Sais e Derivados de API
Os sais dos Ingredientes Farmacêuticos Ativos (API) são compostos formados pela reação de um ácido com uma base, resultando em um equilíbrio iônico. Esses sais frequentemente melhoram a solubilidade e a estabilidade dos APIs, facilitando sua absorção no organismo. Os derivados de API são variantes químicas de um princípio ativo que podem apresentar propriedades aprimoradas ou modificadas para otimizar a eficácia terapêutica. Os sais de APIs são utilizados na formulação de medicamentos orais, injetáveis e tópicos. Além disso, os derivados de API podem melhorar a farmacocinética dos fármacos, permitindo, por exemplo, a liberação controlada de substâncias ativas.
Na CymitQuimica, oferecemos sais e derivados de APIs com a pureza e qualidade necessárias para pesquisa e desenvolvimento de formulações farmacêuticas.
Foram encontrados 79472 produtos de "Sais e Derivados de API"
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2-[3-(Aminocarbonyl)-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic Acid
CAS:Produto Controlado<p>Applications 2-[3-(Aminocarbonyl)-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic acid is an impurity of Febuxostat (F229000), an xanthine oxidase/xanthine dehydrogenase inhibitor used for the treatment of hyperuricemia and chronic gout.<br>References Kadivar, M.H., et al.: J. Pharma. Biomed. Anal., 56, 749 (2011);<br></p>Fórmula:C16H18N2O4SCor e Forma:White To Off-WhitePeso molecular:334.39Cyclosporin C
CAS:Produto Controlado<p>Applications A group of nonpolar cyclic oligopeptides with immunosupppressant activity.<br>References van Wartburg, A., et al.: Prog. Med. Chem., 25, 1 (1988), Jorgensen, K.A., et al.: Scand. J. Imunol., 57, 93 (2003), Vollenbroeker, et al.: Transplant. Proc., 37, 1741 (2005),<br></p>Fórmula:C62H111N11O13Pureza:>80%Cor e Forma:NeatPeso molecular:1218.61N1-[2-(1-Piperazinyl)ethyl]-1,2-ethanediamine Hydrochloride
CAS:Produto ControladoFórmula:C8H20N4•x(HCl)Cor e Forma:NeatPeso molecular:172.273646Probenecid Acyl β-D-Glucuronide >90%
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications The major metabolite of Probenecid (P755000).<br>References Blanckaert, N., et al.: Biochem. J., 171, 203 (1978), Worrall, S., et al.: Life Sci., 56, 1921 (1995), Presle, N., et al.: Drug Metab. Disos., 24, 1050 (1996), Akira, K., et al.: J. Pharmacol. Toxicol. Methods, 37, 237 (1997), Terrier, N., et al.: Mol. Pharmacol., 56, 226 (1999),<br></p>Fórmula:C19H27NO10SPureza:>90%Cor e Forma:NeatPeso molecular:461.485-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic Acid Hydrochloride
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic Acid Hydrochloride is used as a reagent in the synthesis of N-(2-acylaminobenzyl or 2-acylaminoheterocyclylmethyl)thiophene-2-carboxamide derivatives as antithrombotics. It is also used as a reagent in the synthesis of diamide derivatives as FXa inhibitors. 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic Acid Hydrochloride is an intermediate for Edoxaban (E555520).<br>References Mochizuki, A., et al.: Jpn. Kokai Tokkyo Koho. JP 2010120852 A 20100603. Jun 3, 2010; Mochizuki, A., et al.: PCT Int. Appl. WO 2008123017 A1 20081016. Oct 16, 2008<br></p>Fórmula:C8H11ClN2O2SCor e Forma:Light BrownPeso molecular:234.7Selexipag
CAS:Produto Controlado<p>Applications Selexipag is an orally available, highly selective, long-acting prostacyclin (IP) receptor agonist prodrug. It is a potential drug for the treatment of various vascular disorders such as pulmonary arterial hypertension and arteriosclerosis obliterans.<br>References Kuwano, K., et al.: J. Pharm. Exp. Ther., 322, 1181 (2007);<br></p>Fórmula:C26H32N4O4SCor e Forma:Light YellowPeso molecular:496.62Argatroban
CAS:<p>Argatroban (MCI-9038), a specific thrombin inhibitor, which is a non-heparin anticoagulant, prevents the formation of thrombi.</p>Fórmula:C23H36N6O5SPureza:99.77% - >99.99%Cor e Forma:White To Off-White Crystalline SolidPeso molecular:508.63Tenofovir Disoproxil Fumarate IP Impurity A
CAS:Fórmula:C14H22N5O7PC4H4O4Peso molecular:403.3 : 116.12-Cyano-N-[4-(trifluoromethyl)phenyl]acetamide
CAS:Produto Controlado<p>Impurity Leflunomide EP Impurity H<br>Stability Hygroscopic<br>Applications 2-Cyano-N-[4-(trifluoromethyl)phenyl]acetamide (Leflunomide EP Impurity H) is used to prepare aminothiophene carboxylates and carboxamides as adenosine A1 receptor allosteric enhancers. It is also used to synthesize (1,2,3-triazol-4-yl)benzenamines as inhibitors against VEGF receptors 1 and 2.<br>References Nikolakopoulos, G., et al.: Bioorg. Med. Chem., 14, 2358 (2006); Kiselyov, A., et al.: Bioorg. Med. Chem. Lett., 19, 1344 (2009)<br></p>Fórmula:C10H7F3N2OCor e Forma:NeatPeso molecular:228.17
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