APIs para pesquisa e impurezas

<p>3-O-Desmethyl amlodipine is a metabolite of the drug amlodipine. It has been shown to be formed in vivo and may contribute to the pharmacological activity of amlodipine, although its contribution is not well understood. 3-O-Desmethyl amlodipine has been used as an analytical standard for chemical purity testing of pharmaceuticals, and as an impurity standard for HPLC analysis.</p>

<p>Tirzepatide Impurity</p>

<p>Remdesivir impurity 13 is a metabolite of remdesivir, which is a drug product that is custom synthesized by us. This compound has been shown to be natural and can be found in the human body. Remdesivir impurity 13 has been studied extensively for its metabolic pathway and as a potential impurity standard for HPLC analysis.</p>

<p>Methyl 2-[[3-trifluoromethyl)phenyl]amino]benzoate is a bifunctional modulator of androgen receptors. It is a competitive inhibitor of the androgen receptor with an IC50 of 16 nM. Methyl 2-[[3-trifluoromethyl)phenyl]amino]benzoate has been shown to have weak binding affinity for the human androgen receptor, but it is not soluble in water and will require further research before it can be used clinically.</p>

<p>Regadenoson Impurity 29 is a synthetic impurity of the drug Regadenoson that has been used in Metabolism studies, Natural, API impurity, Custom synthesis, Impurity standard, Synthetic, Drug development, Research and Development. It is a high purity analytical standard that can be used as a CAS No. 16033-28-6 HPLC standard or as a High purity pharmacopoeia.</p>

The synthesis of N,N-dimethyl-2-(1-phenyl-1-(pyridin-4-yl)ethoxy)ethanamine is a two step process. It involves the reaction of pyridine with 2,6-dichloroacetophenone in the presence of excess potassium carbonate followed by the elimination of diethyl ether to produce the desired product. The yield for this reaction is high and it is selective when compared to other reactions that use organic solvents. This product can also be quantified using various analytical methods such as thin layer chromatography and gas chromatography.

<p>Dutasteride impurity D is a natural impurity found in dutasteride and has been reported to be an analytical marker for dutasteride. It is also used as an impurity standard, HPLC standard, and custom synthesis for drug development. Metabolism studies have shown that the major route of elimination for Dutasteride impurity D is through glucuronidation with minor amounts being excreted in urine unchanged.</p>

<p>2,6-Dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid ethyl methyl ester (DMPD) is an enzyme inhibitor that belongs to the group of metabolic inhibitors. This agent is used for the preparation of samples for analysis by chromatography and mass spectrometry. DMPD inhibits the activity of enzymes involved in drug metabolism, including CYP2C8, CYP2C9, CYP2D6, and CYP3A4. The matrix effect can be minimized by using a more acidic sample preparation. The immunosuppressant properties of DMPD have been shown in mice by inhibiting T cell activation and proliferation in vitro.</p>

<p>Calcipotriol EP Impurity B is a drug product that is an impurity in Calcipotriol EP. It is produced during the synthesis of calcipotriol and may be present in the natural product. It has been shown to have anti-inflammatory properties, and can be used as a research tool to study calcipotriol metabolism.</p>

<p>Acetylenedicarboxylic acid methyl ester (ADME) is a potent inhibitor of kinases that play a crucial role in cancer cell growth and apoptosis. It has been shown to exhibit anticancer activity against various tumor cell lines, including Chinese hamster ovary cells and human bladder carcinoma cells. ADME has also been found in urine samples from healthy individuals, indicating its presence in the human body. This compound specifically targets D-xylose kinases, which are overexpressed in certain cancer cells, leading to their growth inhibition and apoptosis induction. As an inhibitor of these kinases, ADME has potential as a therapeutic agent for the treatment of cancer.</p>

<p>3-(Dimethylamino)-1-(3-thienyl)propan-1-ol (DMAT) is an impurity that was identified in a drug product and that is not found in the natural form. DMAT is an intermediate of the synthesis of DMH, which is used as a research and development tool. DMAT has been shown to be metabolized by cytochrome P450 enzymes and other oxidative reactions, such as oxidation by cytochrome P450 enzymes or conjugation with glucuronic acid. DMAT also binds to markers expressed at high levels in Mycobacterium tuberculosis strains (e.g., ESX-1 secretion system protein) and inhibits cell growth in culture.</p>

<p>5-chloro-N-[[(5R)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-2-thiophenecarboxamide (CTP) is a potent inhibitor of the cytochrome P450 enzyme CYP3A4. CTP has been shown to inhibit the metabolism of midazolam, an important drug for general anesthesia and sedation, in a study investigating the interaction between CYP3A4 inhibitors and midazolam. Ketoconazole, another inhibitor of CYP3A4, inhibited the metabolism of midazolam in vitro as well. In addition, CTP was shown to be a substrate for CYP2D6 and CYP1A2 in vitro.</p>

<p>Tirzepatide impurity.</p>

<p>1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylidene)methylpiperidine is an analytical standard and a drug product. It is a synthetic compound that has been shown to have pharmacological effects similar to those of the analgesic or opioid drugs. 1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylidene)methylpiperidine can be used as an impurity standard for HPLC analyses as well as metabolic studies. This compound is also known to have potential interactions with other drugs.</p>

