Peptídeos

A synthetic peptide for use as a blocking control in assays to test for specificity of SLC25A6 antibody, catalog no. 70R-6466

Custom research peptide; min purity 95%.

A synthetic peptide for use as a blocking control in assays to test for specificity of ACOX3 antibody, catalog no. 70R-10180

A synthetic peptide for use as a blocking control in assays to test for specificity of PRMT3 antibody, catalog no. 70R-7898

A synthetic peptide for use as a blocking control in assays to test for specificity of LOC653428 antibody, catalog no. 70R-9057

This product contains disulfide bonds between Cys3-Cys14. Somatostatin is a hormone that regulates the release of growth hormones, insulin, and glucagon from the pancreas. It is widely expressed throughout the body for example in the gastrointestinal (GI) tract, hypothalamus, pancreas and the central nervous system. In the central nervous system somatostatin plays a role in neurotransmission modification and it has also demonstrated to be effective against a number of cancers such as squamous carcinoma.

MSH-Release Inhibiting Factor (MRIF) has been shown to be a potent inhibitor of the release of proinflammatory cytokines. It is derived from the acid methyl ester of mouse serum, and has been shown to inhibit the release of tumor necrosis factor-α (TNF-α) in animal studies. MRIF has also been shown to have anti-diabetic effects in mice. MRIF inhibits the production of inflammatory cytokines by blocking TNF-α at a molecular level. This protein binds to progesterone receptor and prevents it from interacting with its ligand, which is necessary for cancer cell growth. The expression system for this protein is E. coli, and it can be used as an immunosuppressant in animal studies.
MRIF also blocks TNF-α activity by inhibiting transcriptional activation of NFκB and AP-1, which are proteins that regulate gene expression.

A synthetic peptide for use as a blocking control in assays to test for specificity of CDH1 antibody, catalog no. 70R-6172

Amino-dPEG®11-ONH-t-boc is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Amino-dPEG®11-ONH-t-boc is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

A synthetic peptide for use as a blocking control in assays to test for specificity of GC antibody, catalog no. 70R-10252

A synthetic peptide for use as a blocking control in assays to test for specificity of SQLE antibody, catalog no. 70R-1955

A synthetic peptide for use as a blocking control in assays to test for specificity of FLJ44894 antibody, catalog no. 70R-8898

A synthetic peptide for use as a blocking control in assays to test for specificity of TRIM59 antibody, catalog no. 70R-1779

Phosphoramidon is a peptide that is used as a research tool. It has been shown to activate the protein kinase C, which plays a role in the regulation of ion channels and other cellular functions. Phosphoramidon binds to the receptor site of protein A and inhibits the binding of phosphorylated erythropoietin (EPO) to its receptor. EPO is an important hormone for red blood cell production.

A synthetic peptide for use as a blocking control in assays to test for specificity of PTPN2 antibody, catalog no. 70R-6410

A synthetic peptide for use as a blocking control in assays to test for specificity of PARP12 antibody, catalog no. 70R-3371

A synthetic peptide for use as a blocking control in assays to test for specificity of DDX28 antibody, catalog no. 70R-5025

A synthetic peptide for use as a blocking control in assays to test for specificity of SDF2 antibody, catalog no. 70R-1569

Bombesin is a small peptide that was first isolated from the skin of a frog, Bombina bombina, with homologs later found to be present in mammalian tissues, including the brain and gastrointestinal tract. It is a member of the bombesin-like peptide family, which includes several related peptides such as gastrin-releasing peptide (GRP) and neuromedin B.
Bombesin acts as a neuromodulator and regulates various physiological functions, including gastrointestinal motility and stimulation of gastrin release from G cells. It also plays a role in the regulation of cardiovascular function and neurotransmitter release. In addition, bombesin has been shown to stimulate the growth and proliferation of certain types of cancer cells, including prostate and lung cancer cells, through its interaction with bombesin receptors. It may therefore be used as a potential biomarker for certain cancers.

