
Peptídeos
Subcategorias de "Peptídeos"
Foram encontrados 29780 produtos de "Peptídeos"
Ac-GRGDSP-NH2
Peptide Ac-GRGDSP-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.LCBiot-RAHEEIYHFFFAKKK-OH
Peptide LCBiot-RAHEEIYHFFFAKKK-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Click SynB3
SynB3 is a cell-penetrating peptide (CPP) with high efficacy at crossing the cell membrane with no significant toxicity. SynB3, like other CPPs, can cross the blood-brain barrier (BBB). Although the mode of crossing remains unclear, synB3 has been conjugated to a few cargoes and shown to be adequately present in the brain. Synb3 provides promise for the delivery of antisense oligonucleotides as therapy for conditions such as Duchenne muscular dystrophy (DMD) and spinal muscular atrophy (SMA). The treatment of these conditions has been hampered by the lack of cargo delivery methods that can be tissue-specific and cross the BBB. SynB3 in mouse models was shown to be an effective method of delivering therapeutics across the BBB for SMA treatment.SynB3 is labelled at the N-terminus with an alkyne attachment for ease of reaction with an opposite Click reactive partner (azide). Azide-alkyne cycloaddition has become the most popular Click reaction. Alkyne-synB3 allows various applications, particularly for protein conjugation, modification, and drug delivery.
Cor e Forma:PowderPeso molecular:1,474.8 g/molH-DAVTYTEHAK^-OH
Peptide H-DAVTYTEHAK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
Serum Amyloid A protein
Serum Amyloid A protein is a custom research peptide; min purity 95%, TFA salt. For different specs please use the Peptide Quote ToolMOCAc-Pro-Cha-Gly-Nva-His-Ala-Dap(Dnp)-NH2
MOCAc-Pro-Cha-Gly-Nva-His-Ala-Dap(Dnp)-NH2 is a peptide that inhibits the activity of various proteases, including collagenase, MMPs and stromelysin. It has been shown to inhibit cancer cells in vitro and to reduce tumor growth in vivo. MOCAc-Pro-Cha-Gly-Nva-His-Ala-Dap(Dnp)-NH2 may be useful for the treatment of angiogenesis and metastasis, which are hallmarks of cancer. MOCAc is an inhibitor of matrix metalloproteinases (MMPs), which are enzymes that break down the extracellular matrix and basement membrane during tissue remodeling. MOCAc inhibits both type I (collagenases) and type II (gelatinases) collagenase activity, as well as other proteolytic activities such as stromelysin or elastFórmula:C51H65N8O13Pureza:Min. 95%Peso molecular:1,100.16 g/molBiot-PICTF-OH
Peptide Biot-PICTF-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.H-IAVSYQTK^-OH
Peptide H-IAVSYQTK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Ac-CGVNNSNEDFREENLKTAN-NH2
Peptide Ac-CGVNNSNEDFREENLKTAN-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Ac-IEGR-OH
Peptide Ac-IEGR-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.H-FASFIER^-OH
Peptide H-FASFIER^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.LL-17-32
This peptide represents the anti-microbial domain of the LL-37 peptide. LL-37 is a member of the large cationic family of anti-microbial peptides called cathelicidins which have broad-spectrum anti-microbial activity and are expressed in many species. The only cathelicidin found in humans is LL-37- this is produced in epithelial cells, by proteolytic cleavage from the C-terminal of the hCAP-18 protein. LL-37 can be processed into different forms of anti-microbial peptides. As well as its anti-microbial properties LL-37 also has anti-cancer properties and regulates many aspects of the innate immune system, overexpression of LL-37 has been linked to autoimmune diseases such as asthma and psoriasis.Peso molecular:2,044.2 g/molH-FSSE-OH
Peptide H-FSSE-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Pureza:Min. 95 Area-%Peso molecular:468.46 g/molH-A^Q-OH
Peptide H-A^Q-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.H-LPSEFDLSAFLR^-OH
Peptide H-LPSEFDLSAFLR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
Des-[Gly77,His78] Myelin Basic Protein (68-84), bovine
CAS:Custom research peptide; min purity 95%. For different specs please use the Peptide Quote ToolFórmula:C73H115N23O26Peso molecular:1,730.87 g/molAc-Rph-NH2
Peptide Ac-Rph-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
H-YQAIFDNTTSLTDK^-OH
Peptide H-YQAIFDNTTSLTDK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.AIP-II
Auto-inducing peptide (AIP) is a cyclic thiolactone quorum sensing peptide from Staphylococcus aureus which is responsible for activating the agr response. AIP is released from the bacteria and its extracellular concentration is then sensed by a two-component system on the bacterial surface, AgrC and AgrA. AgrC is the membrane histidine kinase receptor and AgrA is a response regulator- upon binding of AIP, AgrC phosphorylates AgrA.AIP accumulates during growth activating an AgrC and AgrA cascade when it reaches a critical signal level. This cascade activates P2 and P3 promoters which autoactivate the agr system and upregulate RNAIII transcription. RNAIII regulates the expression of virulence factors including toxins, super-antigens, and exo-enzymes. Extensive research to identify AIP:AgrC inhibitors aims to find therapeutics against pathogens.AgrD is the precursor peptide of AIP, and AgrB is an integral membrane endopeptidase essential to biosynthesize AIP. This AIP system is conserved among many Gram-positive bacteria. S. aureus strains are categorized into four groups (I-IV) according to their AIP signal and cognate extracellular receptor, AgrC.AIP-II has the conserved thiolactone macrocycle of the AIP family. Asn-3, Leu-8, and Phe-9 have been shown to be critical for activation of the agr response while inhibition relies on Leu-8 and Phe-9. The reactive thiol ester bond is only necessary for activation of the agr response. Further work may provide further AIP:AgrC inhibitors.Cor e Forma:PowderPeso molecular:878.4 g/molH-YTFELSR^-OH