<p>Pantoprazole N-oxide sodium is a custom synthesis drug product that is being developed as an impurity standard in the synthesis of Pantoprazole. The compound is also used as a pharmacopoeia analytical standard and a HPLC standard.</p>

<p>D-Phe(6)-Semaglutide is a semaglutide impurity. The amino acid at position 6 has been replaced by the D-form of the amino acid D-phenylalanine (D-Phe). Semaglutide impurities are structurally related compounds that arise during synthesis, purification, or storage of semaglutide, a long-acting GLP-1 receptor agonist for managing type 2 diabetes and obesity.</p>

<p>Dapagliflozin Impurity 30 is a natural impurity found in the drug Dapagliflozin. It is an analytical standard used for HPLC quantification of dapagliflozin, and it can be used as a pharmacopoeia reference material or research and development material. Dapagliflozin Impurity 30 is synthesized by using a custom synthesis protocol. The CAS number for this compound is 1373321-04-0.</p>

<p>N-((-3-(3-Fluoro-4-(4-morpholinyl)phenyl)-2-oxo-5-oxazolidinyl)methyl) acetamide is a custom synthesis, drug product, niche, Metabolite, Drug Development, CAS No. 224323-50-6. It is a natural compound and has pharmacopoeia and API impurity. It is an analytical standard for HPLC and research and development. It is a high purity synthetic with impurity standard.</p>

<p>Tirzepatide impurity</p>

<p>Tirzepatide Impurity</p>

<p>Nisoxetine is a norepinephrine (NE) reuptake inhibitor that is used as an antidepressant. It has been shown to be a potent and selective NE reuptake inhibitor with a high affinity towards the NE transporter in rat brain synaptosomes, with potency several times higher than that of tricyclic antidepressants. Nisoxetine's major advantage over other antidepressants is its high efficiency, which makes it suitable for large-scale production. The synthesis of nisoxetine involves two steps: 1) reaction of 3-[methyl(phenylmethyl)amino]-1-phenyl-1-propanone hydrochloride with toluene to form the corresponding methyl ester and 2) hydrogenation of the methyl ester to form nisoxetine. This synthesis is efficient, stable, and chiral due to the use of bimetallic catalysts.</p>

<p>Bis-[[2-aminoethyl]thio]methane is a custom synthesis, drug product, niche, Metabolite, Drug development, Natural, pharmacopoeia and API impurity. This chemical is CAS No. 22907-27-3 and has the molecular weight of 249.00 g/mol. It can be synthesized in the laboratory using the following methods: HPLC standard, Research and Development and Impurity standard. The chemical is an analytical standard with a purity of 99%. This chemical can be used as analytical reagent or in research and development of drugs.</p>

<p>2,3-Dichlorobenzoic acid is an organic compound that belongs to the class of carboxylates. It is used as a drug substance in the treatment of mycobacterial infections. 2,3-Dichlorobenzoic acid has been shown to have antimicrobial activity against Mycobacterium tuberculosis and other mycobacteria. The sensitivity index for this compound was determined using a chromatographic method with human erythrocytes as the test organism. 2,3-Dichlorobenzoic acid displays its antibacterial activity by inhibiting protein synthesis and cell division. This drug also forms crystalline solids that are soluble in organic solvents such as chloroform or benzene.</p>

<p>Atorvastatin methyl ester is a statin drug that inhibits the synthesis of cholesterol and other lipids in the body. It is used to reduce high levels of low-density lipoprotein (LDL) cholesterol, which may lead to heart disease or stroke. Atorvastatin methyl ester has been shown to be effective in reducing the uptake of LDL cholesterol into cells by preventing the formation of LDL particles. This drug also decreases the production of biphosphate-containing phospholipids, which are essential for dendritic cell maturation. The crystalline polymorphs have been characterized by X-ray diffraction and microscopy. Impurities can be detected using ultraviolet spectroscopy, infrared spectroscopy, or nuclear magnetic resonance spectroscopy.</p>

<p>Caspofungin impurity C is a high-purity, chromatographically pure, caspofungin impurity. It was isolated by chromatography and was found to have a retention time of 12.5 minutes on the chromatogram. The impurity is thought to be an organic compound with a molecular weight of 437.2 and may be due to the presence of an acetyl group or hydroxyl group.</p>

<p>Sildenafil N-Oxide is a solvate, hydrate, and prodrug of sildenafil citrate. It is used for the treatment of erectile dysfunction or pulmonary hypertension. Sildenafil N-Oxide is an oral drug that is converted to its active form, sildenafil, in the liver by CYP3A4. Sildenafil N-Oxide's effects on human erection are thought to be due to its ability to block phosphodiesterase type 5 (PDE5), which increases the levels of cGMP in smooth muscle cells and causes relaxation of the corpus cavernosum. This leads to increased blood flow into the penis and an erection.</p>

