APIs para pesquisa e impurezas

<p>Applications 5beta-Androstan-3alpha,17beta-diol-2,2,3,4,4-d5 (CAS# 1224710-37-5) is a useful isotopically labeled research compound. This compound can be used to detect androgen, estrogen, progestagen abuse in bovine samples using multi-residue urinary assay.<br>References Scarth, J.et.al., Chromatographia, 71,241-252,(2010);<br></p>

<p>Stability Moisture Sensitive, Temperature Sensitive<br>Applications Tetraisopropyl Dichloromethylene Diphosphonate is an intermediate in the sythesis of Clodronic Acid, Disodium Salt, Tetrahydrate, a biphosphonate bone resorption inhibitor.<br></p>

<p>Applications Butachlor ESA Sodium Salt (cas# 1173022-75-7) is a compound useful in organic synthesis.<br></p>

<p>Applications Levophacetoperane Hyrochloride, is a sympathomimetic central nervous system stimulant and is commonly used to treat depression. Levophacetoperane is also a known analeptic and is strongly linked to apnea reversal in dogs after a single intravenous injection.<br>References Dobkin, A. B.: Anaesthesia, 15, 146 (1960); Dugal, R., et al.: J. Anal. Toxicol., 2, 101 (1978)<br></p>

<p>Stability Hygroscopic<br>Applications 3'-Azido-3'-deoxythymidine 5’-Triphosphate Tetraammonium Salt, is used for the preparation of drug against human retroviruses.<br>References Rideout, J.L., et al.: Ger. Offen., 3608606 (1986)<br></p>

<p>Applications A di-substituted resorcinol as skin-lightening agents. Used to reduce skin mutation and DNA damage.<br>References Masse, M., et al.: Int. J. Cosmet. Sci., 4, 235 (1982),<br></p>

<p>Applications Labelled Lamivudine Acid (L172490). Lamivudine Acid is an impurity of Lamivudine (L172500). Labelled Impurity A per European Pharmacopoeia.<br>References Dwyer, O., et al.: Synlett, 11, 1163 (1995),<br></p>

<p>Applications Simvastatin-d11 (2,2-dimethylbutyrate-d11) (CAS# 1002347-74-1) can be used to treat hypercholesterolemia and heart disease. This compound can also be used to treat various diseases by preparing it as HMG-CoA reductase inhibitor.<br>References Czarnik, A., U.S Pat.Appl.Publ., 8,(2008); Gant, T., et.al., PCT Int.Appl.,88,(2008);<br></p>

<p>Applications N,​N-​Diethylethanol-1,1,2,2-d4-amine is deuterium labelled of 2-diethylaminoethanol, which is an inactive metabolite of 2-Chloroprocaine (HCl: C380265) and commonly used for epidural analgesia in obstetrics. It is also hypothesized to cause onset-asthma to humans following brief exposure. 2-Diethylaminoethanol also has the ability to inhibit growth of tomato roots.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Boll, W.: Science, 129, 330 (1959); Cornish, H.: Am. Ind. Hyg. Assoc. J., 26, 479 (1965); Foldes, F. &amp; McNall, P.: Anasthesiology, 13, 287 (1952); Reisner, L., et al.: Anast. Analg., 59, 452 (1980)<br></p>

<p>Applications 2-Desmethylene-2-hydroxymethyl Ethacrynic Acid is a degradation product of Ethacrynic Acid (E676000), a diuretic used to treat high blood pressure and swelling caused by congestive heart failure, liver failure and kidney failure.<br>References Yarwood, R. J., et. al.: J. Pharmaceut. Sci., 74, 220 (1985); Beyer, et al.: J. Pharmacol. Exp. Ther., 147, 1 (1965); Kim., et al.: Am. J. Cardiol., 27, 407 (1971); Williamson, H.E., et al.: J. Clin. Pharmacol., 17, 663 (1977)<br></p>

<p>Applications 1-Chloro-2,4-dinitrobenzene-d3 (CAS# 347840-12-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications The major human labelled metabolite of Flurazepam. Controlled substance.<br>References Ochs, H.R. , et al.: Pharmacology, 36, 166 (1988), Capello, S., et al.: Drug Metab. Dispos., 18, 190 (1990),<br></p>

<p>Applications Deferoxamine Trifluoroacetic Acid Salt is an iron chelating agent used in therapy for patients with sickle cell diseases and iron overload. Studies suggest that it can exert potential antioxidant neuroprotective effects in stroke patients.<br>References Inati, A. et al.: Am. J. Hematol., 85, 782 (2010); Selim, M.: Translat. Stroke Res., 1, 35 (2010); Cappellini, M.D. et al.: Hemoblobin, 33, 258 (2009)<br></p>

<p>Applications A compound closely related to Enterolactone (E558950). A metabolite of sesame lignans (sesamin, sesamolin). Inhibits colonic cancer cell growth by inducing cell cycle arrest and apoptosis. Possible relationship between exposure and reduced risk of breast cancer.<br>References Hirano, T. et al.: Res. Com. Chem. Path. Pharmac., 64, 227 (1989); Ayella, A. et al.: Nut. Res., 30, 762 (2010); Pianjing, P. et al.: J. Agric. Food Chem., 59, 212 (2011); Buck, K. et al.: Am. J. Clinic. Nut., 92, 141 (2010);<br></p>

<p>Applications Intermediate in the production of fentanyl analogs<br>References Dumaitre, B., et al.: J. Med. Chem., 39, 1635 (1996),<br></p>

<p>Applications Bis(3-aminopropyl-d6)amine (CAS# 1219805-55-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Bromotetradecane-1,1,2,2-d4 (CAS# 1219798-81-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications 3-Chloro-6-(chloromethyl)benzene-1,2,4,5-d4 is an isotope-labeled analog of 4-Chlorobenzyl Chloride (C364730), which is a benzylchloride derivative used in the preparation of various biologically active compounds such as bronchodilators and antibacterial agents.<br>References Adams, M. et al.: Synth. Comm., 29, 2419 (1999); Foroumadi, A. et al.: Arch. Pharm. Res., 30, 138 (2007);<br></p>

<p>Applications Dl-Metanephrine:Hcl (A,B,B-D3, 98%) (cas# 1085333-94-3) is a useful research chemical.<br></p>