Peptide H-YTFELSR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Orexin A (monkey)
Orexin A is one of two closely related peptides- the orexins (also known as hypocretins). These small neuropeptides are secreted from orexin-containing neurons, located mainly in the lateral hypothalamus (LH). Orexins function via the binding and activation of two G-protein-coupled receptors (GPCRs)- orexin receptor type 1 (OX1R) and 2 (OX2R).Orexins play several vital roles in a range of physiological activities, including: circadian rhythm, feeding behaviour, energy balance, glucose metabolism, neuroendocrine functions, stress-adaptive responses and reward and addiction. Orexins have also been linked to the pathological processes of neurological diseases such as: narcolepsy- depression- ischemic stroke- drug addiction and Alzheimer's disease.This Orexin A peptide contains two disulphide bridges, one between cysteine 7 and cysteine 13, and the other between cysteine 8 and 15. Orexin-A appears to be the isoform most important for the feeding response.Peso molecular:3,813 g/molBMP 4 Human
BMP 4 Human is a recombinant human protein that is a member of the TGF-β superfamily. It interacts with Ligand, Receptor, and Activator and has been shown to inhibit Ion channels in vitro. BMP 4 Human is a research tool for studying signaling pathways in pharmacology and cell biology.Pureza:>95% By Sds-Page And Rp-HplcSkeletal muscle-targeted peptide MSP
Gene therapy is potentially an ideal treatment for muscle tissue myopathies but targeting remains an issue. The large volume of muscle in the body versus the requirement for tissue-specificity is of particular concern. This heptapeptide has been shown to preferentially bind skeletal myofibers and thus can be used to study targeting of peptide/gene-delivery to muscle tissue. Research into gene therapy of Duchenne muscular dystrophy (DMD) and spinal muscular atrophy (SMA) has been of particular interest with muscle targeting peptides. This product already shows ideal placement to continue that research to overcome some of these issues.Peso molecular:674.4 g/molShepherdin (79 - 87)
Shepherdin is an antagonist of the interaction between the apoptosis protein, survivin, and the molecular chaperone, heat shock protein 90 (Hsp90). The sequence of shepherdin corresponds to the site where Hsp90 binds to survivin. Shepherdin therefore has high affinity for Hsp90 and thus disrupts survivin binding and acts as an inhibitor of Hsp90 ATPase function by competing with ATP.The survivin-Hsp90 complex is a regulator of cell proliferation and cell viability in cancer tissue. Shepherdin has anti-cancer properties and can significantly suppress the growth of lung cancer cell lines and acute myeloid leukaemia (AML) by inducing apoptosis.Cor e Forma:PowderPeso molecular:948.4 g/molH-ADIYTEQVGR^-OH
Peptide H-ADIYTEQVGR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.H-NSILTETLHR^-OH
Peptide H-NSILTETLHR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.CMVpp65 - 33 (HHYPSAAERKHRHLP)
Custom research peptide; min purity 95%. For different specs please use the Peptide Quote ToolPeso molecular:1,836.1 g/molBiotin-Nrf2 (69-84)
Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) and its negative regulator Kelch-Like ECH-Associated Protein 1 (Keap1) provide vital protection in maintaining cellular redox. In parallel, Nrf2 also aids the resolution of inflammation and also tissue repair. In homeostatic conditions, the transcription factor Nrf2 is controlled in a cytoplasmic complex with Keap1 with ubiquitination and protein degradation. Nrf2 has been linked to numerous cancers due to mutations affecting the binding region of Nrf2 to Keap1, resulting in Nrf2 dissociating from the complex. Nrf2 constitutively accumulates in the nucleus and activation of prosurvival genes that promote cancer cell proliferation.The Neh2 region of Nrf2 interacts with Keap1, as shown by nuclear magnetic resonance spectroscopy. The 16 amino acid peptide (AFFAQLQLDEETGEFL) (69-84) flanks the conserved ETGE motif and can replicate the binding to keap1.Therapeutics targeting the Nrf2 signalling pathway and activation of Nrf2 is a keen area of research, with many cancers being linked to Nrf2, particularly pancreatic cancer. Additionally, activation of Nrf2 has become a possible target as a treatment for COVID. Nrf2 (69-84) replicating full-length Nrf2 binding has been helpful in all cases. This Nrf2 (69-84) contains a covalently bonded N-terminal Biotin tag that can be used for detection and purification. If you would prefer the simple peptide, Nrf2 (69-84), it is available from our catalogue.Cor e Forma:PowderPeso molecular:2,083 g/molH-EVYDFAFR^-OH
Peptide H-EVYDFAFR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.3x FLAG peptide
The synthetic canonical Flag sequence has been shown to be most effective with the Asp-Tyr-Lys-Xaa-Xaa-Asp motif triplicated for applications in protein analysis followed by the eight amino acids at the C-terminus of the classic FLAG sequence (Asp-Tyr-Lys-Asp-Asp-Asp-Asp-Lys). Due to the hydrophilic nature of the peptide the Flag tag typically resides on the surface of the recombinant protein thus minimising any effects on the function or transport of the fusion protein. The tag can be used in conjunction with other tags such as HA or myc depending on the application. FLAG is an artificial antigen to which high affinity monoclonal antibodies have been raised, therefore allowing for highly effective protein purification by affinity chromatography as well as accurate localisation of FLAG tagged proteins within living cells, or Western blots. FLAG peptide can be used to effectively purify complexes with multiple proteins as its mild purification procedure tends not to disrupt such complexes. It can be used to obtain proteins of sufficient purity for x-ray crystallography. The 3 x Flag peptide provides powerful detection and purification of recombinant proteins that has been characterised in numerous applications including affinity chromatography, binding assays and structural analysis.Peso molecular:3,649.8 g/mol[5-FAM] Histone H3 (1-14) K4Me3