A synthetic peptide for use as a blocking control in assays to test for specificity of BIVM antibody, catalog no. 70R-3963

A synthetic peptide for use as a blocking control in assays to test for specificity of HELB antibody, catalog no. 70R-1359

A synthetic peptide for use as a blocking control in assays to test for specificity of USP2 antibody, catalog no. 70R-9738

A synthetic peptide for use as a blocking control in assays to test for specificity of AARS antibody, catalog no. 70R-4697

A synthetic peptide for use as a blocking control in assays to test for specificity of XAGE2 antibody, catalog no. 70R-9927

A synthetic peptide for use as a blocking control in assays to test for specificity of hCG_1646157 antibody, catalog no. 70R-9035

A synthetic peptide for use as a blocking control in assays to test for specificity of KLK6 antibody, catalog no. 70R-2466

A synthetic peptide for use as a blocking control in assays to test for specificity of C12orf4 antibody, catalog no. 70R-3506

A synthetic peptide for use as a blocking control in assays to test for specificity of DHX15 antibody, catalog no. 70R-4690

A synthetic peptide for use as a blocking control in assays to test for specificity of ATG4A antibody, catalog no. 70R-2866

A synthetic peptide for use as a blocking control in assays to test for specificity of PI3 antibody, catalog no. 70R-7381

A synthetic peptide for use as a blocking control in assays to test for specificity of PHF11 antibody, catalog no. 70R-8322

MAL-dPEG®24-TFP Ester is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. MAL-dPEG®24-TFP Ester is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

A synthetic peptide for use as a blocking control in assays to test for specificity of ZNF662 antibody, catalog no. 70R-9026

A synthetic peptide for use as a blocking control in assays to test for specificity of OAT antibody, catalog no. 70R-5318

Amyloid β (42- 1) SCR is a peptide that inhibits the interaction of amyloid β with its receptor, which may be useful for research purposes. Amyloid β (42- 1) SCR is an inhibitor that prevents the binding of amyloid β to its receptors. This peptide is a high purity product and has been shown to be effective in inhibiting the interaction between amyloid beta and its receptor.

MAL-dPEG®4-(m-dPEG®4)3 is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. MAL-dPEG®4-(m-dPEG®4)3 is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

A synthetic peptide for use as a blocking control in assays to test for specificity of C7orf38 antibody, catalog no. 70R-7005

A synthetic peptide for use as a blocking control in assays to test for specificity of GNAO1 antibody, catalog no. 70R-5233

A synthetic peptide for use as a blocking control in assays to test for specificity of ATP2B3 antibody, catalog no. 70R-6327

A synthetic peptide for use as a blocking control in assays to test for specificity of DSC3 antibody, catalog no. 70R-6132

NY-ESO-1 (157-165) peptide – SLLMWITQC

A synthetic peptide for use as a blocking control in assays to test for specificity of DDT antibody, catalog no. 70R-2944

Anti ATP Receptor P2X4 (370-388) (Rat) Serum is an antibody that binds to the extracellular domain of the P2X4 receptor. The antibody has been shown to inhibit the ATP-induced increase in intracellular calcium levels. It is a research tool for studying the function of P2X4 receptors and ion channels. It is also used as an inhibitor in pharmacology, cell biology, and protein interactions. Anti ATP Receptor P2X4 (370-388) (Rat) Serum has a CAS number of 12056-07-8.

Centromere protein B (CENP-B) is a protein that belongs to the histone H3 family. It is one of the proteins involved in regulating chromosome segregation during mitosis and meiosis. CENP-B has been shown to be involved in the activation of kinetochores, which are structures on the surface of chromosomes that attach to microtubules and help with mitotic chromosome movement. Centromere protein B can also be used as a ligand or receptor, or a tool for cell biology, immunology, and pharmacology research.

A synthetic peptide for use as a blocking control in assays to test for specificity of TGFB2 antibody, catalog no. 70R-6336

A synthetic peptide for use as a blocking control in assays to test for specificity of ZNF682 antibody, catalog no. 70R-8400

A synthetic peptide for use as a blocking control in assays to test for specificity of ANXA13 antibody, catalog no. 70R-1675

A synthetic peptide for use as a blocking control in assays to test for specificity of TBC1D13 antibody, catalog no. 70R-4389

A synthetic peptide for use as a blocking control in assays to test for specificity of PCGF1 antibody, catalog no. 70R-4454

A synthetic peptide for use as a blocking control in assays to test for specificity of Tmem33 antibody, catalog no. 70R-8682

A synthetic peptide for use as a blocking control in assays to test for specificity of UST antibody, catalog no. 70R-1825

A synthetic peptide for use as a blocking control in assays to test for specificity of GTF2B antibody, catalog no. 70R-9578

A synthetic peptide for use as a blocking control in assays to test for specificity of CAMK2B antibody, catalog no. 70R-10278

A synthetic peptide for use as a blocking control in assays to test for specificity of CARS antibody, catalog no. 70R-4848