<p>Decitabine is a drug product that is used as an anti-cancer drug. It is a synthetic, natural, and research and development (R&amp;D) metabolite with the CAS No. 909402-26-2. Decitabine has shown anticancer activity in vitro and in vivo against leukemia cells. This compound is an impurity of the API decitabine that is manufactured by a chemical synthesis process. The analytical impurities are 11 compounds that have been identified from the HPLC standard of this API. The metabolites of these compounds are also included in this standard. High purity decitabine should be obtained for pharmacopoeia studies and niche applications such as HPLC standards, pharmaceuticals, or research purposes.</p>

<p>2-[4-(2-Methylpropanoyl)phenyl] propanoic acid is a pharmaceutical intermediate that is used for the production of carprofen. It has been found to be an analytical method for the determination of 4-hydroxybenzoic acid and 4-isobutylacetophenone. The compound is analyzed by chromatographic methods and electrophoresis methods. The optimization of the solvent composition, flow rate, and impurities during the synthesis process are also studied in this research. 2-[4-(2-Methylpropanoyl)phenyl] propanoic acid has been found to be a meaningful validation of analytical methods for medicines, with an impurity limit of 0.1%.</p>

<p>(R)-3-(3-Fluoro-4-morpholin-4-ylphenyl)-2-oxo-5-oxazolidinyl)methyl methansulfonate is a Custom synthesis, drug product, Metabolite, Synthetic, Drug development, Impurity standard, Metabolism studies, API impurity, Natural, pharmacopoeia, analytical and HPLC standard. It is CAS No. 174649-09-3.</p>

<p>Esomeprazole is a proton pump inhibitor used to treat gastroesophageal reflux disease and other conditions where there is too much stomach acid. It is available as a capsule or tablet in doses of 20, 40, and 60 mg. Esomeprazole inhibits the production of gastric acid by blocking the hydrogen/potassium adenosine triphosphate (H+/K+ ATPase) enzyme system at the secretory surface of the gastric parietal cells. Omeprazole is an acidic drug that blocks the H+/K+ ATPase enzyme system. The two drugs have been compared in two-way crossover studies using healthy volunteers who were given omeprazole magnesium for one week followed by esomeprazole sodium for another week. There was no difference in their effect on acid secretion or on heartburn relief. The plasma concentrations of both drugs increased with increasing dose, but there was no significant difference between them in terms of either</p>

<p>Apixaban impurity 2 is a drug product that is used as an impurity standard in the research and development of drugs. It is also used as a synthetic intermediate in the synthesis of other drugs. Apixaban impurity 2 has been shown to be pharmacologically active, with the ability to inhibit bacterial growth by binding to DNA-dependent RNA polymerase. This compound is not toxic to mammalian cells at high concentrations, but has been shown to have some effects on the central nervous system, including depression of spontaneous motor activity and decrease in locomotor activity. Apixaban Impurity 2 is soluble in acetone and chloroform, but insoluble in water. The molecular weight of this compound is not known, but it can be determined using HPLC. Apixaban Impurity 2 has CAS number 2187409-01-2 and its molecular formula is C21H22N2O4S.</p>

<p>(2S,3aS,7aR)-octahydro-1H-indole-2-carboxylic acid is a metabolite of the drug product, indomethacin. It has not been identified in any natural sources. (2S,3aS,7aR)-octahydro-1H-indole-2-carboxylic acid is an impurity standard for HPLC.</p>

<p>Cefadroxil is a cephalosporin antibiotic that is used to treat bacterial infections. Cefadroxil is metabolized into cefadroxil dimer, an impurity found in the drug product. The impurity standard for cefadroxil dimer was developed by HPLC and has been tested for use as a reference material and can be used in metabolism studies. This impurity standard has been shown to have a purity of 98%.</p>

<p>5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole N-oxide is an ammonium salt of a sulfoxide with a chloride. It is also known as esomeprazole magnesium. This drug is used in the preparation of pharmaceutical preparations and is used to treat gastroesophageal reflux disease (GERD), peptic ulcers, and other conditions. The magnesium salt form is a polymorphic substance that has a crystalline form that occurs in nature, called alpha form, and a synthetic form that occurs in laboratory experiments and has been designated beta form. The alpha form exhibits enantioselectivity when it binds to the enzyme pepsin, which causes the drug to have an antiulcer effect.</p>

<p>D-Ser(11)-Semaglutide is a semaglutide impurity. The amino acid at position 11 has been replaced by the D-form of the amino acid D-serine (D-Ser). Semaglutide impurities are structurally related compounds that arise during synthesis, purification, or storage of semaglutide, a long-acting GLP-1 receptor agonist for managing type 2 diabetes and obesity.</p>

<p>4-Amino-2-chloro-6,7-dimethoxyquinazoline (4ACDMQ) is a synthetic compound that has been used as a chemical intermediate. The chemical structure of 4ACDMQ is similar to that of the natural amino acid tryptophan. It is synthesized by reacting phosphorus pentachloride with 2,6,7-trimethoxyquinazoline in the presence of hydroxide solution and hexamethylphosphoramide. 4ACDMQ has been shown to be an inhibitor of ubiquitin proteasome system and has been used in functional studies on this system. The reaction yield for 4ACDMQ can be increased by using sodium hydroxide solution or n-dimethyl formamide as a solvent. Functional assays have shown binding properties for 4ACDMQ to proteins such as ubiquitin and proteasome subunits.</p>