Histone H3 (1-14) K4Me3 is derived from Histone 3 (H3) which is one of the four core histones (H2A, H2B, H3 and H4) fundamental in compacting eukaryotic DNA into the nucleosome. The nucleosome arises when 147 base pairs of DNA wrap around a H3-H4 tetramer and two H2A-H2B dimers, forming the histone octamer core. Both H4 and H3 are highly conserved and perform roles in binding to segments of DNA which enter and leave the nucleosome and in chromatin formation. Similar to the other core histone, H3 has a globular domain and a flexible N-terminal domain, 'histone tail' which can undergo modifications such as acetylation, methylation, phosphorylation and ubiquitination. Due to histones containing a large number of lysine and arginine residues they have a positive net charge which interacts in an electrostatic manner with the negatively charged phosphate groups in DNA. The transcriptional activation or silencing of the chromatin is controlled by ATP-dependent chromatin remodelling factors and histone modifying enzymes which target histone proteins. Both processes function to alter to change the positioning of the nucleosome, allowing the DNA it to be either available to the transcription machinery or inaccessible.The Histone H3 (1-14) lysine 4 has been trimethylated and contains 5-Carboxyfluorescein (5-FAM), a widely used green fluorescent tag.Cor e Forma:PowderPeso molecular:1,888 g/molSLC6A14 Blocking Peptide
A synthetic peptide for use as a blocking control in assays to test for specificity of SLC6A14 antibody, catalog no. 70R-6568Pureza:Min. 95%ANP (7-23)
ANP (7-23) is derived from the atrial natriuretic peptide (ANP) which is a cardiac hormone involved in maintaining cardio-renal homeostasis. This occurs through the activation of the guanylyl cyclase-coupled receptor, resulting in the increased concentration of cyclic guanylate monophosphate. Moreover its function in the processes of anti-proliferation and anti-angiogenesis allow it to take part in the cardiovascular remodelling process.ANP is a member of the natriuretic peptide family and it is encoded by the NPPA gene, located on chromosome 1. Once synthesized from the 151 amino acid pre-prohormone into its biologically active form, ANP is secreted by the atrial cardiomyocytes in the circulating forms: ANP (1-98) and ANP (99-126). This synthesis process involves the signal peptide being removed from the pre-prohormone resulting in proANP (1-126) which is converted into the circulating forms by the type II transmembrane serine protease Corin.Cor e Forma:PowderPeso molecular:1,724.8 g/molGLP-1 (1-37)
CAS:Glucagon-like peptide (GLP) 1 is a post-translationally modified version of proglucagon. GLP-1 (1-37) is a naturally produced analog of GLP-1. Unlike truncated GLP-1, GLP-1 (1-37) does not alter food intake in rat models or pancreatic insulin secretion. GLP-1 (1-37) can induce insulin production in developing adult intestinal cells via upregulation of the ngn3 gene and its downstream targets. This can restore glucose homeostasis when implanted into diabetic mice. GLP-1 (1-37) may offer a future treatment for diabetes mellitus. GLP-1 (1-37) can also inhibit chemokine-induced migration of human CD4-positive lymphocytes, an early step in atherogenesis. This raises the possibility that GLP-1 (1-37) is part of a novel mechanism to modulate vascular disease.Peso molecular:4,169.54 g/molN-formylated PSMalpha2
Pathogenic Staphylococcus aureus strains produce N-formylmethionyl containing peptides. Peptides starting with an N-formylated methionyl group constitute a unique hallmark of bacterial as well as mitochondrial metabolism, and professional phagocytes of our innate immune system recognise this microbial/mitochondrial pattern as a danger signal that guides innate immune cells.All PSMα peptides have the same basic functions and promote virulence through effects on discrete neutrophil functions (i.e. chemotaxis) and by being cytotoxic at higher concentrations. PSMα2 and PSMα3 can both bind to FPR2 and trigger superoxide release in neutrophils at low nanomolar concentrations. In addition, at high nanomolar concentrations they display cytotoxicity selectively on apoptotic neutrophil membranes and this occurs in an FPR2 independent manner.Cor e Forma:PowderPeso molecular:2,304.4 g/molBiotin-Jak2 substrate
This peptide is phosphorylated by Janus kinase 2 and 3 (JAK2 and JAK3) and is an ideal substrate for use in kinase assays. The JAK family of kinases is essential for the signalling of a host of immune modulators in tumour, stromal, and immune cells where they are highly expressed. JAK family proteins mediate the signalling of the interferon (IFN), IL-6, and IL-2 families of cytokines.JAK kinases are associated with cytokine receptors. Cytokine binding to these receptors results in activation of JAK kinases and receptor phosphorylation. Phosphorylated cytokine receptors recruit STAT proteins, which are then phosphorylated by the activated JAK kinases. Phosphorylated STAT proteins form homo- and hetero-dimers that translocate into the nucleus and function as transcription factors.This peptide contains an N-terminal biotin tag for easy detection and purification.
