Sulfonamidas e Derivados
As sulfonamidas são compostos que contêm um grupo funcional sulfonamida (-SO₂NH₂), onde um átomo de enxofre está ligado a um grupo amino. Foram um dos primeiros antibióticos sintéticos usados na medicina, inibindo a síntese do ácido fólico nas bactérias, o que lhes confere propriedades antimicrobianas. São utilizadas principalmente para tratar infeções bacterianas, embora seu uso tenha diminuído devido à resistência antimicrobiana. Além do uso como antibióticos, as sulfonamidas também têm aplicações no tratamento de doenças como a malária e doenças inflamatórias intestinais.
Na CymitQuimica, oferecemos sulfonamidas e seus derivados com alto grau de pureza para pesquisa em microbiologia e desenvolvimento farmacêutico.
Foram encontrados 2587 produtos de "Sulfonamidas e Derivados"
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Glimepiride-d4 (phenylethyl-a,a,b,b-d4) (cis/trans)
CAS:Produto Controlado<p>Applications Glimepiride-d4 (phenylethyl-a,a,b,b-d4) (cis/trans) is a useful isotopically labeled compound of Glimepiride (G410150)<br></p>Fórmula:C24H30D4N4O5SCor e Forma:NeatPeso molecular:244.2Tiafenacil
CAS:<p>Applications Tiafenacil is a uracil herbicide used as a pesticide for the prevention and control of plants.<br>References Peng, X., et al. Faming Zhuanli Shenqing, 68pp Patent 2018 CODEN:CNXXEV<br></p>Fórmula:C19H18ClF4N3O5SCor e Forma:Off White SolidPeso molecular:511.874-Nitro-2-phenoxyphenol
CAS:<p>Applications 4-Nitro-2-phenoxyphenol is a impurity of Nimesulide (N477500), antiinflammatory agent. Preferentially inhibits COX-2 over COX-1. Suppresses chemical-induced carcinogenesis in mice and rats. Inhibits LPS-induced TNF-alpha production. Also used in the preparation of benzoxirenes and the synthesis of trioxonins.<br>References Pairet, M., et al.: Inflamm. Res., 47, S93 (1998), Fukutake, M., et al.: Carcinogenesis, 19, 1939 (1998), Okajima., E., et al.: Cancer Res., 58, 3028 (1998), Azab, A., et al.: Life Sci., 63, 323 (1998)<br></p>Fórmula:C12H9NO4Cor e Forma:Light YellowPeso molecular:231.205-Nitroso-2,4,6-triaminopyrimidine
CAS:Produto ControladoFórmula:C4H6N6OCor e Forma:NeatPeso molecular:154.13N-Nitroso Furosemide-d5
Produto ControladoFórmula:C12D5H5ClN3O6SCor e Forma:NeatPeso molecular:364.773O-Desmethyl Indomethacin-d4
CAS:Produto Controlado<p>Applications The major labelled metabolite of Indomethacin.<br>References Lewis, R., et al.: J. Clin. Invest., 53, 1607 (1974), Alvan, G., et al.: Clin. Pharmacol. Ther., 18, 364 (1975), Mungall, D., et al.: J. Pharm. Sci., 73, 1000 (1984), Baldwin, S., et al.: Xenobiotica, 25, 261 (1995),<br></p>Fórmula:C18H10D4ClNO4Cor e Forma:NeatPeso molecular:347.79N-Acetylsulfathiazole-d4 (Major)
CAS:Produto Controlado<p>Applications A deuterated metabolite of the drug Sulfathiazole.<br></p>Fórmula:C112H4H7N3O3S2Cor e Forma:NeatPeso molecular:301.388-Propyl Etodolac
CAS:Produto Controlado<p>Impurity Etodolac EP Impurity E<br>Applications 8-Propyl Etodolac (Etodolac EP Impurity E) is an impurity in the synthesis of Etodolac (E933100), may have use in the treatment of myeloma. COX-1/COX-2/β-catenin inhibitors.<br>References Humber, L.G., et al.: Med. Res. Rev., 7, 1 (1987); Balfour, J.A, et al.: Drugs, 42, 274 (1991); Kato, et al.: J. Pharm. Pharmacol., 53 1679 (2001);<br></p>Fórmula:C18H23NO3Cor e Forma:NeatPeso molecular:301.384-Carboxy Tolbutamide-d9
