Peptídeos

A synthetic peptide for use as a blocking control in assays to test for specificity of WFDC5 antibody, catalog no. 70R-5376

A synthetic peptide for use as a blocking control in assays to test for specificity of CSTB antibody, catalog no. 70R-2262

A synthetic peptide for use as a blocking control in assays to test for specificity of CENPB antibody, catalog no. 70R-5526

A synthetic peptide for use as a blocking control in assays to test for specificity of NCRNA00114 antibody, catalog no. 70R-3296

Analog of the native Melan-A (26-35) decapeptide derives from the melanocyte lineage-specific protein Melan-A/MART-1, which is expressed in almost 75-100% of primary and metastatic melanomas.
The region 26-35 of Melan-A protein acts as an antigenic peptide that is recognized by CD8+ tumor-reactive cytolytic T lymphocytes (CTLs) for designing antigen-specific cancer vaccines1. It has been shown that CD8+ Melan-A-specific CTLs isolated from melanoma patients efficiently lyse the Melan-A-expressing HLA-A*0201+ melanoma cell line. However, CTLs preferentially recognize the Melan-A (26-35) peptide as compared with the Melan-A (27-35) peptide. Moreover, the Melan-A (26-35) A27L analog (ELAGIGILTV) has a higher binding affinity to HLA-A*0201 than the native Melan-A (26-35) peptide (EAAGIGILTV), and consequently displays more potent antigenicity and immunogenicity.
It has been reported that the concentration of Melan-A (26-35) A27L analog required to obtain 50% of maximal antigenic activity (EC50) is 0.01nM, whereas that of the native Melan-A (26-35) peptide is 0.25nM1. Therefore, the relative activity of Melan-A (26-35) A27L analog is 25 fold higher than that of the native Melan-A (26-35) peptide.
Furthermore, functional competition assay has shown that the concentration of Melan-A (26-35) A27L analog required to achieve 50% inhibition (IC50) of tumor lysis is 2nM, which is 10 fold lower than that of the native Melan-A (26-35) peptide. Regarding peptide stability in human serum, the half-lifes (t1/2) of the native Melan-A (26-35) peptide and the A27L analog are quite similar (45 and 40min, respectively) as measured by HPLC-ESI-MS, but much higher than that of the Melan-A (27-35) nonapeptide (5min).

NY-ESO-1 (157-165) peptide – SLLMWITQC

KGF Human is a peptide that belongs to the group of activators. It is a heparin-binding growth factor that belongs to the TGF-β family. KGF Human stimulates cell proliferation, differentiation, and survival in vitro. The binding of KGF Human to its receptor inhibits the activity of ion channels and ligand-gated ion channels, which are involved in the transmission of nerve impulses. KGF Human has been shown to have anti-inflammatory effects in vivo. This peptide can activate erythropoietin production from cultured human erythroleukemia cells and stimulate osteoblast differentiation from human bone marrow stromal cells.

CD20 (188-196) is a short part of a membrane phosphoprotein, CD20, which is expressed on the surface of B cells. CD20 receptor is an important target for immunotherapy against B cell lymphoma. CD20 epitopes are used in antibodies CD20 production, such as the production of the first monoclonal antibody to be approved for the treatment of lymphoma.
Applications of CD20 (188-196):
CD20 (188-196) is involved in research to generate cytotoxic T lymphocytes and stimulate CTL responses against B cell diseases. The production of specific T cells and IFN-γ are quantified by ELISPOT. CD20 (188-196) has been identified as a highly immunogenic HLA-A2 restricted peptide. Results suggest that CD20 (188-196) may serve in immunotherapeutic strategies especially for vaccine development against certain type of blood cancer.
CD20 (188-196) is also used in research on cell therapy as target for T cell receptor. In fact, T cells are modified in vivo to express specific T cell receptor and then inject modified cells in B cells cancer patient in order to recognized malignant B cells and treat them.