Cor e Forma:PowderPeso molecular:1,782.96 g/molMyelin Basic Protein (111-129)
The myelin sheath which is located in both the Central Nervous System (CNS) and the Peripheral Nervous System is crucial for neural insulation and the salutatory conduction of nerve impulses. When this myelin sheath is destroyed neurodegeneration and conduction failure occur and theses occurrences can be observed in demyelinating diseases in the CNS such as: acute disseminated encephalomyelitis and multiple sclerosis and within the PNS: Guillain–Barré syndrome and Charcot–Marie–Tooth disease.Myelin Basic Protein (MBP) from which this product is derived is the second most abundant protein in myelin. It has been found to be an intrinsically disordered protein and depending on the environmental conditions it can change its conformation. It also folds into ⍺-helical structures which allow MBP to bind tightly to lipid bilayer surfaces. MBP also interacts with other proteins, namely cytoskeletal proteins and calmodulin and may be involved in signalling pathways. Although more research needs to be carried out, it is thought that MBP significantly contribute to the pathogenesis of multiple sclerosis. As MBP is an autoantigen it can be recognized and cleaved by autoantibodies and is a substrate for the immunoproteasome. Additional research has found that post-translational modifications of MBP such as the removal of arginine are increased and may be involved in the pathogenesis of multiple sclerosis. Therefore this protein derived from MBP can be used to mimic Neurodegenerative disease phenotypes in research and animal models. One-Letter Formula: LSRFSWGAEGQRPGFGYGGFórmula:C92H129N27O26Pureza:Min. 95%Peso molecular:2,029.22 g/molAc-GAQGHTVEK-OH
Peptide Ac-GAQGHTVEK-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.BDC2.5 mimotope 1040-51
BDC2.5 mimotope 1040-51 is a mimotope of BDC2.5 T cells which can recognise glutamic acid decarboxylase epitopes.Cor e Forma:PowderPeso molecular:1,297.7 g/molH-GNQWVGYDDQESVK^-OH
Peptide H-GNQWVGYDDQESVK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.[5-FAM]-(RFR)4XB
(RXR)4XB is a cationic membrane-penetrating peptide and is effective in delivering phosphorodiamidate morpholino oligonucleotides (PMOs) into eukaryotic cells such as Escherichia coli. It contains 5-carboxyfluorescein (5-FAM), a widely used green fluorescent tag.Peso molecular:2,396.3 g/molGhrelin Rat, Mouse
Ghrelin is involved in several physiological processes, including feeding and lipid accumulation, stress response, anxiety, cardiac performance, immunity and inflammation, taste sensation, reward-seeking behaviour, regulation of glucose metabolism and thermogenesis, memory, motivation and learning.Ghrelin is a peptide hormone that typically has a serine at the third residue and relies on modification with a fatty acid to give ghrelin its functional activity. In its modified form, ghrelin is an endogenous ligand for the pituitary gland's growth hormone receptor (GHS-R) and stimulates growth hormone release. Rat/mouse ghrelin differs from the human form at positions 11 and 12 (RV) in rats to (KA) in humans.Ghrelin acts on the hypothalamic arcuate nucleus as an orexigenic agent to stimulate appetite. Ghrelin is produced in the stomach as a precursor peptide preproghrelin, cleaved to ghrelin. Ghrelin circulates in the blood and can cross the blood-brain barrier. Levels of ghrelin respond to fasting conditions and allow signals about the energy status to be transmitted from the peripheral organs to the central nervous system to maintain energy homeostasis.Ghrelin is a valuable target for treating conditions such as anorexia, cachexia, sarcopenia, cardiopathy, neurodegenerative disorders, renal and pulmonary disease, gastrointestinal disorders, inflammatory disorders and metabolic syndrome.Cor e Forma:PowderPeso molecular:3,314.8 g/molAc-RNQDQQGPFKMC-NH2
Peptide Ac-RNQDQQGPFKMC-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Transportan
Transportan is an amphipathic 27 amino acid peptide that was generated from 12 functional amino acids of galanin and 14 amino acids of mastoparan connected via a lysine residue. Transportan has been functionally characterised as a cell penetrating peptide (CPP) that does not appear to be mediated by endocytosis. All cell types tested were permeated by transportan, initially localising to the outer membrane it then travels to cytoplasmic membrane structures and eventually perfuses to the nucleoli. This CPP has been used for numerous applications and assays to great effect including indirect immunofluorescence and drug delivery.TP reveals some characteristic features of both galanin and mastoparan since it inhibits the binding of galanin to GALR-1 receptor as well as modulates the activity of G proteins due to the inhibition of GTPase activity.Cor e Forma:PowderPeso molecular:2,180.4 g/molAc-LVLRLR-NH2
Peptide Ac-LVLRLR-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Bombesin
Bombesin was originally isolated from the skin of the european fire-bellied toad (Bombina bombina) and has two known homologues Neuromedin B (NMB) and gastrin-releasing peptide (GRP).Bombesin-like peptides are involved in many physiological functions including: regulation of food intake- anxiety and fear-related behaviour, thermoregulation, stress response, learning and memory and in the stimulation of smooth muscle contraction. Bombesin is also a tumour marker for small cell carcinoma in the lung, gastric cancer, pancreatic cancer, and neuroblastoma.The receptors for these two peptides are known as bombesin receptor type 1 (BB1 also known as NMB receptor) and bombesin receptor type 2 (BB2 also known as GRP receptor). Bombesin shows high affinity to both of these receptor subtypes. These bombesin-like peptides and their receptors are widely distributed in the central nervous system (CNS) and gastrointestinal (GI) tract.This peptide contains an N-terminal pyroglutamyl to prevent the intramolecular cyclisation of the N-terminal of glutamine to N-pyroglutamate (pGlu).Peso molecular:1,618.8 g/molFS1 peptide
FS1, a synthetic BH3 peptide used in BH3 profiling, shows promise in enhancing Natural Killer (NK) cell-mediated cancer therapy. By selectively targeting anti-apoptotic BCL-2 family proteins, FS1 can trigger cytochrome c release in sensitive cancer cell lines, promoting apoptosis. This mechanism synergizes with NK cell activity, leading to increased cancer cell death both in vitro and in vivo. Therefore, FS1 represents a potential therapeutic agent for enhancing NK cell-based immunotherapy approaches.
