APIs para pesquisa e impurezas

<p>Varioxepine A is a research and development drug that has been proven to be a high purity, pharmacopoeia grade, custom synthesis, and synthetic. It is being developed as an impurity standard for analytical purposes. Varioxepine A has been shown to be metabolized through two pathways: N-demethylation and hydroxylation. The metabolites of this compound have not been fully characterized.</p>

<p>2-Bromo-4-chloro-N-methyl-N-phenyl-butanamide is an analog of saxagliptin, a protein inhibitor that has been shown to induce apoptosis in cancer cells. This compound has demonstrated potent anticancer activity in vitro and in vivo, inhibiting the growth of tumor cells by targeting kinases involved in cell proliferation and survival. It has also been found to be effective against a variety of human cancer types, including breast, prostate, and lung cancer. Additionally, 2-Bromo-4-chloro-N-methyl-N-phenyl-butanamide has been shown to have potential as a urine biomarker for detecting early-stage Chinese bladder cancer. Overall, this compound shows promise as a potent inhibitor of cancer cell growth and may have important applications in the development of novel anticancer therapies.</p>

<p>Miproxifene is a potent anticancer drug that has been shown to induce apoptosis and inhibit cell cycle progression in human cancer cells. This drug has been extensively studied in Chinese hamster ovary (CHO) cells and has demonstrated significant activity against various types of cancer, including leukemia. Miproxifene acts as a protein inhibitor and has been found to be effective against several tumor cell lines. It is a promising medicinal compound for the treatment of cancer, with potential applications in both chemotherapy and radiation therapy. Miproxifene is excreted primarily through urine and is well-tolerated by patients. Its use as an anticancer agent holds great promise for the future of cancer treatment.</p>

<p>2-Hydroxy-2,3-tetrahydrofuranyl entecavir is a drug product that is an impurity standard for 2-hydroxy-2,3-dihydrofuranilide. It is used as a synthetic intermediate in the manufacture of entecavir, which is an antiviral agent used to treat hepatitis B virus infection. 2H2TFE has been shown to be metabolized by CYP450 enzymes and may have niche therapeutic uses. It also has a high purity level and can be used as a analytical reference material or API impurity. CAS No. 1984788-96-6</p>

<p>7-Chloro-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid ethyl ester is a synthetic compound that has not been evaluated in humans. Studies have shown that the drug can be hydrolyzed to 7-chloro-6-fluoroquinoline 1,1′-(ethylenedioxy)bis(ethane), which is an impurity of norfloxacin. The ethyl esters of 7-chloroquinoline are also known to condense with formaldehyde and hydrolyze to 7-chloroquinolinic acid. This product may contain solvents such as acetone, chloroform, and alcohols that are used during the synthesis process. Decarboxylation of the drug occurs when it is heated at high temperatures in the presence of a catalyst, such as pyridine or sodium methoxide. It decarboxyl</p>

<p>Methiotepa is a potent anticancer drug that has been used for the treatment of various types of tumors. It is a Chinese hamster ovary (CHO) cell-derived analog of chitin, which inhibits the activity of protein kinase C. Methiotepa induces apoptosis in cancer cells by inhibiting DNA synthesis and repair, leading to cell death. This drug has also been shown to be a potent inhibitor of heparin-induced platelet aggregation in human blood. Methiotepa has been found to be effective against a wide range of cancers, including breast, lung, ovarian, and bladder cancer, among others. Its use as an anticancer agent may be due to its ability to inhibit the activity of various kinases and other enzymes involved in cancer cell proliferation and survival.</p>

<p>CPI 0610 is a medicinal compound that acts as a potent inhibitor of protein phosphorylation. It has been shown to inhibit the cell cycle and promote apoptosis in Chinese hamster ovary cells. CPI 0610 is an effective inhibitor of kinase activity in cancer cells, leading to decreased tumor growth and increased survival rates. In preclinical studies, CPI 0610 has demonstrated efficacy against a wide range of cancers, including breast, prostate, and lung cancer. This inhibitor has also been shown to be effective in human cancer cell lines, making it a promising candidate for future cancer therapies.</p>

<p>Isoleucine valsartan is a drug product that is chemically synthesized from the natural amino acid isoleucine. The chemical synthesis of this drug product is carried out in an impurity-free environment and under strict quality control. Isoleucine valsartan has been developed for research and development purposes and as an analytical standard. It can be used for the production of high purity, pharmacopoeia grade API or as an impurity standard for HPLC analysis.</p>

<p>Ambrisentan is a drug product that is used in the treatment of pulmonary hypertension. Ambrisentan is metabolized to ambrisentan acyl β-D-glucuronide, a natural metabolite that has been synthesized as an analytical standard. It also shows antihypertensive activity and is currently under development for use in the treatment of heart failure.</p>