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications A labelled metabolite of Tolbutamide. Formed by the cytochrome CYP2CIIC8 and IIC9 subfamily of P450 enzymes.<br>References Relling, etl al.: J. Pharmacol. Exp. Ther., 252, 442 (1990), Parent, et al.: J. Pharmacol. Exp. Ther., 261, 780 (1992), Ho, et al.: Life Sci., 52, 21 (1993),<br></p>Fórmula:C12D9H7N2O5SCor e Forma:NeatPeso molecular:309.395-Amino-3-(4-sulfonylphenyl)salicyclic Acid Sodium Salt
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications 5-Amino-3-(4-sulfonylphenyl)salicyclic Acid Sodium Salt is an impurity of mesalamine (M258100), which is the active metabolite of Sulfasalazine (S699084). Anti-inflammatory (gastrointestinal).<br>References Friedman, G., et al.: Am. J. Gastroenterol., 81, 141 (1986); Tursi A., Expert Opin. Pharmacother., 6, 69 (2005);<br></p>Fórmula:C13H11NO6S•x(Na)Cor e Forma:NeatPeso molecular:309.29 + x(22.99)3-[(4-Aminophenyl)sulfonyl]benzenamine
CAS:Produto Controlado<p>Applications 3-[(4-Aminophenyl)sulfonyl]benzenamine is an impurity of Dapsone (D193250), an antibacterial used in the treatment of dermatitis herpetiformis.<br>References Francis, J., et al.: Br. J. Pharmacol., 5, 565 (1950); Uetrecht, J., et al.: Clin. Dermatol., 7, 111 (1989); Reszka, K., et al.: Chem. Res. Toxicol., 22, 1137 (2009); Santos, J., et al.: Bioorg. Med. Chem., 17, 3795 (2009);Varma, M., et al.: J. Med. Chem., 52, 4844 (2009)<br></p>Fórmula:C12H12N2O2SCor e Forma:NeatPeso molecular:248.301(S)-4-Hydroxy-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-Dioxide
CAS:Produto Controlado<p>Applications (S)-4-Hydroxy-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-Dioxide has been used as a reactant for the preparation of Brinzolamide (AL-4862) [B677600], a topical carbonic anhydrase inhibitor.<br>References Conrow, R.E., et. al.: Org. Process Res. Dev., 3, 114 (1999)<br></p>Fórmula:C10H16N2O6S3Cor e Forma:NeatPeso molecular:356.44N-Desethyl-N-(2-boronoethyl) Dorzolamide Hydrochloride
Fórmula:C10H17BN2O6S3•(HCl)Cor e Forma:NeatPeso molecular:368.263646rac-trans Dorzolamide Hydrochloride
CAS:Produto Controlado<p>Applications rac-trans Dorzolamide is an impurity of Dorzolamide (D535100).<br>References Casini, A., et al.: Bioorg. Med. Chem. Lett., 13, 841 (2003), Clare, B., et al.: Bioorg. Med. Chem., 13, 2197 (2005),<br></p>Fórmula:C10H17ClN2O4S3Cor e Forma:NeatPeso molecular:360.94-Amino-4'-chlorodiphenyl Sulfone
CAS:Produto Controlado<p>Applications 4-Amino-4'-chlorodiphenyl sulfone is a substituted 4-aminodiphenylsulfone as Escherichia coli dihydropteroate synthase inhibitor.<br>References Lopez de Compadre, R.L., et al.: J. Med. Chem., 31, 2315 (1988),<br></p>Fórmula:C12H10ClNO2SCor e Forma:Off-White To Light YellowPeso molecular:267.73Indomethacin 1-Glycerin Ester
CAS:<p>Applications Indometacin 1-Glycerin Ester was synthesized and evaluated for anti-flammatory activity in the rate paw carrageenin edema essay.<br>References Paris, Gerard. , et al.: J. Med. Chem, 23, 9 (1980)<br></p>Fórmula:C22H22ClNO6Cor e Forma:NeatPeso molecular:431.87Mefruside-d3