cAC 253
Cyclic AC253 is an antagonist of the amylin receptor with neuroprotective effects against Aβ toxicity. Cyclic AC253 eliminates Aβ-induced impairment of hippocampal long-term potentiation and is able to penetrate the blood-brain barrier.Peso molecular:3,007.5 g/molH-LVDQNIFSFYLSR^-OH
Peptide H-LVDQNIFSFYLSR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.MOG (92-106) Mouse, Rat
Myelin oligodendrocyte glycoprotein (MOG) is a member of the immunoglobulin (Ig) protein superfamily and is expressed exclusively in the central nervous system (CNS) on the surface of myelin sheaths and oligodendrocyte processes. MOG is expressed at the onset of myelination, and therefore is a potential marker for oligodendrocyte maturation.MOG contains an extracellular domain, a transmembrane domain, a cytoplasmic loop, a membrane-associated region and a cytoplasmic tail.- MOG may function as a cell surface receptor or cell adhesion molecule. -Fifteen different alternatively spliced isoforms have been detected in humans. These are present either on the cell surface, the endoplasmic reticulum in the endocytic system, or in secreted form.The secreted form of MOG may trigger autoimmunity if released into the cerebrospinal fluid and periphery. MOG is thought to be a key target for autoantibodies and cell-mediated immune responses in inflammatory demyelinating diseases such as multiple sclerosis (MS) and is therefore widely studied in this field.Fragment 92-106 of MOG is able to induce experimental autoimmune/allergic encephalomyelitis (EAE), an animal model that resembles MS.Cor e Forma:PowderPeso molecular:1,823.9 g/molH-DRVY^IHP^FHL-OH
Peptide H-DRVY^IHP^FHL-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Ac-TPSLPTPPTR-NH2
Peptide Ac-TPSLPTPPTR-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
Neuropeptide S rat
Neuropeptide S (NPS) is a neuropeptide found in mammalian brains, primarily in neurons in the lateral parabrachial nucleus, the-peri-locus coeruleus and the principle sensory 5 nucleus of the trigeminus. NPS is involved in several neuroendocrine, behavioural and inflammatory responses, including: reducing anxiety in mice- suppressing appetite and inducing wakefulness and hyperactivity. NPS treatment can be used to improve fear extinction in mice and limit fear memory retrieval after fear reduction training, thus making it an interesting target for treatment of post-traumatic stress disorder. NPS exerts its actions by binding to a G-protein coupled receptor, NPSR
Cor e Forma:PowderPeso molecular:2,209.2 g/molH-GAVDGGLSIPHSTK^-OH
Peptide H-GAVDGGLSIPHSTK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
HPV16 E7 (86-93)
Immunogenic Human Cytotoxic T lymphocytes (CTL) epitope encoded by human papillomavirus 16 type E7 with very high affinity binding to the HLA-A*0201 molecule.
Cor e Forma:PowderPeso molecular:814.5 g/molHyp-Gly dipeptide
A hydroxyproline glycine peptide in acid form. This peptide is a substrate for prolyl dipeptidase. Ingestion of the Hyp-Gly dipeptide can improve skin conditions. Hyp-Gly ingestion improves facial skin moisture and elasticity and reduces facial aging. Additionally, Hyp-Gly enhances fibroblast proliferation.Peso molecular:188.1 g/molH-TGISPLALI^K-OH
Peptide H-TGISPLALI^K-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
Sifuvirtude
Inhibitor of HIV-1-mediated cell-cell fusion in a dose-dependent manner, and exhibits high potency against infections by a wide range of primary and laboratory-adapted HIV-1 isolates from multiple genotypes. Highly effective against T20 resistant strains.Peso molecular:4,725.2 g/molH-ELFSYLIEK^-OH
Peptide H-ELFSYLIEK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Pyroglutamyl beta-Amyloid (4-14) Biotin
Pyroglutamyl β-Amyloid (4-14) Biotin is derived from Amyloid-β, which has been identified as the key subunit of the extracellular plaques found in the brains of patients with Alzheimer's disease (AD) and Down's syndrome (DS). Aβ has therefore been extensively studied as a potential target for treatment of AD.Aβ is formed from the cleavage of the large, transmembrane protein- APP (amyloid precursor protein). Cleavage of APP by β- and then γ-secretases results in the formation of Aβ. Aβ can aggregate to produce amyloid-β oligomers, which are thought to be highly neurotoxic. Over time Aβ can further aggregate to produce the characteristic senile plaques present in AD and DS. Aβ can be degraded by enzymes such as neprilysin, insulin degrading enzyme or endothelin converting enzyme. At physiological levels Aβ may be involved in controlling synaptic activity and neuronal survival.This peptide contains a C-terminal Biotin tag that is covalently bonded via ethylenediamine and can be used for detection and purification. Additionally, there is a Pyroglutamyl molecule located at the N-terminal position.Peso molecular:1,761.8 g/molH-ESTLHLVLRLR^GG-hydrazide
Peptide H-ESTLHLVLRLR^GG-hydrazide is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
IL-33 peptide
IL-33 is a member of the IL-1 superfamily of cytokines, a determination based in part on the molecules β-trefoil structure, a conserved structure type described in other IL-1 cytokines. IL-33 acts intracellularly as a nuclear factor and extracellularly as a cytokine.IL-33 has been associated with several disease states through Genome Wide Association Studies: asthma, allergy, endometriosis and hay fever. A single-nucleotide polymorphism rs928413 (A/G), is located in the 5' upstream region of IL33 gene, and its minor 'G' allele was identified as a susceptible variant for early childhood asthma and atopic asthma development.Peso molecular:1,031.6 g/mol[Tyr]-CNP22, Human
