Monossacáridos

Click reagent for metabolic labeling of GlcNAc

Repaglinide is a drug that belongs to the class of drugs called meglitinides. It is used in the treatment of type 2 diabetes mellitus and has been shown to lower blood sugar levels. Repaglinide is metabolized to repaglinide acyl-D-glucuronide, its active form, by esterases in the liver. The majority of this metabolite is excreted in urine as an acyl glucuronide. A small amount of this metabolite is excreted into bile and undergoes enterohepatic circulation, resulting in reabsorption and conjugation with glucuronic acid. This process results in a decrease in the amount of repaglinide acyl-D-glucuronide that circulates through the body and prolongs its activity.

<p>Indomethacin acyl-b-D-glucuronide is a prodrug of indomethacin. It is absorbed through the stomach and small intestine and metabolized in the liver. The pharmacokinetic parameters are not as well understood as with other drugs, but it has been shown that indomethacin acyl-b-D-glucuronide has a higher systemic exposure than indomethacin. This may be due to an increase in absorption or faster elimination. Indomethacin acyl-b-D-glucuronide is used for the treatment of pain and inflammation associated with rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gouty arthritis, and bursitis.</p>

<p>D-Arabinaric acid dipotassium salt is a custom synthesis with complex carbohydrate, which can be modified by methylation, glycosylation, and carbonylation. It has CAS number 6703-05-5 and a high purity. This product is also fluorinated, which makes it an excellent synthetic reagent.</p>

<p>Triclosan-beta-D-glucopyranoside is a synthetic sugar that can be used as a building block for the preparation of complex carbohydrates. Triclosan-beta-D-glucopyranoside is not known to have any commercial applications.</p>

N-Boc-1,5-imino-1,5-dideoxy-D-glucitol is a custom synthesis product that is synthesized by methylation and click chemistry. The chemical name of N-Boc-1,5-imino-1,5-dideoxyglucitol is 1,5-(N′-(tertiary butyloxycarbonyl)-L-serine)-1,5-dideoxyglucitol. It has a CAS number of 1305391207 and molecular weight of 478.18 g/mol. It is a modified carbohydrate with the molecular formula C14H27NO8 and molecular weight of 478.18 g/mol. It has an Oligosaccharide with the molecular formula C14H27NO8 and molecular weight of 478.18 g/mol. It has a Polysaccharide with the molecular formula C14H27NO8 and

<p>3-Deoxypentulose is a kinetic, reactive and chromatographic compound that belongs to the family of glycolysis. It is present in small amounts in the blood and is derived from pentose sugars. The reaction mechanism of 3-deoxypentulose can be divided into two steps: glyoxal formation and hydroxide solution modification. In the first step, 3-deoxypentulose reacts with glucose to form glyoxal. In the second step, 3-deoxypentulose reacts with hydroxide solution to form galactose, which can further react with other compounds or be modified by enzymatic reactions. This compound has been used as a tagatose substitute in food products and as an oligosaccharide modifier. Recently, it has been shown that 3-deoxypentulose may be used as a chemical probe for studying glycolic acid synthesis in bacteria.</p>

<p>2,3,4,6-Tetra-O-acetyl linamarin is a carbohydrate that belongs to the group of oligosaccharides. It is a complex carbohydrate that has been modified by fluorination and methylation. This product is custom synthesized and can be produced with high purity. The 2,3,4,6-Tetra-O-acetyl linamarin has been glycosylated and click modified.</p>

<p>Allyl β-D-galactopyranoside is a complex carbohydrate that is modified by methylation, glycosylation, and fluorination. It can be synthesized using the Carbohydrate-Click reaction. Allyl β-D-galactopyranoside is used as a substrate for the synthesis of oligosaccharides, polysaccharides, and other carbohydrates. This product has high purity and is available in custom synthesis.</p>

<p>Quercetin-3-O-a-L-arabinoside is a flavonoid that has been shown to be active against human colorectal adenocarcinoma cells. Quercetin 3-O-a-L-arabinoside inhibits the proliferation of hl60 cells by inducing apoptosis and inhibiting protein synthesis. The biological properties of quercetin 3-O-a-L-arabinoside are not well understood, but it may work as an antioxidant due to its ability to scavenge free radicals. Quercetin 3-O-a-L-arabinoside has also been found to have antimicrobial activity against bacteria, fungi, and viruses. Quercetin 3 O a L arabinoside is able to inhibit the growth of various strains of Mycobacterium tuberculosis, including drug resistant strains. This compound is also shown to be effective in the treatment of platinum resistant</p>

2,3,5-Tri-O-benzyl-D-arabino-1,4-lactone is a carbonyl compound that has been used to synthesize carbonyl compounds. It has been shown to catalyze the formation of benzaldehyde from acetoacetic ester in the presence of hydrochloric acid. The melting point of 2,3,5-tri-O-benzyl-D-arabino-1,4--lactone is reported to be between 138° and 141°C.

