Peptídeos
Os peptídeos são cadeias curtas de aminoácidos ligados por ligações peptídicas, desempenhando papéis importantes como moléculas biológicas em processos celulares. Eles funcionam como hormônios, neurotransmissores e moléculas de sinalização, sendo amplamente utilizados em aplicações terapêuticas e diagnósticas. Os peptídeos também são cruciais na pesquisa para estudar interações proteicas, atividades enzimáticas e vias de sinalização celular. Na CymitQuimica, oferecemos uma ampla seleção de peptídeos de alta qualidade para apoiar suas necessidades de pesquisa e desenvolvimento em biotecnologia e farmacêutica.
Subcategorias de "Peptídeos"
Foram encontrados 29635 produtos de "Peptídeos"
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H-SVLLDAASGQLR^-OH
Peptide H-SVLLDAASGQLR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.SARS-CoV-2 Nucleocapsid_3 B7 (HLA-B*07:02)
Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool
H-LQAHLVAQTNLLR^-OH
Peptide H-LQAHLVAQTNLLR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.H-KRAYYIYSGGERVPL-NH2
Peptide H-KRAYYIYSGGERVPL-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.H-TYPVPFQR^-OH
Peptide H-TYPVPFQR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.H-TPPSSGEPPK^-OH
Peptide H-TPPSSGEPPK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.C34, gp41 HIV Fragment
Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool
Fórmula:C184H280N50O64S1Peso molecular:4,248.8 g/molH-TEGDGVYTLNDK^-OH
Peptide H-TEGDGVYTLNDK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
H-ASPAFLASQNTK^-OH
Peptide H-ASPAFLASQNTK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Bid BH3 Peptide
The Bid BH3 Peptide is derived from the pro-apoptotic proteins Bid (BH3-interacting domain death agonist) and BH3, which are both members of the BCL-2 family proteins and activate the BAX and BAK proteins to promote apoptosis.The process of apoptosis can be activated by the intrinsic or extrinsic pathways, the former is activated by stress stimuli such as DNA damage and nutrient deficiency, while the latter is induced through activation of the death receptors FAS and TRAIL.The BCL-2 family's transmembrane anchor at the C-terminus allows them to locate at the mitochondrial outer membrane and play a vital role in apoptosis.Within the mitochondria BH3 molecules, containing the members BID, BIM, PUMA and NOXA, can be activated by the intrinsic pathway. These in turn can initiate the homo-oligomerisation of BAX and BAK which induce mitochondrial outer membrane permeabilisation (MOMP) and the release of cytochrome c into the cytosol. Here cytochrome c associates with APAF-1 and dATP, ultimately activating effector caspase3/7 and apoptosis.In addition to Bid's role in apoptosis, it also plays a role within a mitosis checkpoint and genomic stability maintenance. Bid's main role is in the extrinsic pathway of apoptosis. When the death receptors are activated Caspase-8 generates tBid through the cleavage of Bid. This then locates to and targets Bax to the outer mitochondrial membrane (OMM) where it induces permeabilisation and hence apoptosis.Cor e Forma:PowderPeso molecular:2,308.2 g/molH-DALSSVQESQV^AQQAR-OH
Peptide H-DALSSVQESQV^AQQAR-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Macropin 2
This anti-microbial peptide (AMP) has been shown to cause lysis of several human cancer cell lines. Macropin-2 is most potent against CCRF-CEM T lymphoblastoid (human acute lymphoblastic leukemia) cells. At higher concentrations Macropin-2 also causes lysis of human umbilical vein endothelial cells (HUVEC), rat intestinal epithelial cells (IEC), human cervix carcinoma (HeLa) cells and human colon adenocarcinoma (SW480). Macropin-1 is also available in our catalogue.
Peso molecular:2,007.53 g/molPap12-6
Broad-spectrum antibacterial, active against multidrug-resistant Gram-negative bacteria. Acts though permeabilizing the bacterial membrane and also shows anti-inflammatory activity via a TLR4-mediated NF-KB signaling pathway. Significantly improves survival in a mouse sepsis model.