C-type natriuretic peptide (CNP) is a novel urinary biomarker which is part of the natriuretic peptide family. CNP is produced in the kidney and the endothelium and has been localised to renal tubules. CNP expression has also been detected in cardiomyocytes, vascular endothelium, and bone.CNP is synthesized as the precursor 103 amino acid (AA) protein, proCNP (AA 1-103), which is then cleaved into NT-proCNP (AA 1-50) and CNP53 (AA 51-103) by the intracellular endoprotease furin. CNP53 is then cleaved to give the biologically active mature form CNP22 (AA 82-103) and inactive form NT-CNP53 (51-81). CNP primarily acts as an autocrine or paracrine factor and has anti-proliferative and anti-fibrotic properties, including suppression of fibroblast proliferation and collagen production, inhibition of vascular smooth muscle cell proliferation and accelerated regeneration of endothelial cells. CNP is a vasodilator and potent venodilator and slightly elevated levels have been detected in heart failure and renal disease states. CNP has renoprotective properties and is activated during renal injury, where it helps preserve glomerular function and suppress pro-fibrotic processes. Hypoxia, cytokines and fibrotic growth factors, are stimuli for CNP production and release.CNP selectively activates the cell surface particulate guanylyl cyclase receptor B (GC-B), catalysing the conversion of GTP to the downstream second messenger, cyclic guanosine monophosphate (cGMP).Peso molecular:2,358.2 g/molBiotin-BIM α3 (51-76) (His tag) amide
Custom research peptide; min purity 95%. For different specs please use the Peptide Quote ToolH-GAVGVGK^SA-OH
Peptide H-GAVGVGK^SA-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
H-SYKV-NH2
Peptide H-SYKV-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Galanin (13-20) Mouse
Galanin is widely distributed in the central nervous, peripheral, and endocrine systems. Galanin's overarching function is as an inhibitory, hyper-polarizing neuromodulator for classical neurotransmitters like acetylcholine and serotonin. Galanin interacts with 3 receptor subtypes, GalR1-3 G protein-coupled receptors inserted into the plasma membrane. GalR1 is believed to activate a Gβγ pathway to regulate MAPK activation. GalR2 can also activate the MAPK pathway, but unlike GalR1, there is detectable inositol phosphate production. GalR3 is associated with the Galphai/o pathway. Activation of the receptor leads to a cellular influx of K+. Each receptor has been associated with neurological diseases such as GalR3 and epilepsy.Galanin is a key regulator of growth hormone and insulin release and adrenal secretion however the role galanin plays is not clear. Administration of galanin to animal models leads to inhibition of insulin secretion but this is not replicated in humans.N-terminal galanin fragments naturally occur in vivo, but their relevance is unclear. Some N-terminal fragments reduce metabolic and functional disorders in experimental heart damage. Their relative abundance varies, with fragment (13-20) being one of the lowest quantities detected. The physiological relevance of the galanin fragment (13-20) and its affinity to the various Gal receptors has yet to be made clear. Binding assays and displacement assays in rat brain tissue have been performed with similar N-terminal galanin fragments to try and elucidate their function. Using N-terminal fragments such as galanin (13-20) can help clarify the role of full-length galanin in various roles, such as during myocardial ischemia and reperfusion injury. This may highlight new agonists/antagonists for the galanin GalR receptors that can be therapeutic targets.Peso molecular:957.5 g/molPolybia-MPII
The crude venom of the wasp Polybia paulista consists of 30% polybia-MPII. Polybia-MPII is a mastoparan, it is rapidly distributed around the organism point of inoculation via the circulation. As a secretagogue, polybia-MPII has myotoxic action and minor neurotoxic effects. Polybia-MPII has been injected sub-cutaneously and intra-muscularly into mice for pathology and immunohistochemistry assays.As an antimicrobial agent, polybia-MPII is highly effective, with a lower haemolysis rate compared to other mastoparans. Polybia-MPII also shows considerable anti-fungal activity.Peso molecular:1,612 g/molH-IPNAGTDPNSR^-OH
Peptide H-IPNAGTDPNSR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
SARS-CoV-2 Nucleoprotein (1-17)
The coronavirus (CoV) nucleoprotein is the major component of CoV structural proteins. The nucleoprotein has a critical role in virus assembly and RNA transcription. The nucleoprotein is essential in the formation of helical ribonucleoproteins and in regulating viral RNA synthesis. The nucleoprotein can also regulate infected host cellular mechanisms. It is highly expressed during infection and may induce protective immune responses against SARS-CoV and SARS-CoV-2.The nucleoprotein residues MSDNGPQNQRNAPRITF (1-17) from SARS-CoV-2 have been identified as a T-cell epitope with a predicted HLA restriction. Immune targeting of confirmed epitopes may potentially offer protection against SARS-CoV-2 and help the development of vaccines for long-lasting immunity.Peso molecular:1,944.9 g/mol[5-FAM] Antennapedia peptide amide
