Akt antibody

Ref. 3D-70R-34608

Informação sobre produto

• Nome: Akt antibody
• Marca: Biosynth
• Descrição: Akt, or Protein Kinase B (PKB), is a crucial signaling protein that regulates essential cellular functions, including growth, survival, metabolism, and proliferation. It functions within the PI3K/Akt pathway, a key signaling pathway activated by growth factors and hormones like insulin to support cell survival and growth. Upon activation, Akt moves to the cell membrane, where it is phosphorylated by kinases such as PDK1, achieving full activation. Once active, Akt interacts with downstream pathways to prevent apoptosis, stimulate cell growth via the mTOR pathway, and boost glucose metabolism—vital for effective insulin response.In diseases like cancer and diabetes, Akt's role is especially important. Cancer often involves dysregulated Akt signaling due to mutations in pathway components like PI3K, PTEN, or Akt itself, leading to enhanced cell survival, unchecked growth, and treatment resistance. In diabetes, insulin resistance impairs Akt pathway function, reducing glucose uptake and resulting in high blood glucose levels. Given Akt's regulatory role in cell growth and metabolism, it is a primary focus in therapeutic research for conditions where its function is disrupted.