Peso molecular:1,644.1 g/molHuman Lysozyme (107-115)
Human Lysozyme (107-115) is derived from human lysozyme, a glycosidase enzyme which can kill both gram-positive and gram-negative bacteria. This can be carried out in a catalytic manner through the hydrolysis of peptidoglycan in the cell wall or alternatively in a non-catalytic manner. Due to the surface of bacteria being negatively charged, they are vulnerable to be targeted by the human lysozyme which is cationic. These antimicrobial properties can be used therapeutically as an anti-pseudomonal agent.Structurally the human lysozyme is comprised of four intramolecular disulphide bonds, four alpha helices within an alpha domain and β-sheets within a β-domain. Human lysozyme (107-115) is found within the α-domain.Peso molecular:1,212.7 g/molH-RPILTIITLEDSSGNLLGR^-OH
Peptide H-RPILTIITLEDSSGNLLGR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Temporin SHF
Temporin-SHf is a broad spectrum anti-microbial peptide (AMP) with activity against Gram-positive and Gram-negative bacteria and yeasts, which displays no haemolytic activity. Temporin-SHf was first isolated from the skin of the frog Pelophylax saharica and is a member of the temporin family of AMPs. Temporins are a large family of short, linear, AMPs produced in the skin of frogs belonging to Rana species, but are also found in wasp venom. Temporin-SHf is the smallest natural linear AMP found to date and has a highly hydrophobic sequence (75%) plus the highest percentage of phenylalanine residues of any known peptide (50%).Temporin-SHf works by disrupting the acyl chain packing of anionic lipid bilayers, causing cracks and microbial membrane disintegration through a detergent-like effect. Temporin-SHf is a promising candidate for the development of a new class of anti-microbial drugs.Cor e Forma:PowderPeso molecular:1,075.3 g/molH-TVSLGAGAK^-OH
Peptide H-TVSLGAGAK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
TAT-CHN9 (C-ter)
Trans-activator of transcription protein (Tat) (47-57) is a cell penetrating cationic peptide derived from the N-terminus of the Tat protein from the human immunodeficiency virus (HIV). Chimerin 1, (CHN1) is a GTPase activating protein specific for RAC GTP-binding proteins, expressed primarily in the brain. CHN1 is involved in signal transduction and is a direct effector of proteins involved in axon guidance. CHN1 is transferred to the plasma membrane and negatively regulates Rho-family small GTPases RAC1 and CDC42, to cause morphological changes to axons by pruning the ends of axon dendrites. As a cell penetrating peptide (CPP) TAT aids in the cellular uptake of molecules. TAT (47-57) can be used to deliver proteins, fluorophores, chelators and DNA to target cells.Peso molecular:2,644.6 g/molInfluenza Matrix Protein M1 (58-66)
Influenza Matrix Protein M1 (58-66) is a peptide that is derived from influenza virus peptide 58-66. It has cytotoxic effects on lymphocytes and inhibits H-Gly-Ile-Leu-Gly-Phe-Val-Phe-Thr-Leu, which is the sequence of an enzyme called CEF1. Influenza Matrix Protein M1 (58-66) is a biologically active peptide that can be used as a cancer drug or for the treatment of infectious diseases.
Fórmula:C49H75N9O11Pureza:Min. 95%Peso molecular:966.2 g/molAc-Arg-Gly-Lys(Ac)-AMC
Histone deacetylases (HDACs) are a family of enzymes which are highly evolutionary conserved across all eukaryotes. HDACs modify histones by removing acetyl groups from the tail regions. Histone deacetylation is generally associated with reduced gene expression due to a more compact chromatin state less accessibility for transcription factors (TFs). HDACs are essential for many physiological processes including development and cellular homeostasis. They also play an important role in disease states, including neurodegenerative disorders, genetic diseases and cancers.This peptide is the fluorogenic substrate for assaying histone deacetylase (HDAC) activity in a two-step enzymatic reaction. The assay consists of the initial lysine deacetylation by HDAC followed by the release of the fluorescent group by trypsin. Fluorescence can be detected upon fluorophore release.Peso molecular:600.3 g/molH-MSSYAFFVQTCR^-OH
Peptide H-MSSYAFFVQTCR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Setmelanotide
Pro-opiomelanocortin (POMC)-derived peptides act on neurons expressing the Melanocortin 4 receptor (MC4R) to reduce body weight. Setmelanotide is a highly potent MC4R agonist that leads to weight loss in diet-induced obese animals and obese individuals with complete POMC deficiency.The endogenous ligand alpha-melanocyte-stimulating hormone (alpha-MSH) for MC4R has been shown to have a much lower affinity than Setmelanotide, explaining some of the drug's potency. Administration of Setmelanotide to wildtype mice resulted in significant weight loss while MC4R knockout mice fail to respond. Setmelanotide is in numerous clinical trials and shows promising results. Patients with POMC defects upstream of MC4R show more significant responses to treatment than those with MC4R deficiency or obese controls.Peso molecular:1,117.34 g/molHistone H3 (1-22) K4Me3-Biotin
Histone H3 (1-22) K4Me3 is derived from Histone 3 (H3) which is one of the four core histones (H2A, H2B, H3 and H4) fundamental in compacting eukaryotic DNA into the nucleosome. The nucleosome arises when 147 base pairs of DNA wrap around a H3-H4 tetramer and two H2A-H2B dimers, forming the histone octamer core. Both H4 and H3 are highly conserved and perform roles in binding to segments of DNA which enter and leave the nucleosome and in chromatin formation. Similar to the other core histone, H3 has a globular domain and a flexible N-terminal domain, 'histone tail' which can undergo modifications such as acetylation, methylation, phosphorylation and ubiquitination. Due to histones containing a large number of lysine and arginine residues they have a positive net charge which interacts in an electrostatic manner with the negatively charged phosphate groups in DNA. The transcriptional activation or silencing of the chromatin is controlled by ATP-dependent chromatin remodelling factors and histone modifying enzymes which target histone proteins. Both processes function to alter the positioning of the nucleosome, allowing the DNA it to be either available or inaccessible to the transcription machinery.Another modification process histones can undergo is biotinylation where the covalent attachment of a biotin molecule is catalysed by the enzyme biotinidase. This cleaves biocytin to generate a biotinyl-thiester intermediate. The biotinyl can then be transferred onto the histone lysine ɛ-amino group which in this case it is covalently attached to Histone 3. Overall the biotinylation sites identified in histone 3 are: K4, K9 and K18. The presence of biotinylated histones have been detected in human cells such as lymphocytes and lymphomas.Lysine 4 of H3 (1-22) has been tri-methylated.Peso molecular:2,851.7 g/molβ-Amyloid (11-20) Human
