Peptídeos
Subcategorias de "Peptídeos"
Foram encontrados 30060 produtos de "Peptídeos"
LCBiot-PKYVKQNTLKLAT-OH
Peptide LCBiot-PKYVKQNTLKLAT-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
H-LLDVDNR^-OH
Peptide H-LLDVDNR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.H-Arg(Pbf)-2-ClTrt-Resin (100-200 mesh) 1% DVB
H-Arg(Pbf)-2-ClTrt-Resin (100-200 mesh) 1% DVB is a resin used in the synthesis of peptides. This resin contains two amino acid residues that are used to form peptide bonds. These residues can be either H-Arg or H-Lys, but not both. The resin also contains a reagent called 2,4,6-trichlorophenoxyacetic acid (Troc), which reacts with the NH groups on the amino acids to form an ester linkage. The resin is typically used for building blocks and as an intermediate for synthesizing more complex molecules such as peptides and proteins.
Pureza:Min. 95%[Sar0, D-Phe8, Des-Arg9]-Bradykinin (Human, Rat, Mouse)
Custom research peptide; min purity 95%. For different specs please use the Peptide Quote ToolPeso molecular:975.11 g/molH-NIGELGVEK^-OH
Peptide H-NIGELGVEK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
CTLA-4 isoform 5 / sCTLA (157-174) (Human)
Custom research peptide; min purity 95%. For different specs please use the Peptide Quote ToolPeso molecular:2,077.36 g/molH-GPFPIIV^-OH
Peptide H-GPFPIIV^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
HIV - 1 MN ENV - 23
Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool
Peso molecular:1,916.2 g/molH-IDSLLENDR^-OH
Peptide H-IDSLLENDR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
Ac-WWWH-NH2
Peptide Ac-WWWH-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
H-VAVEEVDEEGK^-OH
Peptide H-VAVEEVDEEGK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
H-STALQLIQR^-OH
Peptide H-STALQLIQR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
Ac-KETWWETWWTEWSQPKKKRKVC-NH2
Peptide Ac-KETWWETWWTEWSQPKKKRKVC-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
CONSENSUS B Tat - 18
Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool
Peso molecular:1,538.7 g/molVal-Val-Val-Gly-Ala-Asp-Gly-Val-Gly-Lys
Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool
Fórmula:C39H69N11O13Peso molecular:900.03 g/molCMVpp65 - 41 (LTVSGLAWTRQQNQW)
Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool
Peso molecular:1,788 g/molAc-Leu-Arg-Ser-Arg-AMC
Interleukin-1 (IL-1) is a protein that is involved in the regulation of many aspects of the immune system. IL-1 is produced by macrophages and other cells, and it stimulates the production of other cytokines and has anti-inflammatory effects. IL-1 can also stimulate the release of certain enzymes such as elastase from neutrophils, which may have a role in chronic inflammatory diseases. Interleukin 1 has been shown to be an MALT1 substrate, a protein that regulates Mucosa Associated Lymphoid Tissue lymphoma translocation protein (MALT). The MALT1 enzyme is involved in regulating inflammation and immunity, as well as tumor progression.Fórmula:C33H51N11O8Pureza:Min. 95%Peso molecular:729.84 g/molFmoc-Leu-Rink-Amide MBHA Resin
Fmoc-Leu-Rink-Amide MBHA Resin is a research tool that is used to purify proteins. It is an activator for ligands and receptors, which are the molecules that bind to cells. This resin has been used in cell biology, where it has been shown to be able to inhibit ion channels and protein interactions. Fmoc-Leu-Rink-Amide MBHA Resin also has potential applications in pharmacology as an inhibitor of peptides or as a reagent for the synthesis of peptides. The purity of this resin is high and it can be used with antibodies or other proteins without interference.Pureza:Min. 95%LY2112688 trifluoroacetate
CAS:Please enquire for more information about LY2112688 trifluoroacetate including the price, delivery time and more detailed product information at the technical inquiry form on this page
Fórmula:C51H70N18O11S2•(C2HF3O2)xPureza:Min. 95%Cor e Forma:PowderPeso molecular:1,175.35 g/molH-SIISMFDR^-OH
Peptide H-SIISMFDR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
H-Met-Asp-OH
CAS:H-Met-Asp-OH is a synthetic formyl peptide that was designed to be hydrolyzed by proteolytic enzymes. It has been shown to be able to inhibit the formation of β-amyloid, which is associated with Alzheimer's disease. H-Met-Asp-OH also has been shown to have physicochemical properties similar to aspirin, and can be used as an antiplatelet agent. In addition, it has been shown to act as a catalase inhibitor in vitro and may have some therapeutic potential for the treatment of diabetes mellitus type 2.
Fórmula:C9H16N2O5SPureza:Min. 95%Cor e Forma:White PowderPeso molecular:264.3 g/molAc-GSARAEVHLRKS-NH2
Peptide Ac-GSARAEVHLRKS-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.H-Ala-Ala-NH2·HCl
CAS:H-Ala-Ala-NH2·HCl is a chiral liquid reagent that can be used in the determination of enantiomeric purity by chiral chromatography. It is also used as an amide, intramolecular hydrogen, hydroxyalkyl and aralkyl reagent. H-Ala-Ala-NH2·HCl is produced from alanine, which has been treated with fluorine gas to produce an optically active compound. This compound is then reacted with hydrochloric acid to yield the desired product.
Fórmula:C6H13N3O2·HClPureza:Min. 95 Area-%Cor e Forma:White Off-White PowderPeso molecular:195.65 g/molFmoc-Val-Gly-OH
CAS:Fmoc-Val-Gly-OH is a Research Chemical that is commonly used in the field of efficient synthesis. It is an amino acyl compound that can be utilized for the synthesis of various molecules. Fmoc-Val-Gly-OH is known for its high efficiency and reliability in producing desired results. It can be easily analyzed using spectrometry techniques, allowing researchers to accurately determine its composition and purity. This versatile compound can react with azides, alcohols, and other compounds to create new chemical entities. With its efficient properties, Fmoc-Val-Gly-OH is an essential tool for scientists and researchers in their quest for innovative discoveries.
Fórmula:C22H24N2O5Pureza:Min. 95%Peso molecular:396.44 g/mol(Sar 1,Ala8)-Angiotensin II
CAS:Angiotensin II is a peptide hormone that is involved in the regulation of blood pressure and fluid and electrolyte balance. It also acts as a vasoconstrictor by binding to angiotensin receptors on vascular smooth muscle cells. Angiotensin II is produced from angiotensin I by the action of renin. The high-resolution linear reformulating (HRLR) technique is used to estimate the spectrum and parameters of this molecule. This technique uses iterative methods for estimating the frequency response function and parameters for each frequency, including nonlinear ones. HRLR has been shown to be an accurate estimator with a frequency range from 0 to 10 kHz, which has not been achieved with other techniques.
Fórmula:C43H67N13O10Pureza:Min. 95 Area-%Cor e Forma:PowderPeso molecular:926.07 g/molGhrelin trifluoroacetate
CAS:Ghrelin is a peptide hormone that regulates appetite and has been shown to have potent anti-cachectic effects in animal models. It is thought to be an important regulator of body weight, insulin resistance, and metabolism. Ghrelin is synthesized in the stomach and released into the bloodstream when the stomach is empty. Ghrelin binds to ghrelin receptors in the hypothalamus, which stimulate growth hormone release from the pituitary gland. This hormone also binds to other cells in the hypothalamus, such as neurons that produce orexin, which may account for its effects on sleep patterns. Ghrelin has been shown to inhibit tumor growth by suppressing angiogenesis and inducing apoptosis. The molecular weight of ghrelin is 3497 Da. The sequence of ghrelin consists of 28 amino acids: Gly-Ser-Ser(octanoyl)-Phe-Leu-Ser-Pro-Glu-His-Gln-Lys-AlaFórmula:C147H245N45O42•(C2HO2F3)xPureza:Min. 95 Area-%Cor e Forma:PowderPeso molecular:3,314.8 g/molH-Ile-Val-OH
CAS:H-Ile-Val-OH is an inhibitor of the enzyme catalysis in cancer cells. The mechanism of inhibition is likely to be competitive with respect to the substrate and reversible by addition of exogenous substrate. The IC50 values for H-Ile-Val-OH were determined in uptake assays and found to be around 100 μM. The IC50 values for H-Ile-Val-OH were also determined in x-ray diffraction data and found to be around 10 μM. H-Ile-Val-OH has been shown to inhibit squamous carcinoma cell growth, which may be due to its ability to inhibit protein synthesis.
Fórmula:C11H22N2O3Pureza:Min. 95%Peso molecular:230.3 g/molFmoc-Cys(Dpm)-OH
CAS:Fmoc-Cys(Dpm)-OH is a chemical that belongs to the group of reaction components. It is a high quality reagent for research and development and can be used as a building block in the synthesis of other fine chemicals. Fmoc-Cys(Dpm)-OH is also an intermediate for the synthesis of complex compounds such as peptides, proteins, and antibiotics. This compound has a broad range of applications in biomedicine, organic chemistry, and pharmaceuticals.
Fórmula:C31H27NO4SPureza:Min. 95%Cor e Forma:White SolidPeso molecular:509.62 g/molMeOSuc-Ala-Phe-Lys-AMC trifluoroacetate salt
CAS:MeOSuc-Ala-Phe-Lys-AMC is a compound that has a destabilizing effect on the vascular wall, due to its ability to inhibit proteolytic activity. It is also able to reduce the level of angiogenic factors, and thus has an anti-angiogenic effect. MeOSuc-Ala-Phe-Lys-AMC has been shown to have a macroscopic effect on vessels in tissue culture, and this can be observed through leucocyte migration. MeOSuc-Ala-Phe-Lys-AMC has also been shown to cause haemorrhagic changes in microvessels and muscle cells. This compound is also able to inhibit placental growth factor and muscle cell proliferation, as well as reducing the number of microvessels in the placenta.Fórmula:C33H41N5O8•C2HF3O2Pureza:Min. 95 Area-%Cor e Forma:PowderPeso molecular:749.73 g/molMca-Tyr-Val-Ala-Asp-Ala-Pro-Lys(Dnp)-OH trifluoroacetate
CAS:Please enquire for more information about Mca-Tyr-Val-Ala-Asp-Ala-Pro-Lys(Dnp)-OH trifluoroacetate including the price, delivery time and more detailed product information at the technical inquiry form on this pageFórmula:C53H64N10O19•(C2HF3O2)xPureza:95%NmrCor e Forma:PowderPeso molecular:1,145.13 g/molGluten Exorphin B5 H-Tyr-Gly-Gly-Trp-Leu-OH
CAS:Gluten Exorphin B5 H-Tyr-Gly-Gly-Trp-Leu-OH is a synthetic opioid peptide that has been shown in animal models to reduce food intake and body weight. This peptide is an analog of the endogenous opioid peptides Met-enkephalin and Leu-enkephalin, which have been implicated in the regulation of food intake and energy expenditure. Gluten exorphin B5 H-Tyr-Gly-Gly-Trp-Leu-OH binds to the μ opioid receptor, which is involved in drug safety. It also binds to the prolactin receptor, which plays a role in drug absorption and distribution.Fórmula:C30H38N6O7Pureza:Min. 95%Cor e Forma:White PowderPeso molecular:594.66 g/molH-Ser-Asp-OH
CAS:H-Ser-Asp-OH is a peptide that is the product of the prokaryotic gene, mycobacterium avium. It has been shown to inhibit the translation of mRNA into protein in mycobacteria. H-Ser-Asp-OH also has an anti-inflammatory effect on human cells by inhibiting the synthesis of prostaglandins. This peptide also has antiviral properties and can be used as a treatment for chronic kidney disease (CKD) and hepatitis C. The drug is not effective against HIV infection or hepatitis B virus, however, because it does not inhibit reverse transcriptase or bind to viral DNA.Fórmula:C7H12N2O6Pureza:Min. 95 Area-%Cor e Forma:PowderPeso molecular:220.18 g/molProstaglandin A1
CAS:Please enquire for more information about Prostaglandin A1 including the price, delivery time and more detailed product information at the technical inquiry form on this page
Fórmula:C20H32O4Pureza:Min. 90 Area-%Peso molecular:336.47 g/molGlutathione disulfide (GSSG) methyl ester
Glutathione Disulfide (GSSG) Methyl Ester is a reactive molecule that is formed by the oxidation of glutathione. It is used in studies on oxidative stress and its role in tumorigenesis. GSSG Methyl Ester has been shown to bind to DNA and inhibit transcription. GSSG Methyl Ester is also used as a fluorescent probe for measuring intracellular glutathione levels. This compound has also been shown to have antioxidant properties, which may be due to its ability to scavenge reactive oxygen species and reduce cellular damage.