Identification of cell penetrating conjugates has aided numerous areas of scientific development. The Drosophila transcription factor Antennapedia contains a homeodomain that can be internalised by cells to the cytoplasm and to the nucleus in a receptor-independent mechanism. The key residues for internalisation have been sequenced (RQIKIWFQNRRMKWKK), named penetratin, and used in several studies to aid entry of fusion proteins into cells.The full 60 amino acid homeodomain was fused to a T cell epitope of the influenza nucleoprotein and successfully internalised into T cells for presentation. The fragment known as penetratin was fused to a ligand for Grb-2 resulting in inhibition of downstream Grb-2 signalling events. Penetratin has also been used in vivo to prime cytotoxic T lymphocytes by conjugating short antigenic peptides to the CPP. Penetratin is provided here as a C-terminal amide with a C-terminal 5-carboxyfluorescein (5-FAM), a widely used green fluorescent tag often preferred over FITC due to its high stability- absorbance 492 (nm), 518 emission (nm).Peso molecular:2,604.04 g/molTeduglutide (GLP2 2G)
CAS:Teduglutide is a GLP-2 analogue, in which the alanine at position 2 has been substituted with glycine making the peptide resistant to degradation by dipeptidyl peptidase-4 (DPP-4)- Teduglutide therefore has a longer half-life than GLP-2 (2-3 hours for teduglutide vs 7 min for GLP-2). Teduglutide has high bioavailability after subcutaneous administration, suggesting that teduglutide has enhanced biological activity, relative to native GLP-2.GLP-2 is a gut hormone produced in the enteroendocrine L cells of gastrointestinal tract by the cleavage of the 160-amino-acid proglucagon molecule. GLP-2 is secreted following the ingestion of food and carries out its activities via the GLP-2 G-protein coupled receptors (GLP-2Rs). GLP-2 has a range of roles within the cell, including: anti-inflammatory effects- promoting the expansion of the intestinal mucosa- stimulating intestinal blood flow- inhibiting gastric acid secretion and gastric emptying- increasing intestinal barrier function and enhancing nutrient and fluid absorption.Fórmula:C164H252N44O55SCor e Forma:PowderPeso molecular:3,749.8 g/molSIVmac239 envelope - 87
Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool
Peso molecular:2,317.9 g/molSuc-LLVY-[AMC]
Fluorogenic substrate peptide of the 20S proteasome. In its intact state this peptide is non-fluorescent, however when aminomethylcoumarin (AMC) is released upon hydrolysation, fluorescence can be detected. This peptide is therefore a useful tool for analysing the activity of the 20S proteasome as well as other chymotrypsin-like proteases and calpains. This peptide is also a substrate for chymase, papain, carboxypeptidase Y, proteinase yscE (kexin) and ingensin.AMC is a fluorescent dye with excitation maxima at around 360 nm and emission maxima at around 450 nm. AMC can be excited with a mercury lamp and observed using a UV filter set.Cor e Forma:PowderPeso molecular:763.4 g/molAcrAP1
Venom peptidomes and proteomes have yielded significant novel drug discoveries. The non-disulphide bridge peptides (NDBPs) have become a particular focus due to their large range of structures as well as biological activity while retaining high specificity.In scorpion venom A. crassicauda, AcrAP1 was identified as a NDBP. Data shows it has antimicrobial activity against bacteria and yeast while also capable of haemolysing of horse erythrocytes. However, AcrAP1 did not affect the growth of the cancerous cell lines tested. Therefore, this peptide could be a useful model for modification to improve its potency. Furthermore, it may allow researchers to identify specific targets in disease pathways for new drug designs. A significant example of this, bradykinin-potentiating peptide Captopril® manages hypertension and originated from the conserved NDBP family.
Peso molecular:1,961.35 g/molHXB2 gag NO-99/aa393 - 407
Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool
Peso molecular:1,663.9 g/molH-YMVIQGEPGAVIR^-OH
Peptide H-YMVIQGEPGAVIR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
CMVpp65 - 115 (KAESTVAPEEDTDED)
Custom research peptide; min purity 95%. For different specs please use the Peptide Quote ToolPeso molecular:1,635.6 g/mol[5-FAM]-EB1
EB1 is a penetratin analogue that was synthesised to be an endosomolytic cell penetrating peptide (CPP). Certain amino acids in the penetratin sequence were replaced with histidine to encourage formation of an alpha helix upon protonation in the acidic endosomes. As a CPP, EB1 has been shown to form a strong interaction with the phospholipid bilayer during insertion with rapid cellular uptake, there is a moderate amount of cell leakage and no significant cytotoxicity. EB1 is provided here as a C-terminal amide with a N-terminal 5-carboxyfluorescein (5-FAM), a widely used green fluorescent tag often preferred due to its high stability absorbance 492 (nm), 518 emission (nm).Peso molecular:3,458.07 g/molAc-TTAI-NH2
AAT is a highly abundant serine protease inhibitor primarily produced in the liver to protect the lung tissue. However, misfolding of AAT can result in significant liver disease, lung disease, and cancers. Defective AAT is characteristic of the misfolding protein diseases known as serpinopathies.Ion mobility mass spectrometry (IM-MS) was used to identify Ac-TTAI-amide as a ligand effecting α1-antitrypsin stability. Interaction of Ac-TTAI-amide with AAT results in increased stability and reduced polymerisation. Thus Ac-TTAI-amide is a useful target for further research in to serpinopathy management.Cor e Forma:PowderPeso molecular:445.3 g/molBoc-Asp(OBzl)-Pro-Arg-AMC·HCl
CAS:Boc-Asp(OBzl)-Pro-Arg-AMC·HCl is a high quality, reagent, complex compound and useful intermediate. It is a fine chemical with the CAS Number 201849-39-0 that is used in research and development. Boc-Asp(OBzl)-Pro-Arg-AMC·HCl is also a versatile building block that can be used in reactions for the synthesis of other compounds.