Alyerserin-2a is a C-terminally α-amidated 17 residue cationic anti-microbial peptide (AMP). Anti-microbial peptides (AMPs) are produced by the innate immune system and are expressed when the host is challenged by a pathogen. The Alyerserin family of peptides was first identified in norepinephrine-stimulated skin secretions of the midwife toad-Alytes obstetricans-(Alytidae). Alyteserin-2a, 2b and -2c show some sequence identity with bombinin H6, a peptide from the skins Bombinatoridae family of frogs.Alyteserin-2a is most potent against the Gram-positive bacteria-Staphylococcus aureus and has weak haemolytic activity against human erythrocytes.Alyteserin contain at least 50% hydrophobic amino acids. Hydrophobic residues contribute to the insertion of the peptide into the hydrophobic membrane core which results in membrane disruption and death of the pathogen. Due to their mechanism of action it is thought to be less likely for resistance to develop towards them compared to conventional antibiotics. Alyteserin-2a has the tendency to adopt an α-helical conformation between residues 9-14 when in membrane-mimetic solvent.

Light chain of the bevacizumab monoclonal antibody, sold as the antitumour therapeutic Avastin. It prevents vascular endothelial growth factor (VEGF) from binding to VEGF receptors 1 and 2 thus inhibiting angiogenesis in tumours.

A synthetic peptide for use as a blocking control in assays to test for specificity of AKAP7 antibody, catalog no. 70R-2673

(Arg)9 is an cell-penetrating peptide made up of 9 arginine residues capable of traversing plasma membranes. It has been shown that Arg9 destabilize and disrupt the phospholipid bilayer allowing flow of ions across the membrane. (Arg)9 peptide plays an important role in efficient cellular uptake. The guanidinium group is a critical structural determinant for tight and rapid interactions with cell membrane. The cationic guanidinium group can form electrostatic interactions with anionic cell membranes components such as phospholipids and sulphated proteoglycans. This interaction can trigger the activation of specific intracellular signalling and cell internalization via various pathways. (Arg)9 peptide is used to deliver a variety of functionally active cargos such as peptides, small interfering RNA, oligonucleotides, plasmid DNA and liposomes into mammalian cells and plant cells with high translocation efficiency. (Arg)9 peptide can also be used to form chemical linkages with the cargo and act as a carrier peptide.

A synthetic peptide for use as a blocking control in assays to test for specificity of TBC1D1 antibody, catalog no. 70R-2415

A synthetic peptide for use as a blocking control in assays to test for specificity of CD38 antibody, catalog no. 70R-9672

A synthetic peptide for use as a blocking control in assays to test for specificity of ZFP14 antibody, catalog no. 70R-8959

A synthetic peptide for use as a blocking control in assays to test for specificity of MB antibody, catalog no. 70R-2242

MAGE-A1 protein:
MAGE-A1 (278-286) is an epitope of Melanoma Antigen Gene A1 expressed by tumors of different histological types such as on the surface of breast carcinoma cell and is a Cancer/Testis Antigens (CTA). MAGE-A1 is a tumor antigen expressed in 40% of melanoma and contains epitope for binding HLA-A*02:01 molecules and that are recognized by cytotoxic T cells.
Applications of MAGE-A1 (278-286):
MAGE-A1 (278-286) is used to stimulate specific cytotoxic T cells in PBMCs and to analyze by ELISPOT peptide epitope specificity and cytokine production like IFN-γ. Immunogenicity of MAGE-A1 (278-286) raised the possibility of developing anticancer immunotherapies or vaccinations. MAGE-A1 is also expressed in lung adenocarcinoma and studies suggest that MAGE-A1 may serve to develop Chimeric Antigen Receptor (CAR) T cell therapy using lentiviral vector and show an encouraging tumor-inhibitory efficacy.

A synthetic peptide for use as a blocking control in assays to test for specificity of ZNF322A antibody, catalog no. 70R-8375

A synthetic peptide for use as a blocking control in assays to test for specificity of ZNF786 antibody, catalog no. 20R-1235

A synthetic peptide for use as a blocking control in assays to test for specificity of ADH1A antibody, catalog no. 70R-3919

A synthetic peptide for use as a blocking control in assays to test for specificity of LIPA antibody, catalog no. 70R-10242

A synthetic peptide for use as a blocking control in assays to test for specificity of ARHGAP19 antibody, catalog no. 70R-10160

A synthetic peptide for use as a blocking control in assays to test for specificity of Gm527 antibody, catalog no. 70R-9128

A synthetic peptide for use as a blocking control in assays to test for specificity of TAF7L antibody, catalog no. 20R-1187

HG1 toxin is a peptide that is found in the venom of the scorpion Heterometrus fulvipes. It is a member of the short-chain scorpion toxins, which are composed of a single chain of amino acids. This protein has been shown to bind to potassium channels and inhibit their function, leading to paralysis of the prey's nervous system. HG1 toxin has been shown to be able to activate or inhibit ion channels and other receptors. It can also bind to ligands such as peptides or antibodies and affect cellular activity. HG1 toxin is produced by recombinant DNA technology and purified by HPLC for use in biochemical research and pharmacological studies.

