Peptídeos
Os peptídeos são cadeias curtas de aminoácidos ligados por ligações peptídicas, desempenhando papéis importantes como moléculas biológicas em processos celulares. Eles funcionam como hormônios, neurotransmissores e moléculas de sinalização, sendo amplamente utilizados em aplicações terapêuticas e diagnósticas. Os peptídeos também são cruciais na pesquisa para estudar interações proteicas, atividades enzimáticas e vias de sinalização celular. Na CymitQuimica, oferecemos uma ampla seleção de peptídeos de alta qualidade para apoiar suas necessidades de pesquisa e desenvolvimento em biotecnologia e farmacêutica.
Subcategorias de "Peptídeos"
Foram encontrados 29613 produtos de "Peptídeos"
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Cyclo[Arg-Gly-Asp-D-Phe-Lys(Azide)]
Cyclo[Arg-Gly-Asp-D-Phe-Lys(Azide)] is a peptide that contains the RGD sequence. It is a synthetic cyclic peptide that has been shown to bind to integrin receptors, which are cell surface receptors found in many cells. These integrins are involved in cellular adhesion and signaling. Cyclo[Arg-Gly-Asp-D-Phe-Lys(Azide)] can be used as a tool for click chemistry, as it can be modified with other molecules such as azides, which can then be used for click reactions with other molecules. This peptide has also been shown to have biological activity against cancer cells and inflammation.Fórmula:C27H39N12O7Pureza:Min. 95%Peso molecular:629.68 g/mol[N-Me-Asp1]-Angiotensin II
[N-Me-Asp1]-Angiotensin II is a peptide that belongs to the peptides and biochemicals group. It is an angiotensin II antagonist, which means that it blocks the action of Angiotensin II on its receptors. This peptide can be used as a vasoconstrictive agent in the treatment of hypertension.Fórmula:C51H73N13O12Pureza:Min. 95%Peso molecular:1,060.23 g/molAc-Pro-Arg-Asn-Lys-Acc-NH2
Ac-Pro-Arg-Asn-Lys-Acc-NH2 is a peptide that is used to study the catalytic mechanism of enzymes. It has been shown to be an effective substrate for tryptase, which is an enzyme that plays a role in the degradation of proteins. Ac-Pro-Arg-Asn-Lys-Acc-NH2 binds to the active site of tryptase and undergoes a series of reactions that lead to its hydrolysis. The rate constants for these reactions have been measured in order to determine kinetic constants.Fórmula:C34H49N11O9Pureza:Min. 95%Peso molecular:755.84 g/mol[Nle4, D-Phe7]-ß-MSH-Amide
Melanocyte Stimulating Hormone (MSH) and Related Peptides are a group of peptides that have a role in the regulation of skin pigmentation. One such peptide is Nle4, D-Phe7]-ß-MSH-amide, which is an agonist of melanocortin receptors. It has been shown to stimulate the proliferation and cause the differentiation of melanocytes in vitro, as well as to increase the number of melanocytes in vivo.Fórmula:C78H111N21O19Pureza:Min. 95%Peso molecular:1,646.88 g/molMet-Leu-pNA (Hydrochloride Form)
Met-Leu-pNA (Hydrochloride Form) is a peptide that binds with high affinity to the N-methyl-D-aspartate receptor, an ion channel protein. It is used in research tools and as an inhibitor. The peptide has been shown to inhibit the activity of the receptor by competitive inhibition, preventing binding of glutamate, which normally activates the ion channel. This inhibition leads to a decrease in neuronal excitability and decreased production of proinflammatory cytokines.Fórmula:C17H26N4O4S•HClPureza:Min. 95%Peso molecular:418.95 g/molCyclorasin 12A
Cyclorasin 12A is a research tool that can be used to activate or block ligands on their receptors. Cyclorasin 12A is a peptide fragment of cyclosporin A, which is an immunosuppressive agent. Cyclorasin 12A binds to the receptor, which activates the ion channels and inhibits the activity of protein kinases. Cyclorasin 12A has been shown to inhibit ion channels in cells and also has been found to reduce inflammation by inhibiting cytokine production.Fórmula:C71H102N27O11FPureza:Min. 95%Peso molecular:1,528.78 g/molFmoc-Ala-Rink-Amide MBHA Resin
Fmoc-Ala-Rink-Amide MBHA Resin is a resin used in peptide synthesis. It is mainly used as an inhibitor of peptidase A or B, and can also be used to inhibit the proteolytic activity of other enzymes. This product has CAS No. 68945-59-6, and is available in a high purity 99% form. Fmoc-Ala-Rink-Amide MBHA Resin is mainly used as a research tool for the study of protein interactions, activator ligands, and receptor ligands. It can also be used for biochemistry experiments involving ion channels and antibodies.Pureza:Min. 95%[FITC]-Ahx-(KKEEE)3K carrier peptide
The [FITC]-Ahx-(KKEEE)3K carrier peptide contains the fluorescent label fluorescein isothiocyanate (FITC), where the isothiocyanate can generate a stable thiourea linkage through reacting with the amine group present on protein molecules. The Ahx group (1,6-aminohexanoic acid) is used as a spacer to N-terminally link the FITC to the (KKEEE)3K carrier peptide. The (KKEEE)3K peptide sequence has shown significant specific renal targeting, thus giving it kidney-specific drug carrier properties. In particular its ability to target drugs to the proximal tubule cells of the kidney suggests potential to aid in the treatment of renal diseases.
