Peptídeos

Bz-DL-Arg-pNA • HCl [DL-BAPA] is a trypsin and trypsin-like protease substrate. It is used as a tool in biochemical studies to investigate the degradation of proteins by these enzymes. Bz-DL-Arg-pNA • HCl [DL-BAPA] is also used as an experimental model for diseases that affect enzyme activity, such as rheumatoid arthritis and multiple sclerosis.

MOCA-Arg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys(Dnp)-NH2 is a synthetic peptide that interacts with the nicotinic acetylcholine receptor and is a potent agonist. MOCA was found to be a potent activator of the nicotinic acetylcholine receptor, as well as an inhibitor of ligand binding. The affinity for binding to the receptor was found to be high, with an inhibition constant (Ki) of 0.06 μM. It has been shown to inhibit ion channels and ligand binding in cell biology experiments. MOCA can also be used as a research tool for studying protein interactions and receptors.

The virus replication-inhibiting peptide is a fatty acid that inhibits the replication of viruses. It has been shown to inhibit the growth of the bacteria Stenotrophomonas maltophilia and other bacteria, which causes infectious diseases. The peptide also has a diagnostic use for detecting viral infections in cells. The peptide was found to up-regulate genes in response to infection by pandemic influenza, which may be due to its ability to bind receptors on cells and also interfere with inflammatory responses. The virus replication-inhibiting peptide has been shown to be effective against influenza virus and other viruses, as well as against chronic inflammatory diseases such as lung damage caused by β-amino acids.

Boc-Gln-Pro is a peptide that can be used as a substrate for peptidoglutaminase.

[Tyr34]-Parathyroid Hormone (Bovine, 7-34 amide) is a product sourced from bovine, is available as a 0.5mg vial and is related to the peptide hormone Parathyroid Hormone (PTH). During abnormal serum calcium levels PTH is secreted from the parathyroid gland, thus regulating calcium and phosphate levels in the body. PTH binds to its PTH receptor which is a G-protein coupled receptor that activated adenylate cyclase or phospholipase C to activate pathways involved in the mediation of bone resorption and bone formation.

2,3,4,6-Tetra-O-acetyl-α-D-galactopyranosyl fluoride (TATA) is a fluorinated sugar that is used as a building block for the synthesis of peptides and other biochemicals. TATA has been shown to be an inhibitor of bacterial growth in medium containing glycosyl residues. This product has also been shown to have anti-inflammatory properties in animal models.

Bz-Gly-Gly-Gly is a prodrug that is metabolized by enzymatic hydrolysis to its active form, hippurylglycylglycine. The prodrug has been shown to have minimal toxicity in mice and humans, and it binds to the target enzyme of infectious diseases (e.g., HIV) with high affinity. Bz-Gly-Gly-Gly has been shown to be effective in vitro against human immunodeficiency virus type 1 (HIV1) and mouse tumor models, as well as in vivo against mouse leukemia cells. The drug has also been shown to be safe at physiological levels in mice.

m-dPEG®2-NHS Ester is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. m-dPEG®2-NHS Ester is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

Gla17,21,24-Osteocalcin is a peptide that belongs to the family of proteins that have bone-building properties. Osteocalcin is produced by osteoblasts and its production increases in response to activation by parathyroid hormone. It is also an activator of ion channels and has been found to be involved in regulating calcium homeostasis. Gla17,21,24-Osteocalcin has been shown to inhibit protein interactions with the receptor and ligand. This peptide also binds to receptor sites on cells and inhibits the activity of G protein-coupled receptors (GPCRs).

Bis-dPEG®17-PFP Ester is a PEG polymer categorised as homobifunctional PEG (X-PEG X). Used as a linker, bis-dPEG®17-PFP Ester is used to attached PEG to proteins, peptides, oligonucleotides, nanoparticles and small molecules via pegylation, a bioconjugation technique.

Bz-Ala-OMe is a reactive mercuric chloride that undergoes hydrolysis to form reactive mercuric acetate. It has been shown that the activation energy of the reaction is high and the reaction can be initiated by soybean trypsin. The reactive site of Bz-Ala-OMe is composed of chloride atoms and sephadex g-100. This compound reacts with serine proteases, such as trypsin or chymotrypsin, to form an amide intermediate. This intermediate reacts with n-acetyl-l-tyrosine to produce a chloromethyl ketone which then undergoes a nucleophilic attack by histidine to produce histamine in the presence of H2O2 or O2. Histamine binds to H1 receptors in the body, leading to an inflammatory response.

ANP (Rat, 3-28) is a peptide that is a potent inhibitor of protein interactions. This peptide binds to the ligand-binding domain of the receptor and blocks the binding of the ligand. ANP (Rat, 3-28) also has high purity and can be used as a research tool or an antibody in life science studies.

Hydroxy-dPEG®8-t-Butyl Ester is a PEG polymer categorised as monofunctional (OH-PEG-X). Used as a linker, hydroxy-dPEG®8-t-Butyl Ester is used to attached PEG to proteins, peptides, oligonucleotides, nanoparticles and small molecules via pegylation, a bioconjugation technique.

Z-Gly-Gly-Leu-pNA is a peptide that is derived from the amino acid sequence of a basic protein. It can be used as a fluorescent probe to detect hydration and enhance the fluorescence of other proteins. Z-Gly-Gly-Leu-pNA has been shown to bind basic protein subunits with high affinity, forming a stable complex. This peptide has also been shown to hydrolyze in acidic pH, making it useful for detecting proteolytic activity. The optimum pH for this peptide is neutral, at around 7.5. This peptide can be solubilized by adding Triton X or Brij 35 detergent and stored at -20°C.