MBP Ac1-9 (4Y)
Ref. 3D-CRB1000255
1mg | 271,00 € | ||
25mg | 1.169,00 € | ||
500µg | 198,00 € |
Informação sobre produto
- Ac-ASQYRPSQR-NH2Acetylated MBP Ac1-9 (4Tyr) MBP Ac1-9 (4Y) Myelin Basic Protein 1-9 (4Y) MBP1-9(4Y)Ac-ASQYRPSQR-amideAc-Ala-Se r-Gln-Tyr-Arg-Pro-Ser-Gln-Arg-NH2Acetylated MBP Ac1-9 (4Tyr)
- Myelin Basic Protein
This peptide constitutes the acetylated N-terminal region of murine myelin basic protein (MBP) and displays high affinity for major histocompatibility complexes (MHC). This high MHC affinity is due to substitution of the native lysine at position 4 for a tyrosine. Substitution increases the MHC binding affinity of the peptide by around 1 million fold, therefore creating a superagonist ligand. MBP is an integral component of myelin found in the central nervous system (CNS) vital for the development and stability of the myelin sheath where it plays a role in membrane adhesion. MBP may be targeted by auto-antibodies in diseases such as multiple sclerosis. The low affinity of the native lysine containing MBP 1-9 peptide for MCH class II may result in MBP auto-reactive T cells escaping central-tolerance where self reactive T cells are usually eliminated. MBPs constitute an extraordinarily varied collection of splice isoforms which show a myriad of post-translational modifications.
Propriedades químicas
Consulta técnica sobre: 3D-CRB1000255 MBP Ac1-9 (4Y)
Se desejar solicitar um orçamento ou fazer uma encomenda, por favor, adicione os produtos ao seu carrinho e depois solicite um orçamento ou encomenda a partir do carrinho. É mais rápido, mais barato e poderá beneficiar-se dos descontos e outras vantagens disponíveis.