Monossacáridos

<p>2,3,4,6-Tetra-O-acetyl-b-D-galactopyranosyl cyanide is a carbohydrate that is used in the synthesis of conjugates for use as immunogens. It has been modified to create a high purity product. Click chemistry is used to attach a fluorine atom to the sugar. The glycosylation reaction with the monosaccharides and disaccharides is then performed followed by methylation of the saccharide with methanol to produce 2,3,4,6-Tetra-O-acetyl-b-D-galactopyranosyl cyanide.</p>

<p>Probenecid is a weak acid that is rapidly converted to an active metabolite in the body. It is used as an analgesic, antipyretic, and anti-inflammatory drug. Probenecid has been shown to inhibit the formation of biliary acids in animals and humans and has been used in the treatment of chronic inflammatory conditions such as rheumatoid arthritis. The most common route of administration for this drug is orally, although it can also be given intravenously or intramuscularly. Probenecid also acts as a nonsteroidal anti-inflammatory drug (NSAID). This means that it inhibits prostaglandin synthesis by blocking cyclooxygenase enzymes. This reduces inflammation, pain, and fever by inhibiting the production of prostaglandins that play a role in these processes.</p>

<p>Propargyl a-D-glucopyranoside is a high purity custom synthesis sugar. It is synthesized by Click modification, fluorination, and glycosylation followed by methylation. Propargyl a-D-glucopyranoside can be used for the modification of oligosaccharides and monosaccharides to produce complex carbohydrates.</p>

<p>3,6-Di-O-methyl-D-glucose is a glycopeptide sugar that is used as a terminal sugar in the cell wall of many gram-positive bacteria. It is found on the surface of most strains of Streptococcus pneumoniae and Staphylococcus aureus. 3,6-Di-O-methyl-D-glucose is an antigen for monoclonal antibodies against the streptococcal M protein and has been used to identify the carbohydrate chemistry of Streptococcus pneumoniae. 3,6-Di-O-methyl glucose may also be useful in the detection of cellulose derivatives by magnetic resonance spectroscopy or nitrocellulose membranes. The terminal sugars found on these membranes are hydrolyzed by acid and dry weight methods before being analyzed by gas chromatography or high performance liquid chromatography.</p>

<p>CMP-Neu5Ac sodium salt (CMP-sialic acid) is a compound of the monosaccharide N-acetylneuraminic acid (Neu5Ac) O-linked with the nucleotide cytidine-5’-monophosphate (CMP). CMP-sialic acid is a substrate for sialyltransferases, which attach sialic acid to a growing oligosaccharide chain. This sugar nucleotide is produced in cytoplasm and then transported into Golgi lumen by a nucleotide-sugar transporter, where it is used in sialylation reactions on glycoproteins and glycolipids.</p>

<p>Methyl 2,3-di-O-benzyl-a-D-glucopyranoside is a chiral sugar that can be synthesized by sulfidation of methyl 1,2,3,4-tetra-O-benzyloxycarbonyl-a-D-glucopyranoside. This sugar was used in the synthesis of oxathianes and sulfones as well as other synthetic methodology.</p>

<p>L-iduronic acid (IdoA) (Collins, 2006) is the major uronic acid component of the glycosaminoglycans dermatan sulfate, chondroitin sulfate and heparin. Iduronic acid is also present in heparan sulfate, although in a minor amount relative to glucuronic acid. Glycosaminoglycans represent a physiologically important group of molecules involved in a variety of biological functions, such as, cell proliferation, cell-to-cell communication, wound healing, coagulation, morphogenesis, and pathogenesis. Glycosaminoglycans present an intriguing target for the design of new approaches for diagnostic and therapeutic agents against various infectious diseases (Kamhi, 2013).</p>

<p>Inhibitor of hexokinase; activator of phosphofructokinase-1</p>

<p>3-Azido-3-deoxy-1,2:5,6-di-O-isopropylidene-a-D-glucofuranose is a synthetic sugar that has been modified by Fluorination, Monosaccharide, Synthetic, Oligosaccharide, complex carbohydrate, CAS No. 13964-23-3 and Glycosylation. It is also a Polysaccharide with modifications of Click modification and Methylation. 3A3DG can be used to modify the sugar content of glycoproteins and glycolipids in order to study their role in cellular processes such as transcriptional regulation and apoptosis. This product is available for custom synthesis in quantities from milligrams to kilograms.</p>

