Morachalcone A
CAS: 76472-88-3
Ref. 3D-BDA47288
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Informação sobre produto
- 2-Propen-1-one, 1-[2,4-dihydroxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(2,4-dihydroxyphenyl)-, (2E)-
- 2-Propen-1-one, 1-[2,4-dihydroxy-3-(3-methyl-2-butenyl)phenyl]-3-(2,4-dihydroxyphenyl)-, (E)-
- (2E)-1-[2,4-Dihydroxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(2,4-dihydroxyphenyl)-2-propen-1-one
- 2-Propen-1-one, 1-[2,4-dihydroxy-3-(3-methyl-2-butenyl)phenyl]-3-(2,4-dihydroxyphenyl)-, (2E)-
Morachalcone A is a mulberrofuran found in Morus alba L. It has potent inhibitory activity against tyrosinase. The inhibitory effect of morachalcone A on tyrosinase is homologous and competitive, with an IC50 of 0.2 μM. The inhibition mechanism of morachalcone A may involve the hydroxyl group on C-3′ and the methyl group on C-2′ as well as a protonated amino group at N-1′. Morachalcone A also has neuroprotective effects, with an EC50 of 0.8 μM against glutamate-induced neurotoxicity in cultured rat cortical neurons. This compound inhibits brain cell death by inhibiting pro-inflammatory cytokine production through its inhibition of enzymes activities including phospholipase C, protein kinase C, and the MAPK pathway.
Propriedades químicas
Consulta técnica sobre: 3D-BDA47288 Morachalcone A
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