Peso molecular:2,578.83 g/molExendin 4 (4-39)
This is a truncated exendin-4 peptide, the original peptide was identified in Gila monster lizard (Heloderma suspectum). Exendin-4 is an incretin mimetic, an analog of glucagon-like-peptide-1 (GLP-1), it stimulates insulin secretion and modulates gastric emptying to slow the entry of ingested sugars into the bloodstream. Exendin-4 is resistant to cleavage by plasma DPP-IV unlike GLP-1. This gives it a longer half-life and duration of action than GLP-1, as well as greater potency in vivo. Exendin-4 increases insulin sensitivity and improves glucose tolerance and is currently used for the treatment of Type 2 diabetes mellitus in its synthetic form Exenatide.Exendin-4 also promotes the production and proliferation of β-cells leading to regeneration of the pancreas. It is a ligand to the exendin receptor and increases pancreatic acinar cell cAMP levels. However, the GLP-1 analog was found to have a toxic effect by inducing hypotension due to relaxation of the cardiac smooth muscle.Cor e Forma:PowderPeso molecular:3,860.9 g/molSakamototide
Sakamototide is phosphorylated by members of the 5'-adenosine monophosphate-activated protein kinase (AMPK) family of kinases as is therefore ideal for use in kinase assays to test the activity of AMPK family members. The AMPK family includes- salt inducible kinases (SIKs), NUAK's, sucrose non-fermenting (Snf1)-related kinase (SNRK), microtubule affinity regulating kinases (MARKs) and brain specific kinase/BR serine/threonine kinase (BRSK). The kinase activity of AMPK and AMPK-related kinases, is dependent on its phosphorylation at Thr175 by the upstream kinase LKB1 (also known as STK11).Cor e Forma:PowderPeso molecular:1,738.9 g/molFibrinopeptide
Fibrinogen is a large plasma glycoprotein with a complex structure, and one of the most abundant proteins in blood. Fibrinogen is important in fibrin clot formation, haemostasis, and inflammatory responses. Increased plasma fibrinogen indicates a proinflammatory state and is a risk factor for vascular inflammatory diseases including hypertension and atherosclerosis. Fibrinogen cleavage products act as inflammatory activators in the pathophysiology of allergic asthma.The conversion of monomeric fibrinogen into polymeric fibrin is mediated by thrombin, which binds to fibrinogen and catalyses cleavage of fibrinopeptide A (FpA) and fibrinopeptide B (FpB). Fibrinopeptide B is protected from modifications such as carbamylation by pyroglutamination of the N-terminal amino acid.Cor e Forma:PowderPeso molecular:1,551.7 g/molSpexin
Spexin is a neuropeptide that is conserved amongst humans and rodents. Spexin activates galanin2/3 receptors, inducing a different active conformation of GalR2 to galanin. The broad distribution of spexin suggests multiple physiological roles including as a regulating factor in obesity and energy metabolism. Spexin is ubiquitously expressed in human tissue, however, a correlation has been found with obesity and age. Obese patients had significantly lower levels of circulating spexin than those with a healthy weight range. The significance of this suggests spexin regulates appetite, feeding behaviour, and energy expenditure. Spexin also specifically inhibits the uptake of long-chain fatty acids by adipocytes.Spexin is a central modulator of cardiovascular and renal function and can elicit central nervous system behavioural responses. As spexin levels decrease with age there is research to understand if it plays a role in age-related pathophysiology of cardiometabolic conditions. Spexin is also being considered an early biomarker for cardiovascular disease due to the magnitude with which it decreases as the pathophysiology progresses.Peso molecular:1,618.8 g/molPAR-4 Agonist (Mouse)
CAS:Thrombin is the main effector of the coagulation cascade- it is a serine protease. Thrombin binds to active protease activated receptor (PAR) which belongs to a subfamily of G-protein coupled receptors (GPCR). Thrombin activation of mouse PAR-4 reveals an amino terminus sequence of GYPGKF. This is the natural ligand for PAR-4. GYPGKF binds internally to the receptor and leads to signalling activation. Identification of GYPGKF as a PAR-4 agonist has allowed better understand of the function of PAR. Addition of GYPGKF to PAR-4 expressing cell lines achieved 55% of the maximal response of thrombin. GYPGKF can provide understanding of PAR-4 and a template for more potent agonists.