Amyloid β-peptide (Aβ) has been identified as the key subunit of the extracellular plaques found in the brains of patients with Alzheimer's disease (AD) and Down's syndrome (DS). Aβ has therefore been extensively studied as a potential target for treatment of AD. Aβ is formed from the cleavage of the large, transmembrane protein APP (amyloid precursor protein). Cleavage of APP by β- and then γ-secretases results in the formation of Aβ. Aβ can aggregate to produce amyloid-β oligomers, which are thought to be highly neurotoxic. Over time Aβ can further aggregate to produce the characteristic senile plaques present in AD and DS. Aβ can be degraded by enzymes such as neprilysin, insulin degrading enzyme or endothelin converting enzyme. At physiological levels Aβ may be involved in controlling synaptic activity and neuronal survival.Peso molecular:1,283.48 g/mol5Fam-RPKPQQFFGLM-OH
Peptide 5Fam-RPKPQQFFGLM-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Calcitonin, Salmon
Calcitonin is a peptide hormone excreted by the thyroid parafollicular cells to regulate calcium and phosphorus levels. Calcitonin acts in opposition to parathyroid hormone (PTH) and vitamin D. Calcitonin functions by inhibiting osteoclast activity in the bones preventing calcium release- there is also inhibition of renal tubular cell reabsorption of calcium and phosphate, so they are excreted preventing a rise in levels.Calcitonin is used for as marker for detection and prognosis of nodular thyroid diseases. Medullary thyroid cancer is one example of the malignant parafollicular cells detectable with the assay, as they present with an increased calcitonin level even at an early stage.Since the discovery of calcitonin over 50 years ago the salmon sourced peptide has been used in numerous treatments including bone metastases, Paget disease, hypercalcaemia, and postmenopausal osteoporosis. The salmon calcitonin has been shown to be equivalent to human form but more active and can be synthetically generated.Peso molecular:3,429.7 g/molAc-SHQESTRGRSRGRSGRSGS-NH2
Peptide Ac-SHQESTRGRSRGRSGRSGS-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
TAT-AKAP79 (326-336) amide
The activation of transient receptor potential cation channel subfamily V member 1 (TRPV1) is believed to play a role in hyperalgesia, asthma, and hypertension. TRPV1 is important for neuronal pain detection as well as the detection of heat, capsaicin, protons, and the neurotransmitter anandamide.- The scaffold protein AKAP79 targets kinases to phosphorylate TRPV1, however it has been shown that inflammatory intermediates prostaglandin-E2 or bradykinin can activate these kinases creating a route for inflammation to cause hyperalgesia.This product is composed of the TRPV1 interacting residues of AKAP79 reordered into a scrambled sequence and conjugated to the cell penetrating TAT domain at the N-terminus. This product was shown in vivo to have a potent analgesic affect due to interaction with TRPV1 but not affect the pain threshold. This product is a vital tool for research into suitable TRPV1 antagonists.Peso molecular:2,877.6 g/molH-VVAQGVGIPEDSIFTMADR^-OH
Peptide H-VVAQGVGIPEDSIFTMADR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
[5-FAM]-GLP-1 (7-36)
The native form of GLP-1 in humans is the GLP-1 (7-36) amide. GLP-1 (7-36) amide is highly unstable (half-life <-2 minutes) due to proteolytic degradation by the serine protease- dipeptidyl peptidase-IV (DPP-IV). DPP-IV cleaves the N-terminal histidine and alanine residues from GLP-1 to generate two equipotent forms: GLP-1 (9-37) and GLP-1 (9-36) amide. This degradation mitigates against the therapeutic use of GLP-1 itself, therefore DPP-IV-resistant peptide analogues have been developed and licensed for clinical useThis peptide contains N-terminal 5-Carboxyfluorescein (5-FAM), a widely used green fluorescent tag
Peso molecular:3,653.7 g/molH-HSGFEDELSEVLENQSSQAEL^K^-OH
Peptide H-HSGFEDELSEVLENQSSQAEL^K^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.nef protein (75-82) [Human immunodeficiency virus 1]
Nef is an accessory protein highly conserved amongst all primate lentiviruses, it is essential for viral replication in vivo- it is expressed by human immunodeficiency virus (HIV) HIV-1 and HIV-2. Nef acts as a downregulator of class I human leukocyte antigens (HLA) expression in HIV-infected cells to help circumvent the immune response, such as cytotoxic T lymphocytes (CTL) activity. An intact nef gene is critical for high viral loads, linked to development of acquired immunodeficiency syndrome (AIDS). Certain alleles of HLA have been associated with maintaining a seronegative status such as HLA-A*1101. This nef peptide sequence (75-82) was crystallised within the class I B allele HLA B*3501 suggesting an importance of key residues required for HLA interaction resulting in a nonstandard conformational binding.Peso molecular:975.5 g/mol[Cys]-Galanin (1-30) Human
