Moduladores enzimáticos
Moduladores de enzimas são compostos que podem aumentar ou inibir a atividade de enzimas, regulando assim a taxa de reações bioquímicas. Esses moduladores desempenham um papel crucial no controle de vias metabólicas, sinalização celular e vários processos fisiológicos. Os moduladores de enzimas são amplamente utilizados em pesquisa e desenvolvimento de medicamentos para estudar as funções enzimáticas e desenvolver agentes terapêuticos. Na CymitQuimica, oferecemos uma ampla gama de moduladores de enzimas de alta qualidade para apoiar sua pesquisa em regulação enzimática e descoberta de medicamentos.
Subcategorias de "Moduladores enzimáticos"
Foram encontrados 693 produtos de "Moduladores enzimáticos"
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9-(4-Chlorobenzyl)-6- methoxy-1-methyl-4,9-dihydro-3H-pyrido[3,4-b]indol
CAS:novel tricyclic indole; promising new treatment for a variety of diseases
Fórmula:C20H19ClN2OPureza:Min. 99 Area-%Cor e Forma:Slightly Brown PowderPeso molecular:338.83 g/molEtoricoxib - Bio-X ™
CAS:Produto ControladoEtoricoxib is a cyclooxygenase-2 (COX-2) inhibitor, which is a type of nonsteroidal anti-inflammatory drug (NSAID). It works by blocking the enzyme COX-2 that is involved in the production of certain hormones called prostaglandins. These hormones are involved in the inflammation (swelling and heat) associated with conditions such as arthritis. By blocking the action of the COX-2 enzyme, Etoricoxib reduces the production of prostaglandins and thus, reduces the inflammation and pain. Etoricoxib is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Fórmula:C18H15ClN2O2SPureza:Min. 95%Cor e Forma:PowderPeso molecular:358.84 g/molTofacitinib
CAS:JAK3 enzyme inhibitorFórmula:C16H20N6OPureza:Min. 98 Area-%Cor e Forma:PowderPeso molecular:312.37 g/molFloctafenine
CAS:Nonsteroidal anti-inflammatory (NSAID)Fórmula:C20H17F3N2O4Pureza:Min. 95%Cor e Forma:Off-White PowderPeso molecular:406.36 g/molLomeguatrib
CAS:Inhibitor and pseudosubstrate of DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT). It is used as a sensitizer for the treatment of advanced solid tumors, including prostate, colorectal and central nervous system malignancies. Lomeguatrib inhibits the repair mechanism of DNA damage induced by alkylating agents such as temozolomide, and therefore potentiates its anti-cancer effects.Fórmula:C10H8BrN5OSPureza:Min. 95%Cor e Forma:SolidPeso molecular:326.17 g/molMLN120B
CAS:Inhibitor of IKKβ serine kinaseFórmula:C19H15ClN4O2Pureza:Min. 95%Cor e Forma:PowderPeso molecular:366.8 g/molEpalrestat - Bio-X ™
CAS:Epalrestat is a carboxylic acid derivative that is used for the treatment of diabetic neuropathy. This drug is an aldose reductase inhibitor and aims to reduce the accumulation of intracellular sorbitol. Studies in rats have shown this drug to improve morphological abnormalities of nerves.Fórmula:C15H13NO3S2Pureza:Min. 95%Cor e Forma:PowderPeso molecular:319.4 g/molUbenimex - Bio-X ™
CAS:Ubenimex is a protease inhibitor drug that is being studied for the treatment of acute myelocytic leukemia. This drug is an aminopeptidase N, B and leukotriene A4 hydrolase inhibitor. It is also used in the treatment of hypercholesterolaemia.Fórmula:C16H24N2O4Pureza:Min. 95%Cor e Forma:PowderPeso molecular:308.37 g/molSU 5416
CAS:Inhibitor of Flk-1/KDR receptor tyrosine kinases, a vascular endothelial growth factor receptor (VEGF) receptor expressed on precursor and mature forms of endothelial cells. SU 5416 also inhibits other tyrosine kinases, including c-KIT and FLT-3. Has therapeutic potential as an anti-angiogenic agent for the treatment of cancer.Fórmula:C15H14N2OPureza:Min. 95%Cor e Forma:PowderPeso molecular:238.28 g/molDecitabine - Bio-X ™
CAS:Decitabine is a synthetic cytosine analogue that incorporates into DNA and prevents DNA methylation via DNA (cytosine-5)-methyltransferase 1 (DNMT1) inhibition. It has demonstrated potent anti-leukaemic effects attributed to cell cycle arrest and induction of apoptosis. Also, it has anti-growth effects on solid tumor cell lines. Decitabine is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Fórmula:C8H12N4O4Pureza:Min. 95%Cor e Forma:PowderPeso molecular:228.21 g/molMevastatin - Bio-X ™
CAS:Mevastatin is a drug that inhibits the synthesis of cholesterol and has been used to treat hypercholesterolemia. It binds to the hydroxyl group at position 3 on the mevalonate molecule, which prevents the formation of 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) and consequently reduces the production of cholesterol. Mevastatin has been shown to inhibit mitochondrial functions in wild-type strain yeast cells and myeloma cell lines, which may be due to receptor activity.