A synthetic peptide for use as a blocking control in assays to test for specificity of TMEM79 antibody, catalog no. 70R-6744

A synthetic peptide for use as a blocking control in assays to test for specificity of CCDC19 antibody, catalog no. 70R-4111

A synthetic peptide for use as a blocking control in assays to test for specificity of SDHB antibody, catalog no. 70R-2436

α7 nAChR selective blocker

Omega-Conotoxin MVIIA is a neurotoxin that inhibits voltage-dependent calcium channels and has been shown to be effective against neuropathic pain, chronic pain, and inflammatory pain. The long-term efficacy of this drug is due to its ability to block cytosolic calcium, which leads to the activation of neurotrophic factors. Omega-Conotoxin MVIIA binds to specific protein targets and inhibits ion channel activity in neurons. This toxin can also inhibit the production of proinflammatory cytokines by blocking the activation of NF-κB through intracellular targets. Omega-Conotoxin MVIIA has been shown to have a wide range of therapeutic potentials, including as an analgesic for acute and chronic pain, as an anti-inflammatory agent, and as a neuroprotective agent for treating neuronal degeneration.

H-Thr-Glu-OH is a nucleotide that is a component of RNA. It is one of the 20 natural amino acids and it is found in proteins as well as in RNA molecules. H-Thr-Glu-OH can be synthesized by hydrolysis of proteins with an enzyme called glutamic acid hydrolase. H-Thr-Glu-OH has been shown to have a high affinity for lysine, which has been shown to be required for the enzymatic activity of many protein enzymes. This amino acid can also be found in large quantities in cheese, soy sauce, and yogurt.

A synthetic peptide for use as a blocking control in assays to test for specificity of MARVELD3 antibody, catalog no. 70R-6394

α-Defensin-1, human is a peptide that belongs to the class of defensins. It is an activator of ion channels and a ligand for receptors. α-Defensin-1, human also inhibits protein interactions with the receptor. It is purified to high purity and has CAS number 99287-08-8. This product can be used as a research tool in cell biology and pharmacology.

A synthetic peptide for use as a blocking control in assays to test for specificity of MOBKL2A antibody, catalog no. 70R-9186

A synthetic peptide for use as a blocking control in assays to test for specificity of FAH antibody, catalog no. 70R-2625

A synthetic peptide for use as a blocking control in assays to test for specificity of ZNF681 antibody, catalog no. 70R-9108

A synthetic peptide for use as a blocking control in assays to test for specificity of CXorf20 antibody, catalog no. 70R-4187

A synthetic peptide for use as a blocking control in assays to test for specificity of KRR1 antibody, catalog no. 70R-4702

A synthetic peptide for use as a blocking control in assays to test for specificity of CCL5 antibody, catalog no. 20R-1137

A synthetic peptide for use as a blocking control in assays to test for specificity of ZIM3 antibody, catalog no. 70R-8107

A synthetic peptide for use as a blocking control in assays to test for specificity of PGAM2 antibody, catalog no. 70R-4102

A synthetic peptide for use as a blocking control in assays to test for specificity of LGALS14 antibody, catalog no. 70R-3934

A synthetic peptide for use as a blocking control in assays to test for specificity of ZCCHC17 antibody, catalog no. 70R-4746

A synthetic peptide for use as a blocking control in assays to test for specificity of TTC27 antibody, catalog no. 70R-9467

A synthetic peptide for use as a blocking control in assays to test for specificity of Slc16a3 antibody, catalog no. 70R-8575

A synthetic peptide for use as a blocking control in assays to test for specificity of HCCS antibody, catalog no. 70R-10236

A synthetic peptide for use as a blocking control in assays to test for specificity of CLCNKB antibody, catalog no. 70R-5147

A synthetic peptide for use as a blocking control in assays to test for specificity of TMEM123 antibody, catalog no. 70R-7328

A synthetic peptide for use as a blocking control in assays to test for specificity of MCM7 antibody, catalog no. 70R-1621

A synthetic peptide for use as a blocking control in assays to test for specificity of SOD2 antibody, catalog no. 70R-5749

A synthetic peptide for use as a blocking control in assays to test for specificity of GOT2 antibody, catalog no. 70R-1561

A synthetic peptide for use as a blocking control in assays to test for specificity of CRLF1 antibody, catalog no. 70R-5737

A synthetic peptide for use as a blocking control in assays to test for specificity of TMEM161B antibody, catalog no. 70R-7081