Ácidos Graxos e Derivados Lipídicos

<p>Please enquire for more information about Rosuvastatin impurity E calcium including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>A potent modulator of cell proliferation and differentiation.</p>

<p>Orlistat is a lipase inhibitor that is used as a weight-loss drug. It works by inhibiting the absorption of dietary fats and their subsequent conversion into triglycerides in the intestines, thereby limiting the calories absorbed. Orlistat has been shown to be effective in lymphatic and fatty acid transport, but oral bioavailability is low due to extensive first-pass metabolism. Orlistat inhibits pancreatic lipase, which may lead to reduced intestinal fat absorption and decreased systemic exposure. This drug also inhibits long-chain fatty acids from being absorbed through the intestinal wall and prevents them from being metabolized, thereby reducing lipid formulations in the blood.</p>

<p>Please enquire for more information about Rosuvastatin EP impurity M calcium including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Simvastatin acid is the active form of simvastatin, a drug used to lower blood cholesterol levels. Simvastatin acid inhibits HMG-CoA reductase, the enzyme that converts HMG-CoA to mevalonate. This conversion is a rate-limiting step in the synthesis of cholesterol and other lipids. Simvastatin acid binds to polymerase chain and drug transporter proteins, which leads to cell lysis. The concentration–time curve for simvastatin acid is linear and the half-life is approximately 12 hours. When simvastatin acid is administered with drugs that are potent inducers of CYP3A4 or UGT1A1 enzymes, there may be an increased risk for drug interactions. Simvastatin acid has shown no significant human pharmacokinetic interactions with food or grapefruit juice at doses up to 200 mg/day. There are limited data on the pharmacokinetics of simvastatin</p>

<p>Ezetimibe ketone is a lipid-lowering agent that inhibits cholesterol absorption through the inhibition of Niemann-Pick C1-like 1 (NPC1L1). Ezetimibe ketone is used to reduce the levels of low-density lipoprotein cholesterol (LDL-C) in patients with primary hypercholesterolemia, sitosterolemia, and familial combined hyperlipidemia. Ezetimibe ketone has been shown to be bioequivalent to ezetimibe, which is an oral drug that inhibits cholesterol absorption by blocking NPC1L1. The drug binds to the NPC1L1 receptor in the brush border membrane of enterocytes and prevents cholesterol uptake. Ezetimibe ketone has a high solubility in organic solvents such as dichloromethane or chloroform. It also has a high melting point, which makes it suitable for use on chromatographic columns.</p>

<p>Vildagliptin Related Compound 2 is a synthetic compound that has been shown to be an inhibitor of DPP-4. It is a white solid that can be synthesized by condensation of vildagliptin with chloroacetyl chloride in the presence of an alkali. The compound was found to have impurities, including 1-(2-chlorophenyl)ethanol and 3-chlorobenzaldehyde.</p>

<p>Please enquire for more information about Vildagliptin carboxylic acid methyl ester including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Vildagliptin related compound F (VRCF) is a drug product that has been custom synthesized. VRCF is a high purity, analytical standard. It is metabolized in the body and can be used as a research and development standard to study the metabolism of vildagliptin. VRCF is a natural metabolite that has been identified as an impurity in the drug product Vildagliptin. VRCF has not been recognized by the USP or EP for use as an impurity standard. CAS no: 1789703-36-1</p>

<p>Atorvastatin tert-butyl ester is an acid that is used to treat high cholesterol. It is a synthetic statin that inhibits the enzyme HMG-CoA reductase and blocks the production of cholesterol in the liver. This drug is administered orally, as a tablet or capsule, or in liquid form as a suspension. The drug has a bitter taste and evaporation may occur if it comes into contact with skin or clothes. Atorvastatin tert-butyl ester may be found in polymorphic forms (including dihydropyridine, dihydrospirocyclopentane, and dihydrobenzoquinoline). These forms are inactive, but can be activated by exposure to light or heat. These reactions produce an acidic compound that can react with other compounds to form new compounds.</p>

<p>Atorvastatin lactam phenanthrene calcium salt impurity is a high purity, custom synthesis drug product. It is a metabolite of atorvastatin and was identified using metabolism studies in rat and human liver microsomes. This impurity has been shown to be an analytical standard for HPLC. Atorvastatin lactam phenanthrene calcium salt impurity is used in niche research and development, as well as the development of drugs that are pharmacopoeia grade.</p>

<p>Desfluoro ezetimibe is a synthetic cholesterol-lowering drug that inhibits intestinal cholesterol absorption. It is chemically synthesized, and the process includes the introduction of fluorine at the 3-position of the C-ring. Desfluoro ezetimibe is not metabolized in humans, but it may be subject to oxidative degradation. The product is also subject to oxidation by light and air, which may result in formation of impurities. The drug substance has been validated as well as its isomers and efficiencies in mass spectrometry detection.</p>

<p>Atorvastatin is a drug product with an impurity of atorvastatin cyclic sodium salt (isopropyl). The synthesis of this compound can be found in the natural and synthetic routes. Impurity standard is used to identify impurities in drugs and is necessary for pharmacopoeia, research and development, and analytical work. This compound has been shown to have high purity, analytical, metabolism studies, natural, drug development, and pharmacopoeia. CAS No. 1316291-19-6 is the impurity standard for this compound.</p>

<p>L-161982 is a selective EP4 receptor antagonist that inhibits PGE2-induced ERK phosphorylation and cell proliferation in HCA-7 cells.Cost-effective and quality-assured.</p>

<p>Zopolrestat (CP 73850) is a potent inhibitor of aldose reductase (IC50 = 3.1 nM).</p>

<p>BAY 73-1449 is a selective and potent antagonist of the prostacyclin receptor(IC50&lt;0.1 nM).</p>

<p>(3R,5R)-Rosuvastatin is the (3R,5R)-enantiomer of Rosuvastatin. Rosuvastatin is a competitive HMG-CoA reductase inhibitor (IC50: 11 nM).</p>

<p>AMG 837 calcium hydrate is a potent GPR40 agonist with an EC50 of 13 nM.</p>

<p>Atorvastatin is a drug that belongs to the class of statins. It is used for the treatment of high cholesterol levels and other related diseases, such as cardiovascular disease. Atorvastatin calcium trihydrate EP Impurity G is an impurity that may be present in atorvastatin calcium trihydrate. This compound has not been found to have any pharmacological activity.</p>

<p>Iloprost (Ciloprost) is an inhibitor of platelet aggregation and vasodilatation used in the study of cardiovascular disease.</p>