Galanin (1-30) is an endogenous neuropeptide with endocrine, metabolic and behavioural effects. Galanin has a role in intestinal smooth muscle contraction, insulin and somatostatin release, and synaptic neurotransmission.Galanin is widely distributed in the central nervous, peripheral, and endocrine systems. Galanin's overarching function is as an inhibitory, hyper-polarizing neuromodulator for classical neurotransmitters like acetylcholine and serotonin. Galanin interacts with 3 receptor subtypes, GalR1-3 G protein-coupled receptors inserted into the plasma membrane. GalR1 is believed to activate a Gβγ pathway to regulate MAPK activation. GalR2 can also activate the MAPK pathway, but unlike GalR1, there is detectable inositol phosphate production. GalR3 is associated with the G alpha i/o pathway receptor activation leads to a cellular influx of K+. Each receptor has been associated with neurological diseases such as GalR3 and epilepsy.Galanin protects against various physiological insults in vitro, including excitotoxicity and β-amyloid toxicity. Changes in galanin have been widely studied concerning Alzheimer's disease, and galaninergic neurons are spared in late-stage Alzheimer's relative to non-galaninergic neurones.Galanin (1-30) has been used as an agonist for the GalR2 receptor in vitro for calcium mobilisation assays to understand the role Galanin/GalR2 play in multiple sclerosis.An N-terminal cysteine residue has been included on the galanin (1-30) peptide to allow ease of site-specific conjugation to various molecules.Peso molecular:3,258.6 g/molH-VGVNGF^G^R-OH
Peptide H-VGVNGF^G^R-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
Biot-EGPWLEEEEAYGWMDF-NH2
Peptide Biot-EGPWLEEEEAYGWMDF-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.(Tos-YASR)2-[Rh110]
Optimal peptide substrate for kallikrein-related peptidase 14 (KLK14). In its intact state this peptide is not fluorescent, however when this substrate peptide is cleaved by KLK14, Rhodamine 110 is released and thus fluorescence can then be detected. This peptide therefore allows for the quantification of KLK14 peptidase activity. KLK14 is most abundant in the skin, with lower levels in breast and prostate and may form part of the protease cascade responsible for maintaining the epidermal barrier. Aberrant KLK14 proteolytic activity is linked to several skin pathologies. Overexpression of KLK14 seen in several hormone-dependent cancers, including prostate, colon, ovarian, and breast, correlating with higher risk of disease progression. Therefore KLK14 is a potential point of therapeutic intervention in a variety of pathologies.Contains rhodamine 110 group, a widely used red fluorescent tag. The terminal carboxylic acids in this peptide have been activated by the addition of the p-tosyl moiety, allowing for easy addition of functional groups or further peptide residues.Peso molecular:1,592.6 g/molH-ELQDLALQGAK^-OH
Peptide H-ELQDLALQGAK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Biotin-β-Amyloid (1-15) human
β-Amyloid 1-15 (Aβ1-15) is one of many short Aβ species found in vivo and is formed by the cleavage of amyloid β precursor protein by β- and alpha-secretase.Amyloid β-protein (Aβ) has been identified as the key subunit of the extracellular plaques found in the brains of patients with Alzheimer's disease (AD) and Down's syndrome (DS). Aβ has therefore been extensively studied as a potential target for treatment of AD.Aβ is formed from the cleavage of the large, transmembrane protein- APP (amyloid precursor protein). Cleavage of APP by β- and then γ-secretases results in the formation of Aβ. Aβ can aggregate to produce amyloid-β oligomers, which are thought to be highly neurotoxic. Over time Aβ can further aggregate to produce the characteristic senile plaques present in AD and DS. Aβ can be degraded by enzymes such as neprilysin, insulin degrading enzyme or endothelin converting enzyme. At physiological levels Aβ may be involved in controlling synaptic activity and neuronal survival.This peptide contains a covalently attached N-Terminal biotin tag for convenient detection and purification.Peso molecular:2,052.8 g/molH-R^PPGFSPF-OH
Peptide H-R^PPGFSPF-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.H-TSSSFEVR^-OH
Peptide H-TSSSFEVR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
H-CPSGGKKATQASQEY-NH2
Peptide H-CPSGGKKATQASQEY-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.H-SYFQNCPRG-NH2
Peptide H-SYFQNCPRG-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Ac-SGGDDDWTHLS-NH2
Peptide Ac-SGGDDDWTHLS-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Cys38, Oxyntomodulin amide, (human, mouse, rat)
Custom research peptide; min purity 95%. For different specs please use the Peptide Quote ToolFórmula:C195H301N63O60S2Peso molecular:4,552.2 g/molPyClocK®
CAS:PyClocK® is a monoclonal antibody that binds to the HIV-1 surface protein, gp120. It is used in diagnostic immunoassays for the detection of anti-HIV antibodies and in preparative high performance liquid chromatography (HPLC) of glycopeptides, which are cyclic peptides that are produced by bacteria. PyClocK® also has been shown to bind to vasoactive intestinal peptide and cyclic peptide receptors, which may be involved in autoimmune diseases or metabolic disorders. The conformational properties of this antibody have been determined using X-ray crystallography on the monoclonal antibody.Fórmula:C18H27N6OF6ClP2Pureza:Min. 98.0 Area-%Peso molecular:554.85 g/molH-LDVDQALNR^-OH
Peptide H-LDVDQALNR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
ERAAP substrate Ep
Ep is a peptide-based fluorescent probe that can detect the intracellular amino-peptidase- ER aminopeptidase associated with antigen processing (ERAAP). ERAAP cleaves peptides presented by major histocompatibility complex (MHC) class I molecules to determine which are displayed on cell surfaces for T cell recognition. Down-regulation of ERAAP alters these cell surface peptides resulting in the cell being recognised as foreign. Therefore ERAAP is a potential target for increasing the immune response towards tumours. Down-regulation of ERAAP is also implicated in auto-immunity.Ep contains the fluorescent dye BODIPY and the fluorescent quencher dinitrophenyl (DNP), conjugated to the KK-SIINFECL peptide which is based on a known ERAAP-substrate. Ep initially has low fluorescence due to the proximity of the DNP quencher, however after ERAAP cleaves the N-terminal amino acid of Ep and releases the DNP quencher, a dramatic 20 fold increase in fluorescence is seen.Ep can detect ERAAP in cells in a highly sensitive and specific manner. Ep can detect ERAAP activity in live cells and in high-throughput-screens (HTS), and can compete with endogenous cellular substrates for ERAAP.Peso molecular:1,773.7 g/molGuanylin
CAS:Guanylin peptide hormone which is an activator of the transmembrane receptor Guanylate Cyclase C located on the surface of intestinal epithelial cells. It is sourced from Rat, Mouse species and contains disulfide bonds between Cys4-Cys12 and Cys7-Cys15.