Fórmula:C24H40N6O12S2Pureza:Min. 95%Peso molecular:668.75 g/mol(Asp-Glu-Val-Asp)2-Rh110
(Asp-Glu-Val-Asp)2-Rh110 is a peptide substrate for caspase 3 and 7. It has been shown to be an effective inhibitor of peptidyl prolyl cis, trans isomerase (PPIase) in vitro and in vivo, which may lead to a possible therapeutic target for the treatment of neurodegenerative disorders.
Fórmula:C72H78N10O27Pureza:Min. 95%Peso molecular:1,515.48 g/molAF488 Maleimide
Please enquire for more information about AF488 Maleimide including the price, delivery time and more detailed product information at the technical inquiry form on this pagePureza:Min. 95%Nesfatin-1 (30-59) (Human)
Nesfatin-1 (30-59) is a peptide that is isolated from the brain and has been shown to have the ability to regulate feeding behavior. It is thought to be involved in the regulation of appetite and body weight. Nesfatin-1 (30-59) has been shown to inhibit ghrelin secretion, which is a hormone involved in hunger and satiety. This peptide also appears to stimulate insulin secretion by pancreatic beta cells, which may contribute to its anti-diabetic effects.
Fórmula:C167H263N41O54Pureza:Min. 95%Peso molecular:3,709.2 g/mol[Cys(AF488)]-Penetratin
The Drosophila Antennapedia homeoprotein is able to interact with the phospholipid bilayer to cross into the cell. The 16 residues of penetratin were identified that allowed translocation across the membrane of the cell in to the nucleus. Penatratin has been used as a CPP conjugate in a wide variety of fields particularly to transport hydrophilic molecules.The penetratin domain is present here fused to the green-fluorescent dye Alexa Fluor Dye 488. The tag is suitable for use in imaging and flow cytometry, excitation/ emission at 490/525nm. This fluorescent CPP can be used as a conjugate for intracellular drug delivery or detection of biological structures and thus a key research tool. This peptide is produced to research quality and therefore for research purposes only, and not for use in a therapeutic setting.
Pureza:Min. 95%Peso molecular:3,045.4 g/molH-LCL-OH
H-LCL-OH is a custom research peptide; min purity 95%, TFA salt. For different specs please use the Peptide Quote Tool
H-Pro-Ile-OH
CAS:H-Pro-Ile-OH is an amino acid that is found in the mitochondria of cells. It is a prodrug that binds to angiotensin and blocks its conversion to angiotensin II, which has been shown to have blood pressure lowering effects. H-Pro-Ile-OH has been shown to be a competitive inhibitor of oligopeptidase, with a half maximal inhibitory concentration (IC50) of 0.5 mM, and has also been shown to have antihypertensive properties.
Fórmula:C11H20N2O3Pureza:Min. 95%Cor e Forma:PowderPeso molecular:228.29 g/molAc-Gly-D-Arg-Gly-Asp-Ser-Pro-Ala-Ser-Ser-Lys-(Gly)4-Ser-D-Arg-(Leu)6-D-Arg-NH2
This synthetic peptide is a hydrophobic RGD Fibronectin Peptide which enhances cell attachment and adhesion. This is due to it containing the Arg-Gly-Asp (RGD) sequence, is a highly conserved integrin recognition sequence within fibronectin. As a result it can promote the adhesion of cells to fibronectin, a protein found in the extracellular matrix and also promotes adhesin of cells to collagen and laminin. One-Letter Formula: Ac-GrGDSPASSKGGGGSrLLLLLLr-AmideFórmula:C98H174N34O30Pureza:Min. 95%Peso molecular:2,308.69 g/molBPC 157 trifluoroacetate
CAS:Produto ControladoBody Protecting Compound (BPC) 157 is a pentadecapeptide gut peptide with free radical scavenging activity. As a gastric juice pentadecapeptide fragment, BPC 157 stimulates nitric oxide synthase generation, offering significant gastric cytoprotection. It has been shown to heal lesions in experimental models of bowel disease, Unlike many other peptides, BPC 157 effectively acts without a carrier, notably aiding in muscle healing, such as in the treatment of gastrocnemius muscle complex injuries. BPC 157 is also an anti-inflammatory agent that has been shown to have clinical relevance in patients with congestive heart failure. BPC 157 has been shown to inhibit inflammation by blocking the production of proinflammatory mediators such as prostaglandins and leukotrienes. It also suppresses the production of proinflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β). BPC 157 also downregulates genes that are involved in liver fibrosis, which may account for its efficacy in patients with liver cirrhosis. BPC 157 increases the production of hepatocyte growth factors (HGFs), which stimulate cell proliferation and promote tissue repair. It also upregulates genes involved in wound healing. Additionally, BPC 157 displays antianxiety and antidepressant effects. At the cellular level, it fosters proliferation, migration, and tube formation in human umbilical vein endothelial cells by activating ERK1/2 phosphorylation.
Fórmula:C62H98N16O22•(C2HF3O2)xPureza:Min. 95%Cor e Forma:PowderPeso molecular:1,419.53 g/molH-Lys-Val-Pro-Arg-Asn-Gln-Asp-Trp-Leu-OH
H-Lys-Val-Pro-Arg-Asn-Gln-Asp-Trp-Leu-OH is a peptide that was derived from the human HGP1 protein. The peptide, which is MHC class I restricted, has been shown to have an epitope that is recognized by CD8+ T cells in mice. This peptide has also been shown to be biologically active and heteroclitic.Fórmula:C52H82N16O14Pureza:Min. 95%Peso molecular:1,155.33 g/molFmoc8-Lys4-Lys2-Lys-ß-Ala-Wang Resin (100-200 mesh) 1% DVB
Fmoc8-Lys4-Lys2-Lys-ß-Ala-Wang resin is an inhibitor of protein interactions. It is a peptide that contains a sequence of amino acids that binds to other proteins and prevents them from forming. Fmoc8-Lys4-Lys2-Lys-ß-Ala-Wang resin can be used in the study of protein interactions and receptor binding, as well as for the production of antibodies.Pureza:Min. 95%Angiotensin I, human
CAS:Angiotensin I is a protein encoded by the AGTR1 gene. It is a precursor to angiotensin II, which causes vasoconstriction and has other effects on blood vessels, kidneys, and the heart. Angiotensin I is produced by proteolytic cleavage of pro-angiotensinogen in the liver. The mouse monoclonal antibody to human angiotensin I (mAb-HAI) recognizes both human and bovine angiotensin I. This antibody can be used for immunohistochemistry or Western blot analysis of cells from mice that have been injected with mAb-HAI. It has also been shown to reduce kidney fibrosis in mice when it is administered as a subcutaneous injection three times per week.Fórmula:C62H89N17O14Pureza:Min. 95%Peso molecular:1,296.48 g/molSDF-1β (human) trifluoroacetate salt
CAS:Please enquire for more information about SDF-1beta (human) trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this pageFórmula:C382H620N114O97S5Pureza:Min. 95%Peso molecular:8,522.05 g/molH-Arg(Me)-OH acetate salt
CAS:Produto ControladoH-Arg(Me)-OH acetate salt is a chemically synthesized amino acid derivative, specifically designed for research purposes in the field of biochemistry and molecular biology. This compound is a methylated form of the naturally occurring amino acid arginine, often used as a reagent in peptide synthesis and enzymatic studies.
Fórmula:C7H16N4O2·C2H4O2Pureza:Min. 95%Cor e Forma:PowderPeso molecular:248.28 g/molZ-Gly-Ala-Met-AMC
CAS:Z-Gly-Ala-Met-AMC is a protease inhibitor that has been shown to inhibit the amyloidogenic processing of β-amyloid and reduce the formation of amyloid plaques in vivo. It also inhibits the degradation of normal proteins by proteases, which leads to cell death. Z-Gly-Ala-Met-AMC is used as a marker for identifying and quantifying proteolytic activity in cells with high levels of proteolytic activity. The drug has been shown to be effective in assays using cell populations and homogenous assays.
Fórmula:C28H32N4O7SPureza:Min. 95 Area-%Cor e Forma:PowderPeso molecular:568.64 g/molAc-Nle-Pro-Nle-Asp-AMC
CAS:Ac-Nle-Pro-Nle-Asp-AMC is a reactive molecule that has been shown to be neuroprotective and to inhibit insulin resistance in mammalian cells. Ac-Nle-Pro-Nle-Asp-AMC is able to stop neuronal death by binding to the proteolytic enzymes, such as ubiquitin ligases, and inhibiting their activity. This drug also inhibits the activity of c2c12 myotubes, which are muscle cells that have been used in research studies. Ac-Nle-Pro-Nle-Asp AMC binds to ubiquitin and prevents it from being degraded by the proteasome system, which is a cellular protein degradation pathway. Ac-Nle-Pro-Nle -Asp AMC also inhibits the release of inflammatory factors from c2c12 myotubes, which may be due to its ability to block ubiquitin ligases.
Fórmula:C33H45N5O9Pureza:Min. 97 Area-%Cor e Forma:PowderPeso molecular:655.74 g/molHepcidin/LEAP-1 (Human) (Bulk)
CAS:Human Hepcidin peptide hormone product also know as LEAP-1 (liver-expressed antimicrobial peptide), where the disulfides are formed by random oxidation. Hepcidin is a peptide hormone that is synthesized in the liver and is an important regulator of iron homeostasis. Through binding to ferroportin Hepcidin prevents the exportation of iron thus reducing the amount of circulating iron. Furthermore through inflammatory cytokine induction Hepcidin leads to the internalization and degradation of ferroportin thus further reducing the amount of iron in circulation. This in turn make conditions unfavourable to invading pathogens. This demonstrates Hepcidin's ability as an anti-microbial peptide. This antimicrobial behaviour can be used in research into the elimination of pathogens but also in combatting diseases where iron dysregulation is prevalant.Disulfide bonds between C7-C23; C10-C13; C11-C19; C14-C22Fórmula:C113H170N34O31S9Pureza:Min. 95%Peso molecular:2,789.4 g/molHead activator (7-11) acetate
CAS:Please enquire for more information about Head activator (7-11) acetate including the price, delivery time and more detailed product information at the technical inquiry form on this pageFórmula:C32H54N6O6•(C2H4O2)xPureza:Min. 95%Peso molecular:618.81 g/molCRF (human, rat) acetate
CAS:CRF (human, rat) acetate is a synthetic chemical that has been shown to produce long-term changes in the brain. It is chemically similar to CRF, which is an endogenous hormone produced by the hypothalamus. This drug is used for the treatment of cerebral edema and intracranial hypertension caused by various conditions, such as cancer. The effects of CRF (human, rat) acetate on humans are not well understood as this drug has only been tested in women who have undergone surgery to remove their ovaries. These women had increased levels of corticotropin-releasing hormone (CRH), which could be due to CRF (human, rat) acetate or its metabolites. There is also some evidence that it may cause corrosion in long-term use.
Fórmula:C208H344N60O63S2Pureza:Min. 95%Cor e Forma:White PowderPeso molecular:4,757.46 g/molCyclo(-Leu-Trp)
CAS:Cyclo(-Leu-Trp) is a sweetener that has been used in the food industry for many years. Cyclo(-Leu-Trp) is able to bind with quinine and form a complex that can be detected using analytical methods. Cyclo(-Leu-Trp) has been investigated as a ligand that may be able to bind to receptors on cancer cells, which could lead to new treatments for cancer. Cyclo(-Leu-Trp) also has amphipathic properties and can form liposomes at high concentrations. This molecule has also been studied for its ability to induce transduction of DNA into bacterial cells and cellular thermogenesis.Fórmula:C17H21N3O2Pureza:Min. 98 Area-%Cor e Forma:PowderPeso molecular:299.37 g/molH-Trp-Trp-Trp-OH
CAS:H-Trp-Trp-Trp-OH is a protonated tripeptide that has hydrophobic properties. It is highly soluble in water, but not in organic solvents. The protonation of the amino acid residues in H-Trp-Trp-Trp-OH has been shown to be pH dependent. This compound is synthesized by reacting an amino acid with a carboxylic acid, which gives the product a bitter taste. The synthesis of this compound also yields reaction products that are acidic and exhibit anti tumor effects. This product can be used as a prebiotic to promote the growth of beneficial bacteria in the gastrointestinal tract.
