Click Tat (47-59)

Ref. 3D-CRB1000107

Informação sobre produto

• Nome: Click Tat (47-59)
• Sinónimos: 4pentynyl-GRKKRRQRRRPPQ-NH2
• Marca: Biosynth
• Descrição: Tat (47-59) is a cell penetrating cationic peptide derived from the N-terminus of the Tat protein, which is a trans-activator of the transcription protein present in the human immunodeficiency virus (HIV). Specifically, TAT (47-57) is located within the arginine-rich basic domain of the TAT peptide. TAT has three domains which function to aid HIV through transactivation, DNA binding and nuclear transport. As a cell penetrating peptide (CPP) TAT aids in the cellular uptake of molecules and hence serves a valuable purpose in transduction methods. This property has been demonstrated through its ability of allowing toxins such as the neurotoxin Botulinum neurotoxin Type A, produced by the Clostridium botulinum type A bacteria to penetrate the skin barrier non-invasively.Tat (47-59) is provided here with a N-terminal alkyne attachment. Two of the most regularly encountered functional groups for click chemistry are azides and alkynes, and the azide-alkyne cycloaddition has become the most popular click reaction. The use of click chemistry with alkyne-Tat (47-59) allows a wide variety of applications particularly for conjugation, modification, and peptide design.

Propriedades químicas

• Peso molecular: 1,797.1 g/mol
• Cor/forma: Powder