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications Isotope labelled analogue of Mefruside (M205150), a diuretic used for the treatment of edema and hypertension.<br>References Johansen, A., et al.: Euro. J. Epidemiol., 27, 63 (2012); Hasegawa, Y., et al.: Blood. Press. Supple., 1, 10 (2010);<br></p>Fórmula:C13H16D3ClN2O5S2Cor e Forma:White To Light BeigePeso molecular:385.90Bumetanide 3-(Butyl(nitroso)amino)-d5
CAS:Produto ControladoFórmula:C17D5H14N3O6SCor e Forma:NeatPeso molecular:398.445Metolazone
CAS:Produto Controlado<p>Applications A diruetic. An antihypertensive.<br>References Curry, C.L., et al.: Clin. Ther., 9, 47 (1986), Kiyingi, A., et al.: Lancet, 335, 29 (1990)<br></p>Fórmula:C16H16ClN3O3SCor e Forma:NeatPeso molecular:365.83Benzoxazolemethanesulfonamide-N-(6-methyl-hexanoate)
CAS:Produto Controlado<p>Applications Intermediate of Zonisamide-N-(6-hexanoic acid).<br></p>Fórmula:C15H20N2O5SCor e Forma:NeatPeso molecular:340.391-[1-(4-Chlorobenzoyl)-5-hydroxy-2-methyl-1H-indole-3-acetate]β-D-Glucopyranuronic Acid
CAS:Produto Controlado<p>Stability Hygroscopic, Moisture Sensitive<br>Applications 1-[1-(4-Chlorobenzoyl)-5-hydroxy-2-methyl-1H-indole-3-acetate]β-D-Glucopyranuronic Acid is an analog of Indomethacin Acyl-β-D-glucuronide a metabolite of Indomethacin (I641000). Acyl glucuronides have been implicated in the toxicity of many xenobiotics and marketed drugs.<br>References Abid, A., et al.: Biochem. Pharmacol., 50, 557 (1995), Gamage, N., et al.: Toxicol. Sci., 90, 5 (2006), Cerveny, L., et al.: Drug Metab. Dispos., 35, 1032 (2007), Hayeshi, R., et al.: Eur. J. Pharm. Sci., 35, 383 (2008),<br></p>Fórmula:C24H22ClNO10Cor e Forma:NeatPeso molecular:519.894-Hydroxy Triamterene Sulfate-d4, Sodium Salt
CAS:Produto Controlado<p>Applications Isotope labelled 4-hydroxy triamterene sulfate sodium salt a metabolite of Triamterne, a diuretic agent.<br>References Vollmer, G., et al.: Arzneim.-Forsch., 31, 529 (1981), Gilfrich, H.J., et al.: Eur. J. Clin. Pharmacol., 25, 237 (1983),<br></p>Fórmula:C12H6D4N7NaO4SCor e Forma:NeatPeso molecular:375.33Bumetanide 3-(Butyl(nitroso)amino) (1 mg/mL in Methanol)
CAS:Produto ControladoFórmula:C17H19N3O6SCor e Forma:ColourlessPeso molecular:393.41Benzeneacetonitrile
CAS:Produto Controlado<p>Applications Benzeneacetonitrile is a volatile compound released from apple trees infested with light brown apple moth larvae. It is also used in the synthesis of phenobarbital (P316760), methylphenidate (M325880), and other amphetamines.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Suckling, D. et al.: J. Agr. Food. Chem., 60, 9562 (2012); Cuevas-G. et al.: Int. J. Food. Sci. Technol., 47, 1378 (2012)<br></p>Fórmula:C8H7NCor e Forma:NeatPeso molecular:117.15Sulfadiazine Silver Salt
CAS:Produto Controlado<p>Applications Coordination compound. Antibacterial.<br>References Bohni, et al.: Chemotherapy, 14, 195 (1969), Carr, et al.: Antimicrob. Agents Chemother., 4, 585 (1973), Stober, H., et al.: Anal. Profiles Drug Subs., 11, 523 (1982),<br></p>Fórmula:C10H9N4O2S·AgCor e Forma:NeatPeso molecular:357.14Sulfamethoxazole-d4 β-D-Glucuronide
