 213 (1999)<br></p>Fórmula:C16H22F3N5O4S2Cor e Forma:NeatPeso molecular:469.56-Deoxypenciclovir hydrochloride
CAS:<p>Applications Hydrochloride salt metabolite of a metabolite of Famciclovir, an antiviral.<br>References Harnden, M.R., et al.: J. Med. Chem., 32, 1738 (1989)<br></p>Fórmula:C10H15N5O2·ClHCor e Forma:White SolidPeso molecular:273.72UDP-3-O[R-3-Hydroxymyristoyl]-N-acetylglucosamine Tris Salt (90%)
CAS:Produto Controlado<p>Applications UDP-3-O[R-3-Hydroxymyristoyl]-N-acetylglucosamine Tris Salt is a lipid A precursor for Escherichia coli.<br>References Anderson, M. S. et al.: Biochem., 27, 1908 (1988);<br></p>Fórmula:C35H64N4O22P2Pureza:90%Cor e Forma:NeatPeso molecular:954.84N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-2-ethylbutyl Ester L-Alanine
CAS:Produto Controlado<p>Applications N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-2-ethylbutyl Ester L-Alanine is used for the treatment of ebola and emerging viruses.<br>References Siegel, D., et al.: J. Med. Chem., 60, 1648-1661 (2017)<br></p>Fórmula:C21H27N2O7PCor e Forma:NeatPeso molecular:450.422Adenosine
CAS:<p>Applications Adenosine is a nucleotide.<br>References Long, X., et al.: J. Pharmacol. Exper. Ther., 335, 781 (2010); Ham, M., et al.: J. Pharmacol. Exper. Ther., 335, 607 (2010);<br></p>Fórmula:C10H13N5O4Cor e Forma:NeatPeso molecular:267.24Melphalan-d8 Dihydrochloride
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications Antineoplastic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ross, W.C.J., et al.: Biochem. Pharmacol., 13, 969 (1964); Donelli, M.G., et al.: J. Pharm. Pharmacol., 18, 760 (1966), Furner, R.L., et al.: Cancer Treat. Rep., 64, 559 (1980),<br></p>Fórmula:C13H12D8Cl4N2O2Cor e Forma:NeatPeso molecular:386.17Cladribine 5’-Monophosphate Ammonium (>85%)
CAS:Produto Controlado<p>Applications Cladribine 5’-Monophosphate Ammonium Salt can be used as an antiviral, antibacterial and antileukemic agent.<br>References Cook, P., et al.: U.S., US 4719295 A 19880112 (1988);<br></p>Fórmula:C10H16ClN6O6PPureza:>85%Cor e Forma:NeatPeso molecular:382.7Thymine
CAS:Produto Controlado<p>Impurity Zidovudine EP Impurity C<br>Applications Thymine (Zidovudine EP Impurity C) is a nitrogenous base component in the nucleic acid of DNA.<br>References Keum, Y., et al.: App. Microbiol. Biotechnol., 80, 863 (2008); Redzic, Z., et al.: Neurochem. Res., 34, 566 (2009); Lanevskij, K., et al.: J. Pharm. Sci., 98, 122 (2009); Rajendar, B., et al.: Bioorg. Med. Chem., 17, 351 (2009);<br></p>Fórmula:C5H6N2O2Cor e Forma:WhitePeso molecular:126.11Zanamivir Amine
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications A synthetic precursor of Zanamivir.<br>References Gonzalez-Diaz, H., et al.: Bioorg. Med. Chem. Lett., 15, 1651 (2005), Bergmann, R., et al.: J. Med. Chem., 50, 2708 (2007), Lue, W., et al.: Eur. J. Med. Chem., 43, 569 (2008),<br></p>Fórmula:C11H18N2O7Cor e Forma:NeatPeso molecular:290.276-Methylmercaptopurine
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications Metabolite of 6-Mercaptopurine, an immunosuppressive drug used to treat leukemia.<br>References Chou, C., et al.: Biochem. Pharmacol., 75, 1601 (2008), Conejo-Garcia, A., et al.: Eur. J. Med. Chem., 43, 1742 (2008), Hawwa, A., et al.: Brit. J. Clin. Pharmacol., 66, 826 (2008), Askanase, A., et al.: J. Rheumatol., 36, 89 (2009),<br></p>Fórmula:C6H6N4SCor e Forma:White To BeigePeso molecular:166.20Cytarabine 5’-Monophosphate