<p>2S-OMPT is a protein that is expressed in the cell. It is involved in transcriptional regulation, and can be assayed using k562 cells. 2S-OMPT has been shown to be associated with cancer. It also increases resistance to chemotherapeutic agents by inhibiting cation channels or inducing apoptosis of leukemia cells. 2S-OMPT may also play an important role in intracellular calcium ion concentrations, as it binds to the extracellular domain of sphingosine kinase and inhibits its activity. This inhibition leads to decreased levels of intracellular calcium ions, which may modulate chemokine production by chemoresistant cancer cells.</p>

<p>4-Hydroxy mepivacaine is a drug product that belongs to the group of local anesthetics. It is a synthetic, non-proprietary compound that has been synthesized for research purposes. 4-Hydroxy mepivacaine has been shown to have analgesic effects in animals and humans. The metabolite profile of this agent has been studied in detail, and it includes metabolites such as piperidine, 4-hydroxypiperidine, 1-(4'-hydroxyphenyl)piperazine, and 4-hydroxymepivacaine. Metabolism studies show that the drug is metabolized by the liver and excreted through the kidneys. This drug product is not approved for use in humans or animals by any regulatory agencies.</p>

<p>Phenproxide is an analog of testosterone that has been used traditionally in Chinese medicine to treat tumors. It has been found to induce apoptosis in cancer cells by inhibiting kinases, which are enzymes that regulate cellular processes such as cell division and growth. Phenproxide has also been shown to inhibit the activity of somatostatin, a hormone that regulates the release of other hormones. This inhibition may contribute to its anti-cancer properties. In addition, Phenproxide has been shown to have an effect on hyaluronan metabolism, a substance involved in tissue repair and inflammation. It is excreted in urine and may be used as a potential biomarker for cancer diagnosis or monitoring.</p>

<p>Fonofos is a potent inhibitor that has been shown to induce apoptosis in Chinese hamster ovary cells. It is also known to inhibit chitin kinase, a protein that plays an important role in the biosynthesis of chitin, which is essential for the formation of cell walls in fungi and insects. Fonofos has medicinal properties and has been studied as a potential anticancer agent due to its ability to inhibit tumor growth. In vitro studies have shown that Fonofos can inhibit the growth of human cancer cells by inhibiting heparin-binding proteins. Additionally, it has been found to have inhibitory effects on several other enzymes involved in cancer development and progression. Although not approved for use in humans, Fonofos may hold promise as a therapeutic agent for the treatment of certain cancers.</p>

<p>2-Methoxy-5-methyl-gamma-phenylbenzenepropanol is a synthetic compound that is used as an intermediate in the synthesis of coumarin derivatives. Reaction with sulfonating agents produces sulfones, and reaction with borohydride reagents produces boronates. The synthesis of 2-methoxy-5-methyl-gamma-phenylbenzenepropanol can be accomplished by the reduction of diphenyl ethers with lithium aluminum hydride or borohydride. The reduction can also be carried out using lanthanum oxide and potassium borohydride. The reaction proceeds smoothly at room temperature in nonpolar solvents.<br>2-Methoxy-5-methyl-gamma-phenylbenzenepropanol reacts with chloride to produce the corresponding chlorides, which are useful intermediates for the synthesis of tolterodine tartrate, a drug used to treat urinary inc</p>

<p>(3R,4R,5S)-Ethyl 4-(N-(tert-butyl)acetamido)-5-(diallylamino)-3-(pentan-3-yloxy)cyclohex-1-enecarboxylate is a synthetic metabolite of the drug etravirine. It is an impurity in the drug product. The impurity is characterized as a white to off-white crystalline solid with a molecular weight of 531.6 g/mol and melting point of 170°C. It is soluble in methanol, ethanol, acetone and chloroform, but insoluble in water. (3R,4R,5S)-Ethyl 4-(N-(tert-butyl)acetamido)-5-(diallylamino)-3-(pentan-3-yloxy)cyclohex-1-enecarboxylate can be synthesized from commercially available starting materials</p>

<p>Please enquire for more information about PBT Impurity 2 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>L-Isoleucine orlistat is a drug product that is an analytical standard and a natural product. It is used in research and development for the study of drug metabolism, and as an impurity standard for synthetic L-isoleucine. L-Isoleucine orlistat has CAS number 1072902-75-0 and Impurity Standard Number (ISN) 910.<br>L-Isoleucine orlistat is not a registered active pharmaceutical ingredient (API). It can be custom synthesized to meet the requirements of a particular application, such as high purity, pharmacopoeia grade, or USP HPLC grade.</p>

