Peptídeos
Subcategorias de "Peptídeos"
Foram encontrados 29863 produtos de "Peptídeos"
Histone H3 (1-22) K9Me1-Biotin
Histone H3 (1-22) K9Me1-Biotin is derived from Histone 3 (H3) which is one of the four core histones (H2A, H2B, H3 and H4) fundamental in compacting eukaryotic DNA into the nucleosome. The nucleosome arises when 147 base pairs of DNA wrap around a H3-H4 tetramer and two H2A-H2B dimers, forming the histone octamer core. Both H4 and H3 are highly conserved and perform roles in binding to segments of DNA which enter and leave the nucleosome and in chromatin formation. Similar to the other core histone, H3 has a globular domain and a flexible N-terminal domain, 'histone tail' which can undergo modifications such as acetylation, methylation, phosphorylation and ubiquitination. Due to histones containing a large number of lysine and arginine residues they have a positive net charge which interacts in an electrostatic manner with the negatively charged phosphate groups in DNA. The transcriptional activation or silencing of the chromatin is controlled by ATP-dependent chromatin remodelling factors and histone modifying enzymes which target histone proteins. Both processes function to alter the positioning of the nucleosome, allowing the DNA it to be either available or inaccessible to the transcription machinery.Another modification process histones can undergo is biotinylation where the covalent attachment of a biotin molecule is catalysed by the enzyme Biotinidase. This cleaves biocytin to generate a biotinyl-thiester intermediate. The biotinyl can then be transferred onto the histone lysine ɛ-amino group which in this case it is covalently attached to Histone 3. Overall the biotinylation sites identified in histone 3 are: K4, K9 and K18. The presence of biotinylated histones have been detected in human cells such as lymphocytes and lymphomas.Cor e Forma:PowderPeso molecular:2,823.7 g/molSARS-CoV-2 ORF7a-10 (69-86)
ORF7a is an accessory protein that is key to SARS-CoV-2 evading the immune system. ORF7a acts on the secretory pathway to lower surface MHC-I expression by specifically interacting with the MHC-I heavy chain and delaying its export from the endoplasmic reticulum. These factors make the ORF6 protein a viable target for developing new antiviral drugs. In addition, the identification of epitopes within the ORF7a-10 protein sequence can help design more effective SARS-CoV-2 vaccines.Models have predicted epitopes exhibiting antigenicity, stability and interactions with MHC class-I and class-II molecules. ORF7a-10 protein (69-86) is an epitope candidate with various predicted HLA restrictions. This epitope can be used to better vaccine design for more durable CD4+ and CD8+ T cell responses for long-lasting immunity.Peso molecular:2,052.2 g/molHsTX1
HsTX1 is a peptide toxin obtained from the venom of the scorpion Heterometrus spinnifer. It blocks potassium channels and inhibits the activity of Kv1.3 channels, which are responsible for neuronal repolarization and firing. This peptide is also a blocker of voltage-gated sodium channels, but has no effect on calcium channels. HsTX1 is used in medical research as a tool to study ion channel function.Fórmula:C149H246N54O46S9Pureza:Min. 95%Peso molecular:3,818.53 g/molH-ENEGFTVTAEGK^-OH
Peptide H-ENEGFTVTAEGK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
M12 muscle-homing peptide
Gene therapy is potentially an ideal treatment for muscle tissue myopathies but targeting remains an issue. The large volume of muscle in the body versus the requirement for tissue-specificity is of particular concern. This heptapeptide has been shown to preferentially bind myofibers and thus can be used to study targeting of peptide/gene- delivery to muscle tissue. Research into gene therapy of Duchenne muscular dystrophy (DMD) and Spinal muscular atrophy (SMA) has been of particular interest with muscle targeting peptides.- This product has been shown to orientate to muscle and heart tissue and when conjugated to a phosphorodiamidate morpholino oligomer (PMO)-increases dystrophin expression by 25%. This product already shows ideal placement to continue cardiac research to overcome some of these issues.Cor e Forma:PowderPeso molecular:1,416.8 g/molC7
Selective peptide ligand for FRalpha, demonstrating specific binding to FRalpha expression cells and tumour targeting ability in vivo.Peso molecular:1,374.7 g/molBIM 187
