4-Methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile
CAS: 675126-26-8
Ref. 3D-ACB12626
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Informação sobre produto
- 2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile
- 2-Nitro-4-Methoxy-5-(3-Morpholinopropoxy)benzonitrile
- 2-Nitro-4-methoxy-5-[3-(morpholin-4-yl)]propoxybenzonitrile
- 4-Methoxy-5-[3-(4-morpholinyl)propoxy]-2-nitrobenzonitrile
- Gefitinib Intermediate 1
4-Methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile is a synthetic intermediate for the synthesis of gefitinib, an anticancer medicine that is used to treat non-small cell lung cancer. The compound reacts with chloro-, 3-chloro-4-fluoroaniline and benzamide in the presence of phosphoric acid to produce the desired product. The reaction proceeds through a transfer hydrogenation mechanism, which is catalyzed by palladium chloride. This process produces 4-methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile at high yield and with excellent purity. It has been shown that the reaction intermediates can be salified with hydrochloric acid or hydrobromic acid to form a stable salt.
Propriedades químicas
Consulta técnica sobre: 3D-ACB12626 4-Methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile
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