CAS:Produto Controlado<p>Stability Hygroscopic, Unstable in Solution<br>Applications A derivative of Cytarabine, a potent cytotoxic-antiviral nucleoside.<br>References Kufe, D., et al.: J. Biol. Chem., 255, 8997 (1980), Ross, D., et al.: Cancer Res., 50, 2658 (1990), Bhalla, K., et al.: Blood, 80, 2883 (1992), Tonetti, D., et al.: J. Biol. Chem., 269, 23230 (1994),<br></p>Fórmula:C9H14N3O8PCor e Forma:NeatPeso molecular:323.204-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene
CAS:Produto Controlado<p>Applications 4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene is used as a reagent in the synthesis of Dapagliflozin (D185370); a potent, selective renal sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes.<br>References Meng, W., et al.: J. Med. Chem., 51, 1145 (2008);<br></p>Fórmula:C15H14BrClOCor e Forma:White To Off-WhitePeso molecular:325.63Pteroic Acid (>85%)
CAS:Produto Controlado<p>Impurity Methotrexate EP Impurity D N-Desmethyl Impurity<br>Applications Pteroic Acid (Methotrexate EP Impurity D N-Desmethyl Impurity) is a constituent as well as a degradation product of Folic Acid (F680300) formed via enzymatic hydrolysis. has been shown to activate the glutamylation of methotrexate by folylpolyglutamate synthetase.<br>References Vickers, P.J. et al.: Can. J. Biochem. Cell Biol., 63, 777 (1985): Tafolla, W.H. et al.: J. Pharmac. Sci., 70, 1273 (1981); Iwai, K. et al.: J. Butrit. Sci. Vitaminol., 23, 95 (1977);<br></p>Fórmula:C14H12N6O3Pureza:>85%Cor e Forma:NeatPeso molecular:312.285-Amino-1-methyl-4-nitroimidazole
CAS:Produto Controlado<p>Applications 5-Amino-1-methyl-4-nitroimidazole is a moiety of Azathioprine (A803350); an immunosuppressive antimetabolite that is also active as a disease modifying antirheumatic drug (DMARD).<br>References Mitrou, P.S., et al.: Arzneim.-Forsch., 29, 483, 662 (1979); Ding, T.L., et al.: Drug. Metab. Dispos., 7, 373 (1979); Chan, G.L.C., et al.: Pharmacotherapy, 7, 165 (1987); Sandborn, W.J., et al.: Scand. J. Gastroenterol., 33, Suppl. 225, 92 (1998)<br></p>Fórmula:C4H6N4O2Cor e Forma:NeatPeso molecular:142.12Methyl 1,2,4-Triazole-3-carboxylate
CAS:Produto ControladoFórmula:C4H5N3O2Cor e Forma:Off-WhitePeso molecular:127.1Gemcitabine
CAS:<p>Applications Gemcitabine is used for breast cancer treatment. First-line treatment for locally advanced pancreatic cancer.<br>References Hamsici, S., et al.: Bioconjugate Chem., (2017); Peng, T., et al.: J. Cell. Biochem., (2017)<br></p>Fórmula:C9H11F2N3O4Cor e Forma:Off-WhitePeso molecular:263.22-Deoxy-D-ribose
CAS:Produto Controlado<p>Applications 2-Deoxy-D-ribose induces apoptosis by inhibiting the synthesis and increasing the efflux of glutathione.<br>References Fico, A., et al.: Free Radical Biology & Medicine, 45, 211 (2008),<br></p>Fórmula:C5H10O4Cor e Forma:NeatPeso molecular:134.13Melphalan
CAS:Produto Controlado<p>Applications Melphalan is an antineoplastic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ross, W.C.J., et al.: Biochem. Pharmacol., 13, 969 (1964); Donelli, M.G., et al.: J. Pharm. Pharmacol., 18, 760 (1966), Furner, R.L., et al.: Cancer Treat. Rep., 64, 559 (1980),<br></p>Fórmula:C13H18Cl2N2O2Cor e Forma:NeatPeso molecular:305.205’-O-Acetyl Ribavirin
CAS:Produto Controlado<p>Applications 5’-O-Acetyl Ribavirin is an impurity of Ribavirin (R414475). Ribavirin impurity F.<br>References Zakharieva., et al.: Bioorganic. Medicinal. Chem., 1994, 4, 2831 (1994), Reichard., et al.: The Lancet, 351, 83 (1998),<br></p>Fórmula:C10H14N4O6Cor e Forma:NeatPeso molecular:286.24Iso Cytosine