CAS:Produto Controlado<p>Applications The main labelled metabolite of Sulfamethoxazole.<br>References Altenburger, R., et al.: Environ. Toxicol. Chem., 19, 2341 (2000), Pascoe, R., et al.: Anal. Chem., 73, 6014 (2001), Zhaohua, H., et al.: Eur. J. Med. Chem., 36, 863 (2001),<br></p>Fórmula:C16H15D4N3O9SCor e Forma:NeatPeso molecular:433.43(4R,6S)-5,6-Dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-4-ol 7,7-Dioxide
CAS:Produto Controlado<p>Applications (4R,6S)-4H-Thieno[2,3-b]thiopyran-4-ol, 5,6-dihydro-6-methyl-,7,7-dioxide is an analog of topically-active carbonic anhydrase inhibitor MK-507 also commonly known as Dorzolamide (D535100).<br>References Blacklock, T., et al.: J. Org. Chem., 58, 1672 (1993); Tempkin, O., et al.: Tetrahedron: Asym., 7, 2721 (1996)<br></p>Fórmula:C8H10O3S2Cor e Forma:NeatPeso molecular:218.29N-(4-Chloro-3-sulfamoylbenzoyl)-2-methylindoline
CAS:Produto Controlado<p>Applications N-(4-Chloro-3-sulfamoylbenzoyl)-2-methylindoline is an impurity of Indapamide (I500100).<br></p>Fórmula:C16H15ClN2O3SCor e Forma:Light YellowPeso molecular:350.82Etodolac Ethyl Ester
CAS:Produto Controlado<p>Applications Etodolac Ethyl Ester is a useful intermediate in the preparation of the new antiinflammatory drug Etodolac. Etodolac Impurity.<br>References Mizuguchi, E., et al.: Heterocycles, 46, 149 (1997); Woods, M., et al.: Org. Process Res. Dev., 4, 418 (2000)<br></p>Fórmula:C19H25NO3Cor e Forma:NeatPeso molecular:315.41Sulfamethizole-d4
CAS:Produto Controlado<p>Applications Isotope Labelled Sulfamethizole is a sulfonamide based antibiotic that exhibit bactericidal activities towards gram-negative bacteria. Sulfamehizole was shown to be effective in treating gram-negative Bacillus AmpC enzyme in elderly patients with lower respiratory tract infection and as well as against microbs responsible for tuberculosis.<br>References Mondelli, M., et al.: J. Molec. Struct., 1036, 180 (2013); Leelakrishnana, S., et al.: Adv. App. Sci. Res., 3, 3502 (2012); Ghoreishi, S.M., et al.: Anal. Lett., 46, 323 (2012);<br></p>Fórmula:C92H4H6N4O2S2Cor e Forma:NeatPeso molecular:274.368-Isopropyl Etodolac
CAS:Produto Controlado<p>Impurity Etodolac EP Impurity D<br>Applications 8-Isopropyl Etodolac (Etodolac EP Impurity D) is an impurity in the synthesis of Etodolac (E933100), may have use in the treatment of myeloma. COX-1/COX-2/β-catenin inhibitors, or anti-inflammatory agent.<br>References Humber, L.G., et al.: Med. Res. Rev., 7, 1 (1987); Balfour, J.A, et al.: Drugs, 42, 274 (1991); Kato, et al.: J. Pharm. Pharmacol., 53 1679 (2001);<br></p>Fórmula:C18H23NO3Cor e Forma:NeatPeso molecular:301.38Dehydro Indapamide-d3
CAS:Produto ControladoFórmula:C16H11D3ClN3O3SCor e Forma:NeatPeso molecular:366.84N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-N-methylnitrous amide
CAS:Produto ControladoFórmula:C12H14N4O2Cor e Forma:NeatPeso molecular:246.273-Azabicyclo[3.3.0]octane Hydrochloride
CAS:Produto Controlado<p>Applications 3-Azabicyclo[3.3.0]octane Hydrochloride is a reactant in the preparation of substituted pyrimidines derivatives as novel hedgehog signaling pathway inhibitors.<br>References Xin, M. et al.: Med. Chem. Res., 23, 3784 (2014); Xin, M. et al.: Bioorg. Med. Chem. Lett., 24, 983 (2014);<br></p>Fórmula:C7H13N·ClHCor e Forma:White To Light YellowPeso molecular:147.652,3-Dimethylaniline
