Sulfonamidas e Derivados

<p>Stability Light Sensitive<br>Applications The isotopically labelled drug Sulfadiazine. Antibacterial.<br>References Bohni, et al.: Chemotherapy, 14, 195 (1969), Carr, et al.: Antimicrob. Agents Chemother., 4, 585 (1973), Stober, H., et al.: Anal. Profiles Drug Subs., 11, 523 (1982),<br></p>

<p>Applications Sulfasalazine is an anti-inflammatory (gastrointestinal). Sulfasalazine has been used in granulomatous colitis.<br>References Schroder, H., et al.: Clin. Pharmacol. Ther.,13, 539 (1972), McDonnell, J.P., et al.: Anal. Profiles Drug Subs., 5, 515 (1976), Klotz, U., et al.: Clin. Pharmacokinet.,10, 285 (1985),<br></p>

<p>Applications Labelled Sulfamonomethoxine. Protein binding. Inhibitor of enzyme. Sulfamonomethoxine and Trimethoprim are used for treating porcine unknown hyperpyrexia.<br>References Bridges, et al.: Biochem. J., et al.: 96, 829 (1965), Hong, Y.-L., et al.: Antimicrob. Agents Chemother., 39, 1756 (1995)<br></p>

<p>Impurity Nimesulide EP Impurity C<br>Stability Hygroscopic<br>Applications 2-Phenoxylaniline (Nimesulide EP Impurity C) is an impurity of Nimesulide (N477500) which is an antiinflammatory agent that preferentially inhibits COX-2 over COX-1.<br>References Pairet, M., et al.: Inflamm. Res., 47, S93 (1998), Fukutake, M., et al.: Carcinogenesis, 19, 1939 (1998), Okajima., E., et al.: Cancer Res., 58, 3028 (1998), Azab, A., et al.: Life Sci., 63, 323 (1998)<br></p>

<p>Applications An impurity of the anti-inflammatory drug indomnethacin (I641000). Indomethacin inhibits cyclooxygenase (IC50=0.1uM) selectively over liposygenases (IC50=100uM for 5-,12- and 15-LO). A clinically useful NAISD.<br>References Salari, H., et al.: Prostagland. Leukotrienes Med., 13, 53 (1984), Lehmann, J.M., et al.: J. Biol. Chem., 272, 3406 (1997)<br></p>

<p>Impurity Etodolac EP Impurity A<br>Applications 8-Desethyl Etodolac (Etodolac EP Impurity A) is an impurity of Etodolac (E933100) which was examined for mutagenicity in reverse mutation tests on bacteria. Etodolac impurity A.<br>References Franke, L., et al.: J. Med. Chem., 48, 6997 (2005), Fox, T., et al.: Curr. Top Med. Chem., 6, 1579 (2006),<br></p>

<p>Applications A labelled diuretic and antihypertensive.<br>References Wagieh, N., et al.: Drug Test. Anal., 2, 113 (2010), Prado-Prado, F., et al.: Bioorg. Med. Chem., 18, 2225 (2010), Dresen, S., et al.: Anal. Bioanal. Chem., 396, 2425 (2010),<br></p>

<p>Impurity Sulfamethoxazole EP Impurity A<br>Applications A metabolite of Sulfamethoxazole.<br>References Ciolino, H., et al.: Cancer Res., 58 , 2754 (1998), Larsen, T., et al.: Environ. Sci. Technol., 35, 192 (2001), Heberer, T., et al.: Toxicol. Lett., 131, 5 (2002), Larsen, T., et al.: J. Biotechnol., 113, 295 (2004),<br></p>

<p>Stability Hygroscopic<br>Applications Mefruside is a diuretic used for the treatment of edema and hypertension.<br>References Johansen, A., et al.: Euro. J. Epidemiol., 27, 63 (2012); Hasegawa, Y., et al.: Blood. Press. Supple., 1, 10 (2010);<br></p>

<p>Applications p-Butyl Ibuprofen (cas# 3585-49-7) is a useful research chemical.<br></p>

<p>Applications Labelled 1,3-Dipalmitoyl-2-chloropropanediol is used in the synthesis of some prodrugs of Piroxicam and Lornoxicam to improve their bioavailability.<br>References Passarotti, C.M., et al.: Bollettino Chimico Farmaceutico, 134, 161 (1995),<br></p>