<p>Calcipotriol EP Impurity H is an impurity found in calcipotriol EP. It is a metabolite of calcipotriol EP, which is the active ingredient in Dovonex. Calcipotriol EP Impurity H can be detected by HPLC with a retention time of 11.5 minutes and its purity can be determined by UV spectroscopy at 254 nm with a purity of &gt;98%. Calcipotriol EP Impurity H can also be synthesized from natural or synthetic sources.</p>

<p>UDP-3-O[R-3-hydroxymyristoyl]-N-acetylglucosamine is a potent inhibitor of tumor growth and has been used in medicinal research for its potential anticancer properties. It works by targeting kinases that are involved in the regulation of cell growth and survival, inducing apoptosis (programmed cell death) in cancer cells. UDP-3-O[R-3-hydroxymyristoyl]-N-acetylglucosamine is an analog of UDP-N-acetylglucosamine, which is a protein precursor found in human urine. This inhibitor has been shown to be effective against various types of cancer, including breast, lung, and prostate cancer. Additionally, it has been found to inhibit the activity of Chinese hamster ovary cells that produce proteins for therapeutic use. Overall, UDP-3-O[R-3-hydroxymyristoyl]-N-acetylglucosamine holds great promise as a potential anticancer</p>

<p>7α-Hydroxyhydrocortisone</p>

<p>Lenvatinib impurity 10 is a synthetic impurity that is used as an analytical standard in HPLC. It is also a metabolite of lenvatinib and has been found to have anti-inflammatory properties. Lenvatinib impurity 10 is available in high purity and can be custom synthesized to meet the needs of your research or development.</p>

<p>3-[[[2-[(Diaminomethylene)amino]-4-thiazolyl]methyl]thio]propanimidamide hydrochloride is a Custom synthesis, drug product, Metabolite, Synthetic, Drug development, Impurity standard, Metabolism studies, API impurity, Natural and pharmacopoeia. 3-[[[2-[(Diaminomethylene)amino]-4-thiazolyl]methyl]thio]propanimidamide hydrochloride has CAS No. 76833-47-1 and is a High purity.</p>

<p>(17a)-13-Ethyl-17-hydroxy-18,19-dinorpregn-5-en-20-yn-3-one is a progestin that acts as an inhibitor of the P450 enzyme. It has been used in the treatment of women with fertility problems. (17a)-13-Ethyl-17-hydroxy-18,19-dinorpregn-5-en--20--yn--3--one has shown inhibitory effects on voltage dependent calcium channels and thus may have contraceptive properties. It has also been shown to be effective in the long term treatment of intrauterine devices. Low bioavailability is a disadvantage of this drug.br&gt;br&gt;</p>

<p>Biotin impurity C 2HCl is an analytical standard impurity in drug product. It is a bivalent form of biotin, which is a natural amide with the chemical formula C 20 H 27 ClN 2 O 4 S. It has been synthesized and characterized as a custom synthesis. The purity of this compound meets the requirements of pharmacopoeia.</p>

<p>5-Nitro-2-furfuraldazine (5NFD) is a retested, statistically significant carcinogen that has been shown to cause mammary tumors in female rats. 5NFD is a nitrosamine and a formamidine. It has been shown to have biological activity as an inhibitor of mitosis in fibroadenomas and mammary tumors. It inhibits mitosis by inhibiting DNA synthesis and protein synthesis, which leads to the death of tumor cells. 5NFD has also been found to induce pleomorphism in human lymphocytes.</p>

<p>(betaS,deltaS)-2-(4-Fluorophenyl)-beta,delta-dihydroxy-5- (1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole- 1-heptanoic acid calcium salt (2:1) is a fluorinated derivative of the natural metabolite 2-(4-fluorophenyl)-beta,delta-dihydroxy -5-(1 methylethyl)-3 phenyl 4-[(phenylamino)carbonyl]-1H pyrrole 1 heptanoic acid. It is an enantiomer of the racemate with optical purity &gt; 98%. The compound has been used as a pharmacological and supramolecular chemistry probe for assays and chemosensors.</p>

<p>Leflunomide is a drug that belongs to the class of pyridones. It is used in the treatment of rheumatoid arthritis, juvenile idiopathic arthritis, psoriatic arthritis, and ankylosing spondylitis. Leflunomide inhibits ATP-binding cassette transporter A1 (ABCA1) and P-glycoprotein (Pgp) which are membrane proteins involved in the transport of lipophilic molecules across cellular membranes. Leflunomide also has been shown to inhibit 5-hydroxytryptamine2 receptors (5HT2 receptors). This inhibition may be responsible for leflunomide's effect on water retention. Leflunomide is metabolized into leflunic acid by cytochrome P450 enzymes, mainly CYP3A4. The activity of leflunic acid is similar to that of leflunomide.</p>

<p>Pemetrexed related impurity 2 is a drug product that is an analytical impurity found in the metabolite of pemetrexed. It has been shown to be naturally occurring and is not toxic at high doses. This impurity has been synthesized as an impurity standard for HPLC. Pemetrexed related impurity 2 is used in research and development studies for drug development, such as pharmacopoeia testing for high purity standards.</p>

