Aminoácidos (AA)

Applications L-threo-α-Phenyl-2-piperidineacetamide-d10 is an labelled intermediate in the synthesis of labelled L-threo-Ritalinic Acid (R533132).
References Chavan, A.B. et al.: Otg. Proc. Res. Dev., 14, 1473 (2010);

Applications 2-Fluoro-4-methylbenzyl Bromide is used as a reagent in the synthesis of tetrahydrocarboline derivatives which can serve as inhibitors of ectonucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2). 2-Fluoro-4-methylbenzyl Bromide is also used as a reagent in the preparation of benzamide derivatives as angiogenesis inhibitors for treatment of cancer, metastasis.
References Ohata, A., et al.: PCT Int. Appl. WO 2012005227 A1 20120112. Jan 12, 2012; Koyano, H., et al.: PCT Int. Appl. WO 2005063689 A1 20050714. Jul 14, 2005

Applications L-Valine-d8-N-t-BOC (CAS# 153568-33-3) is a useful isotopically labeled research compound.

Applications 3-(3-Chloropropyl)-5-methylisoxazole, is a building block used in chemical synthesis of more complex compounds.

Impurity Ritonavir EP Impurity D
Applications [4-[(2-Amino-3-methyl-1-oxobutyl)amino]-2-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]-carbamic Acid 5-Thiazolylmethyl Ester, is an intermediate that can be used for the synthesis of Ritonavir (R535000), which is a selective HIV protease inhibitor.
References Daluge, S., et al.: Antimicrob. Agents Chemother., 38, 1590 (1994), Ammaranond, P., et al.: J. Clin. Virol., 26, 153 (2003), Harrigan, P., et al.: J. Infect. Dis., 191, 339 (2005), Miller, J., et al.: Bioorg. Med. Chem. Lett., 16, 1788(2006); Kempf, D., et al.: J. Med. Chem., 41, 602 (1998),

Applications An intermediate of Rosuvastatin (R700500).

Applications 4-Methylpyridine-2,6-diamine is a reactant in the preparation of N-(pyridin-2-yl) arylsulfonamides with potent 11β-hydroxysteroid dehydrogenase type 1 activity.
References Nair, S.K., et. al.: Bioorg. Med. Chem. Lett., 23, 2344 (2013)

Applications N-(2-Methylphenyl)-2-butenamide, is used as an intermediate in the synthesis of Crotamiton, which is a drug that can be used as scabicidal, and antipuritic (anti-itching drug).
References Hirota, M. et al.: Therp. Res., 34, 235 (2013);

Stability Light Sensitive
Applications A new chiral glycine equivalent; used for the preparation of enantiomerically pure α-tertiary and α-quaternary α-amino acids. ABacillus spore germination alanine analog.
References Yasuda, Y., et al.: Microb. Immun., 29(3), 229 (1985), Boatto, G., et al.: Chirality, 15, 494 (2003),

Applications alpha-Methylene-gamma-valerolactone (cas# 62873-16-9) is a useful research chemical.

Applications 2-Methyl-4,5,7-trichloroquinoline (cas# 203626-80-6) is a useful research chemical.

Applications N-[(2E)-6,6-Dimethyl-2-hepten-4-yn-1-yl]-N-methyl-2-naphthalenemethanamine-d3 hydrochloride is an labelled impurity of Terbinafine (T107500), an orally active, antimycotic allylamine and a specific inhibitor of squalene epoxidase.
References Petranyi, G., et al.: Science, 224, 1239 (1984); Ryder, N.S., et al.: Antimicrob. Agents Chemother., 27, 252 (1985); Evans, E.G.V., et al.: Br. Med. J., 318, 1031 (1999);

Applications 4-Methyl-4-nitro-1-pentene is an nitroalkane and a substituent in the synthesis of Clenhexerol (C572600), a classical β-adrenergic agonist in retina in interlaboratory study.
References Grenning, A. J., et al.: Org. Lett., 12, 740 (2010); Budzinska, A., et al.: Tetrahedron., 57, 2021 (2001);