Endotoxin Inhibitor

CAS: 147396-10-9

Ref. 01-4014453

Informação sobre produto

• Nome: Endotoxin Inhibitor
• Sinónimos: K-T-K-C-K-F-L-K-K-C
• Marca: Bachem
• Descrição: The cyclic peptide KTKCKFLKKC has ben shown to form a strong complex with lipid A, the toxic component of the endotoxin lipopolysaccharide (LPS) with Ka = 0.56 · 10⁷ M⁻¹. It detoxifies LPS in vitro and prevents LPS-induced cytokine release and lethality in vivo. Furthermore, it shows neither antibiotic activity nor toxicity and might therefore be useful in the prophylaxis and treatment of LPS-mediated diseases. KTKCKFLKKC bears a structural resemblance to the peptide antibiotic and endotoxin inhibitor polymyxin B. It could be of use as an adjuvant for antibiotic therapy.

Propriedades químicas

• Peso molecular: 1224.6
• Fórmula: C₅₅H₉₇N₁₅O₁₂S₂
• Pureza: 98.8%
• Cor/forma: White Powder