Fórmula:C33H32N6O4Pureza:Min. 95%Cor e Forma:PowderPeso molecular:576.65 g/molPeptide M trifluoroacetate
Please enquire for more information about Peptide M trifluoroacetate including the price, delivery time and more detailed product information at the technical inquiry form on this page
Fórmula:C81H141N21O31•(C2HF3O2)xPureza:Min. 95 Area-%Cor e Forma:PowderH-Gly-Pro-pNA•hydrochloride
CAS:H-Gly-Pro-pNA is an antidiabetic drug that inhibits the activity of dipeptidyl peptidase IV (DPP IV), a family of enzymes that catalyses the cleavage of the amino acid sequence of proline and arginine. The inhibitory effect on DPP IV by H-Gly-Pro-pNA was demonstrated using magnetic resonance spectroscopy, chromatographic assays, and electrospray ionization mass spectrometry. H-Gly-Pro-pNA also has hydrophobic properties and can interact with other drugs that are lipophilic. In vitro assays have been used to determine the inhibition activity of H-Gly-Pro-pNA against various proteins involved in diabetes mellitus, including aminopeptidases, carboxypeptidases and endopeptidases.Fórmula:C13H16N4O4•HClPureza:Min. 95%Cor e Forma:White PowderPeso molecular:328.75 g/molH-Glu-Val-OH
CAS:H-Glu-Val-OH is a coordination complex that contains the metal scandium. It is used as a ligand to form complexes with other metals and organic molecules. This compound is also used in peptide synthesis and has been shown to have a strong interaction with nitrate, serine, and formiate. H-Glu-Val-OH is soluble in solutions such as water or formiate. The tripeptide Ser-Gly-Val can be formed from this compound by hydrolysis of the hydroxo group.
Fórmula:C10H18N2O5Pureza:Min. 95 Area-%Cor e Forma:PowderPeso molecular:246.26 g/molCyclo(-Arg-Gly-Asp-D-Phe-Lys) trifluoroacetate
CAS:Cyclo(-Arg-Gly-Asp-D-Phe-Lys) trifluoroacetate is a cyclic peptide that has been shown to be an effective chemotherapeutic agent against bladder cancer. Cyclo(-Arg-Gly-Asp-D-Phe-Lys) trifluoroacetate binds to the integrin receptor on the tumor cell surface and blocks the formation of new blood vessels, which may lead to tumor growth inhibition. The hypoxic tumor environment is characterized by low oxygen levels, which causes the mitochondria in cells to produce more hydrogen peroxide. Cyclo(-Arg-Gly-Asp-D-Phe-Lys) trifluoroacetate has been shown to decrease the production of hydrogen peroxide in hypoxic tumors. This drug also inhibits angiogenesis and cellular proliferation. Cyclo(-Arg-Gly-Asp) trifluoroacetate hasFórmula:C27H41N9O7•C2HF3O2Pureza:Min. 98 Area-%Cor e Forma:White Off-White PowderPeso molecular:717.7 g/molApelin-17 trifluoroacetate
CAS:Apelin-17 trifluoroacetate is a reaction component, reagent and useful scaffold for the synthesis of complex compounds. It is a high quality, research chemical that is used in the synthesis of fine chemicals. Apelin-17 trifluoroacetate has versatile building block and can be used as a useful intermediate or as a speciality chemical. It also has high reactivity and is soluble in organic solvents.
Fórmula:C96H156N34O20S•C2HF3O2Pureza:Min. 95%Cor e Forma:PowderPeso molecular:2,252.57 g/molAC-SDKP TRIFLUOROACETATE
CAS:AC-SDKP TRIFLUOROACETATE is a synthetic peptide, which is a derivative of the naturally occurring tetrapeptide L-seryl-L-aspartyl-L-lysyl-L-proline. This product is typically sourced through chemical synthesis, enabling precise structural and functional consistency.The mode of action of AC-SDKP involves its role as an endogenous antifibrotic agent. It functions by inhibiting the proliferation and differentiation of fibroblasts, thereby reducing collagen deposition. This action largely contributes to its ability to prevent fibrosis in various tissues. Additionally, AC-SDKP is known for its cardiovascular protective effects, partially through its interaction with the renin-angiotensin system and its ability to reduce inflammation.AC-SDKP TRIFLUOROACETATE is primarily used in scientific research focused on fibrotic diseases and cardiovascular disorders. It is a valuable tool for studying pathological mechanisms underlying fibrosis and developing potential therapeutic strategies. Its applications extend to investigating myocardial fibrosis, renal fibrosis, and idiopathic pulmonary fibrosis, among others, providing insights into treatment approaches that aim to mitigate disease progression.
Fórmula:C20H33N5O9•C2HF3O2Peso molecular:601.53 g/molAbarelix acetate - Bio-X ™
CAS:This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Fórmula:C72H95ClN14O14•(C2H4O2)xPureza:Min. 95%Cor e Forma:PowderPeso molecular:1,416.06 g/molAc-QKRAA-NH2
Peptide Ac-QKRAA-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
H-LAAAWGGSGSEAYR^-OH
Peptide H-LAAAWGGSGSEAYR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
Gluten Exorphin A5
CAS:Gluten Exorphin A5 is a δ opioid that has been synthetically produced. It binds to the μ-opioid receptor, which is found on cells in the gastrointestinal tract, and can be used to treat inflammatory diseases and autoimmune diseases. Gluten Exorphin A5 also has anti-cancer properties, as it inhibits cell proliferation and induces apoptosis in colon cancer cells by binding to their surface. Gluten Exorphin A5 is orally active and can be used for the treatment of infectious diseases. This drug also binds to bacterial surfaces and blocks the pain response induced by naloxone. The molecular weight of Gluten Exorphin A5 has been determined using a spectrometer after purification.Fórmula:C29H37N5O9Pureza:Min. 95%Cor e Forma:White PowderPeso molecular:599.63 g/molH-Lys-Pro-AMC hydrochloride
CAS:H-Lys-Pro-AMC hydrochloride is a fine chemical that is a versatile building block, useful intermediate, and speciality chemical. It can be used as a reaction component or in research or production of other chemicals. H-Lys-Pro-AMC hydrochloride can be used to make high quality reagents for use in research and production of other chemicals. This compound has been shown to be useful as a scaffold for the synthesis of complex compounds.Fórmula:C21H28N4O4·HClPureza:Min. 98 Area-%Cor e Forma:SolidPeso molecular:436.93 g/molMca-Ala-Pro-Lys(Dnp)-OH trifluoroacetate salt
CAS:Mca-Ala-Pro-Lys(Dnp)-OH trifluoroacetate salt is a high quality, versatile, and speciality chemical that is used as an intermediate in the synthesis of complex compounds. Mca-Ala-Pro-Lys(Dnp)-OH trifluoroacetate salt is also a useful scaffold for building block molecules and a versatile building block for peptide synthesis. This compound can be utilized in the manufacture of research chemicals and speciality chemicals.Pureza:Min. 98 Area-%Cor e Forma:PowderPeso molecular:696.66 g/molH-D-Glu(Gly-OH)-OH
CAS:H-D-Glu(Gly-OH)-OH is a peptide that is used to study the mechanism of glutamate receptors. It has been shown to have an excitatory effect on mouse hippocampal and cerebellar purkinje neurons, with affinity values for membrane channels. It also has been shown to reduce gamma-aminobutyric acid (GABA) levels in the hippocampus and striatum, which may be due to its ability to inhibit glutamic acid decarboxylase. H-D-Glu(Gly-OH)-OH is a potent antagonist of glutamate, binding competitively at the glutamate site on ionotropic receptors. It also inhibits acidic pH and calcium ion concentrations, which are necessary for ionotropic receptor activation.Fórmula:C7H12N2O5Pureza:Min. 98 Area-%Cor e Forma:White PowderPeso molecular:204.18 g/molFmoc-Glu(OtBu)-Rink-Amide MBHA Resin
Fmoc-Glu(OtBu)-Rink-Amide MBHA Resin is a high purity, ion channel ligand that is used in research as a pharmacological tool. It is an activator of Kv1.3 channels and inhibits the function of Kv1.2 channels. This product can be used for the study of protein interactions and receptor pharmacology. Fmoc-Glu(OtBu)-Rink-Amide MBHA Resin also has been found to inhibit the binding of antibodies to cells and can be used for immunoprecipitation experiments. This product has CAS number 188476-46-4 and is available in 1 g and 5 g sizes.Pureza:Min. 95%Stichodactyla Toxin (ShK) (Amide)
A synthetic sea anemone toxin peptide, that can be applied as a voltage dependent K+ channel (A Channel) blocker.Fórmula:C169H275N55O47S7Pureza:Min. 95%Peso molecular:4,053.86 g/molLixisenatide acetate
CAS:Lixisenatide is a glucagon-like peptide-1 (GLP-1) receptor agonist that is used to treat type 2 diabetes. Lixisenatide has been shown to be safe and effective in patients with renal impairment, hepatic impairment, or congestive heart failure. The pharmacokinetics of lixisenatide have been studied in healthy subjects and patients with chronic renal failure receiving dialysis. Lixisenatide has been shown to have a linear pharmacokinetic profile in both populations and has not been found to accumulate in the plasma after repeated doses. Lixisenatide does not bind tightly to human serum albumin, which may make it more suitable for use in patients with atherosclerotic cardiovascular disease who exhibit hyperlipidemia because it will be less likely to affect lipid profiles.Fórmula:C215H347N61O65S•(C2H4O2)xPureza:Min. 95%Cor e Forma:PowderFmoc-Tyr(tBu)-Rink-Amide MBHA Resin
Fmoc-Tyr(tBu)-Rink-Amide MBHA Resin is a solid phase peptide synthesis resin that is used for the production of small scale peptides. This resin has high purity and can be used in the synthesis of proteins, antibodies, and other bioactive molecules. Fmoc-Tyr(tBu)-Rink-Amide MBHA Resin is an ion-exchange resin that can be used to purify peptides by binding to their charged side chains. It is also useful as a research tool for cell biology, receptor pharmacology, and as an inhibitor.Pureza:Min. 95%2-Furoyl-LIGRLO-amide trifluoroacetate salt
CAS:Potent agonist of proteinase-activated receptor-2 (PAR2)Fórmula:C36H63N11O8Cor e Forma:PowderPeso molecular:777.96 g/molH-SCDKTHTCPPCPAPELLGGPSVFLFPPKPK-OH
Peptide H-SCDKTHTCPPCPAPELLGGPSVFLFPPKPK-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Fórmula:C144H221N35O38S3Peso molecular:3,164.72 g/molH-GDELADSALEIFK-OH
Peptide H-GDELADSALEIFK-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Fórmula:C62H96N14O22Peso molecular:1,407.52 g/molH-LIETYFSK-OH TFA salt
Peptide H-LIETYFSK-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Fórmula:C48H71N9O13Peso molecular:1,000.15 g/molBLf tryptic digestion peptide
BLf tryptic digestion peptide is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Fórmula:C35H57N7O9Peso molecular:737.88 g/molH-GLLSKSLVF-OH
Peptide H-GLLSKSLVF-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
Fórmula:C46H76N10O11Peso molecular:963.17 g/molH-GVLTESNKK-OH
Peptide H-GVLTESNKK-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Fórmula:C41H72N12O14Peso molecular:975.1 g/molH-PGPSDTPILPQ-OH TFA salt
Peptide H-PGPSDTPILPQ-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Fórmula:C50H78N12O16Peso molecular:1,121.24 g/molH-FADLSEAANR-OH
Peptide H-FADLSEAANR-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
Fórmula:C46H70N14O16Peso molecular:1,093.15 g/molFibrin knob B mimic peptide
Fibrin knob B mimic peptide is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Fórmula:C41H62N14O9Peso molecular:913.03 g/molΒ-sheet peptide monomer
Β-sheet peptide monomer is a synthetic β-sheet forming peptides show promise as anti-microbials. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Fórmula:C34H44N10O4Peso molecular:674.79 g/molKeap1 peptide fragment
Keap1 peptide fragment is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Fórmula:C66H94N18O18SPeso molecular:1,477.64 g/molH-IEIPLPFGGK-OH