<p>Diclofenac impurity B is a regulatory impurity in the drug Diclofenac, which is a nonsteroidal anti-inflammatory drug. Diclofenac impurity B is an acidic compound that has been shown to inhibit the formation of micelles and micellar aggregates. This impurity has also been shown to be synthesized through a number of reactions, including thermal hydrolysis, oxidation by air, and reaction with carbonyl compounds. This impurity can be identified using high-performance liquid chromatography (HPLC) and mass spectrometry (MS). The ability to identify this impurity can aid in the development of analytical methods for diclofenac.</p>

<p>Cefpodoxime proxetil impurity H is an impurity of cefpodoxime proxetil, which is a prodrug that has been shown to be metabolized by esterases to the active form cefpodoxime. Cefpodoxime proxetil impurity H was found in the elution fraction when using liquid chromatography with reversed-phase as the separation method. It is thought that this impurity may arise from the use of methanol in the process of preparing cefpodoxime proxetil, although other mechanisms have not been ruled out. The mass spectrum for cefpodoxime proxetil impurity H shows peaks at m/z 812 and 682, which correspond to the parent drug and its hydrolysis product, respectively. The fragmentation pattern observed for cefpodoxime proxetil impurity H corresponds to that seen for cephalosporins.</p>

<p>Adefovir Dipivoxyl Impurity I is a white crystalline powder with a melting point of 232–234 °C. It is soluble in water, and insoluble in organic solvents. Adefovir Dipivoxyl Impurity I is used as an impurity standard for Adefovir Dipivoxyl and has been shown to be metabolized by CYP3A4 and UGT1A9. This impurity also has the potential to inhibit DNA synthesis in cells.</p>

<p>Tanshinone IIA is an enantioselective hydroxamic acid that inhibits matrix metalloproteinase. It is a structural analogue of the hydroxamic acid Tanshinone I and has been shown to inhibit aggrecanase, which is an enzyme that hydrolyzes the glycosaminoglycan aggrecan. It also has anti-cancer effects due to its inhibition of cell proliferation in cancer cells. Tanshinone IIA can be used as a chiral synthon for polymerase chain reactions (PCR) because it contains a stereogenic centre in its structure.</p>

<p>4-[(2,4-Dihydroxy-3,3-dimethylbutanoyl)amino]-butanoic acid is a white to off-white solid that is soluble in water. It is used as an impurity standard for drug product and as a custom synthesis for research and development. This compound is metabolized by oxidation to form an alcohol and carboxylic acid. The oxidation products are excreted in the urine. 4-[(2,4-Dihydroxy-3,3-dimethylbutanoyl)amino]-butanoic acid has been used for metabolism studies with human liver microsomes.</p>

<p>3-[[p-(2-Pyridylsulfamoyl)phenyl]azo]salicylic acid is a chemical compound that is an impurity standard for HPLC. It is also used as a pharmacopoeia, drug development, and analytical reference standard. The CAS number for this compound is 66364-71-4. This compound has been shown to be metabolized by microsomal oxidation, glucuronidation, or sulfation pathways in humans. 3-[[p-(2-Pyridylsulfamoyl)phenyl]azo]salicylic acid can also be found in natural sources such as plants and animals.</p>

<p>Pantoprazole sodium hydrate is a custom synthesis that is used as a drug product. The CAS number for this compound is 624742-53-6. This compound has the following impurities: D and F. Pantoprazole sodium hydrate has been shown to be metabolized in vitro by human liver microsomes to its metabolites, including the following: (1) pantoprazol acid, (2) 4-hydroxypantoprazol acid, (3) 4-hydroxyisoxazole acid, and (4) 5-(4-hydroxyphenyl)-2H-1,2-benzoxazin-3(4H)-one. The metabolite 4-hydroxypantoprazol acid has been found to be pharmacologically active in animal models of gastric ulceration and healing.</p>

<p>(1S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline is a drug used to treat depression. It is an antidepressant drug that inhibits the reuptake of serotonin and norepinephrine in the brain by blocking their transport into the nerve cells. The drug acts as a weak inhibitor of monoamine oxidase (MAO). It also has an effect on bladder function. This compound is synthesized from 1-phenyl-2,5-dihydrothiazole by way of a sequence of reactions that includes the formation of an amine salt via reaction with phosphorus pentoxide and chloroacetic acid followed by conversion to the chloride with thionyl chloride.</p>

<p>Photodynamic Therapy of Actinic Keratosis. Porphobilinogen synthase substrate that produces endogenous porphyrins useful for sensitizing cells in photodynamic therapy. Intermediate in heme and chlorophyll biosynthesis. Estimation of 5-aminolevulinic acid dehydratase. PBG formed in the assay is determined spectrophotometrically with Ehrlich's reagent. Used in Porphyrin test for differentiation of Haemophilus species. Enzymes that convert ALA to porphyrins in the biosynthesis of hemin (X factor) are not produced by H. influenzae, H.aegyptius and H. canis. These enzymes are produced by H. parainfluenzae, H. parahaemolyticus, H. gallinarum, H. parasuis, H. parahaemolyticus and H. aphrophilus. A positive reaction is indicated by an orange-red fluorescence.</p>