Fórmula:C60H90N16O22S4Pureza:Min. 95%Peso molecular:1,515.7 g/molH-LLQVAVEDR^-OH
Peptide H-LLQVAVEDR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.H-GWIFGTTLDSK^-OH
Peptide H-GWIFGTTLDSK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Fmoc-D-Asp(OtBu)-OH
CAS:Fmoc-D-Asp(OtBu)-OH is a cell biology research tool that can be used to study protein interactions and ion channels. It also has been used as an inhibitor for the activation of receptor tyrosine kinases, including human epidermal growth factor receptor 2 (HER2) in breast cancer cells. Fmoc-D-Asp(OtBu)-OH is a high purity compound that is available with CAS No. 112883-39-3.
Fórmula:C23H25NO6Pureza:Min. 95%Peso molecular:411.46 g/molCarcinoembryonic antigen-related cell adhesion molecule 5 (653-667)
Custom research peptide; min purity 95%. For different specs please use the Peptide Quote ToolH-LAV^YQAGAR-OH
Peptide H-LAV^YQAGAR-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.N-methylated ERAP1substrate
Non-hydrolysable ERAP1 substrate. An optimized ERAP1 substrate with N-methylation of the first amide bond to prevent its degradation by ERAP1.Endoplasmic reticulum aminopeptidase 1 and 2 (ERAP1 and ERAP2) are ER-resident, interferon-γ inducible, metalloaminopeptidase which critically shape the major histocompatibility complex I (MHC I) immunopeptidome. The ERAPs remove N-terminal residues from antigenic precursor peptides and generate optimal-length peptides (i.e. 8-10-mers) to fit into the MHC class I groove. The immune recognition of surface MHC I/peptide complexes initiates activation of CD8+ T cells as a critical step in the elimination of pathogens.ERAP1 has unique substrate preferences, trimming long peptides while sparing shorter ones as well as sequence preferences. ERAP1 and ERAP2 can form a heterodimer (ERAP1/ERAP2) with distinct functional properties. Allelic variants of ERAP1 have been linked to a number of human diseases, including the autoimmune disease ankylosing spondylitis (AS), diabetes, some forms of cervical cancer, and hypertension.Cor e Forma:PowderPeso molecular:1,035.6 g/molAmyloid Beta-Protein (40-1)
CAS:Amyloid Beta-Protein (40-1) is a peptide that is found in the brain, and is thought to be involved in Alzheimer’s disease. Amyloid Beta-Protein (40-1) has been shown to inhibit protein interactions and activator functions, as well as act as a ligand for receptors. This protein can be used as a research tool for studying ion channels and antibodies. It also has high purity and can be used for life science experiments.Fórmula:C194H295N53O58SPureza:Min. 95%Peso molecular:4,329.8 g/molCRF human, rat
The peptide CRF, also known as the Corticotropin Releasing Factor is a 14 amino acid neuropeptide which is produced by the hypothalamus, within the hypothalamic-pituitary adrenal axis in response to stress stimuli. The CRF family exert their function by binding to Corticotropin-releasing factor receptors 1 and 2. During stress the production of CRF stimulates downstream hormones such as glucocorticoids and adrenocorticotropin (ACTH) through binding to CRF1 in the anterior pituitary gland. A negative feedback look is generated through glucocorticoids thus preventing the further release of CRF from the hypothalamus.Studies have shown CRF to be overproduced in patients with depression and can contribute to symptoms such as, reduced quality of sleep, anxiety, reduced appetite and analgesia. Furthermore higher CRF levels has been associated with immune cell dysfunction through preventing T-cell proliferation.Cor e Forma:PowderPeso molecular:4,754.5 g/molH-Ala-Tyr-Pro-Gly-Lys-Phe-OH
CAS:H-Ala-Tyr-Pro-Gly-Lys-Phe-OH is a peptide that activates toll-like receptor 4 (TLR4). It is a potent inhibitor of the enzyme phospholipase A2 and has been shown to inhibit the production of proinflammatory cytokines, such as IL1β, IL6, IL8, and TNFα. This peptide also has anti-inflammatory effects on autoimmune diseases, such as rheumatoid arthritis. H-Ala-Tyr-Pro-Gly-Lys-Phe-OH has been shown to inhibit prostate cancer cell growth in vitro and in vivo. It appears to exert its action by interfering with the transcriptional process at the level of RNA polymerase II. The mechanism may involve inhibition of the activation of basic fibroblast cells or suppression of epidermal growth factor signaling. H-Ala-Tyr - Pro - Gly - Lys - Phe -
Fórmula:C34H47N7O8Pureza:Min. 95%Peso molecular:681.78 g/molH-EHLAEVTLSVK^-OH
Peptide H-EHLAEVTLSVK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
H-YQYNTDVVFDSQGK^-OH
Peptide H-YQYNTDVVFDSQGK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
Histone H3 (1-20) pT3, K4Me3-GG-[Lys(5-FAM)]
Histone 3 (H3) is one of the four core histones (H2A, H2B, H3 and H4) fundamental in compacting eukaryotic DNA into the nucleosome. Similar to the other core histone, H3 has a globular domain and a flexible N-terminal domain, 'histone tail' which can undergo modifications such as acetylation, methylation, phosphorylation and ubiquitination. The transcriptional activation or silencing of the chromatin is controlled by ATP-dependent chromatin remodelling factors and histone modifying enzymes which target histone proteins. Both processes function to alter the positioning of the nucleosome, allowing the DNA it to be either available or inaccessible to the transcription machinery.The lysine at position 4 of this peptide has been tri-methylated and it is implicated in studies that this modification may remodel the chromatin so that it is more accessible to transcription factors, which may ultimately increase the level of gene expression. Moreover, the threonine at position 3 has been phosphorylated. It is implicated in recent studies that H3T3 phosphorylation regulates chromosome cohesion and is necessary for chromosomes to be able to align on the metaphase plate.The this peptide is labelled with 5-Carboxyfluorescein (5-FAM), a widely used green fluorescent tag.