CAS:Produto Controlado<p>Applications A useful intermediate for chemical modifications of base and sugar moieties in natural nucleosides.<br>References Sashaki, T., et al.: J. Org. Chem., 40(1), 106 (1975)<br></p>Fórmula:C4H5N3OCor e Forma:NeatPeso molecular:111.103'-Azido-3'-deoxy-5'-O-tritylthymidine
CAS:Produto ControladoFórmula:C29H27N5O4Cor e Forma:NeatPeso molecular:509.56Lamivudine Triphosphate Triethylamine Salt (90%)
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications A metabolite of Lamivudine (L172500).<br>References Burgess, K., et al.: Chem. Rev., 100, 2047 (2000), Gallois-Montbrun, S., et al.: Biochem. Pharmacol., 68, 1749 (2004),<br></p>Fórmula:C8H14N3O12P3SC6H15NxPureza:90%Cor e Forma:NeatPeso molecular:469.2010119Guanine
CAS:<p>Impurity Aciclovir EP Impurity B<br>Applications Guanine is one of the five nucleobases incorporated into biological nucleic acids. Guanine, along with adenine and cytosine, is present in both DNA and RNA, whereas thymine is usually seen only in DNA, and uracil only in RNA. Aciclovir EP Impurity B.<br>References Geslain, R., et al.: J. Biol. Chem., 284, 27760 (2009); Manini, P., et al.: Toxicol. Lett., 190, 41 (2009); Gong, B., et al.: Biochem., 48, 11961 (2009); Sugimoto, M., et al.: J. Agric. Food Chem., 58, 374 (2010);<br></p>Fórmula:C5H5N5OCor e Forma:White To Off-WhitePeso molecular:151.13Cytidine 5'-Diphosphocholine
CAS:Produto Controlado<p>Stability Moisture Sensitive<br>Applications Cytidine 5'-diphosphocholine (cas# 987-78-0) is a useful research chemical.<br></p>Fórmula:C14H26N4O11P2Cor e Forma:Off-WhitePeso molecular:488.32Emtricitabine-13C,15N2
CAS:Produto Controlado<p>Stability Very Hygroscopic<br>Applications Labelled Emtricitabine. A reverse transcriptase inhibitor. It is an effective antiviral agent against HIV, HBV, and other viruses replicating in a similar manner. A nucleoside analog structurally related to Lamivudine (L172500).<br>References Schinazi, R.F., et al.: Antimicrob. Ag. Chemother., 36, 2423 (1992), Shockeor, J.P., et al.: Xenobioica, 26, 189 (1996), Feng, J.Y., et al.: FASEB J., 13, 1511 (1999), Molina, J.-M., et al.: J. Infec. Dis., 182, 599 (2000)<br></p>Fórmula:CC7H10F15N2NO3SCor e Forma:White To Light YellowPeso molecular:250.23Melamine (1 mg/10 mL in 84:16% ACN:H2O)
CAS:Produto ControladoFórmula:C3H6N6Cor e Forma:Single SolutionPeso molecular:126.122-Amino-6-(chloromethyl)-4(3H)-pteridinone (>90%)
CAS:Produto Controlado<p>Applications 2-Amino-6-(chloromethyl)-4(3H)-pteridinone is a reagent/intermediate used in the preparation of Folic Acid (F680300) and its derivatives.<br>References Qi, Y., et al.: Faming Zhuanli Shenqing. CN 103755706 A 20140430. Apr 30, 2014;<br></p>Fórmula:C7H6ClN5OPureza:>90%Cor e Forma:NeatPeso molecular:211.616-Benzylaminopurine 9-(β-D-glucoside)
CAS:<p>Applications 6-Benzylaminopurine 9-(β-D-glucoside) (cas# 4294-17-1) is a compound useful in organic synthesis.<br></p>Fórmula:C18H21N5O5Cor e Forma:NeatPeso molecular:387.39Iso Ribavirin (Ribavirin Impurity G)
CAS:Produto ControladoFórmula:C8H12N4O5Cor e Forma:NeatPeso molecular:244.2Phosphoric Acid Dibenzyl Ester
CAS:<p>Stability Moisture Sensitive<br>Applications Eye irritant.<br>References Bagley, D. M. et al.; Toxicol. In Vitro 13, 505 (1999); Gilleron, L. et al.; Toxicol. In Vitro 11, 641 (1997)<br></p>Fórmula:C14H15O4PCor e Forma:NeatPeso molecular:278.24Adenine