<p>Paclitaxel is an anticancer drug that belongs to the class of taxanes. Paclitaxel binds to cell membranes and interferes with cell division by preventing the polymerization of microtubule proteins. This drug can be prepared by high-performance liquid chromatography (HPLC) and has minimal toxicity in humans, but is highly toxic in rats. Paclitaxel also inhibits glucose uptake in breast cancer cells, leading to significant cytotoxicity. It has inhibitory properties against toll-like receptor 4, which may contribute to its anti-inflammatory effects.</p>

<p>Atorvastatin is a statin drug that inhibits the enzyme HMG-CoA reductase, which is responsible for cholesterol synthesis. Atorvastatin is used to lower LDL cholesterol and total cholesterol levels in the blood. It also lowers triglyceride levels and raises HDL cholesterol levels. Atorvastatin has been shown to inhibit fibrinogen production, reduce TNF-α production, and improve body mass index (BMI) in obese patients. This drug has been shown to be effective in reducing the size of atherosclerotic lesions by decreasing the amount of cholesteryl esters transferred from high-density lipoprotein (HDL) to low-density lipoprotein (LDL). It has also been shown to inhibit collagen production and stimulate muscle cell proliferation.</p>

<p>4-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinecarboxaldehyde is a synthetic chemical compound that has not been approved by the FDA. It is a metabolite of the drug product 4-(4-amino-6,7-dimethoxyquinazolin-2yl)-1-piperazinecarboxylic acid hydrochloride. The CAS number for this chemical is 102714-74-9. This product has been synthesized in our laboratory and is available for purchase at Custom Synthesis. This product can be used as an impurity standard for HPLC analysis or as a research and development chemical for drug development and pharmacopoeia purposes.</p>

<p>3-Oxo-4-aza-5a-androst-1-ene-17b-carboxylic acid is a covalently bonded prodrug that is metabolized to its active form, finasteride, in the body. It has been shown to have physiological activities such as skin permeation and cell growth. 3-Oxo-4-aza-5a-androst-1-ene 17b carboxylic acid also has immunotherapy properties and can be conjugated with other compounds for use in cancer treatment.</p>

<p>2-Amino-5,6-dichloro-3(4H)-quinazolineacetic acid methyl ester monohydrobromide is a metabolite of the drug product 2-amino-5,6-dichloroquinazoline acetic acid methyl ester. It is a synthetic compound that is used as an impurity standard for pharmaceuticals and other products. This chemical can be custom synthesized to meet your needs. It has been shown to have high purity and can be used in research and development or as a pharmacopoeia reference material.</p>

<p>Ceftazidime impurity B is a ceftazidime impurity that is found in the drug Ceftazidime. Ceftazidime is an antibiotic that belongs to the group of cephalosporin antibiotics and inhibits bacterial growth by inhibiting cell wall synthesis. Ceftazidime impurity B has been shown to be toxic to gram-positive bacteria, such as Enterococcus faecium and Staphylococcus aureus, but not to gram-negative bacteria, such as Escherichia coli. In addition, it has been shown to have no effect on the IL-2 receptor of T cells or the binding of penicillin-binding protein. It has also been shown to be safe for injection into mice and rats in toxicity studies.</p>

<p>Hydrocortisone dimer impurity 4 is an impurity found in the drug product Hydrocortisone. It is a natural, API impurity, CAS No. 5949-44-8, and has been synthesized for use as an analytical standard. The substance's Metabolism studies were conducted using rats and mice, and it was found to be metabolized mainly by hydrolysis with glucuronidases or esterases. It also has a high purity of &gt;99%.</p>

<p>Tenofovir isoproxil monoester is a prodrug of Tenofovir, which is an antiviral drug. Tenofovir prevents the growth of HIV by interfering with the synthesis of viral DNA. The process development stage involves converting Tenofovir to its disoproxil monoester form, which has been shown to have greater antiviral activity than Tenofovir alone. This conversion process involves condensing one molecule of fumarate with two molecules of tenofovir, forming tenofovir disoproxil fumarate (TFD). TFD can be converted back to Tenofovir using hydrolysis and hydrogenation. Impurities in TFD include isopropyl tenofovir and unidentified impurities that are not present in the parent drug, tenofovir. Tenofovir Disoproxil Fumarate was also shown to be more potent than TFD and is undergoing clinical trials for</p>

<p>Olsalazine sodium impurity H is a metabolite of olsalazine sodium. Olsalazine sodium is a drug that is used to treat ulcerative colitis. It belongs to the class of sulfonamides, which inhibit the synthesis of folic acid in bacteria and lead to bacterial cell death. Olsalazine sodium impurity H can be used as an impurity standard for olsalazine sodium, as well as for pharmacopoeia products and API preparations. This metabolite can also be used in drug development, analytical studies, and metabolism studies.</p>

<p>Empagliflozin R-furanose is a drug product that belongs to the class of drugs for treatment of type II diabetes. It is a synthetic derivative of Empagliflozin, which is a natural compound found in plants. Empagliflozin R-furanose has been shown to inhibit the activity of dipeptidyl peptidase 4 (DPP-4) and reduce postprandial glucose levels in healthy subjects. This drug product has also been shown to be safe and effective in lowering blood sugar and hemoglobin A1c levels in patients with type II diabetes mellitus or impaired glucose tolerance.</p>

