Peptídeos

α7 nAChR selective blocker

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Light chain of the bevacizumab monoclonal antibody, sold as the antitumour therapeutic Avastin. It prevents vascular endothelial growth factor (VEGF) from binding to VEGF receptors 1 and 2 thus inhibiting angiogenesis in tumours.

Cysteine peptide (Ac RFAAKAA COOH) is used in combination with Lysinepeptide (Ac RFAACAA COOH) in the Direct Peptide Reactivity Assay (DPRA) test.
Direct Peptide Reactivity Assay is used in cosmetic applications for the characterization of the skin sensitizing potential of a substance, framed by OECD Guideline no 442.
The molecular initiating event (MIE) in skin sensitization is a binding between epidermal proteins and the sensitizing chemical substance. MIE is part of the adverse outcome pathway (AOP) of skin sensitization.
It is thanks to the properties of Lysine peptide and Cysteine peptide that the chemical binding will be able to take place, so these synthetic heptapeptides will mimic the reaction of a skin exposed to a substance.
Binding between nucleophilic proteins and electrophile substance will be measured by High Performance Liquid Chromatography (HPLC). Therefore, the decrease in Lysine peptide and Cysteine peptide levels will be a sign of sensitizing event. Depending on the rate of depletion, the sensitizing character of a molecule will be determined (see table at the bottom of the page).
In chemico DPRA test also has wider applications such as hazard classification in cosmetics, but also for pharmaceuticals and biocides. It is a good alternative to animal experimentation.

Insulin is a peptide hormone that is produced by beta cells in the pancreas. Insulin has several important functions, including regulation of blood sugar levels, lipid metabolism and protein synthesis. It is also involved in the regulation of cellular growth and proliferation. Insulin binds to insulin receptors on the surface of cells, activating them and allowing for the uptake of glucose into cells and storage as glycogen. Insulin is a ligand for the insulin receptor. It can also bind to other receptors, such as IGF1R, which causes activation of PI3K/AKT pathway. Insulin is an antibody that can be used as research tool or cell biology reagent.
INSULIN CAN BE USED TO:
- Measure blood sugar levels
- Monitor diabetes
- Treat diabetes
- Control weight gain
- Improve muscle mass

Anti IL-1alpha (Rat) Serum is a serum that provides an inhibitor for IL-1alpha. The serum is used in the study of peptides and cell biology. This serum is made from high purity, life science grade material and has been shown to be effective in inhibiting the activation of ion channels.

A synthetic peptide for use as a blocking control in assays to test for specificity of ZCCHC13 antibody, catalog no. 70R-4279

A synthetic peptide for use as a blocking control in assays to test for specificity of MTHFS antibody, catalog no. 70R-3776

A synthetic peptide for use as a blocking control in assays to test for specificity of Zfp275 antibody, catalog no. 70R-8773

A synthetic peptide for use as a blocking control in assays to test for specificity of EIF2C4 antibody, catalog no. 70R-3041

Urocortin is a peptide hormone that belongs to the corticotropin-releasing factor (CRF) family. It stimulates the release of adrenocorticotropic hormone (ACTH) and other hormones from the anterior pituitary gland. Urocortin has been shown to bind to three different types of ion channels: voltage-gated calcium channels, potassium channels, and chloride channels. The purified peptide is a colorless or white crystalline powder with a molecular weight of 542.6 Daltons. The antibody against urocortin is used in pharmacological research as an activator or inhibitor of protein interactions.

Custom research peptide; min purity 95%.

Secretin is a peptide that is used as a research tool in the study of ion channels, cell biology, and pharmacology. Secretin is a peptide hormone that is produced in the duodenum and is involved in the regulation of pancreatic bicarbonate, gastric acid and osmoregulation. Secretin binds to secretin receptors which are G-protein coupled receptors and are expressed in pancreatic centroacinar cells. Secretin binds to these receptors and activates adenylate cyclase which converts ATP into cAMP which results in the secretion of bicarbonate from the pancreas. Secretin plays a role in osmoregulation through its effects on the kidney, pitutiary gland and the hypothalamus. This product is available as a 0.5mg vial.

Custom research peptide; min purity 95%.

A synthetic peptide for use as a blocking control in assays to test for specificity of SLC1A4 antibody, catalog no. 70R-6961

A synthetic peptide for use as a blocking control in assays to test for specificity of PSMD1 antibody, catalog no. 70R-5638

A synthetic peptide for use as a blocking control in assays to test for specificity of FCRL1 antibody, catalog no. 70R-1853

A synthetic peptide for use as a blocking control in assays to test for specificity of ASL antibody, catalog no. 70R-1176

A synthetic peptide for use as a blocking control in assays to test for specificity of AGXT2L1 antibody, catalog no. 70R-2601

1-Deoxyfructosyl-Val-His (1DFVH) is a research tool that belongs to the group of activators. It has been shown to activate receptors and ion channels, as well as inhibit antibody production. 1DFVH also has an effect on cell biology, which may be due to its ability to interact with proteins in a variety of ways. 1DFVH binds to the receptor by competitive inhibition and activates the receptor by mimicking the natural ligand. This compound has been shown to activate ion channels in cells through the opening of potassium channels, leading to depolarization and increased calcium influx into cells.