<p>Applications Hydrochlorothiazide-d2 is the labeled analogue of Hydrochlorothiazide (H714560), a carbonic anhydrase inhibitor as a diuretic.<br>References Piala, J.J., et al.: J. Pharmacol. Exp. Ther., 134, 273 (1961); Deppeler, H.P., et al.: Anal. Profiles Drug Subs., 10, 405 (1981)<br></p>

<p>Impurity Ibuprofen EP Impurity D<br>Applications 2-(p-Tolyl)propionic acid (Ibuprofen EP Impurity D) is an impurity of Ibuprofen (I140000). Ibuprofen impurity D.<br>References Jia, C., et al.: Science, 287, 1992 (2000), Yu, J., et al.: Org. Biomol. Chem., 4, 4041 (2006),<br></p>

<p>Impurity Acetazolamide EP Impurity A<br>Applications N-(5-Chloro-1,3,4-thiadiazol-2-yl)acetamide is an impurity of Acetazolamide (A161500). Acetazolamide EP Impurity A<br>References Zarghi, A., et al.: J. Pharm. Biomed. Anal., 28, 169 (2002), Subbarao, D., et al.: J. Chromatogr., 67, 841 (2008),<br></p>

<p>Impurity Glipizide EP Impurity D<br>Applications 4-[β-(6-Methylpyrazinyl-2-carboxamido)ethyl]benzene Sulfonamide (Glipizide EP Impurity D) is an intermediate in the synthesis of the impurity 5-Desmethyl-6-methyl Glipizide (D292550).<br></p>

<p>Applications Carbonic anhydrase inhibitor. Diuretic.<br>References Parasrampuria, J., et al.: Anal. Profiles Drug Subs. Excip. 22, 1 (1993),<br></p>

<p>Applications Acetaminophen-d3 is deuterium labeled Acetaminophen (A161220), an analgesic and antipyretic agent used as a pain reliever to treat headache, muscle aches, and arthritis (1,2,3).<br>References (1) McGill, M. R. and Jaeschke, H. Pharm Res. 30, 2174 (2013)(2) Fairbrother, J.E., et al.: Anal. Profiles Drug Subs., 3, 1 (1974) (3) Hinson, J.A., et al.: Rev. Biochem. Toxicol., 2, 103 (1980)<br></p>

<p>Applications Acetaminophen-d4 (major) is deuterium labeled Acetaminophen (A161220), an analgesic and antipyretic agent used as a pain reliever to treat headache, muscle aches, and arthritis (1,2,3).<br>References (1) McGill, M. R. and Jaeschke, H. Pharm Res. 30, 2174 (2013)(2) Fairbrother, J.E., et al.: Anal. Profiles Drug Subs., 3, 1 (1974)(3) Hinson, J.A., et al.: Rev. Biochem. Toxicol., 2, 103 (1980)<br></p>

<p>Applications rac-Acetaminophen Mercapturate-d5 (Major), is a labeled analogue and free acid of 3-(N-Acetyl-L-cystein-S-yl) Acetaminophen Disodium Salt (A172100), which is a metabolite of Acetaminophen (A161220). Acetaminophen is an analgesic and antipyretic agent used as a pain reliever to treat headache, muscle aches, and arthritis (1,2,3).<br>References van der Hooft, J.,et al.: Metabolomics, 12, 1 (2016)<br></p>

<p>Impurity Etodolac EP Impurity B<br>Applications 8-Methyl Etodolac (Etodolac EP Impurity B) is an impurity of Etodolac (E933100) which was examined for mutagenicity in reverse mutation tests on bacteria. Etodolac impurity B.<br>References Franke, L., et al.: J. Med. Chem., 48, 6997 (2005), Fox, T., et al.: Curr. Top Med. Chem., 6, 1579 (2006),<br></p>

<p>Applications Sulfadiazine Sodium Salt can be used as reactant/reagent in preparation and crystal structure of aminophenyl sulfonamide tetrahalides, hydrochloride and hydrobromide cocrystals with iodine.<br>References Pan, F., et al.: CrystEngComm, 17, 6641 (2015)<br></p>