Fórmula:C37H47N7O9·HClPureza:Min. 98 Area-%Cor e Forma:White PowderPeso molecular:770.27 g/molH-VGYMHWYQQKPGK^-OH
Peptide H-VGYMHWYQQKPGK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
gp100 (476 - 485)
Custom research peptide; min purity 95%. For different specs please use the Peptide Quote ToolFórmula:C57H83N13O15Peso molecular:1,190.38 g/molH-Glu[Cyclo(Arg-Gly-Asp-D-Tyr-Lys)]2
H-Glu[Cyclo(Arg-Gly-Asp-D-Tyr-Lys)]2 is a cyclic peptide that contains the sequence of amino acids Arg, Gly, Asp, D, Tyr and Lys. It is a peptide macrocycle that has been shown to be effective against tumor cells. This peptide has been derivatized for targeting purposes and has been shown to be an effective imaging agent for tumor cells in vivo. H-Glu[Cyclo(Arg-Gly-Asp-D-Tyr-Lys)]2 is also biochemically active and can inhibit the growth of cancer cells through multiple mechanisms.Fórmula:C59H87N19O18Pureza:Min. 95%Peso molecular:1,350.47 g/molHXB2 gag NO-87
Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool
Peso molecular:1,502.8 g/molFluor-HEHRKRG-OH
Peptide Fluor-HEHRKRG-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.C-telopeptide
C-terminal telopeptide is produced when type I collagen in the bone is degraded and so released into the blood. Within collagen structure, made up of a triple helix of 3 amino acid chains, C-telopeptide is located at the C-terminus, and at the N-terminus there is an N-telopeptide. Both the N and the C-telopeptides are involved in the formation of collagen enzymatic cross links which are crucial for Collagen properties in the connective tissues of the body such as the bone and skin. Collagen properties allow connective tissues to be strong, stiff and maintain their structural integrity. Furthermore collagen acts as a scaffold for other extracellular matrix proteins.Due to the presence of C-telopeptide in the blood following the degradation of type 1 collagen, C-telopeptide can be used to monitor the progression of bone diseases where the pathogenesis commonly involves bone degradation.Cor e Forma:PowderPeso molecular:868.4 g/molH-SVNELIYK^-OH
Peptide H-SVNELIYK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
HIV - 1 MN ENV - 170
Custom research peptide; min purity 95%. For different specs please use the Peptide Quote ToolPeso molecular:1,897.4 g/molAbz-Lys-Lys-Gln-Arg-Ala-Gly-Val-Leu-Tyr(NO2)-NH2
Abz-Lys-Lys-Gln-Arg-Ala-Gly-Val-Leu-Tyr(NO2)-NH2 is a peptide that is used as an inhibitor of the Dengue Fever Virus protease. It has been shown to inhibit the activity of the nonstructural protein NS1, which is an enzyme that plays a role in the replication cycle of the virus. This peptide binds to the active site of serine proteases and prevents them from cleaving other proteins. It also inhibits HIV protease, cathepsin L, and trypsin.
Fórmula:C55H88N18O14Pureza:Min. 95%Peso molecular:1,225.43 g/molH-FYGAEIVSALEYLHSR^-OH
Peptide H-FYGAEIVSALEYLHSR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.H-GALALAQAVQR^-OH
Peptide H-GALALAQAVQR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.4-Fluorobenzoyl-A20FMDV2
A20FMDV2, a peptide derived from the foot and mouth disease virus, inhibits the epithelial-specific integrin alphavβ6 and here is labelled with 4-fluorobenzoyl as the light version of the PET ligand 4-[18F]Fluorobenzoyl A20FMDV2 which can be used for in vivo imaging.Peso molecular:2,283.3 g/molDynorphin A (1-11), porcine
Catalogue peptide; min. 95% purityFórmula:C63H103N21O13Peso molecular:1,362.66 g/mol(Gly106)-Cytochrome C (92-107) (Manduca sexta)
CAS:Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool
Fórmula:C77H129N23O24Peso molecular:1,761.01 g/molSteroid Receptor Coactivator-1 (SRC-1) (686-700)
There are three members of the p160 family of steroid receptor coactivators, SRC-1, SRC-2, and SRC-3. These steroid receptor coactivators control the functional output of numerous genetic programs and serve as pleiotropic rheostats for diverse physiological processes. Coactivator proteins interact with nuclear receptors in a ligand-dependent manner and augment transcription.Peso molecular:1,770 g/molClick MAP
Cell penetrating peptides (CPP) are a useful tool for drug delivery, but their cell-specific uptake is still being improved. Work with the model amphipathic peptide (MAP) has been important in this field. CPP MAP is an amphipathic α-helix and has been well characterised for its ability to spontaneously permeate the cell membrane by interacting with the lipid bilayer. As a CPP, MAP causes increased membrane permeability and a degree of cell leakage. MAP is being extensively studied to optimise drug delivery in numerous cell lines with the target of creating a viable clinical method. Interestingly, the CPP function of MAP also provides it with bactericidal properties by effecting the membrane permeability. MAP is a potent antimicrobial peptide (AMP) against gram negative Neisseria meningitidis, the pathogen of meningococcal disease.MAP is provided here with a N-terminal alkyne attachment. Two of the most regularly encountered functional groups for click chemistry are azides and alkynes, and the azide-alkyne cycloaddition has become the most popular click reaction. The use of click chemistry with alkyne-MAP allows a wide variety of applications particularly for conjugation, modification, and peptide design.Cor e Forma:PowderPeso molecular:2,234.8 g/mol