Peso molecular:2,904.5 g/molFmoc-Lys(Palmitoyl-Glu-OtBu)-OH
CAS:This is a building block for peptide synthesis. It is a protected lysine derivative that can be used in the formation of peptides. This functionalized lysine derivative can be deprotected and reacted with other amino acids to form peptides. The protecting group, Fmoc, protects the lysine from unwanted reactions during the synthesis process. The side chain, Palmitoyl-Glu-OtBu, allows for the attachment of other molecules to the lysine side chain.Fórmula:C46H69N3O8Pureza:Min. 95%Peso molecular:792.08 g/molAntennapedia peptide Arg
Identification of cell penetrating conjugates has aided numerous areas of scientific development. The Drosophila transcription factor Antennapedia contains a homeodomain that can be internalised by cells in a receptor-independent mechanism to the cytoplasm and to the nucleus. The key residues for internalisation have been sequenced (RQIKIWFQNRRMKWKK) and used in several studies to aid entry of recombinant proteins into cells.To further the scope of cell penetrating peptides (CPPs), analogues of penetratin have been generated. This arginine rich acid sequence was made and found to be a strong antimicrobial/antifungal agent while also retaining its CPP properties. The activity was tested against the pathogenic strains Candida albicans, Cryptococcus neoformans, Staphylococcus aureus, and Escherichia coli. The degree of arginine content is linked to the rate of cellular uptake and antimicrobial activity.Peso molecular:2,358.79 g/molH-DADAVDK^-OH
Peptide H-DADAVDK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
H-DRVY^IHP^FHL-OH
Peptide H-DRVY^IHP^FHL-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.H-TYETTLEK^-OH
Peptide H-TYETTLEK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Duck liver-derived peptide 4
Duck liver-derived peptide 4 is a bioactive peptide with high antioxidant activity. The antioxidant activity is attributed to forming hydrogen bonds between their amino acid residues and free radical molecules. Duck liver-derived peptide 4 increases the activities and mRNA expression levels of intracellular antioxidant enzymes (SOD, CAT, and GSH-Px) in HepG2 oxidative damage cell models. Duck liver-derived peptide 4 can reduce the content of malondialdehyde (MDA) and reactive oxygen species (ROS) accumulation, thereby inhibiting intracellular oxidative damage. Duck liver-derived peptide 4 has the following activity: ACE inhibitor, dipeptidyl peptidase IV inhibitor, antioxidant, and antithrombotic. It may be used in the research for food-derived bioactive peptides for modified-food development.Peso molecular:943.5 g/molBiotin-Axltide Peptide substrate
Axltide-is a substrate peptide for use in kinase assays and is based on the mouse insulin receptor substrate 1 (IRS1) (amino acid 979-989).IRS1 is a membrane-proximal adaptor protein, which binds to, and is phosphorylated by, the insulin receptor (IR) at its tyrosine residue. IRS1 transmits the extracellular signal for insulin to serine/threonine kinases, such as Akt which then deliver the signal into the cell to mediate the various actions of insulin.Contains an N-terminal biotin tag for easy detection and purification.Cor e Forma:PowderPeso molecular:1,854.2 g/molSARS-CoV-2 Spike (236-250)
The SARS-CoV-2 spike protein is present on the outside of the virus particles and can bind to angiotensin-converting enzyme II (ACE2) present on the host cells. The C-terminal receptor binding domain (RBD) of the spike protein binds to the N-terminal peptidase M2 domain of ACE2. This receptor binding results in the internalisation of the virus-receptor complex and is, therefore the mechanism of entry of SARS-CoV-2 into host cells.The spike protein residues TRFQTLLALHRSYLT (236-250) from C have been identified as a T-cell epitope with a predicted HLA restriction. Immune targeting of confirmed epitopes may potentially offer protection against SARS-CoV-2 and help the development of vaccines for long-lasting immunity.Peso molecular:1,819 g/molH-LQAEAFQ^AR-OH
Peptide H-LQAEAFQ^AR-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Activity-Dependent Neurotrophic Factor, ADNF
Custom research peptide; min purity 95%. For different specs please use the Peptide Quote ToolFórmula:C41H74N12O12Peso molecular:927.12 g/molAlbumin (51-62) Bovine
Albumin (51-62) Bovine is derived from the globular protein Albumin and is found in the blood plasma of humans (known as Human Serum Albumin, HSA) where it serves to maintain plasma pressure and nutritional balance. Another role it carries out is the transportation of bound molecules through the blood. Bovine serum albumin (BSA), composed of 583 amino acids, is very similar to HSA thus allowing BSA to be used as a successful model and a standard protein in laboratory experiments.Although BSA and HAS share homology in their three domains, I, II and III, BSA contains 2 tryptophan whereas HAS only contains 1 tryptophan residue.In agriculture the presence of the albumin protein has been used to assess the health of cows to ensure that a suitable quality of milk and meat are produced. Moreover it is important to detect bovine albumin in food and pharmaceutical products due to it being an allergenic protein.Cor e Forma:PowderPeso molecular:1,510.8 g/molPal-RWKFGGFKWR-OH
