Ácidos Graxos e Derivados Lipídicos

<p>Simvastatin 4'-methyl ether is a metabolite of simvastatin. It is an impurity in the drug product and can be used as an analytical standard for HPLC. It is not a drug product or a pharmaceutical ingredient, but it can serve as an impurity standard for pharmacopoeia.</p>

<p>N-(3-hydroxytricyclo[3.3.1.1]dec-1-yl)glycyl-L-prolinamide is a metabolite that is formed when the drug product, ticagrelor, undergoes metabolism in the liver. Ticagrelor is a prodrug that requires conversion to its active form, which is N-(3-hydroxytricyclo[3.3.1.1]dec-1-yl)glycyl-L-prolinamide, before it can be used as a platelet inhibitor and antiplatelet agent for the prevention of thrombotic events such as heart attack and stroke. It has been shown to have an excellent stability profile and high purity when produced by HPLC or synthesized using the latest methodology under GMP conditions.</p>

<p>5-Oxo pitavastatin is a research and development drug product that is synthesized by custom synthesis. It is an impurity standard that is used as a reference in the analysis of pharmaceuticals and metabolites. The purity of this compound is over 99% with no detectable heavy metals, solvents, or other impurities. This product can be found in the pharmacopoeia, which lists it as an analytical reagent. 5-Oxo pitavastatin is used to develop drugs for niche markets and can be used to study metabolism.</p>

<p>3alpha-Hydroxy pravastatin sodium salt is a white to off-white crystalline powder. It is used as an analytical standard for 3alpha-hydroxypravastatin and its metabolites. The CAS number is 81093-43-8, and the molecular weight of this compound is 467.6 g/mol. This product can be custom synthesized to meet your needs.</p>

<p>N-Formyl-L-leucine (1S)-1-[[(2R,3R)-3-hexyl-4-oxo-2-oxetanyl] methyl] dodecyl ester is an impurity in the drug product. It can be used as a custom synthesis or natural standard and has been shown to have metabolites that are toxic to human cells. This impurity can be synthesized for HPLC analysis and research purposes.</p>

<p>Please enquire for more information about Defluoro pitavastatin including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>iso-Gemfibrozil is a natural, synthetic drug product. It is an impurity standard for the pharmacopoeia and analytical standards for HPLC. iso-Gemfibrozil is metabolized in the liver to its active form, gemfibrozil. Impurities are not detected by HPLC and can be found in low levels in the API impurity standard. It has been used as a research and development candidate in clinical studies on atherosclerosis, hyperlipidemia, and diabetes mellitus.</p>

<p>3-[4-(4-Chlorobenzoyl)phenoxy]-2-butanone is an impurity in the drug product, N-{3-[4-(4-chlorobenzoyl)phenoxy]-2-butenyl}acetamide. It can be used as an analytical reference standard for determining the presence of impurities in pharmaceutical products. 3-[4-(4-Chlorobenzoyl)phenoxy]-2-butanone is not a natural component of the API and is typically synthesized with high purity. This compound has been shown to be metabolized by human liver microsomes and rat lung microsomes. The metabolic pathways are unknown but may include oxidation, hydrolysis, or conjugation reactions.</p>

<p>(betaR,deltaR)-2,3-Bis(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid hemicalcium salt is an impurity that is used in the production of a drug product. This product is metabolized to (betaR,deltaR)-2,3-bis(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-4-[(phenylamino)carbonyl]-1H-pyrrole 1 heptanoic acid which is used as an analytical standard for HPLC.</p>

<p>Atorvastatin is a potent inhibitor of the enzyme HMG-CoA reductase, which is responsible for the conversion of HMG-CoA to mevalonate. This inhibition reduces the production of cholesterol and other lipids in the liver. Metabolism studies have shown that atorvastatin undergoes extensive presystemic metabolism by cytochrome P450 enzymes, primarily CYP3A4 and CYP2C9. The drug is converted to inactive metabolites that are eliminated primarily through renal excretion. Atorvastatin has not been found to inhibit any of the following: cytochrome P450 1A1/2, 2C8/9, 2D6, 2E1, 3A4/5 or glucuronidases.</p>

<p>2''-Desethyl- 2''- vinyl Simvastatin is a high purity, custom synthesis, impurity standard that is available for sale. The CAS number for this product is 1449248-72-9. This product can be used as a research and development product or as an analytical standard. It has an Impurity Standardization (IS) of 10% at a concentration of 10 mg/mL. This product has been classified by the USP and the European Pharmacopoeia (EP). The excipient in this product is acetonitrile, which is classified as natural.</p>

<p>Mevalonic acid is essential for cell growth and proliferation,Mevalonic acid is a precursor in the mevalonate pathway.</p>

<p>(3S,5R)-Rosuvastatin is the (3R,5R)-enantiomer of Rosuvastatin. Rosuvastatin is a competitive HMG-CoA reductase inhibitor (IC50: 11 nM).</p>

<p>Cis-Tadalafil is a potent inhibitor of phosphodiesterase 5, which is used to treat erectile dysfunction (ED) and primary pulmonary hypertension (PPH). It works by increasing blood flow to the penis, allowing men with ED to achieve and maintain an erection. Cis-Tadalafil is also used to treat symptoms of prostatic hyperplasia (enlarged prostate) in men. This drug has been shown to be effective in treating PPH by reducing pulmonary arterial pressure and improving exercise capacity. Cis-Tadalafil belongs to the carboline class of drugs and is a phosphodiesterase 5 inhibitor that selectively inhibits cGMP-specific phosphodiesterase type 5 (PDE5). This drug has been shown to be highly effective in treating both ED and PPH with minimal side effects.</p>

<p>Prasugrel Maleic acid: oral P2Y12 antagonist, thienopyridine prodrug, inhibits ADP-induced platelet aggregation.</p>

<p>Carboprost (15(S)-15-Methyl Prostaglandin F2α) is a synthetic prostaglandin analogue of PGF2α which has the effect of oxytocic.</p>

<p>Please enquire for more information about Rosuvastatin EP impurity M calcium including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Rosuvastatin impurity E calcium including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Vildagliptin related compound F (VRCF) is a drug product that has been custom synthesized. VRCF is a high purity, analytical standard. It is metabolized in the body and can be used as a research and development standard to study the metabolism of vildagliptin. VRCF is a natural metabolite that has been identified as an impurity in the drug product Vildagliptin. VRCF has not been recognized by the USP or EP for use as an impurity standard. CAS no: 1789703-36-1</p>

<p>Please enquire for more information about Rosuvastatin (3R,5R) isomer calcium including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>