Peptide H-IEIPLPFGGK-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
Fórmula:C52H81N11O12Peso molecular:1,070.28 g/molH-QLLQHLIGL-OH TFA salt
Peptide H-QLLQHLIGL-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Fórmula:C48H81N13O11Peso molecular:1,034.25 g/molH-LCPGNKYEM-OH TFA salt
Peptide H-LCPGNKYEM-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Fórmula:C45H69N11O13S2Peso molecular:1,054.24 g/molH-TSALLAGTITSGWTF-OH
Peptide H-TSALLAGTITSGWTF-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Fórmula:C70H106N16O21Peso molecular:1,525.7 g/molH-KIGDFGLATEK-OH
Peptide H-KIGDFGLATEK-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Fórmula:C53H85N13O16Peso molecular:1,178.33 g/molH-SGSDEVQVGQQR-OH
Peptide H-SGSDEVQVGQQR-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
Fórmula:C50H82N18O21Peso molecular:1,289.31 g/molH-RLTDQSRWSW-OH
Peptide H-RLTDQSRWSW-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
Fórmula:C59H85N19O16Peso molecular:1,334.44 g/molH-GVYYPDKVFR-OH
Peptide H-GVYYPDKVFR-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Fórmula:C60H84N14O14Peso molecular:1,243.41 g/molAnnexin A5 peptide
Annexin A5 peptide can be used in early detection of lung adenocarcinoma. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Fórmula:C61H91N17O19Peso molecular:1,384.49 g/molH-VYDPLQPEL-OH TFA salt
Peptide H-VYDPLQPEL-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Fórmula:C50H74N10O15Peso molecular:1,073.2 g/molH-PRRVRLK-OH
Peptide H-PRRVRLK-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Fórmula:C40H75N17O7Peso molecular:924.15 g/molH-IIPGGAAAQDGR-OH TFA salt
Peptide H-IIPGGAAAQDGR-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Fórmula:C47H78N16O15Peso molecular:1,125.24 g/molH-FPLKRHDKVDDLSK-OH
Peptide H-FPLKRHDKVDDLSK-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Fórmula:C76H122N22O21Peso molecular:1,697.93 g/molH-VDWENVSPELNSTDQ-OH TFA salt
Peptide H-VDWENVSPELNSTDQ-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Fórmula:C73H107N19O29Peso molecular:1,732.76 g/molH-IYNEYIYDL-OH
Peptide H-IYNEYIYDL-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
Fórmula:C58H78N10O17Peso molecular:1,205.31 g/molH-TSNQVAVLY-OH
Peptide H-TSNQVAVLY-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
Fórmula:C44H69N11O14Peso molecular:994.1 g/molH-IGNEQGVSR-OH
Peptide H-IGNEQGVSR-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
Fórmula:C38H64N14O14Peso molecular:959.02 g/molCyclo[Arg-Gly-Asp-D-Phe-Lys(H-Ser)]
Cyclo[Arg-Gly-Asp-D-Phe-Lys(H-Ser)], is a peptide that mimics the amino acid sequence of the RGD motif found in fibronectin, which has been shown to be involved in cell attachment and proliferation. Cyclo[Arg-Gly-Asp-D-Phe-Lys(H-Ser)] binds to integrin receptors and inhibits tumor growth. It also shows potential as a targeting agent for anticancer drugs. Cyclo[Arg-Gly-Asp-D-Phe-Lys(H-Ser)] is a cyclic peptide that can be derivatized with reactive groups such as azides, alcohols, esters, haloalkanes, and isocyanates.Fórmula:C30H46N10O9Pureza:Min. 95%Peso molecular:690.76 g/molUbiquitin Carboxyl-Terminal Esterase L5 , human, recombinant
Ubiquitin carboxyl-terminal esterase L5 is a peptide that belongs to the ubiquitin carboxyl-terminal hydrolase family. It is expressed in humans as an approximately 20 kDa protein. Ubiquitin carboxyl-terminal esterase L5 is an activator of the ion channel TRPM4 and also inhibits the protein interactions of SH2 domain proteins. This enzyme has been used as a research tool for studying ion channels, cell biology, and pharmacology.Pureza:Min. 95%H-Thr(tBu)-2-ClTrt-Resin (100-200 mesh) 1% DVB
H-Thr(tBu)-2-ClTrt-Resin (100-200 mesh) 1% DVB is a resin for peptide synthesis. It is used to immobilize amino acids, thiols, and other building blocks in order to synthesize peptides. This resin can be used for a variety of applications, including the synthesis of small organic molecules, oligonucleotides, and polysaccharides. H-Thr(tBu)-2-ClTrt-Resin (100-200 mesh) 1% DVB has been shown to react with amines and thiols.
Pureza:Min. 95%CLEAR-Base Resin (HCl) (100-200 mesh)
CLEAR-Base Resin (HCl) is a high-purity resin that has been used in the study of protein interactions, such as receptor and ligand binding. CLEAR-Base Resin (HCl) is also an inhibitor that can be used to block ion channels.Pureza:Min. 95%Fmoc-Lys(Alloc)-Wang Resin (100-200 mesh)
Fmoc-Lys(Alloc)-Wang Resin (100-200 mesh) is a research tool that is used in the study of protein interactions. It has been shown to be an effective inhibitor for ion channels and cell biology. This resin can also be used to identify ligands and receptors, as well as their binding affinities. Fmoc-Lys(Alloc)-Wang Resin (100-200 mesh) is a high purity product that can be used in pharmacology and peptide synthesis.Pureza:Min. 95%Cyclo[Arg-Ala-Asp-D-Phe-Lys(PEG-PEG)]
Cyclo[Arg-Ala-Asp-D-Phe-Lys(PEG-PEG)] is a peptide containing polyethylene glycol (PEG) as spacer to alter their pharmacokinetic properties and pharmodynamics.Fórmula:C40H65N11O13Pureza:Min. 95%Peso molecular:908.03 g/molZ-Val-Met-OH
CAS:Z-Val-Met-OH is a high purity synthetic compound that can be used as a research tool in cell biology, ion channels and peptides. This compound is an activator of the receptor for bradykinin and has been shown to inhibit the activity of protein kinase C. Z-Val-Met-OH is also a ligand for the acetylcholine receptor and has been shown to inhibit acetylcholinesterase, leading to an increase in acetylcholine levels. Z-Val-Met-OH binds to the receptor for insulin and can be used as an inhibitor of insulin release from pancreatic beta cells.
Fórmula:C18H26N2O5SPureza:Min. 95%Peso molecular:382.48 g/molH-SVINDPVYK^-OH
Peptide H-SVINDPVYK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
β-2 Microglobulin Human
Beta-2 Microglobulin Human is a research tool that can be used to study the activation of receptors, ion channels, and protein interactions. It is a ligand that binds to cell surface receptors. It is also an inhibitor that blocks the formation of antibodies by binding to human immunoglobulin G (IgG) and prevents it from binding to antigens. Beta-2 Microglobulin Human is a high purity protein with a CAS number of 1768-01-7.Pureza:Min. 95%Aoa-DYKDDDDK-OH
Peptide Aoa-DYKDDDDK-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.H-Leu-Ser-Ile-Gly-Arg-Leu-NH2
H-Leu-Ser-Ile-Gly-Arg-Leu-NH2 is a peptide that has been shown to have coagulation and cardiovascular effects. It also has protease-activated receptor (PAR) and PAR2 activity, which may be the mechanism for its observed antihypertensive effects. H-Leu-Ser-Ile-Gly-Arg-Leu NH2 is a biologically active peptide that belongs to the group of protease activated receptor (PAR) peptides. It has been shown to activate PAR2 in human endothelial cells and stimulate vasodilation and nitric oxide production.Fórmula:C29H56N10O7Pureza:Min. 95%Peso molecular:656.83 g/molIL 13 Human
IL-13 is a cytokine that belongs to the IL-4 family of cytokines. IL-13 is an activator of B cells and mast cells. It binds to the IL-4 receptor and can activate lymphocytes, macrophages, eosinophils, basophils, and neutrophils. This cytokine has been shown to inhibit ion channels in airway epithelium cells and also bind to the alpha1 subunit of the N-methyl d-aspartate receptor. IL-13 is also a ligand for the IL-4 receptor, which may be important for its function as a regulator of other cytokines such as TNFα or IFNγ.Pureza:>95% By Sds-Page And Rp-Hplc.ProTx-II
CAS:ProTx-II is a synthetic peptide that activates the TRPV1 receptor, a member of the capsaicin receptor family. ProTx-II has been shown to inhibit NGF-induced neurite outgrowth, and can be used as a research tool in studying the structure and function of TRPV1 receptors. ProTx-II is also an inhibitor of protein interactions with the TNF receptor, and has been shown to selectively inhibit NFκB activation by inhibiting IKK kinase activity.Fórmula:C168H250N46O41S8Pureza:Min. 95%Peso molecular:3,826.6 g/molH-Asp(OtBu)-2-ClTrt-Resin (200-400 mesh) 1% DVB
H-Asp(OtBu)-2-ClTrt-Resin (200-400 mesh) 1% DVB is a tool for peptide synthesis. It contains a set of building blocks including thiols, alcohols, amines, and resin. The resin is used as the solid support for peptide synthesis. The thiols react with the resin to form a covalent bond that anchors the building blocks to the solid support. The alcohols and amines can be reacted with amino acids or other activated carboxylic acids to synthesize peptides on this type of resin.Pureza:Min. 95%H-Asn-2-ClTrt-Resin (100-200 mesh) 1% DVB
H-Asn-2-ClTrt-Resin (100-200 mesh) 1% DVB is a building block for the synthesis of peptides. It is a resin that contains amines, thiols, and alcohols. The resin has a particle size of 100 to 200 mesh and contains 1% DVB.Pureza:Min. 95%Cyclo[Arg-Ala-Asp-D-Phe-Lys(Biotin-PEG-PEG)]
Cyclo[Arg-Ala-Asp-D-Phe-Lys(Biotin-PEG-PEG)] is a peptide containing polyethylene glycol (PEG) as spacer to alter their pharmacokinetic properties and pharmodynamics.Fórmula:C50H79N13O15SPureza:Min. 95%Peso molecular:1,134.33 g/mol[Glu1]-Fibrinopeptide B
Fibrinopeptide B is a peptidic, biologically active peptide with the sequence Glu-Lys-Arg-Val. It is an epitope of the fibrinogen protein and has been reported to be involved in various biological processes such as cell proliferation, inflammation, and coagulation. Fibrinopeptide B is also a mass spectrometry standard for calibrating mass spectrometers. Biochemicals such as peptides and proteins can be identified by using this peptide. Fibrinopeptide B may also play a role in cancer metastasis and atherosclerosis.Fórmula:C66H95N19O26Pureza:Min. 95%Peso molecular:1,570.6 g/molAc-Leu-Pro-N-Me-Phe-Phe-Asp-NH2
Ac-Leu-Pro-N-Me-Phe-Phe-Asp-NH2 is a peptide that inhibits amyloid beta protein related peptides. It has been shown to inhibit the fibrillogenesis of amyloid beta, which is the main cause of Alzheimer's Disease. Ac-Leu-Pro-N-Me-Phe-Phe-Asp NH2 also has neuroprotective effects by reducing the accumulation of amyloid beta in neuronal cells.Fórmula:C36H48N6O8Pureza:Min. 95%Peso molecular:692.82 g/molPhe4,9 [Ring D5]-Hepcidin (Rat)
A Deuterium Stable Isotope-Labeled Hepcidin for use as an internal standard and in the study of the biological activity of Hepcidin. This product consists of the disulfide bonds: Cys7-Cys23, Cys10-Cys13, Cys11-Cys19, and Cys14-Cys22.Fórmula:C111H161D10N29O34S8Pureza:Min. 95%Peso molecular:2,722.37 g/molCyclo(Arg-Gly-Glu-D-Phe-Lys)
Cyclo(Arg-Gly-Glu-D-Phe-Lys) is a cyclic peptide that has been used as an inhibitor of the signaling pathway in cells. Cyclo(Arg-Gly-Glu-D-Phe-Lys) binds to the receptor, which may be associated with an ion channel and the activation of a G protein. This peptide can act as a competitive inhibitor of other ligands for this receptor. Cyclo(Arg-Gly-Glu-D-Phe-Lys) is also known to be an activator for some receptors, including the angiotensin II type 1 receptor (AT1). This peptide has been used as a research tool to study receptor function and cellular signaling pathways. It is also being investigated for use in antibody production.Fórmula:C28H43N9O7Pureza:Min. 95%Peso molecular:617.71 g/molH-Gly-2-ClTrt-Resin (100-200 mesh) 1% DVB
H-Gly-2-ClTrt-Resin (100-200 mesh) 1% DVB is a building block that is used as an amine or thiol in peptide synthesis. It is also used as a tool for the synthesis of alcohols and resins.