Peptide Pal-RWKFGGFKWR-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
Biotinylated L57
The blood-brain barrier (BBB) is a major obstacle to drug delivery into the central nervous system (CNS), in particular for macromolecules such as peptides and proteins. However, certain macromolecules can reach the CNS via a receptor-mediated transcytosis (RMT) pathway, and low-density lipoprotein receptor-related protein 1 (LRP1) is one of the promising receptors for RMT. Recent studies have shown that biotinylated L57 binds to LRP1 (CL4)-Fc more efficiently than Angiopep-7 (a different LRP1 ligand), which might explain the improved BBB permeability of L57.Peso molecular:3,110.6 g/molDabcyl-SFNFPQIT-Edans
Peptide Dabcyl-SFNFPQIT-Edans is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Ac-NRRRRWRERQR-NH2
Peptide Ac-NRRRRWRERQR-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Hp1404
Antimicrobial peptides (AMP) are proving a lucrative area for antibiotics in the era of bacterial resistance. Of note, the scorpion Heterometrus petersii was found to produce Hp1404, an amphipathic cationic peptide with specific activity against Gram-positive bacteria- Hp1404 was shown to be effective against methicillin-resistant Staphylococcus aureus (MRSA). The mode of action is by membrane penetration and disruption. MRSA did not gain resistance after several exposures to Hp1404 suggesting it may be a key agent against the rise of antibiotic resistance. Importantly, bacterial lethality was maintained with low toxicity to mammalian cells. Hp1404 is being used to generate analogues with reduced toxicity to mammalian cells and improved antimicrobial potency against a wider range of organisms.Cor e Forma:PowderPeso molecular:1,544.9 g/molH-SNTSESF-NH2
Peptide H-SNTSESF-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
Influenza Virus Nucleoprotein (311 - 325)
The Influenza Virus Nucleoprotein (311 - 325) is a component of the viral ribonucleotide complex, derived from the influenza virus and it is involved in viral replication, RNA packing and nuclear trafficking. As a monomer it contains basic residues which allow it to bind to single stranded RNA and through its flexible tail loop it has the ability to form NP oligomers.Furthermore NP is able to support the viral polymerase structurally, through associating with the two subunits PB1 and PB2, and it allows the viral ribonucleotide complex to be transported in and out of the nucleus due to its nuclear localisation and nuclear export signals.During influenza viral replication messenger RNA, viral genome RNA and complementary positive-sense RNA are produced and NP is crucial for this replication.Inhibitors of NP have potential to be used to prevent the influenza virus in humans.Peso molecular:1,764.9 g/molH-Phe-Ser-Leu-Leu-Arg-Tyr-NH2
CAS:This is a synthetic peptide that was originally isolated from human colon tissue. It has been shown to sensitize dorsal root ganglia neurons in vitro, producing a response to the neurotransmitter acetylcholine. This peptide also induces apoptosis in neuronal cells and increases the permeability of blood vessels in tissues by activating vasoactive intestinal peptide (VIP) receptors. The effects of this peptide were studied in humans with bowel disease or inflammatory bowel disease. It was found that it may be effective for treating these diseases as well as necrosis factor-mediated inflammation. This peptide is also known to activate IL-10, which is an anti-inflammatory cytokine.Fórmula:C39H60N10O8Pureza:Min. 95%Peso molecular:796.98 g/molH-FSPDDSAGASALLR^-OH
Peptide H-FSPDDSAGASALLR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.H-Ser-Phe-Leu-Leu-Arg-Asn-Pro-Asn-Asp-Lys-Tyr-Glu-Pro-Phe-NH2
CAS:H-Ser-Phe-Leu-Leu-Arg-Asn-Pro-Asn-Asp-Lys-Tyr-Glu-Pro-Phe is a peptide that is activated by incubation with collagen. It has been shown to have an inhibitory effect on thrombin receptor and the activation of coagulation factors, which may be due to its ability to desensitize the receptor. HSLRAPAP can also be used in cancer therapy. In animal studies, it has been shown to inhibit tumor growth and metastasis. HSLRAPAP has also been shown to stimulate the production of platelets in animals, which may account for its antiplatelet properties.Fórmula:C83H120F3N21O24Pureza:Min. 95%Ac-AKFVAAWTLK-NH2
Peptide Ac-AKFVAAWTLK-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.H-TLDPER^-OH
Peptide H-TLDPER^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
GRP (18-27) (human, porcine, canine)
Mammalian bombesin-like neuropeptide first isolated from pig spinal cord, which can stimulate rat uterine smooth muscle contraction and gastrin and somatostatin secretion in vitro. Increases blood pressure and pancreatic exocrine secretion in dogs.Cor e Forma:PowderPeso molecular:1,119.5 g/molGP120 - W61D - 5