Fórmula:C23H34O5Pureza:Min. 98 Area-%Cor e Forma:PowderPeso molecular:390.51 g/mol1,4-Dideoxy-1,4-imino-D-arabinitol hydrochloride
CAS:Inhibitor of glycogen phosphorylase and alpha-glucosidasesFórmula:C5H11NO3·HClPureza:Min. 96 Area-%Cor e Forma:PowderPeso molecular:169.61 g/molSquarunkin A
CAS:Selective inhibitor of the interaction between the UNC119 chaperone and its cargo. Squarunkin A inhibits activation of Src kinase by interrupting the interaction between the myristoylated peptide at the N-terminus of the Src kinase and UNC119A chaperone (IC50 = 10 nM). Squarunkin A impairs the UNC119-mediated enrichment of plasma membrane with non-receptor protein tyrosine kinase Src, resulting in the decrease in Src autophosphorylation and decreased oncogenic Src signalling.Fórmula:C25H32F3N5O4Pureza:Min. 95%Cor e Forma:SolidPeso molecular:523.55 g/molOrlistat - Bio-X ™
CAS:Orlistat is a drug that has been approved for the treatment of obesity. It inhibits gastric and pancreatic lipases, which are enzymes that break down dietary fats into smaller molecules to facilitate absorption. Orlistat has been shown to reduce coronary heart disease in patients with type 2 diabetes. Orlistat has also been shown to have a significant upregulation of gene expression associated with disease activity when injected into the skin of patients with primary pulmonary hypertension. Orlistat is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Fórmula:C29H53NO5Cor e Forma:PowderPeso molecular:495.73 g/molKLSDW (EYGF-33)
During extraction of lecithin from egg yolk, peptide by-products can be isolated and purified by gel filtration. Within the by-products this has led to the discovery of biologically active value-added products. The egg yolk gel filtration (EFGF) fractions were analysed for their antioxidant and angiotensin converting enzyme (ACE) inhibitory activities. EYGF-33 predominantly contained 3 peptides - KLSDW, YPSPV, and MPVHTDAD). KLSDW in EYGF-33 was found to have strong antioxidant activity linked to the presence of the tryptophan residue. KLSDW had nearly comparable activity to the synthetic antioxidant BHA. KLSDW did not show any notable angiotensin converting enzyme (ACE) inhibitory activity.Pureza:Min. 95%Peso molecular:646.3 g/molKU 55933
CAS:Inhibitor of ataxia telangiectasia mutated (ATM) kinase and AKT kinase with anti-cancer activity. ATM is a nuclear protein kinase and a signal transducer sensing DNA damage as well as controlling double strand DNA break (DSB) repair. It is a radiotherapy and chemotherapy sensitizer, especially in tumors sensitive to DNA alkylating agents (such as temozolomide). Moreover, KU 55933 inhibits phosphorylation of cytoplasmic AKT kinase, downregulates synthesis of cyclin D1 and induces cell cycle arrest in G1 phase.Fórmula:C21H17NO3S2Pureza:Min. 95%Cor e Forma:White To Off-White SolidPeso molecular:395.06499[G]-JAK1 peptide (1015-1027)
This peptide is phosphorylated by Janus kinase 1 (JAK1) and is an ideal substrate for use in kinase assays. The JAK family of kinases is essential for the signalling of a host of immune modulators in tumour, stromal, and immune cells where they are highly expressed. JAK family proteins mediate the signalling of the interferon (IFN), IL-6, and IL-2 families of cytokines.JAK kinases are associated with cytokine receptors. Cytokine binding to these receptors results in activation of JAK kinases and receptor phosphorylation. Phosphorylated cytokine receptors recruit STAT proteins, which are then phosphorylated by the activated JAK kinases. Phosphorylated STAT proteins form homo- and hetero-dimers that translocate into the nucleus and function as transcription factors.This JAK1 substrate peptide contains an N-terminal glycine-residue.Pureza:Min. 95%Cor e Forma:PowderPeso molecular:1,630.8 g/molMBMT (136-147) human
MGMT, known as O6-methylguanine-DNA methyltransferase, is a DNA repair enzyme that plays an important role in chemoresistance to alkylating agents. MGMT repairs the toxic DNA O6-Methylguanine lesion caused by Temozolomide (TMZ), an oral alkylating agent used for the treatment of glioblastoma. MGMT repairs damaged guanine nucleotides by transferring the methyl at O6 site of guanine to its cysteine residues, thus avoiding gene mutation, cell death and tumorigenesis. The expression of MGMT gene is mainly regulated by epigenetic modification. Loss of MGMT expression is due to methylation of the CpG island of MGMT promoter.Pureza:Min. 95%Peso molecular:1,314.7 g/molAMARA peptide
CAS:AMARA peptide is a fragment containing the phosphorylation site for AMP activated protein kinase (AMPK) and is a substrate for all AMPK subfamily kinases. As such it is used to measure AMPK related kinase activity.Pureza:Min. 95%Cor e Forma:PowderPeso molecular:1,541.9 g/molBAY 73-6691
CAS:Potent inhibitor of phosphodiesterase type 9 (PDE9), tested in human and murine in vitro assays (IC50 values: 55 nM and 100 nM, respectively). BAY 73-6691 induces long-term potentiation and improves memory in rodents. BAY 73-6691 has been studied as a potential therapy for Alzheimer’s disease.
Fórmula:C15H12ClF3N4OPureza:Min. 95%Cor e Forma:PowderPeso molecular:356.73 g/mol
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