Pureza:Min. 95%Orexin A (human) TFA
CAS:Orexin A (human) TFA is a high quality reagent that can be used as an intermediate in the synthesis of complex compounds, useful for research and development. It has many potential uses, including as a fine chemical, speciality chemical and reaction component. Orexin A (human) TFA is a versatile building block with many applications, such as being a useful scaffold or building block in reactions where it can be used in the synthesis of other compounds. It is also a valuable research chemical that can be used to study orexin receptors and their ligands.
Fórmula:C152H243N47O44S4•C2HF3O2Pureza:Min. 95 Area-%Cor e Forma:White Off-White PowderPeso molecular:3,675.13 g/molH-Tyr(tBu)-2-ClTrt-Resin (100-200 mesh) 1% DVB
H-Tyr(tBu)-2-ClTrt-Resin (100-200 mesh) 1% DVB is a building block that is used in peptide synthesis. It is a thiol-reactive resin with a pendant amine group. H-Tyr(tBu)-2-ClTrt-Resin (100-200 mesh) 1% DVB is soluble in common organic solvents and can be used for the synthesis of peptides with amino acids containing aromatic rings.Pureza:Min. 95%Amyloid β peptide(1-40) trifluoroxalate - synthetic
CAS:Amyloid beta peptide (Aβ) is a neurotrophic factor that is involved in the pathogenic mechanism of Alzheimer's disease. This drug inhibits the production of Aβ by binding to the enzyme, secretase. It has been shown that Aβ binds to a transporter protein and is transported into cells, where it accumulates in the cytoplasm. The physiological levels of Aβ are regulated by proteins called "gene chaperones" which prevent Aβ from aggregating into plaques. Dextran sulfate inhibits this process by binding to amyloid and preventing it from accumulating in the cytoplasm. Amyloid beta peptide trifluoroxalate (ATFX) has been shown to inhibit the production of Aβ with structural analysis, inhibition of cellular uptake and secretion, and inhibition of fibrillization. ATFX also has potential as a biomarker for Alzheimer's disease because it can be detected at low concentrations in urine or serumFórmula:C194H295N53O58S·C2HF3O2Pureza:Min. 95%Cor e Forma:White PowderPeso molecular:4,443.83 g/molMOG (40-54)
Amino acids 40-54 derived from the Immunogenic Myelin Oligodendrocyte protein (MOG). Produced by oligodendrocytes, MOG is an integral part of the oligodendrocyte surface membrane, located in the central nervous system (CNS) and plays an important role in the maintenance and disintegration of the myelin sheath. Unique within their immunoglobulin superfamily, MOG is composed of a transmembrane hydrophobic domain, an extracellular immunoglobulin variable (IgV) domain, a short cytoplasmic loop and within the membrane bilayer there is a second hydrophobic region and after this, a cytoplasmic end. In addition to 218 amino acids of the mature MOG protein, it contains a 29 amino acids long signal peptide. MOG has not only been found to be expressed in the CNS but also at low levels in the peripheral nervous system. Generally MOG is expressed during myelination and functions to maintain the myelin sheath’s structurally integrity through mediating interactions between the myelin and the immune system. This is possible due to its adhesion characteristics and its external location which makes it accessible to antibodies and T-cells. Furthermore is has been suggested that MOG is involved in regulating oligodendrocyte microtubule stability and it can be used as a differentiation marker for oligodendrocyte maturation.Myelin forms a lipid layer around neurons which insulates them. MOG has immunodmainant epitopes: 1-22; 35-55 and 92-106 and this is located at the dimer interface which is formed by MOG IgV domains forming a dimer. These MOG epitopes are recognized by encepalitogenic T cells as foreign antigens. As a result demyelination occurs and this happens in the disease state of Multiple Sclerosis (MS). As MOG is associated with inflammatory demyelinating diseases within the CNS such as neuromyelitis optica spectrum disorders and acute disseminated encephalomyelitis, this MOG (40-54) product can be used to induce these disease states in animals models. One-Letter Formula: YRSPFSRVVHLYRNGFórmula:C84H127N27O21Pureza:Min. 95%Peso molecular:1,851.12 g/molCLEAR-Acid Resin (100-200 mesh)
CLEAR-Acid Resin (100-200 mesh) is a high purity resin that is used for peptide synthesis. It has been used in research as an activator and inhibitor of protein interactions, such as receptor-ligand and antibody-antigen. CLEAR-Acid Resin (100-200 mesh) is often used in antibody production, where it binds to the antigen and activates the immune response against it. CLEAR-Acid Resin (100-200 mesh) has also been used for ion channel research due to its ability to inhibit potassium channels in neuronal cells. The CAS Number for CLEAR-Acid Resin (100-200 mesh) isPureza:Min. 95%Fmoc-Trp-Wang Resin (100-200 mesh) 1% DVB
Fmoc-Trp-Wang Resin (100-200 mesh) 1% DVB is a peptide resin that is used in the solid phase synthesis of peptides and small molecules. This product has been shown to be an effective inhibitor for Ion channels, Receptor, Ligand, and even Cell Biology. It is also a high purity reagent that can be used in a variety of applications including Pharmacology and Protein interactions. The Fmoc-Trp-Wang Resin (100-200 mesh) 1% DVB is available for purchase with CAS No. 680904-06-4.Pureza:Min. 95%MOG (92-106)
MOG (92-106) is a peptide that is derived from myelin basic protein. It has been shown to be immunogenic and can induce the production of antibodies in animals. MOG (92-106) also induces demyelination in mice.Fórmula:C80H104N21O27SPureza:Min. 95%Peso molecular:1,823.91 g/molFmoc-Asp(OtBu)-Wang Resin (100-200 mesh) 1% DVB
Fmoc-Asp(OtBu)-Wang resin is a 1% DVB resin that can be used as an inhibitor of peptide synthesis. It has been shown to selectively inhibit the binding of the L-type calcium channel, which is a cell membrane protein that affects the transport of calcium ions in and out of cells. Fmoc-Asp(OtBu)-Wang resin binds to the receptor site, preventing the natural ligand from binding. This inhibition prevents the activation of ion channels and reduces calcium ion influx into cells, leading to an anti-inflammatory effect.Pureza:Min. 95%Suc-Ala-Pro-Ala-pNA
CAS:Suc-Ala-Pro-Ala-pNA is a synthetic substrate that inhibits serine proteases. It has been shown to inhibit thrombin, trypsin, and chymotrypsin at low concentrations. Suc-Ala-Pro-Ala-pNA is used as an anticoagulant in rat neutrophils and it has also been found to have chemotactic activity for neutrophils at high concentrations. The substrate was also found to be an efficient method of detecting the presence of protease activity in plant physiology experiments. In addition to its use as a proteinase inhibitor, Suc-Ala-Pro-Ala-pNA can also be used as an antiplatelet agent.Fórmula:C21H27N5O8Pureza:Min. 95%Peso molecular:477.47 g/molUrokinase-Derived Peptide A6
Urokinase-Derived Peptide A6 (UDP-A6) is a protein derived from the urokinase enzyme. It has been shown to have antiproliferative effects on tumour cells and has been studied as a potential treatment for inflammatory diseases such as rheumatoid arthritis. The mechanism of action is not fully understood, but it is thought that UDP-A6 binds to a specific receptor on the surface of cells, called the leukocyte antigen, which causes them to stop proliferating. UDP-A6 has also been shown to bind to the surface glycoprotein of cancer cells and cause them to die.Fórmula:C39H62N10O15Pureza:Min. 95%Peso molecular:910.99 g/molH-Gly-Asp-Gly-Val-D-Ile-Thr-Arg-Ile-Arg-OH
H-Gly-Asp-Gly-Val-D-Ile-Thr-Arg-Ile-Arg-OH is a peptide that is used in biochemical research. It is a synthetic peptide that has been shown to inhibit the enzyme phospholipase A2 in vitro and has been demonstrated to be a potent inhibitor of the growth of cancer cells.Fórmula:C41H75N15O13Pureza:Min. 95%Peso molecular:986.15 g/molFmoc-Ile-Wang Resin (100-200 mesh) 1% DVB
Fmoc-Ile-Wang resin is a polystyrene resin which is used in the synthesis of peptides. It has a high loading capacity, and can be cleaved with hydrofluoric acid. The Fmoc-Ile-Wang resin contains 1% DVB as an acidic scavenger to prevent the formation of side products. The resin is also available in 100-200 mesh size.Pureza:Min. 95%RhTx
A 27 amino acid peptide toxin from the venom of the Chinese red-headed centipede and a potent activator of TRPV1 capsaicin receptor, inducing intense pain. This product is available in the salt form: trifluoroacetate and has the following disulfide Bonds: Cys1-Cys3, Cys2-Cys4.Fórmula:C123H201N37O40S4Pureza:Min. 95%Peso molecular:2,966.45 g/molIL 2 Human
IL-2 is a cytokine that regulates the immune system. It is a protein that is produced by T lymphocytes and natural killer cells, and stimulates the production of other white blood cells. IL-2 has two receptor chains: an alpha chain that binds to IL-2 and a beta chain that binds to IL-2 with high affinity. The receptor chains are encoded by genes in the human major histocompatibility complex (MHC) on chromosome 6. IL-2 has been shown to be an activator of ion channels and ligand for antibody molecules. It also has been used as a research tool in cell biology and as an inhibitor for cancer treatment.br>br> IL 2 Human is a recombinant form of Interleukin 2, which is a type of immunotherapy that is used to treat cancer patients who have not responded well to chemotherapy or radiation therapy. This form of Interleukin 2 is purified from E. coli bacteria, which means it doesPureza:Min. 95%Cyclo[Arg-Gly-Asp-D-Phe-Lys(Ac-SCH2CO)]
This product is an RGD Peptide containing a Thioacetyl Group for Linking to Liposomes. It may require further derivatization and deprotection before use
Fórmula:C31H45N9O9SPureza:Min. 95%Peso molecular:719.82 g/molCyclo[Arg-Gly-Asp-D-Phe-Lys(Azide)]
Cyclo[Arg-Gly-Asp-D-Phe-Lys(Azide)] is a peptide that contains the RGD sequence. It is a synthetic cyclic peptide that has been shown to bind to integrin receptors, which are cell surface receptors found in many cells. These integrins are involved in cellular adhesion and signaling. Cyclo[Arg-Gly-Asp-D-Phe-Lys(Azide)] can be used as a tool for click chemistry, as it can be modified with other molecules such as azides, which can then be used for click reactions with other molecules. This peptide has also been shown to have biological activity against cancer cells and inflammation.Fórmula:C27H39N12O7Pureza:Min. 95%Peso molecular:629.68 g/mol[N-Me-Asp1]-Angiotensin II
[N-Me-Asp1]-Angiotensin II is a peptide that belongs to the peptides and biochemicals group. It is an angiotensin II antagonist, which means that it blocks the action of Angiotensin II on its receptors. This peptide can be used as a vasoconstrictive agent in the treatment of hypertension.
Fórmula:C51H73N13O12Pureza:Min. 95%Peso molecular:1,060.23 g/molBoc-L-Glutamic Acid bis-Propargyl Amide
Boc-L-Glutamic Acid bis-Propargyl Amide is a building block for Click Chemistry. It is a white solid that is soluble in DMF, DMSO and other organic solvents. This product can be used as a reagent for peptide synthesis and as an intermediate for the synthesis of amino acids. Boc-L-Glutamic Acid bis-Propargyl Amide reacts with dimethylaminoethanol to form the corresponding amide. It has been shown that this product can be used in click chemistry reactions to form amides and ureas.
Fórmula:C16H23N3O4Pureza:Min. 95%Peso molecular:321.3 g/molDes 1-10 Obestatin (Human)
A human truncated analog of Obestatin, a 23 amino acid gastrointestinal peptide, encoded for by the ghrelin gene and is known to reduce food intake through supressing appetite. This peptide has been found to influence the pancreas, cardiovascular system and adipose tissues as well as the gastrointestinal system. One study showed that when high-fat diet fed rats were given chronic administration of obestatin it prevented the development of non-alcoholic fatty liver disease. Consequently Obestatin has the potential to be used in preventing obesity-related diseases.Fórmula:C63H100N20O20Pureza:Min. 95%Peso molecular:1,457.62 g/molH-D-Ala-2-ClTrt-Resin (100-200 mesh) 1% DVB
H-D-Ala-2-ClTrt-Resin (100-200 mesh) 1% DVB is a resin for the synthesis of peptides. It is an amino acid resin with D,L-alanyl side chains, which can be cleaved by hydrochloric acid to release the desired amino acid and trityl resin. This resin is used in peptide synthesis reactions to provide a protecting group for the N-terminal amino acid.