<p>Torachrysone 8-O-glucoside is a natural product found in the rhizome of Chinese medicinal plant Rhubarb. It is an antiinflammatory that has been shown to be effective in vitro against inflammation induced by spleen, blood, and the stomach. Torachrysone 8-O-glucoside has also been shown to have protective effects on the kidney and bladder.</p>

<p>Benzyl a-D-xylopyranoside is a benzyl galactofuranose that is synthesized from the condensation of benzaldehyde and D-xylose. This compound has been shown to be an excellent target molecule for the detection of Mycobacterium tuberculosis, as it constitutes about 10% of the mycolic acid in this organism. Benzyl a-D-xylopyranoside can also be used to detect other bacteria such as Actinomyces, Streptomyces, and Corynebacterium. The yield of this compound is high and its regiospecificity is complete.</p>

<p>2,3,4-Tri-O-acetyl-a-D-glucuronide methyl ester trichloroacetimidate (TOG) is a synthetic glycosylation reagent that has been used for the synthesis of complex carbohydrates. It is an O-glycosidase inhibitor and is used in the preparation of saccharides with a high degree of substitution. TOG can be used to modify saccharides, oligosaccharides, and polysaccharides.</p>

<p>D-ribono-1,5-lactone is a useful intermediate for the synthesis of bioactive compounds including antivirals.</p>

<p>Triclosan-beta-D-glucopyranoside is a synthetic sugar that can be used as a building block for the preparation of complex carbohydrates. Triclosan-beta-D-glucopyranoside is not known to have any commercial applications.</p>

<p>N-Acetyl-D-galactosamine-4-O-sulphate sodium salt is a carbohydrate, modification. It is a synthetic, custom synthesis, high purity, monosaccharide, glycosylation and methylation product. The CAS number of this product is 660839-03-2.</p>

<p>2,3,4,6-Tetra-O-benzyl-a-D-glucopyranosyl fluoride is a modification of a carbohydrate. It is a complex carbohydrate that has the CAS No. 89025-46-7 and is custom synthesized. The product contains an oligosaccharide and high purity that are synthetic and monosaccharides that are methylated, glycosylated, and polysaccharides that are sugars with fluorination. The product also contains saccharides with glycosylation and polysaccharide sugar units.</p>

<p>Phenyl 4,6-O-benzylidene-b-D-glucopyranoside is a white crystalline powder that belongs to the group of glycoconjugates. It has been made by the modification of glycosides and saccharides. This product can be used as a fluorination agent in organic synthesis, or as a click modification in carbohydrate chemistry. Phenyl 4,6-O-benzylidene-b-D-glucopyranoside can also be used for glycosylation reactions and methylation reactions.</p>

<p>2-Acetamido-2-deoxy-4,6-O-isopropylidene-D-glucopyranose is a modification of 2,3,4,5,6 tetraacetamido 1,2,3,4,5 pentaoxo 1,2 deoxy D glucose. It is an oligosaccharide that has been synthesized for the first time in 1977. The monosaccharide can be methylated and glycosylated to form polysaccharides such as mannans and galactans. The chemical structure of this product can be modified with fluorination or saccharide substitution.</p>

<p>Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is an enzyme that catalyzes the conversion of glyceraldehyde-3-phosphate to 1,3 bisphosphoglycerate. GAPDH is involved in glycolysis and the pentose phosphate pathway. It has been shown to be an important player in mediating cellular responses to hypoxia, inflammation, and oxidative stress. The glyceraldehyde-3-phosphate dehydrogenase gene has been found to be mutated in a number of cancers including breast cancer and colon cancer. This gene also has a role in inflammatory lesion development as well as energy metabolism. GAPDH also participates in the biochemical reactions that lead to neuronal death during neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease.</p>

<p>Intermediate in the synthesis of dapagliflozin</p>