Bombesin/GRP receptor agonist derived from the pro-apoptotic protein BIM, which is a member of the BCL-2 family proteins and activates the BAX and BAK proteins to promote apoptosis.The process of apoptosis can be activated by the intrinsic or extrinsic pathways, the former is activated by stress stimuli such as DNA damage and nutrient deficiency, while the latter is induced through activation of the death receptors FAS and TRAIL.The BCL-2 family's transmembrane anchor at the C-terminus allows them to locate at the mitochondrial outer membrane and play a vital role in apoptosis.Within the mitochondria BIM is a member of the BH3 molecules alongside, BIM, PUMA and NOXA which can all be activated by the intrinsic pathway. These in turn can initiate the homo-oligomerisation of BAX and BAK which induce mitochondrial outer membrane permeabilisation (MOMP) and the release of cytochrome c into the cytosol. Here cytochrome c associates with APAF-1 and dATP, ultimately activating effector caspase3/7 and apoptosis.BIM can be activated by CHOP-mediated transcription and phosphatase 2A-mediated dephosphorylation during endoplasmic reticulum stress. However when BIM is phosphorylated it undergoes degradation by the proteasome.Peso molecular:1,068.6 g/molH-VTSIQDWVQ^K^-OH
Peptide H-VTSIQDWVQ^K^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Dystrophin (396-405)
Forms of inherited muscular dystrophy such as Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD) result from mutations targeting the dystrophin gene. These disorders are X-linked, progressive, and cause the gradual weakening of the muscles leading to respiratory failure and ultimately reduces the patient lifespan.In DMD, mutations lead to the production of premature stop codons and hence the truncated dystrophin protein product is vulnerable to nonsense mediated decay and degradation. Therefore, dystrophin production in muscle cells is reduced. On the other hand, nonsense mutations which also contribute to DMD, cause exon skipping in BMD and result in an internally truncated protein product which are partially functional. The symptoms of BMD are later onset compared with DMD which develop in patients between 2 to 7 years.Treatments of dystrophin disorders are in clinical trials including antisense oligonucleotide exon skipping and gene therapy. However, the efficacies of these treatments are not easily quantified. Currently levels of muscular dystrophin are quantified by western blot which can be unreliable. The peptide provided here, aligning residues dystrophin (396-405), has been shown to provide absolute quantification of dystrophin levels from biopsies using parallel reaction monitoring. This will hopefully allow better management of dystrophin disorders with better quantifications tools based on dystrophin (396-405). Further study with this dystrophin fragment could prove to be a vital step in the understanding and treatment of dystrophin disorders. Within our catalogue we also have other peptides tested for dystrophin quantification available plus the full-length dystrophin protein.
H-2Kb Mouse L protein LEYDFNKL
Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tooldodecapeptide AR71
The dodecapeptide AR71 prevents melanoma inhibitory activity (MIA) dimerisation and hence inhibits (MIA). It therefore has the potential to be used as a therapeutic in melanoma.
Peso molecular:1,550.8 g/molH-ELNYFAK^-OH
Peptide H-ELNYFAK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Ac-LKSKKGQSTS-NH2
Peptide Ac-LKSKKGQSTS-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.H-GQPLSPEK^-OH
Peptide H-GQPLSPEK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
CALP3 - Calcium like peptide 3
CAS:Cell-permeable calmodulin (CaM) agonist that binds to the EF-hand/Ca2+-binding site and can activate phosphodiesterase in the absence of Ca2+ and inhibit Ca2+ mediated cytotoxicity and apoptosis.Fórmula:C44H68N10O9Peso molecular:881.07 g/molCE dipeptide
CE-acid is a dipeptide of glutamate and cysteine. CE-acid has a formal charge of 0 and a range of biological and chemical uses. EC-acid is also available in our catalogue.
Peso molecular:250.1 g/molH-KSAPATGGVKKPHR^-OH
Peptide H-KSAPATGGVKKPHR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.H-HP^DASVNFSEFSK-OH
Peptide H-HP^DASVNFSEFSK-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Hemopexin [069-079]
Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool
Ac-CTHGTSMNRVIEEDGTSA-OH PAB-406-1589A
Peptide Ac-CTHGTSMNRVIEEDGTSA-OH PAB-406-1589A is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
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