Pureza:Min. 95%Mob-S-Mercaptoproprionic acid
Mob-S-Mercaptoproprionic acid is a reagent that can be used to synthesize peptides. It is also a Building Block for the synthesis of other molecules. Mob-S-Mercaptoproprionic acid is hydrolyzed to form the corresponding carboxylate and mercaptoacyl amide, which can be used in peptide synthesis by condensation with an amino acid.
Fórmula:C11H14O3SPureza:Min. 95%Peso molecular:226.3 g/molUrate Oxidase Recombinant
Urate oxidase is a flavoenzyme that catalyses the oxidation of uric acid to allantoin. It is present in many organisms, including fungi and primates. Urate oxidase catalyzes the oxidation of uric acid to allantoin via the reduction of oxygen to water with concomitant production of hydrogen peroxide. There are four forms of urate oxidase found in nature: tetrameric, dimeric, monomeric, and recombinant. The recombinant form has been shown to be effective against hyperuricaemia in primates and humans with lymphoid malignancies.
Fórmula:C1523H2383N417O462S7Pureza:>90% By Sds-PageBNP Human, recombinant
BNP Human, recombinant is a research tool that is an activator of the BNP receptor. It has been used to study the interactions and functions of ion channels, cell biology, and pharmacology. The purified protein is a ligand for the BNP receptor. BNP Human, recombinant has been shown to inhibit peptide bonds in proteins by specific binding to the carboxyl terminus of peptides with a sequence of C-terminal arginine residues.
Pureza:Min. 95%Fmoc-Ala-Rink-Amide MBHA Resin
Fmoc-Ala-Rink-Amide MBHA Resin is a resin used in peptide synthesis. It is mainly used as an inhibitor of peptidase A or B, and can also be used to inhibit the proteolytic activity of other enzymes. This product has CAS No. 68945-59-6, and is available in a high purity 99% form. Fmoc-Ala-Rink-Amide MBHA Resin is mainly used as a research tool for the study of protein interactions, activator ligands, and receptor ligands. It can also be used for biochemistry experiments involving ion channels and antibodies.Pureza:Min. 95%H-Glu(OtBu)-2-ClTrt-Resin (100-200 mesh) 1% DVB
This resin is a building block for peptide synthesis that can be used as a solid support in solid phase peptide synthesis. It has been used in the synthesis of a number of biologically active molecules. The resin is prepared by coupling an amine and thiol in the presence of triethylamine and 1-hydroxybenzotriazole. The resin contains 1% DVB, which serves as the protecting agent for the amino acid side chain during coupling reactions.Pureza:Min. 95%JzTx-V Peptide
A synthetic tarantula spider toxin sourced from the chinese earth tiger tarantula, Chilobrachys jingzhao. This product has the following disulfide bonds: Cys1-Cys4, Cys2-Cys5, Cys3-Cys6 and is available as a trifluoroacetate Salt.Fórmula:C157H243N47O38S7Pureza:Min. 95%Peso molecular:3,621.43 g/molProlactin-releasing peptide (PrRP20)
Prolactin-releasing peptide (PrRP20) was originally identified for being able to stimulate lactin release. However, that is not considered its function anymore, it is reclassified as a neuropeptide with a role in energy balance, and an inhibitor of appetite. PrRP20 is considered a central neuromodulator found within the A1 and A2 noradrenergic neurons and neurons of the dorsomedial nucleus of the hypothalamus. PrRP20 binds with high affinity to the G protein coupled receptor GPR10. Binding can lead to activation of numerous signalling pathways including activation of mitogen-activated protein kinase/extracellular-regulated kinase (MAPK/ERK1/2) and cAMP response element-binding protein (CREB). Not much is known about the binding mechanism and activation of GPR10. Use of PrRP20 and its analogs have aimed to provide greater insight to the binding and activation of GRP10 to better understand how this effects energy balance. With new links being made between diabetes and obesity with Alzheimer's disease it raises the question of whether PrRP20 and GP10 may be a factor in the disease development due to the colocalization in the same brain regions. Further study may lead to novel therapies for obesity, diabetes, and Alzheimer's disease in the future.Peso molecular:2,271.2 g/molAntennapedia peptide amide
Penetratin is a cell-penetrating peptide (CPP), also known as a protein transduction domain (PTD), of which the first 16 amino acids are derived from the third helix of the Antennapedia protein homeodomain. Penetratin linked to a phosphodiester oligonucleotide is capable of permeating through neuronal cell membranes and down-regulating genes.
Peso molecular:2,245.75 g/molGhrelin Human
Ghrelin is involved in several physiological processes, including feeding and lipid accumulation, stress response, anxiety, cardiac performance, immunity and inflammation, taste sensation, reward-seeking behaviour, regulation of glucose metabolism and thermogenesis, memory, motivation and learning.Ghrelin is a peptide hormone that typically has a serine at the third residue and relies on modification with a fatty acid to give ghrelin its functional activity. In its modified form, ghrelin is an endogenous ligand for the pituitary gland's growth hormone receptor (GHS-R) and stimulates growth hormone release.Ghrelin acts on the hypothalamic arcuate nucleus as an orexigenic agent to stimulate appetite. Ghrelin is produced in the stomach as a precursor peptide preproghrelin, cleaved to ghrelin. Ghrelin circulates in the blood and can cross the blood-brain barrier. Levels of ghrelin respond to fasting conditions and allow signals about the energy status to be transmitted from the peripheral organs to the central nervous system to maintain energy homeostasis.Ghrelin is a valuable target for treating conditions such as anorexia, cachexia, sarcopenia, cardiopathy, neurodegenerative disorders, renal and pulmonary disease, gastrointestinal disorders, inflammatory disorders and metabolic syndrome.
Cor e Forma:PowderPeso molecular:3,370.86 g/mol[5-FAM]-PR9
CPPs can transport molecules such as nucleic acids, proteins and imaging agents into cells of inter-est. PR9, Pas non-arginine, is an arginine rich CPP. It is composed of the nona-arginine: R9 and Pas which is a peptide penetrating accelerating sequence and it functions to export molecules out of endocytic vesicles. During a study in which PR9 was in complex with a Quantum dot probe (QD) it was evident that the PR9/QD complex was transported into the cell through endocytosis where it co-localises with actins, lysosomes, early endosomes and the nucleus. Due to the non-toxicity of the PR9/QD complex it can be used as a safe vector for biomedical purposes.It contains 5-Carboxyfluorescein (5-FAM), a widely used green fluorescent tag.Peso molecular:2,584.01 g/molBim BH3, Peptide IV
A 26-residue fragment from BH3 only protein Bim, BH3 only proteins constitute a major proportion of pro-apoptotic members of the B-cell lymphoma 2 (Bcl-2) family of apoptotic regulatory proteins and participate in embryonic development, tissue homeostasis and immunity.
Cor e Forma:PowderPeso molecular:3,267.6 g/molPAR-3 Agonist (Mouse)
Protease activated receptors (PARs) are a distinctive four-member family of seven transmembrane G protein-coupled receptors (GPCRs) widely expressed in inflammatory cells. PARs are cleaved by certain serine proteases to expose a tethered ligand domain, this ligand domain then binds to and activates the receptors to initiate multiple signalling cascades. These PAR-activating proteases therefore represent PAR agonists. This PAR-2 agonist peptide mimics the sequence of the 'tethered ligand' and is therefore capable of activating the receptor independently of N-terminal proteolysis.PAR-3 is required for intercellular adhesion molecule 1 (ICAM-1) expression in endothelial cells and PAR-3 cooperates with PAR-1 to mediate the effect of thrombin on cytokine production and vascular cell adhesion molecule (VCAM-) 1 expression.PAR activation has been linked to inflammation, therefore compounds that mimic or interfere with the PAR-activating processes are attractive therapeutic candidates.
Peso molecular:576.3 g/molSapecin B
The peptide Sapecin B exhibits antimicrobial properties against gram-positive bacteria. It is originally derived from the sarcophaga peregrine embryonic cell line, NIH-Sape-4.Peso molecular:1,094.8 g/mola-Gliadin (229-246)
a-Gliadin (229-246) is derived from Gliadin peptides, the component of wheat involved in the gastrointestinal symptoms of wheat allergy and Celiac Disease (CD). During wheat allergies histamines and leukotrienes are secreted due to gliadin peptide sequences cross-linking two IgE molecules on mast cells and basophils.The glutamine and proline rich peptides of which Gliadin is composed of are resistant to proteolysis during digestion, leaving them active in the gastrointestinal tract. Subsequently these are deamidated by tissue transglutaminase and can bind to HLA-DQ2 or DQ8. As a result in patients with the autoimmune disease CD, there is a Th1-mediated inflammatory immune response against these gliadin peptides.Gliadin can exert additional effects on the intestinal microbiota and ileal barrier function. It has been found that gut microbiota members such as Bifidobacterium and lactobacillus have the ability to digest and inactivate gliadin peptides hence reducing their inflammatory effects in the gastrointestinal system.
Peso molecular:2,083.1 g/molExendin-4 [Lys(AF647)]
Exendin-4 is part of a group of peptide hormones, the exendins. These are members of the glucagon superfamily of peptides and are secreted from the Gila monster lizard (Heloderma suspectum) venom gland. Exendins stimulate insulin secretion in response to rising blood glucose levels and modulate gastric emptying to slow the entry of ingested sugars into the bloodstream. Exendin-4 increases insulin sensitivity and improves glucose tolerance in humans and animals with diabetes. Exendin-4 is currently used for treating type 2 diabetes mellitus in its synthetic form, Exenatide.Exendin-4 shares 53% sequence homology, and specific activities, with glucagon-like-peptide-1 (GLP-1). Enteroendocrine L-cells produce GLP-1 upon nutrient ingestion, its central role relates to insulin secretion. Unlike GLP-1, exendin-4 is resistant to cleavage by plasma dipeptidyl peptidase IV (DPP-IV), resulting in a longer half-life and duration of action than GLP-1, as well as greater potency in vivo. Exendin-4 binds and activates the glucagon-like peptide-1 receptor (GLP-1R). In addition to its role in insulin sensitivity, exendin-4 also has a role in pancreas development and has anti-cancer properties.This exendin-4 contains AF647, a structural analog to Alexa Fluor® 647, a widely used far-red fluorescent dye. Its excitation is ideally suited to 594nm or 633nm. This dye is suited for low abundance targets as it has high initial brightness and a high photostability allowing detection of low abundance peptides. If you desire an alternative dye, please contact us to request a custom synthesis.Peso molecular:5,454.4 g/molbeta-Amyloid (10-20) Human
Amyloid β-peptide (Aβ) has been identified as the key subunit of the extracellular plaques found in the brains of patients with Alzheimer's disease (AD) and Down's syndrome (DS). Aβ has therefore been extensively studied as a potential target for treatment of AD. Aβ is formed from the cleavage of the large, transmembrane protein APP (amyloid precursor protein). Cleavage of APP by β- and then γ-secretases results in the formation of Aβ. Aβ can aggregate to produce amyloid-β oligomers, which are thought to be highly neurotoxic. Over time Aβ can further aggregate to produce the characteristic senile plaques present in AD and DS. Aβ can be degraded by enzymes such as neprilysin, insulin degrading enzyme or endothelin converting enzyme. At physiological levels Aβ may be involved in controlling synaptic activity and neuronal survival.
Peso molecular:1,446.65 g/molClick EB1
EB1 is a penetratin analogue that was synthesised to be an endosomolytic cell penetrating peptide (CPP). Certain amino acids in the penetratin sequence were replaced with histidine to encourage formation of an alpha helix upon protonation in the acidic endosomes. As a CPP, EB1 has been shown to form a strong interaction with the phospholipid bilayer during insertion with rapid cellular uptake, there is a moderate amount of cell leakage and no significant cytotoxicity.EB1 is provided here with a N-terminal alkyne attachment. Two of the most regularly encountered functional groups for click chemistry are azides and alkynes, and the azide-alkyne cycloaddition has become the most popular click reaction. The use of click chemistry with alkyne-EB1 allows a wide variety of applications particularly for conjugation, modification and peptide design.
Cor e Forma:PowderPeso molecular:3,177.9 g/molEchinotocin neuropeptide
Echinotocin is a neurophysin containing precursor neuropeptide derived from the sea urchin Strongylocentrotus purpuratus.Cor e Forma:PowderPeso molecular:964.4 g/molTAT-Pro ADAM10 (709-729)
Peptide obtained by linking the 11 amino acid human HIV Tat transporter to a 21 amino acid sequence corresponding to the ADAM10 proline-rich domains.