Fórmula:C33H46N8O7Cor e Forma:PowderPeso molecular:666.3 g/molAcetyl-Histone H4 (1-21)
Histone 4 (H4) is one of the four core histones (H2A, H2B, H3 and H4) which are essential for compacting eukaryotic DNA into the nucleosome. Due to the high lysine and arginine content, histones have a net positive charge and therefore electrostatically interact with negatively charged DNA. The nucleosome arises when 147 base pairs of DNA wrap around a H3-H4 tetramer and two H2A-H2B dimers, forming the histone octamer core. Like other core histones, H4 has a globular domain and a flexible N-terminal domain, the histone tail, which can undergo modifications such as acetylation, methylation, phosphorylation and ubiquitination.Gene transcriptional activation or inactivation is controlled by ATP-dependent chromatin remodelling factors and histone modifying enzymes. Both processes function to alter the positioning of the nucleosome, allowing the DNA within to be either accessible to the transcription machinery or inaccessible. H4 lysine rich tail plays a role in the higher order chromatin folding.Acetyl-Histone H4 (1-21)-has an uncharged C-terminal amide and is protected from N-terminal modifications by a covalently bonded acetyl group.Peso molecular:2,131.3 g/molSETD8 Peptide
Setd8 is a member of the SET domain containing family of proteins and is the sole methyltransferase that catalyses monomethylation of lysine 20 on histone H4 (H4K20me1). This histone modification is involved in regulating DNA replication, chromosome condensation and gene expression.Setd8 is widely expressed and in addition to modifying histone H4, it can modify non-histone proteins, including p53. Setd8 has been shown to play a role in maintaining skin differentiation and is dysregulated in multiple cancer types.Peso molecular:1,076.7 g/molh-Chemerin-9 (149-157)
A Chemerin-9 peptide derived from chemerin, a protein that is involved in a variety of functions such as autocrine, angiogenic, reproductive and chemotactic processes. Chemerin-9 binds to the chemerin receptor 23 (G-protein coupled receptor) and causes the receptors internalisation.Peso molecular:1,063.5 g/molHLA-A*02:01 HBV core (18-27)
HLA-A*02 is a class I major histocompatibility complex (MHC) allele which is part of the HLA-A group of human major histocompatibility complex (MHC) leukocyte antigens (HLA). HLA-A is a human MHC class I cell surface receptor and is involved in presenting short polypeptides to the immune system. These polypeptides are typically 7-11 amino acids in length and originate from proteins being expressed by the cell. Cytotoxic T cells in the blood "read" the peptide presented by the complex and should only bind to non-self peptides. If binding occurs, a series of events is initiated culminating in cell death via apoptosis. This peptide corresponds to the Hepatitis B variant (HBV) core sequence which is presented on the MHC class I antigen HLA-A*02.Peso molecular:1,154.6 g/molUrumin
Urumin is a veridical host defence peptide against influenza A virus.The peptide specifically targets the evolutionarily conserved H1 hemagglutinin stalk region of H1-containing influenza A viruses.Urumin has been used against drug-resistant influenza A viruses that are resistant against oseltamivir, zanamivir and peramivir. While its mechanism of action is not fully understood, urumin seems to inhibit viral growth by physically destroying influenza A virions, and is able to protect naive mice from doses of influenza A infection as high as 2 times the LD50. Because of its specific targeting of the hemagglutinin stalk region of the influenza A virus, the mechanism of action of urumin is similar to that of antibodies induced in the body by universal influenza vaccines.Peso molecular:2,959.4 g/molAlbumin (mouse, rat)
Albumin is a family of globular, water soluble, un-glycosylated proteins commonly found in blood plasma. Albumins generally act as transport proteins that bind to various ligands to transport them around.The most common member of this family is serum albumin. Serum albumin is produced by the liver and is the most abundant plasma protein, it provides oncotic pressure, transports bilirubin, steroids, fatty acids, thyroid hormones and other hormones, and serves as an extracellular antioxidant agent.Too much or too little circulating serum albumin may be harmful. Perturbations in serum albumin concentration is associated with both type 2 diabetes and metabolic syndrome (MetS). Increase in serum albumin concentration might protect against early glycemic deterioration and progression to type 2 diabetes even in subjects without MetS. Albumin in the urine usually denotes the presence of kidney disease.Peso molecular:1,055.7 g/molHIV p17 Gag (77-85)
The HIV gag gene encodes p17 and p24. P17 Gag is a matrix protein that is vital to HIV life cycle, it targets viral RNA to the nucleus and Gag polyproteins to the cell membrane- p17 Gag accumulates in the extracellular space of tissue while interacting with receptors on various cell types to deregulate cell function.During HIV infection the cytotoxic T lymphocyte (CTL) response is key to attenuating viral replication. CTL recognition epitope of p17 Gag is identified as residues 77-85 to activate the immune response. HIV p17 Gag CTL epitope has been used in IgG titres and has been suggested as a suitable prognostic tool for onset of AIDS. A high affinity of IgG for p17 Gag was correlated to patients remaining in an asymptomatic state. p17 Gag epitope has been shown to induce a strong CTL response in the majority of chronically infected HIV patients. This makes the p17 Gag epitope a target for molecular therapy for HIV treatment and potentially a vaccine development.Cor e Forma:PowderPeso molecular:980.5 g/mol
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