Custom research peptide; min purity 95%. For different specs please use the Peptide Quote ToolPeso molecular:1,541 g/molMyr-RLYRKRIWRSAGR-OH
Peptide Myr-RLYRKRIWRSAGR-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.[5-FAM] EGFR/kinKDR peptide substrate
Peptide substrate of the epidermal growth factor receptor (EGFR), a member of the receptor tyrosine kinase family known as ErbBs or HER receptors. These receptors are involved in the regulation of cell proliferation, survival, differentiation and migration. When these receptors are dysregulated many diseases, including cancer, can arise.Binding to the ligand binding domain of the EGFR causes receptor dimerization. This is sequentially followed by the tyrosine kinase domain being activated and the tyrosine residues on the C-terminal tail of the receptor becoming phosphorylated, activating downstream signalling pathways.This peptide contains an N-terminal 5-Carboxyfluorescein (5-FAM) moiety, a widely used green fluorescent tag.Peso molecular:1,978.9 g/molBiot-ASRMEEVD-OH
Peptide Biot-ASRMEEVD-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Ac-GKPIPNPLLGLDST-NH2
Peptide Ac-GKPIPNPLLGLDST-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.[Pyr]-Apelin-13
CAS:[Pyr1]-Apelin-13 acts as a ligand for the apelin receptor (APJ) G protein-coupled receptor and is a substrate for angiotensin-converting enzyme 2. Apelin is a member of the adipokine hormone family from adipose tissue. Adipokines are involved in processes such as vascular homeostasis and angiogenesis.Apelin and the apelin receptor are widely distributed throughout the body. Apelin is associated with cardiovascular diseases, obesity, diabetes and cancer. Apelin is expressed in the spinal cord and the human brain. Immunohistochemistry shows that apelin-17 is significantly expressed in the human heart, brain, lungs and endothelial cells. Studies show myocardial infarction apelin mRNA expression is greater during human heart failure than in healthy tissue. Apelin protects against heart failure due to the pyroglutamic form of apelin, [Pyr1]-Apelin-13, which decreases infarct size of myocardial infarctions. Furthermore, rats with hypertension have reduced levels of apelin and APJ. [Pyr1]-Apelin-13 exhibits higher APJ agonist potency than Apelin-13. We also have the alternative available.Fórmula:C69H108N22O16SCor e Forma:PowderPeso molecular:1,533.8 g/molCrotonic-HFRRHL-OH
Peptide Crotonic-HFRRHL-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
H-VAQELEEK^^-OH
Peptide H-VAQELEEK^^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Pep - 1: Chariot
Pep-1 is a synthetic cell-penetrating peptide (CPP), and has been successfully used to deliver a variety of proteins and other biopharmaceutical macromolecules into cells in a non-disruptive manner. It is a CPP with primary amphipathicity, which results from its amino acid sequence as opposed to its folding structure. The primary structure of Pep-1: Chariot comprises three main domains: a tryptophan-rich, hydrophobic domain, and a hydrophilic domain derived from an NLS (nuclear localisation signal) of SV40 (simian virus 40) large T-antigen, and a spacer.
Cor e Forma:PowderPeso molecular:2,846.5 g/molH-Ser-Phe-Leu-Leu-Arg-OH
CAS:H-Ser-Phe-Leu-Leu-Arg-OH is a cyclic peptide that has been shown to have cytotoxic effects against cells of the atherosclerotic lesion in vivo. It also has antioxidant properties and can be used as a biocompatible polymer for the treatment of autoimmune disease. This drug is not potent enough to be used as an antibacterial agent but is effective against some strains of Mycobacterium tuberculosis and Mycobacterium avium complex. This drug binds to integrin receptors on cells, which may account for its low potency.Fórmula:C30H50N8O7Pureza:Min. 95%Peso molecular:634.77 g/molH-EPVAGDAVPGPK^-OH
Peptide H-EPVAGDAVPGPK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
SARS-CoV-2 NSP13 (226-240)
The SARS-CoV-2 non-structural protein 13 (NSP13) has been identified as a target for anti-viral therapeutics due to its highly conserved sequence and is essential for viral replication. NSP13 is part of the helicase superfamily 1B. As an NTPase and RNA helicase, NSP13 binds to RNA-dependent RNA polymerase and acts in concert with the replication-transcription complex to stimulate backtracking and further activate NSP13 helicase activity. These factors make NSP13 a good target for developing new antiviral drugs. In addition, the identification of epitopes within the NSP13 sequence can help design more effective SARS-CoV-2 vaccines.Models have predicted epitopes exhibiting antigenicity, stability and interactions with MHC class-I and class-II molecules. NSP13 (226-240) is an epitope candidate with various HLA restrictions. This epitope can be used to better vaccine design for more durable CD4+ and CD8+ T cell responses for long-lasting immunity.Peso molecular:1,565.9 g/mol
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