Peso molecular:3,912.7 g/molFdM
FdM, ferredoxin maquette is a synthetic peptide which can bind a [4Fe-4S] cluster and contains a bacterial ferredoxin consensus motif (CIACGAC).
Peso molecular:1,525.6 g/molSRC Substrate Peptide
Src is a member of the Src family tyrosine kinases (SFKs), a large cytosolic, non-receptor, kinase family that controls multiple signalling pathways in animal cells. SFKs play key roles in cell morphology and differentiation, motility, proliferation and survival. Src contains an N-terminal 14-carbon myristoyl group, a unique segment, an SH3 domain, an SH2 domain, a protein-tyrosine kinase domain and a C-terminal regulatory tail. Src is expressed ubiquitously however it is seen at far higher levels in the brain, osteoclasts, and platelets. Src is a proto-oncogene and elevated levels of Src protein are seen in different tumours including: breast- lung- thyroid- glioblastoma- colorectal- pancreatic- prostate- gastric- biliary tract, ovarian and skin cancer. Src levels are often associated with tumour progression, metastasis and a poor clinical outcome and therefore Src has been investigated as a therapeutic target.
Cor e Forma:PowderPeso molecular:1,668.9 g/molTAT-Beclin Scrambled
TAT-Beclin Scrambled is a scrambled version of the peptide derived from a region of the Beclin 1 protein. The original peptide interacts with a newly identified negative regulator of autophagy, GAPR-1 (also called GLIPR2) to act as a potent inducer of autophagy. Autophagy is an essential process that maintains cellular homeostasis and carries out lysosome-mediated degradation of unwanted proteins in the cytoplasm. It is often examined when looking at disease pathways because of this regulatory function. While the immune system initiates the removal of viruses and pathogens through the autophagic pathway, some viruses (such as HIV) are able to evade this process.The scrambled sequence in this peptide means it can be used as an effective negative control in such experiments because whilst it contains the same amino acids as Beclin-1 (and thus has the same molecular weight), it does not express the same properties as the original peptide.TAT (47-57) is present due to its properties as a cell penetrating cationic peptide (CPP). It derived from the N-terminus of the Tat protein, which is a trans-activator of the transcription protein present in the human immunodeficiency virus (HIV). As a CPP, TAT (47-57) is able facilitate the delivery of the Beclin Scrambled protein across the plasma membrane.This peptide contains a GG linker between the C-terminus of TAT (47-57) and the N-terminus of Beclin Scrambled.Cor e Forma:PowderPeso molecular:3,738.9 g/mol[5-FAM] Kemptide
Kemptide is a synthetic substrate of the PKA catalytically active subunit (PKAc), and can bind along with ATP to PKAc. It contains 5-Carboxyfluorescein (5-FAM), a widely used green fluorescent tag.
Peso molecular:1,129.5 g/molPEN-FFW
Sal-like4 (SALL4) derived peptide able to antagonise the SALL4-NuRD complex in hepatocellular carcinoma, turning SALL4 from a dual transcription repressor-activator to a singular transcription activator. Displays antitumour effects in xenograft mouse models.Cor e Forma:PowderTAT-TRPV1 (736-745)
TAT-TRPV1 (736-745) is a cell-permeable TRPV1 fragment (capsaicin receptor and the vanilloid receptor 1), that can inhibit the interaction of TRPV1 and A-kinase anchoring protein 79 (AKAP79). TAT- TRPV1 (736-745) consists of amino acids 736-749 from the TRPV1 C-terminal domain, combined with amino acids 47-57 of TAT to promote uptake across neuronal cell membranes. TAT-TRPV1 (736-745) inhibits both the first and the second phase of pain behaviour in the formalin test, implying an effect on both acute and inflammatory pain.A-kinase anchoring protein 79 (AKAP79) is a protein that targets kinases to TRPV1. Inflammation causes hyperalgesia but can be reduced when TRPV1 is blocked. a key region on AKAP79, amino acids 326-336, is responsible for its interaction with TRPV1. TAT-TRPV1 (736-745) promotes uptake across the cell membrane and TRPV1 (736-745) inhibited inflammatory hyperalgesia in mice. TAT-TRPV1 (736-745) did not affect pain thresholds in the absence of inflammation. These results suggest that antagonizing the TRPV1-AKAP79 interaction will be a useful strategy for inhibiting inflammatory hyperalgesia and TAT is an effective delivery system.
Peso molecular:2,927.6 g/molTAT-NR2B (C-ter)
N-methyl-D-aspartate receptors (NMDARs) are ligand-gated ionotropic glutamate receptors that mediate excitatory synaptic transmission and play important roles in many aspects of nervous system function including: synaptic plasticity- learning and memory- neuronal development and circuit formation. NMDARs have been implicated in various neuronal disorders. NMDARs are heteromers consisting of an obligate NR1 subunit and most commonly one or two kinds of NR2 subunits or occasionally NR3 subunits. NR2B is the predominant subunit found in the postnatal brain, however over time the number of NRA2 subunits increase and eventually outnumber NR2B subunits in a process known as the NR2B-NR2A developmental switch. The greater ratios of the NR2B subunit in post-natal brains leads to NMDA receptors which remain open longer compared to those with more NR2A subunits, this may be related to the greater memory abilities in the immediate postnatal period compared to late in life. NR2B improves synaptic plasticity and memory when over-expressed in neurones. The involvement of NMDAR in the central nervous system (CNS) has become a focus area for neurodegenerative diseases such as Alzheimer's disease, epilepsy and ischemic neuronal cell death.The TAT peptide is present due to its properties as a cell penetrating cationic peptide (CPP). It derived from the N-terminus of the Tat protein, which is a trans-activator of the transcription protein present in the human immunodeficiency virus (HIV). As a CPP, TAT is able facilitate the delivery of NR2B (C-ter) across the plasma membrane.
Cor e Forma:PowderPeso molecular:2,517.4 g/molCalcitonin, Rat
The hormone Calcitonin, reduces the amount of serum calcium during hypercalcemia and is released from the C-cells of the thyroid gland. Within its structure it contains a disulphide bridge between cysteine 1 and 7 and a proline at its carboxy terminal.Calcitonin is used therapeutically in the treatment of hypercalcemia diseases such as Paget disease, Sudeck atrophy, bone metastases and vitamin-D intoxication.The level of calcitonin in the plasma can also be used as a marker for medullary thyroid carcinoma, while procalcitonin is used to diagnose sepsis.
Peso molecular:3,397.6 g/mol[Azhx]-ANP (Human)
ANP (human) is derived from the atrial natriuretic peptide (ANP) which is a cardiac hormone involved in maintaining cardio-renal homeostasis. This occurs through the activation of the guanylyl cyclase-coupled receptor, resulting in the increased concentration of cyclic guanylate monophosphate. Moreover its function in the processes of anti-proliferation and anti-angiogenesis allow it to take part in cardiovascular remodelling.ANP is a member of the natriuretic peptide family and it is encoded by the NPPA gene, located on chromosome 1. Once synthesized from the 151 amino acid pre-prohormone into its biologically active form, ANP is secreted by the atrial cardiomyocytes in the circulating forms: ANP (1-98) and ANP (99-126). This synthesis process involves the signal peptide being removed from the pre-prohormone resulting in pro-ANP (1-126) which is converted into the circulating forms by the type II transmembrane serine protease Corin.At the N-terminus Azhx, 6-azidohexanoic acid, is present.
Peso molecular:3,219.5 g/molClickPTD-5
protein transduction domain PTD-5 is a cell-penetrating peptide (CPP). PTD-5 is well characterised for its ability to carry conjugates into the cell with high efficiency and induce low toxicity. Several papers have demonstrated the efficacy of PTD-5 as a CPP- PTD-5 was also conjugated to KLA to produce a pro-apoptotic peptide named DP1 which is selective for mitochondrial and bacterial membranes.PTD-5 is labelled at the N-terminus with an alkyne attachment for ease of reaction with an opposite Click reactive partner (azide). Azide-alkyne cycloaddition has become the most popular Click reaction. Alkyne-PTD-5 allows various applications, particularly for protein conjugation, modification, and drug delivery.
Cor e Forma:PowderPolybia-MPI
Polybia-MPI is a short cationic alpha-helical amphiphilic anti-microbial peptide which was first isolated from the venom of the social wasp Polybia paulista. Polybia-MPI displays potent anti-bacterial activity against both Gram-positive and Gram-negative bacteria and is able to disrupt biofilms. Polybia-MPI also has anti-fungal activity against C. albicans and C. galbrata and selective toxicity toward cancer cells. Polybia-MPI has low toxicity to normal fibroblasts and human red blood cells, showing no haemolytic activity.
Peso molecular:1,653 g/molεV1-2
εV1-2 is a selective inhibitor of ε protein kinase C.ε protein kinase C is an isoymes of the protein kinase C family, which is a family involved in controlling the function of other proteins via phosphorylation of hydroxyl groups of serine and threonine amino acid residues.In vitro studies have shown εV1-2 to exhibit inhibitory properties on endothelial cell proliferation.Cor e Forma:PowderPeso molecular:843.5 g/molThrombin Receptor Antagonist
Thrombin is the main effector of the coagulation cascade- it is a serine protease. Thrombin binds to active protease activated receptor 1 (PAR-1) which belongs to a subfamily of G-protein coupled receptors (GPCR). However, thrombin generated during cardiopulmonary bypass can activate PAR-1 leading to platelet dysfunction and unwanted bleeding. FLLRN is found to be a potent PAR-1 antagonist. Use of FLLRN and variants has aided the study of platelet aggregation dynamics. Further study may provide a suitable clinical application.Peso molecular:661.4 g/molJelleine 4
Jelleines are a family of very small (8-9 amino acid residues long) host defence peptides (HDPs) isolated from the royal jelly of honey bees (Apis mellifera). Jelleines do not present any similarity with other HDPs from other honeybees and are produced by the workers and secreted into Royal Jelly and provide abroad-spectrum protection of the bee hive against microbial infections. The Jelleines are not considered cytolytic or directly involved with inflammatory effects.PLEASE NOTE that in several published articles the sequence of Jelleine-3 has been printed as TPFKISLH -NH2, due to a mistake in the original reference: Fontana et al., (2004). The correct sequence, is TPFKISIH -NH2.
Peso molecular:940.6 g/molGGG-C(AF647) C-Terminal Sortagging
GGG-C(AF647) C-Terminal Sortagging
Cor e Forma:PowderPeso molecular:1,285.4 g/mol[5-FAM]/[Lys(Dabcyl)]-CoV Main Protease (Mpro) Substrate
FRET peptide substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro). The substrate sequence is derived from residues P4-P5' of the SARS-CoV Mpro N-terminal autoprocessing site which has the sequence AVLQSGFRK. SARS-CoV Mpro is a key antiviral target.This peptide contains an N-terminal 5-Carboxyfluorescein (5-FAM), a widely used green fluorescent tag and the Dabcyl fluorescence quencher. When the peptide is intact, fluorescence is undetectable due to the proximity of the Dabcyl quencher to the 5-FAM fluorophore. However upon cleavage of the peptide by SARS-CoV Mpro, the 5-FAM group and the Dabcyl quencher are separated and fluorescence can be detected. This therefore represents a useful tool for investigating SARS-CoV Mpro activity.Cor e Forma:PowderPeso molecular:1,740.8 g/mol[5-FAM]-VGB4
Antagonist peptide of VEGF-A and VEGF-B reproducing two binding regions of VEGF-B (loop 1 and loop3) linked together by a receptor binding region of VEGF-A (loop3). Binds to both VEGFR1 and VEGFR2 and inhibits VEGF-A driven proliferation, migration and tube formation in HUVECs. It contains 5-carboxyfluorescein (5-FAM), a widely used green fluorescent tag.