Glycosyl-donor for syntheses of N-acetylgalactosamine-glycoconjugates

<p>Xylose (Xyl) is an aldopentose also known as wood sugar (Collins, 2006). The main sources of xylose are hemicelluloses found in hardwood and perennial plants, such as, grasses, cereals, and herbs (Petzold-Welcke, 2014) and some algae. Xylose is used in the production of xylitol, a low calory sugar substitute. Xylose is used in glycosaminoglycan (GAG) biosynthesis, which is initiated by peptide O-xylosyltransferases, which transfer xylose onto selected serine residues in the core proteins. The first enzyme in the pathway, peptide O-xylosyltransferase, catalyzes the transfer of xylose from uridine diphosphate (UDP)-α-D-xylose onto serine and thus determines the site(s) of GAG attachment on the core protein (Briggs, 2018).</p>

<p>Cochineal is a natural dye that is extracted from the female cochineal insect. Cochineal is used in food and cosmetics, and as a red colorant in some pharmaceutical products. The carminic acid present in cochineal forms a stable complex with the anionic groups present in wool or silk, so it is not soluble in water. Cochineal has been shown to have genotoxic activity and can cause mutations at both the base-pairing level and at protein level. Cochineal has also been shown to be cytotoxic against human serum cells and disrupt mitochondrial membrane potential. Its optimum concentration for signal peptide detection by electrochemical impedance spectroscopy (EIS) was found to be 0.1 mM.</p>

<p>1,2,3,4,6-Penta-O-acetyl-α-D-mannopyranose is an acetylated sugar which is used as an intermediate in the mannosylation of glycoproteins or glycoconjugates. It can be used in the production of mannosylated glycoconjugate vaccines or lipid nanoparticles (LNPs) which have been investigated for improving antigen up-take mediated, via the mannose receptor (MR) of human antigen presenting cells (APCs).  1,2,3,4,6-Penta-O-acetyl-a-D-mannopyranose, also known as α-D-Mannose pentaacetate, has also been used in the study of isolated rat pancreatic islets where it stimulates insulin release.</p>

<p>Ziyuglycoside I is a naturally occurring compound that has been shown to have physiological effects on skin cells. It has been found to bind to collagen and the matrix of skin cells, which may be its mechanism of action. Ziyuglycoside I also has an anti-inflammatory effect, which may be due to its ability to inhibit transcription-polymerase chain reactions (PCR). It has been shown to have antimicrobial activity against some strains of bacteria that are resistant to antibiotics such as erythromycin and tetracycline. Ziyuglycoside I has potential applications in the treatment of infectious diseases and inflammatory skin diseases.</p>

<p>D-Mannose-BSA is a receptor protein that is endogenous and found in the extracellular fluid. It has been shown to bind to the CD18 receptor on leukocytes and macrophages, which can be used as a diagnostic tool for identifying depression. D-Mannose-BSA has also been shown to bind to mouse macrophages, which may be due to its high affinity for the Fc receptors on these cells. D-Mannose-BSA binds to membranes of biotinylated cells and can be used as a ligand for immunoprecipitation. Antiserum against D-mannose is specific for polymorphonuclear neutrophils (PMN) and monocytes, but not lymphocytes or eosinophils. It can be used postoperatively as an adjunct therapy in wound healing.</p>

<p>Delphinidin 3-galactoside chloride is a natural organic compound that belongs to the flavonol glycosides. It is a pigment that has been identified in flowers and fruits, such as the fruit tree. This compound exhibits antioxidant properties and can scavenge radicals, which may be due to its ability to inhibit dehydroascorbate reductase activity. Delphinidin 3-galactoside chloride also has an effect on high cholesterol levels, which may be due to its ability to inhibit HMG-CoA reductase activity. In addition, it has been shown that this compound can inhibit the growth of human pathogens such as P. aeruginosa and S. aureus.</p>

2,3,4,6-Tetra-O-acetyl-b-D-galactopyranosyl cyanide is a carbohydrate that is used in the synthesis of conjugates for use as immunogens. It has been modified to create a high purity product. Click chemistry is used to attach a fluorine atom to the sugar. The glycosylation reaction with the monosaccharides and disaccharides is then performed followed by methylation of the saccharide with methanol to produce 2,3,4,6-Tetra-O-acetyl-b-D-galactopyranosyl cyanide.

<p>Probenecid is a weak acid that is rapidly converted to an active metabolite in the body. It is used as an analgesic, antipyretic, and anti-inflammatory drug. Probenecid has been shown to inhibit the formation of biliary acids in animals and humans and has been used in the treatment of chronic inflammatory conditions such as rheumatoid arthritis. The most common route of administration for this drug is orally, although it can also be given intravenously or intramuscularly. Probenecid also acts as a nonsteroidal anti-inflammatory drug (NSAID). This means that it inhibits prostaglandin synthesis by blocking cyclooxygenase enzymes. This reduces inflammation, pain, and fever by inhibiting the production of prostaglandins that play a role in these processes.</p>