A synthetic peptide for use as a blocking control in assays to test for specificity of ZNF41 antibody, catalog no. 70R-8765

A synthetic peptide for use as a blocking control in assays to test for specificity of GLIS3 antibody, catalog no. 20R-1239

A synthetic peptide for use as a blocking control in assays to test for specificity of Igf2bp3 antibody, catalog no. 70R-8484

A synthetic peptide for use as a blocking control in assays to test for specificity of FCER1G antibody, catalog no. 70R-8649

A synthetic peptide for use as a blocking control in assays to test for specificity of ENOX1 antibody, catalog no. 70R-4808

A synthetic peptide for use as a blocking control in assays to test for specificity of ZDHHC19 antibody, catalog no. 70R-7030

A synthetic peptide for use as a blocking control in assays to test for specificity of ZNF90 antibody, catalog no. 70R-9123

A synthetic peptide for use as a blocking control in assays to test for specificity of TROVE2 antibody, catalog no. 70R-1372

A synthetic peptide for use as a blocking control in assays to test for specificity of SENP6 antibody, catalog no. 70R-8941

A synthetic peptide for use as a blocking control in assays to test for specificity of ATP6AP1 antibody, catalog no. 70R-4520

A synthetic peptide for use as a blocking control in assays to test for specificity of FAM62B antibody, catalog no. 70R-6901

A synthetic peptide for use as a blocking control in assays to test for specificity of Gns antibody, catalog no. 70R-8622

A synthetic peptide for use as a blocking control in assays to test for specificity of ZNF418 antibody, catalog no. 70R-8986

A synthetic peptide for use as a blocking control in assays to test for specificity of FNDC3B antibody, catalog no. 70R-1835

A synthetic peptide for use as a blocking control in assays to test for specificity of CDC2 antibody, catalog no. 70R-5615

A synthetic peptide for use as a blocking control in assays to test for specificity of MAP2K2 antibody, catalog no. 70R-2007

A synthetic peptide for use as a blocking control in assays to test for specificity of FLJ14213 antibody, catalog no. 70R-1281

A synthetic peptide for use as a blocking control in assays to test for specificity of FAM53A antibody, catalog no. 70R-9126

A synthetic peptide for use as a blocking control in assays to test for specificity of NEDD4 antibody, catalog no. 70R-3090

A synthetic peptide for use as a blocking control in assays to test for specificity of PTBP1 antibody, catalog no. 70R-4626

A synthetic peptide for use as a blocking control in assays to test for specificity of CD36 antibody, catalog no. 70R-6104

A synthetic peptide for use as a blocking control in assays to test for specificity of ZNFN1A5 antibody, catalog no. 70R-7977

A synthetic peptide for use as a blocking control in assays to test for specificity of MGC50722 antibody, catalog no. 70R-4281

A synthetic peptide for use as a blocking control in assays to test for specificity of OMG antibody, catalog no. 70R-6385

A synthetic peptide for use as a blocking control in assays to test for specificity of Mbtd1 antibody, catalog no. 70R-8947

A synthetic peptide for use as a blocking control in assays to test for specificity of FBXW10 antibody, catalog no. 70R-3251

A synthetic peptide for use as a blocking control in assays to test for specificity of UGT2A3 antibody, catalog no. 70R-7441

A synthetic peptide for use as a blocking control in assays to test for specificity of POLR3F antibody, catalog no. 70R-2962

A synthetic peptide for use as a blocking control in assays to test for specificity of ERCC5 antibody, catalog no. 70R-3326

A synthetic peptide for use as a blocking control in assays to test for specificity of TJAP1 antibody, catalog no. 70R-2649

A synthetic peptide for use as a blocking control in assays to test for specificity of RP11-78J21.1 antibody, catalog no. 70R-4772

A synthetic peptide for use as a blocking control in assays to test for specificity of DDX1 antibody, catalog no. 70R-4821

A synthetic peptide for use as a blocking control in assays to test for specificity of TC2N antibody, catalog no. 70R-3749

A synthetic peptide for use as a blocking control in assays to test for specificity of CX40.1 antibody, catalog no. 70R-1697

A synthetic peptide for use as a blocking control in assays to test for specificity of TRIM23 antibody, catalog no. 20R-1190

A synthetic peptide for use as a blocking control in assays to test for specificity of CMTM2 antibody, catalog no. 70R-6338

A synthetic peptide for use as a blocking control in assays to test for specificity of SPINT2 antibody, catalog no. 70R-9690

A synthetic peptide for use as a blocking control in assays to test for specificity of AKAP8 antibody, catalog no. 70R-7945

A synthetic peptide for use as a blocking control in assays to test for specificity of GAMT antibody, catalog no. 70R-2584

A synthetic peptide for use as a blocking control in assays to test for specificity of PLA2G5 antibody, catalog no. 70R-5272

A synthetic peptide for use as a blocking control in assays to test for specificity of DPH1 antibody, catalog no. 70R-4122

A synthetic peptide for use as a blocking control in assays to test for specificity of COBLL1 antibody, catalog no. 70R-3931