<p>Applications 3-(p-Chlorophenyl)-3-hydroxyphthalimidine is an analog of Chlorthalidone (C427500) and has potential antidiuretic and hyperglycemic activities.<br>References Wales, J.K., et al.: P. Soc. Exp. Biol. Med., 128, 581 (1968)<br></p>

<p>Applications Labelled Indapamide. Used as an antihypertensive. Diuretic.<br>References Leary, et al.: Curr. Ther. Res., 15, 571 (1973), Kyncl, J., et al.: Arzneim.-Forsch., 25, 1491 (1975), DiFeo, T.J., et al.: Anal. Profiles Drug Subs. Excip., 23, 229 (1994),<br></p>

<p>Applications 8-Methylquinoline is used in QSAR treatment of mutagenicity and cytotoxicity of quinolines.<br>References Smith, C. J., et al.: Mutat. Res., Fund. Mol. Mech. Mut., 379, 167 (1997)<br></p>

<p>Impurity Gliclazide EP Impurity C<br>Applications Tosylurethane (Gliclazide EP Impurity C) is an intermediate in the synthesis of Gliclazide (G409877), a sulfonylurea hypoglycemic agent. Used as an antidiabetic.<br>References Duhault, J., et al.: Arzneimittel-Forsch., 22, 1686 (1972); Holmes, B., et al.: Drugs, 27, 301 (1984)<br></p>

<p>Applications Acetaminophen-13C2, 15N1 is doubly labeled Acetaminophen (A161220), an analgesic and antipyretic agent used as a pain reliever to treat headache, muscle aches, and arthritis (1,2,3).<br>References (1) McGill, M. R. and Jaeschke, H. Pharm Res. 30, 2174 (2013)(2) Fairbrother, J.E., et al.: Anal. Profiles Drug Subs., 3, 1 (1974) (3) Hinson, J.A., et al.: Rev. Biochem. Toxicol., 2, 103 (1980)<br></p>

<p>Piroxicam is a nonsteroidal anti-inflammatory drug (NSAID) that belongs to the group of carboxylic acid esters. It has been approved for the treatment of pain and inflammation caused by osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and other conditions. Piroxicam is available in tablets, capsules, injectable solutions, and topical creams. The pharmacokinetics of piroxicam have been studied using intravenous and oral administration in healthy volunteers. Tolerability and side effects are minimal with piroxicam.</p>

<p>Gliclazide is a sulfonylurea drug that is used to treat type 2 diabetes. The impurity F, which is an impurity standard, can be synthesized by reacting 1-chloro-2,6-difluoroaniline with sodium methoxide in methanol. It is also an API impurity found in the synthesis of gliclazide and can be custom synthesized for research and development purposes. Gliclazide impurity F has a CAS number of 1076198-18-9 and the molecular formula C8H4ClF3NOS. This product has a purity of &gt;99% and is classified as synthetic. It has been shown to have pharmacopoeia activity and can also be used for niche applications such as drug development.</p>

<p>Acetaminophen acetate is a cholinergic amine that binds to the active site of the enzyme acetylcholine esterase, preventing it from breaking down acetylcholine. Acetaminophen is used as a pain reliever and antipyretic agent. It is also used for its anti-inflammatory effects in the treatment of rheumatoid arthritis and other inflammatory conditions. Acetaminophen has been shown to have anticancer properties, which may be due to its ability to bind to cancer cells, inhibit their growth, and induce apoptosis. Acetaminophen acetate is also an acylation reaction product that can be isolated by liquid chromatography in phase with fluorescence properties.</p>

<p>Methyl 2-disazobenzoate hydrochloride is a drug product that is used as an HPLC standard and as a metabolite in the development of drugs. It has been found to be naturally occurring and is a research and development metabolite. Methyl 2-disazobenzoate hydrochloride is also an impurity of API, which can be quantified in analytical studies. It is a synthetic compound with CAS No. 35358-78-2 and it can be used to manufacture high purity pharmaceuticals. Methyl 2-disazobenzoate hydrochloride has been shown to have niche pharmacological effects, such as anti-inflammatory activities.</p>