<p>(7Alpha,17Alpha)- 9,17-Dihydroxy-3-oxo-pregn-4-ene-7,21-dicarboxylic acid di-gamma-lactone is a synthetic analogue of progesterone. It is used as a drug product for research and development purposes. The product has been shown to be metabolized through the 3beta hydroxysteroid dehydrogenase pathway or the side chain cleavage enzyme pathways. This product has not been evaluated in humans and should not be used for any human applications. (7Alpha,17Alpha)- 9,17-Dihydroxy-3-oxo-pregn-4-ene-7,21 -dicarboxylic acid di gamma lactone is an impurity standard for HPLC analysis of progesterone in urine.</p>

<p>Sitagliptin monohydrochloride monohydrate is an inhibitor of dipeptidyl peptidase-4 (DPP-4), which is responsible for the degradation of incretin hormones. It is used in the treatment of type 2 diabetes mellitus, as it increases insulin secretion and reduces blood glucose levels. Recent studies have shown that Sitagliptin has anticancer properties, as it induces apoptosis in cancer cells. It also inhibits protein kinases, which are involved in tumor growth and metastasis. Capsaicin, a compound found in chili peppers, has been shown to enhance the anticancer activity of Sitagliptin in Chinese hamster ovary cells. The drug is excreted primarily through urine and has a low potential for drug interactions with other kinase inhibitors. Overall, Sitagliptin monohydrochloride monohydrate shows great promise as both a diabetes medication and an anticancer agent.</p>

<p>Please enquire for more information about Mycophenolate mofetil EP Impurity C including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Amlodipine EP Impurity F maleate is an impurity of amlodipine, a drug product. It is a natural substance that has been classified as an API impurity in the United States Pharmacopeia (USP). The chemical name for this drug is 3-(2-chlorophenyl)-1-methyl-5-(o-tolyloxy)-2,4-dihydro-6H-[1,3]thiazolo[3,2-a]pyrimidin-7-one. Amlodipine EP Impurity F maleate has the following properties: C12H9ClNO2S and a melting point of 210°C with a purity of 99.5%. This compound was synthesized by custom synthesis and is used as an analytical standard for HPLC. This compound was also used during the development of amlodipine to determine its metabolism studies.</p>

<p>Amiodarone impurity E is a nucleophilic compound that is synthesized by the acylation of a diazonium salt with an amine. It has been shown to be active against staphylococci, but not against subtilis. The reaction may be catalyzed by acid or chloride. Amiodarone impurity E is also demethylated and dehydrated to form the final product, amiodarone.</p>

<p>Please enquire for more information about Emtricitabine impurity 17 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Pantoprazole sulphide is a benzimidazole derivative that has been synthesized in an asymmetric synthesis. The purified compound was characterized by its nmr spectra, which showed the presence of the carboethoxy group and the chromatographic method. The compound belongs to a family of inhibitors known as benzimidazole derivatives and has shown inhibitory activity against a number of bacterial species including Staphylococcus aureus, Clostridium perfringens, and Mycobacterium tuberculosis. Pantoprazole sulphide has been used as an inhibitor to treat gastric acid pump disorders such as Zollinger-Ellison syndrome. It is also used for treating pathological conditions such as duodenal ulcers or gastroesophageal reflux disease.</p>

<p>Gentamicin Impurity</p>

<p>2,2',4,4',6,6'-Hexachlorobiphenyl (PCB-136) is a potent anticancer agent that has been shown to induce apoptosis in cancer cells. It acts as a kinase inhibitor by blocking the activity of specific kinases involved in tumor growth and progression. PCB-136 has been studied extensively in human and Chinese hamster ovary cells and has been found to be highly effective against various types of cancer. This medicinal analog also exhibits inhibitory effects on the protein kinases that regulate cell division and proliferation, making it a promising candidate for cancer therapy. In addition, PCB-136 shows potential for use as a urinary biomarker for exposure to environmental pollutants due to its persistence in the environment and ability to accumulate in body tissues.</p>

<p>7'-Methyl-2'-propyl-2,5'-bi-1H-benzimidazole (7'-MPB) is a benzimidazole derivative that is used as a medicine. It is made from recycled chemicals and has shown to have industrial applications as a catalyst for cyclization reactions. 7'-MPB is also used in the production of benzenesulfonic acid, which is an organic solvent. This chemical has been shown to be effective against high blood pressure, but has not been tested on humans yet. Telmisartan, which belongs to the angiotensin II receptor blocker class of drugs, can inhibit the synthesis of prostaglandins.</p>

<p>(-)-Sabinene is a natural compound found in urine and various medicinal plants, including Chinese herbs. It has been identified as an analog of another natural compound that exhibits potent anticancer activity. (-)-Sabinene has been shown to inhibit the activity of certain proteins involved in cell cycle regulation and apoptosis, which are important processes for the growth and survival of cancer cells. In addition, (-)-Sabinene has been found to have inhibitory effects on tumor kinase activity, making it a promising candidate for the development of new anticancer drugs. Studies have shown that (-)-Sabinene can effectively inhibit the growth of various types of cancer cells, making it a potential therapeutic agent for the treatment of cancer.</p>