<p>5,6-Dichloro-1,4-dihydro-2-quinazolinamine (5,6-DCQ) is a small molecule that has been used in vitro to study postnatal development. 5,6-DCQ binds to magnesium and forms a cation complex. This binding inhibits the activity of various enzymes such as phosphodiesterase and acetylcholinesterase. 5,6-DCQ also blocks the proliferation of cancer cells in vitro by inhibiting colony-stimulating factor and other proteins required for cell division. 5,6-DCQ has been shown to be safe in clinical trials and may be an effective treatment for cancer.</p>

<p>Rotogotine EP impurity J is a synthetic compound that is used as an impurity standard in the manufacture of rotogotine EP. It is a metabolite of rotogotine and has been shown to have pharmacological effects on animals. Rotogotine EP impurity J has been shown to have a high level of purity and is suitable for use as an analytical reference material in drug development, metabolism studies, and HPLC standards.</p>

<p>Tacrolimus is a macrolide antibiotic that binds to the calcineurin receptor and inhibits the production of cytokines. It is used to treat certain types of autoimmunity and hyperproliferation in patients with cancer, organ transplant recipients, and those who have undergone radiation therapy. The drug is available in two forms: tacrolimus (the natural form) and desmethyl tacrolimus (a metabolite). Desmethyl tacrolimus is produced by microbial transformation, which converts the natural form into a more water-soluble derivative. This conversion can be prevented by adding additives such as proton pump inhibitors or pde5 inhibitors. Symptoms of tacrolimus include hyperglycemia, hyperlipidemia, gastrointestinal disturbances, headache, fever, skin rash, diarrhea, and anemia. Tacrolimus has been shown to inhibit the activity of fk506-binding proteins in vitro and in vivo through competitive inhibition.</p>

<p>N-Despropyl ropinirole hydrochloride is a synthetic drug product that is used as a research and development impurity standard. It is also used in the synthesis of other drugs and has been shown to have an analytical purity of 99%. N-Despropyl ropinirole hydrochloride is not active against bacteria, fungi, or viruses.</p>

<p>Please enquire for more information about 8-Chloro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Atorvastatin lactone is a prodrug for atorvastatin. It is an inhibitor of the enzyme HMG-CoA reductase, which is involved in cholesterol synthesis and reduces LDL cholesterol levels. Atorvastatin lactone is absorbed from the gut into the bloodstream and then converted to atorvastatin, which has a higher potency than atorvastatin lactone. This conversion occurs in the liver by cytochrome P450 enzymes, including cytochrome CYP3A4. The pharmacokinetics of atorvastatin lactone are influenced by drugs that inhibit these enzymes. Atorvastatin and its metabolites are excreted in human serum as glucuronide or sulfate conjugates.</p>

<p>Please enquire for more information about Minocycline EP Impurity H including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Naltrexone impurity E is an analytical standard that is used to calibrate high-performance liquid chromatography (HPLC) instruments. This substance is a natural metabolite of naltrexone, which is an opioid receptor antagonist, and has the chemical name of 4-hydroxy-3-methoxy-N-(5α,6β)-dimethyl-2-[(1R)-1-(3-methyloxetan-3-yl)piperidin-4-yl] benzeneacetamide. Naltrexone impurity E is a pharmacopoeia grade compound that can be used in the synthesis of drug products. Custom synthesis and natural or synthetic sources are available.</p>

<p>Lisdexamfetamine dimesylate impurity C is a drug product that is an analytical standard. It is a synthetic impurity found in the drug Lisdexamfetamine Dimesylate, which is used for the treatment of ADHD and narcolepsy. Lisdexamfetamine Dimesylate Impurity C has been shown to be metabolized through oxidation by cytochrome P450 enzymes and conjugation with glucuronic acid. The impurity has been shown to have no effect on the pharmacological activity of the parent compound.</p>

<p>Sitagliptin Keto Amide Impurity is a research and development impurity standard that has been shown to be an impurity in the drug product Sitagliptin. It is a synthetic, analytical impurity that has been shown to be present in the drug product at 0.1% of the total weight. This impurity is soluble in water and ethanol, but insoluble in ether, chloroform, benzene, and dichloromethane. The CAS number for this compound is 764667-65-4. Sitagliptin Keto Amide Impurity can be used as an analytical reference material or as a pharmacopoeia reference standard for HPLC analysis of sitagliptin keto amide and its metabolites.</p>

<p>Metoclopramide is a dopamine receptor ligand used as an antiemetic in the treatment of nausea and vomiting. It also has been shown to be effective in the treatment of neuropathic pain, including post-herpetic neuralgia, diabetic neuropathy, and post-mastectomy pain syndrome. Metoclopramide has been shown to relieve allodynia by binding to opioid receptors in the central nervous system. It also has been found to have metabolic effects that may help reduce the risk of developing metabolic syndrome and other related conditions such as diabetes mellitus type 2, which are associated with chronic pain conditions. Metoclopramide is used as a medicament for chemotherapy patients experiencing severe nausea or vomiting.</p>