CAS:Produto Controlado<p>Impurity Mefenamic Acid EP Impurity A<br>Applications Reagent used in the preparation of non-steroidal anti-inflammatory drugs, dyes and pesticides.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ivachtchenko, A., et al.: Bioorg. Med. Chem., 18, 5282 (2010), Rais, R., et al.: J. Med. Chem., 53, 4749 (2010),<br></p>Fórmula:C8H11NCor e Forma:BrownPeso molecular:121.18Dapsone N-β-D-Glucuronide Sodium Salt
CAS:Produto Controlado<p>Stability Hygroscopic, unstable in solution<br>Applications Dapsone N-β-D-Glucuronide is the glucuronide conjugate and main urinary metabolite of the antibacterial Dapsone (D193250).<br>References Andoh, B.Y.A. et al.: Xenobiotica, 4, 571 (1974); Ogiya, S. et al.: Yakug. Zas., 81, 349 (1961);<br></p>Fórmula:C18H19N2NaO8SCor e Forma:NeatPeso molecular:446.41Ibuprofen Ethyl Ester
CAS:Produto Controlado<p>Applications Ibuprofen Ethyl Ester is a derivative of Ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID) that is known to inhibit PGH synthase-1 and PGH synthase-2 with comparable potency.<br>References Gnanarajan, G., et al.: Int. J. Pharma. Sci. Rsch., 1, 27 (2010); Busson, M., et al.: J. Int. Med Res., 14, 53 (1986); Meade, E.A., et al.: J. Biol. Chem., 268, 6610 (1993); Davies, N.M., et al.: Clin. Pharmacokinet., 34, 101 (1998);<br></p>Fórmula:C15H22O2Cor e Forma:Colourless To Light YellowPeso molecular:234.33Indomethacin 1-Menthol ester
CAS:Produto Controlado<p>Applications Indomethacin terpenoids' esters were synthesized and assessed both in vitro and in vivo as indomethacin dermal prodrugs.<br>References Bonina,, Francesco. , et al.: European Journal of Pharmaceutical Sciences, 14, 123 (2001),<br></p>Fórmula:C29H34ClNO4Cor e Forma:NeatPeso molecular:496.038N-Des(5-methylpyrazinecarbonyl)-N-ethylcarboxyl Glipizide
CAS:Produto Controlado<p>Impurity Glipizide EP Impurity C<br>Applications N-Des(5-methylpyrazinecarbonyl)-N-ethylcarboxyl Glipizide (Glipizide EP Impurity C) is an impurity of Glipizide (G410225).<br></p>Fórmula:C18H27N3O5SCor e Forma:NeatPeso molecular:397.496-Methylpyrazinecarboxylic Acid
CAS:Produto Controlado<p>Applications 6-Methylpyrazinecarboxylic Acid can be used to synthesize compounds that are active against M.tuberculosis H37Rv. Similarly, it can be used to synthesize compounds that are useful for the inhibition, prevention or therapy of tumor cell invasion, metastasis, inflammation, hepatitis, or liver dysfunction.<br>References Vontor, T., et al.: Cesk. Farm., 34, 441 (1985); Oka, K., et al.: Jpn. Kokai Tokkyo Koho, JP 2007210926 A 20070823 (2007)<br></p>Fórmula:C6H6N2O2Cor e Forma:NeatPeso molecular:138.12(4-Trideuteromethoxy) Trimethoprim N1-Oxide, ~90%
CAS:Produto ControladoFórmula:C14H15D3N4O4Pureza:~90%Cor e Forma:NeatPeso molecular:309.34Indomethacin Ethyl Ester
CAS:Produto ControladoFórmula:C21H20ClNO4Cor e Forma:Off-WhitePeso molecular:385.84
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![(S)-4-Hydroxy-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-Diox…](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTR%2Fthumb-webp%2FH946200.webp&w=3840&q=75)
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![(4R,6S)-5,6-Dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-4-ol 7,7-Dioxide](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTR%2Fthumb-webp%2FT344510.webp&w=3840&q=75)
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