<p>4-Hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylic acid, ethyl ester 1,1-dioxide (4HMBC) is an organic compound that is used as a precursor in the synthesis of other chemicals. 4HMBC is used to produce xylene, sulfoxide and diethyl ether by reacting with magnesium and ethylene. It is also used in the production of dimethylformamide, a solvent that is useful for the manufacture of many products including pharmaceuticals. 4HMBC reacts with methyl iodide to form 4-(dimethylamino)pyridine which can be used for the synthesis of piroxicam. The chemical has been shown to be effective as an insecticide against ants and cockroaches. It can also be used to synthesize dyes or pigments. The chemical can be obtained by methylating 4HBC with methanol in the presence</p>

<p>3-Oxo-1,2-benzisothiazole-2(3H)-acetic acid ethyl ester 1,1-dioxide is an impurity in the synthesis of a drug. It is not active and has no known therapeutic value. 3-Oxo-1,2-benzisothiazole-2(3H)-acetic acid ethyl ester 1,1-dioxide is used as a reference standard for HPLC and has been shown to be metabolized by cytochrome P450 enzymes.</p>

<p>2-[4-(2-Methylpropanoyl)phenyl] propanoic acid is a pharmaceutical intermediate that is used for the production of carprofen. It has been found to be an analytical method for the determination of 4-hydroxybenzoic acid and 4-isobutylacetophenone. The compound is analyzed by chromatographic methods and electrophoresis methods. The optimization of the solvent composition, flow rate, and impurities during the synthesis process are also studied in this research. 2-[4-(2-Methylpropanoyl)phenyl] propanoic acid has been found to be a meaningful validation of analytical methods for medicines, with an impurity limit of 0.1%.</p>

<p>Aceclofenac methyl ester is an analgesic that belongs to the arylpropionic acid derivatives. It has been developed for the treatment of acute pain. Aceclofenac methyl ester has a structural formula of CH3CO-O-CH3 and a molecular weight of 164.2 g/mol. Aceclofenac is metabolized by CYP450 enzymes, which are located in the liver and other organs, to form acetic acid and 5-hydroxyaceclofenac. The reaction time is approximately 1 hour and tetrahydrofuranyl (THF) is used as a nucleophile in this reaction. This product can be synthesized by reacting ethyl acetate with acetonitrile in high yield, making it stable and anhydrous. The analgesic effects of aceclofenac methyl ester are due to its ability to block the transmission of pain signals from nerves to the brain at the spinal cord level</p>

<p>3-[[p-(2-Pyridylsulfamoyl)phenyl]azo]salicylic acid is a chemical compound that is an impurity standard for HPLC. It is also used as a pharmacopoeia, drug development, and analytical reference standard. The CAS number for this compound is 66364-71-4. This compound has been shown to be metabolized by microsomal oxidation, glucuronidation, or sulfation pathways in humans. 3-[[p-(2-Pyridylsulfamoyl)phenyl]azo]salicylic acid can also be found in natural sources such as plants and animals.</p>

<p>Methyl 4-hydroxy-2-methyl-(2H)-1,2-benzothiazine-3-carboxylate-1,1-dioxide is a centrosymmetric molecule with an aspergillus flavus conformation. It is an acetanilide derivative that has been shown to be an effective antioxidant and medicine for the treatment of cancer. This product is also used in the production of hydrogen bonds and linkers in organic synthesis. The yields are high and it can be oriented during irradiation.</p>

<p>N-Methyl zonisamide is a drug that is an impurity in Zonisamide. It is an analog of the drug and has been used as a research and development standard for Zonisamide. N-Methyl zonisamide can be synthesized from the corresponding nitrobenzene, aminobenzene, and formaldehyde. The synthesis can be performed by converting nitrobenzene to aminobenzene with sodium hydroxide in methanol, followed by conversion to N-methyl zonisamide with formaldehyde in ethanol. Pharmacopoeia standards for this compound are available from Sigma Aldrich, which can be purchased from our website.</p>

<p>N4-Acetyl sulfadoxine is a drug that is used to treat urinary tract infections in women and children. It is also used to treat bacterial infections of the skin, lungs, and joints. N4-Acetyl sulfadoxine may be effective against prostatitis caused by E. coli or Mycoplasma pneumoniae by inhibiting the production of prostaglandins. This drug works by binding to dihydropteroate synthase, which prevents folic acid from being incorporated into the bacterial cell wall, thereby inhibiting bacterial growth.</p>