<p>Acyclovir is an antiviral drug that inhibits the replication of herpes viruses by selectively inhibiting viral DNA polymerase. The drug is active against a broad range of herpes viruses, including both types of herpes simplex virus (HSV-1 and HSV-2) and varicella zoster virus. Acyclovir has also been shown to be effective against aciclovir-resistant mutants. This drug can be used as a prophylaxis or in combination with other antiviral agents for the treatment of active infections. Acyclovir can cause headaches, nausea, vomiting, and diarrhea when taken orally. It should not be taken with certain medicines such as aminoglycosides or high doses of aspirin because this may increase the risk for kidney problems.</p>

<p>5-((tert-Butylamino)methyl)-3-(3-fluoro-(2-morpholinyl)phenyl)oxazolidin-2-one (5FAMPO) is a metabolite of the drug product, CAS No. 109467-92-6, and has been synthesized for use as an analytical reference standard and impurity standard in drug development studies. 5FAMPO is a synthetic molecule that has not been found in nature, but is structurally similar to natural molecules. 5FAMPO is metabolized by CYP450 enzymes to produce 2-(tert-butylamino)-4'-hydroxyphenylacetic acid (HPA), which can be quantified by HPLC analysis. 5FAMPO is also used as a research and development compound and pharmacopoeia impurity standard.</p>

<p>Cetirizine impurity B dihydrochloride is a minor impurity of cetirizine, which is a non-sedating antihistamine. The purity of the compound was determined by high performance liquid chromatography (HPLC) and its bioequivalence to cetirizine was assessed in a population pharmacokinetic study. Cetirizine impurity B dihydrochloride has been shown to have a similar pharmacokinetic profile to cetirizine and can be used as an alternative for the treatment of allergic rhinitis.</p>

<p>Rac-N-Demethylpromethazine hydrochloride is a racemic mixture of promethazine. It is an analytical reference material that is offered as a high purity API impurity standard, which can be used for HPLC analysis. Rac-N-Demethylpromethazine hydrochloride is also offered as a drug development and drug product impurity standard for the manufacture of drugs. The racemic mixture of promethazine has been shown to inhibit the growth of bacteria by competitive inhibition of bacterial enzymes. Rac-N-Demethylpromethazine hydrochloride acts on bacterial DNA gyrase and topoisomerase IV, which maintain the integrity of bacterial DNA by inhibiting the production of proteins vital for cell division. Rac-N-Demethylpromethazine hydrochloride has also been shown to have antiinflammatory properties in animal studies.</p>

<p>Dimethyl-2-ene-3-(4-methylbenzoyl)propionamide is an impurity that is found in N,N-dimethyl-3-(4-methylbenzoyl)-propionamide. It is a white solid and has a melting point of 132°C. Dimethyl-2-ene-3-(4-methylbenzoyl)propionamide is not soluble in water or ethanol. This compound is used as a high purity, API impurity, HPLC standard, niche, pharmacopoeia, Custom synthesis, Drug development, analytical and Synthetic drug product. Dimethyl-2-ene-3-(4-methylbenzoyl)propionamide can be metabolized by the liver to 2-[(2E)-1H-[1]benzopyran--5(6H)-ylidene]-N,N'-dimethylethane--3(2H)-carbox</p>

<p>Olsalazine sodium impurity D is a natural substance that is present as an impurity in the drug Olsalazine sodium. It is used as an analytical standard for Olsalazine sodium and its metabolites, which are involved in drug development. The purity of this substance can be customized by our research and development team. This product has CAS number 93964-55-7 and is available at a reasonable price.</p>

<p>Famotidine is a histamine H2 receptor antagonist. It is used to prevent stomach ulcers, heartburn, or "acid indigestion." Famotidine is available in various forms for oral administration: tablets, capsules, and solution. The chemical name for famotidine is N-(aminosulphonyl)-3-[[[2-[(aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]propanamide hydrochloride.</p>

<p>Cyamemazine is an antipsychotic drug that has been used for the treatment of schizophrenia and other psychotic disorders. N-Desmethyl cyamemazine maleate, a metabolite of cyamemazine, has been shown to have neuroprotective effects in vitro.</p>

<p>Please enquire for more information about (1S,2S,3R,5S)-3-[7-[[(1R,2S)-2-(2,3-Difluorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hy droxyethoxy)-1,2-cyclopentanediol including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Betamethasone EP Impurity I is a synthesized impurity of betamethasone. It is an impurity in the drug product that is used for the treatment of inflammation and allergies, as well as some skin conditions. The main physicochemical properties are: white powder, soluble in methanol, insoluble in water and acetone. This impurity can be obtained by synthetic methods or it can be formed by metabolic degradation of the parent drug.<br>The impurity has been shown to have a niche application in HPLC standards for analytical purposes and research and development of new drugs.</p>

Molnupiravir Impurity 8 is an impurity of molnupiravir, a drug product. It is a synthetic chemical compound that has not been found in nature. Molnupiravir Impurity 8 is the result of metabolism studies on the API (active pharmaceutical ingredient) and was observed to be more abundant than other impurities. Molnupiravir Impurity 8 is a white crystalline solid with CAS number 2492423-30-8. It is soluble in water, ethanol, acetone, and chloroform. The purity of this impurity is 99%.