Peso molecular:3,066.5 g/molHistone H3 (1-20) K4Me3, K9Ac, pS10-GG-Biotin
Histone H3 (1 - 20) K4Me3 is derived from Histone 3 (H3), which is one of the four core histones (H2A, H2B, H3 and H4) fundamental in compacting eukaryotic DNA into the nucleosome. The nucleosome arises when 147 base pairs of DNA wrap around a H3-H4 tetramer and two H2A-H2B dimers, forming the histone octamer core. H4 and H3 are highly conserved and perform roles in binding to segments of DNA which enter and leave the nucleosome and in chromatin formation. Like the other core histone, H3 has a globular domain and a flexible N-terminal domain, 'histone tail' which can undergo modifications such as acetylation, methylation, phosphorylation and ubiquitination. Due to histones containing many lysine and arginine residues, they have a positive net charge which interacts electrostatically with the negatively charged phosphate groups in DNA. The transcriptional activation or silencing of the chromatin is controlled by ATP-dependent chromatin remodelling factors and histone-modifying enzymes which target histone proteins. Both processes alter the positioning of the nucleosome, allowing the DNA to be either available or inaccessible to the transcription machinery.Histone tails can undergo multiple modifications, including acetylation, methylation, ubiquitylation and sumoylation. The modification pattern is believed to alter chromatin function/structure. Lysine 4 of histone H3 (1 - 20) K4Me3 has been tri-methylated, lysine 9 has been acetylated, and serine 10 has been phosphorylated and labelled with Biotin. This peptide can be used to study the function of this pattern on chromatin availability and histone effectors via crystallisation, pull-down assays and protein blots.
Peso molecular:2,814.5 g/molSARS-CoV-2 Spike (781-795)
The SARS-CoV-2 spike protein is present on the outside of the virus particles and can bind to angiotensin-converting enzyme II (ACE2) present on the host cells. The C-terminal receptor binding domain (RBD) of the spike protein binds to the N-terminal peptidase M2 domain of ACE2. This receptor binding results in the internalisation of the virus-receptor complex and is, therefore the mechanism of entry of SARS-CoV-2 into host cells.The spike protein residues VFAQVKQIYKTPPIK (781-795) from C have been identified as a T-cell epitope with a predicted HLA restriction. Immune targeting of confirmed epitopes may potentially offer protection against SARS-CoV-2 and help the development of vaccines for long-lasting immunity.
Peso molecular:1,759 g/molLasioglossin-III
Lasioglossin-III (Lasio-III) is a naturally-occurring salt-resistant anti-microbial peptide (AMP) found in-Lasioglossum laticeps-(broad-faced furrow bee). Lasioglossin-III has broad spectrum anti-microbial activity and anti-biofilm properties against Gram negative and Gram positive bacteria, including strong anti-microbial activity against-E. coli,-S. aureus, and-P aeruginosa-under physiological salt concentration, with low toxicity.AMPs form an important part of the innate immune system in plants, animals and insects-and are reported to be effective even against several antibiotic resistant strains due to differing modes of pathogen killing from those of conventional antibiotics. Lasio-III has a membranolytic mode of action. It can bind both the outer and inner membranes of bacteria. Lasio-III possesses a fast killing ability toward both Gram positive and negative bacteria compared to many other active AMPs.
Peso molecular:1,764.2 g/mol[Aurora™ Fluor 647]-RGD peptide
The RGD motif has been found in wide range of eukaryotic proteins allowing cell adhesion to the ECM. The tripeptide RGD is the primary domain to bind integrin found in extracellular matrix (ECM) proteins including fibronectin, fibrinogen and osteopontin. It has been shown to effectively adhere various cell types to a wide range of biomaterials. This is a key research tool in the flourishing area of tissue engineering and wound healing using synthetic peptides that are either inert or can be potentially beneficial. RGD is a suitable ligand for targeting nanomolecules and cancer drugs to specific tissues due to its biocompatibility and safety.This RGD peptide is supplied with an Aurora Fluor 647 fluorophore attached and produced to research grade quality. Aurora Fluor 647 excitation suited to 594nm and emission peaked at 671nm. The Molecular Probes Alexa Fluor dyes provide a number of benefits including: more intense fluorescence than other spectrally similar conjugates better photostability, allowing more time for image capture availability of conjugates in an array of distinct fluorescent colours from blue to infrared- and pH insensitivity that enables the dyes to remain highly fluorescent over a broad pH range and high water solubility.Cor e Forma:PowderTKD (450-463)
Heat shock proteins (Hsps) are highly conserved and stress inducible. Hsp70 has been found in tumour cell lines to be highly expressed with a higher plasma membrane localisation. This is correlated to the cell sensitivity to natural killer (NK) cell-mediated lysis. Investigation identified that Hsp70 N-terminal extended peptide TKD (450-463) was critical for this to occur. TKD (450-463) with low dose interleukin (IL-2) has the same capacity to induce NK cell proliferation and activity as the full-length protein Hsp70. Excess of Hsp70 and TKD (450-463) both inhibit cytolytic activity by NK cells. Other related sequences tested did not lead to NK cell-mediated lysis. Further study with the TKD (450-463) epitope could elucidate how NK cells are activated by Hsp70s as the mechanism remains unclear.Peso molecular:1,562.8 g/molPantinin-2
Pantinin-2, like other pantinin peptides, has high activity against Gram-positive bacteria yet weak activity against Gram-negative bacteria. Pantinin-2 also displays activity against Candida tropicalis and has relatively mild haemolytic activity against human red blood cells.
Cor e Forma:PowderPeso molecular:1,403.8 g/molACTH (7-38) Human
Segment 7-38 of adrenocorticotropic hormone (ACTH). ACTH, also known as corticotropin, is a cleavage product from a larger precursor proopiomelanocortin (POMC). This 39 amino acid-peptide hormone is produced in the anterior pituitary gland upon stimulation by the corticotropin releasing hormone from the hypothalamus in response to stress. It stimulates the secretion of steroid hormone, specifically glucocorticoids in the adrenal cortex by acting through a cell membrane receptor (ACTH-R). In mammals, the action of ACTH is limited to those areas of the adrenal cortex in which the glucocorticoid hormones cortisol (hydrocortisone) and corticosterone are formed. ACTH has little control over the secretion of aldosterone, the other major steroid hormone from the adrenal cortex.
Peso molecular:3,659.11 g/molBiotin-PEG2-Claudin-9
Biotin-PEG2-Claudin-9 is derived from the tight junction protein Claudin-9 which is encoded by the CLDN6 gene and can be found within epithelial cell to cell contacts. Structurally, the Claudin family, of which Claudin-9 is a member, are transmembrane proteins containing two extracellular loops and are involved in maintaining cell polarity and controlling paracellular ion flux.Reduction in the number of Claudins has been associated with tumour formation. This may be due to Claudin role in maintaining cell detachment and migration.Claudin-9 has been shown to be overexpressed in hepatocellular carcinoma (HCC) and has the ability to increase the metastasis of hepatocytes. It further influences the activation of the Stat3 signalling pathway through tyrosine kinase 2. Overall CLDN9 demonstrates itself to be a HCC proto-oncogene.This peptide has a covalently bonded N-terminal Biotin tag that can be used for detection and purification and contains a polyethylene glycol spacer (PEG2).Cor e Forma:PowderPeso molecular:2,881.5 g/molAc-RLR-[AMC] Proteasome Substrate
Fluorogenic substrate peptide to assay trypsin-like activity. In its intact state this peptide is non-fluorescent, however when aminomethylcoumarin (AMC) is released upon hydrolysation, fluorescence can be detected. This peptide is therefore a useful tool for analysing trypsin-like enzyme activity.AMC is a fluorescent dye with excitation maxima at around 360 nm and emission maxima at around 450 nm. AMC can be excited with a mercury lamp and observed using a UV filter set.Peso molecular:642.4 g/molIFNB1 (118-132) Human
Recombinant human interferon-β (IFNB) is a therapeutic for certain stages of multiple sclerosis (MS). However, a significant portion of patients develop neutralising antibodies within 2 years and prevent clinical efficacy of the treatment, this was correlated to a specific rise in IgG. Sequencing of IFNB1 revealed a CD4+ T cell epitope residues (118-132) that contains critical T cell activation residues. The identification of this sequences can now allow it to be manipulated to hopefully provide new interferon treatments that reduces the capacity for induction of neutralising antibodies in MS patients. The IFNB1 (118-132) epitope can be used for immunological investigations such as T cell activation, antibody recognition via immunoassays and immunohistochemistry. This may provide further insights into certain haplotypes correlating to IFNB responses in MS treatment.
Peso molecular:1,906.23 g/molTetanus Toxin P2 (830 - 844)
Tetanus Toxin P2 (830 - 844) is a protein that is derived from the single-chain polypeptide neurotoxin produced by Clostridium tetani. The neurotoxins produced by Clostridium tetani are among the most potent molecules known to humankind. Once in the body, the toxin binds to the basal lamina at the neuromuscular junction. From here, the toxin is transported to inhibitory interneurons in the spinal cord, where it prevents the release of neurotransmitters, which causes spastic paralysis.The P2 protein has antigenic properties that are reflective of the neurotoxin released by Clostridium tetani. Therefore, P2 is a suitable epitopes for CD4+ T cells and can be used to stimulate the release of IFNg, which is a cytokine that promotes macrophage activity and coordinates lymphocyte endothelium interactions.
Cor e Forma:PowderPeso molecular:1,724 g/mol[5-FAM]-TAT (47-57) amide
[5-FAM]-TAT (47-57) is a cell penetrating cationic peptide derived from the N-terminus of the Tat protein, which is a trans-activator of the transcription protein present in the human immunodeficiency virus (HIV). Specifically TAT (47-57) is located within the arginine-rich basic domain 48-60 of the TAT peptide which as a whole has three domains which function to aid HIV through transactivation, DNA binding and nuclear transport. As a cell penetrating peptide (CPP) TAT aids in the cellular uptake of molecules and hence serves a valuable purpose in transduction methods. This property has been demonstrated through its ability of allowing toxins such as the neurotoxin Botulinum neurotoxin Type A, produced by the Clostridium botulinum type A bacteria to penetrate the skin barrier non-invasively. Additionally TAT (47-57) can be used to deliver proteins, fluorophores, chelators and DNA to target cells.It contains 5-carboxyfluorescein (5-FAM), a widely used green fluorescent tag.
Peso molecular:1,917.14 g/molInsulin A Chain (A12-21)
Type I diabetes is an autoimmune condition caused by the destruction of insulin-producing β cells. The initiation mechanism is unclear but involves activating autoreactive T cells against the β-cell-specific antigen, insulin.RIP-B7.1 mice express CD80 on pancreatic β cells and are a model for studying de novo induction of diabetogenic CD8 T cells. Immunization of RIP-B7.1 mice with preproinsulin (ppins)-encoding plasmid DNA induces experimental autoimmune diabetes (EAD). EAD is associated with significant induction of CD8 T cells specific for the (A12-21) restricted epitope leading to the destruction of β cells.The Insulin A Chain (A12-21) epitope is recognised by pancreas-infiltrating CD8 T cells isolated from immunized, diabetic RIP-B7.1 mice as shown by flow cytometry. The Insulin A Chain (A12-21) epitope can also be used to stimulate inducible IFN- expression of ppins-primed CD8 T cells ex vivo as determined by flow cytometry. GFP fusion has shown the expression of insulin A chain (A12-21) epitope in HeLa cells.Peso molecular:1,246.3 g/molLocustatachykinin I
Locustatachykinin I(LTK1 or Lom-TK-I) is a potent, rapid and persistent secretion stimulator in locust Malphigian tubules which controls primary urine production, tubule writhing and local sphincter functions.- LTK1 shares sequence homology with mammalian tachykinins such as substance P.- Two putative tachykinin receptors, Drosophila tachykinin-receptor (DTKR) and neurokinin receptor from Drosophila (NK0) have been identified.
Peso molecular:937.5 g/molGanglioside GM1-binding peptides p3
Ganglioside GM1-binding peptides p3.
Cor e Forma:PowderPeso molecular:1,777.1 g/molMBP Ac1-9 (4Y)
This peptide constitutes the acetylated N-terminal region of murine myelin basic protein (MBP) and displays high affinity for major histocompatibility complexes (MHC). This high MHC affinity is due to substitution of the native lysine at position 4 for a tyrosine. Substitution increases the MHC binding affinity of the peptide by around 1 million fold, therefore creating a superagonist ligand. MBP is an integral component of myelin found in the central nervous system (CNS) vital for the development and stability of the myelin sheath where it plays a role in membrane adhesion. MBP may be targeted by auto-antibodies in diseases such as multiple sclerosis. The low affinity of the native lysine containing MBP 1-9 peptide for MCH class II may result in MBP auto-reactive T cells escaping central-tolerance where self reactive T cells are usually eliminated. MBPs constitute an extraordinarily varied collection of splice isoforms which show a myriad of post-translational modifications.
Cor e Forma:PowderPeso molecular:1,133.22 g/mol
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