CAS:Produto Controlado<p>Applications Widespread throughout animal and plant tissues combined with niacinamide, d-ribose, and phosphoric acids; a constituent of nucleic acids and coenzymes, such as codehydrase I and II, adenylic acid, coalaninedehydrase. It is used in microbial determination of niacin; in research on heredity, virus diseases, and cancer.<br>References Philips, et al.: J. Pharmacol. Exp. Ther., 20, 104 (1952), Lambertucci, C., et al.: Bioorg. Med. Chem., 17, 2812 (2009),<br></p>Fórmula:C5H5N5Cor e Forma:Light YellowPeso molecular:135.135-Fluorodihydropyrimidine-2,4-dione
CAS:Produto Controlado<p>Applications A metabolite of 5-Fluorouracil. (F596000)<br>References Bocci, G., et al.: Eur. J. Clin. Pharmacol., 58, 593 (2002), Longley, D.B., Nature Rev. Cancer, 3, 330 (2003), Fischel, J., et al.: Anti-Cancer Drugs, 15, 969 (2004)<br></p>Fórmula:C4H5FN2O2Cor e Forma:NeatPeso molecular:132.093Levomefolic Acid
CAS:<p>Applications A natural, active form of folic acid used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine among other functions. It is a coenzymated form of folic acid. It has been proposed for treatment of cardiovascular disease.<br>References Willems, F. et al.: Br. J. Pharmacol., 145, 823 (2004); Prinz-Langhebohi, R.: et al., Br. J. Pharmacol., 158, 2014 (2009); Wright, A. et al.: Brit, J. Nutrit., 103, 724 (2010)<br></p>Fórmula:C20H25N7O6Cor e Forma:NeatPeso molecular:459.46Melphalan-d8 Monohydrochloride
CAS:Produto ControladoFórmula:C13H10D8Cl2N2O2·HClCor e Forma:WhitePeso molecular:349.71Cytarabine-13C3
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications Labelled Cytarabine, a compound used as an antineoplastic and antiviral. A selective inhibitor of DNA synthesis. Does not inhibit RNA synthesis.<br>References Donehower, R.C., et al.: Cancer Treat. Rep., 70, 1059 (1986)<br></p>Fórmula:C613C3H13N3O5Cor e Forma:BeigePeso molecular:246.19Thymidine
CAS:Produto Controlado<p>Applications Constituent of deoxyribonucleic acid.<br>References Levene, L., et al.: J. Bil. Chem. 83, 793 (1929), Tollin, et al.: Nature 217, 1148 (1968), Redzic, Z., et al.: Neurochem. Res., 34, 566 (2009), Hazra, S., et al.: Biochem., 48, 1256 (2009), Yang, I., et al.: J. Biol. Chem., 284, 191 (2009),<br></p>Fórmula:C10H14N2O5Cor e Forma:White To Off-WhitePeso molecular:242.23Adenosine 5'-monophosphate monohydrate
CAS:Produto ControladoFórmula:C10H14N5O7P·H2OCor e Forma:NeatPeso molecular:365.2310-Formyl Folic Acid-d4
CAS:Produto Controlado<p>Stability Air Sensitive<br>Applications A labelled Folic acid (F680300) derivative (or folate) found in daily dietary intake that is often used in cancer risk correlation studies.<br>References Keszei, A.P. et al.: Cancer Epidimiol. Biomarker Prev., 18, 1785 (2009); Koning, E.J. et al.: Cancer, 95, 1421 (2002);<br></p>Fórmula:C20H15D4N7O7Cor e Forma:NeatPeso molecular:473.43Zanamivir-13C,15N2
CAS:Produto Controlado<p>Applications Influenza viral neuraminidase inhibitor; structural analog of the sialic acid. Antiviral.<br>References Woods, J.M., et al.: Antimicrob. Agents Chemother., 37, 1473 (1993), Pegg, M.S., et al.: Biochem. Mol. Biol. Int., 32, 851 (1994), Monto, A.S., et al.: J. Am. Med. Assoc., 282, 31 (1999),<br></p>Fórmula:CC11H2015N2N2O7Cor e Forma:NeatPeso molecular:335.29
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