PD-1 (27-41)
Ref. 3D-CRB1000340
| 1mg | 271,00 € | ||
| 500µg | 198,00 € |
Informação sobre produto
- H-SPDRPWNPPTFSPAL-NH2CD_antigenCD279SPDRP-W-NPPTFSPAL-amideH-Ser-Pro-Asp-Arg-Pro-Trp-Asn-Pro-Pro-Thr-Phe-Ser-Pro-Ala-Leu-NH2CD_ antigen: CD279CD_antigen: CD279
PD-1 (27-41) peptide is derived from the programmed cell death-1 (PD-1) which interacts with its ligand, PD-L1 to regulate immune homeostasis. PD-1 and its ligand PD-L1 are critical in regulating T cell activation, tolerance and immuno-pathology. PD-1 is an immune checkpoint and guards against autoimmunity through two mechanisms. First, it promotes apoptosis of antigen-specific T-cells in lymph nodes. Second, it reduces apoptosis in regulatory T cells.Several types of cancer cells overexpress PD-L1 in order to escape from the PD-1/PD-L1 immuno-surveillance mechanism. Consequently PD-1 inhibitors and PD-L1 inhibitors could be used as a therapeutic in the treatment of cancers.
Propriedades químicas
Consulta técnica sobre: 3D-CRB1000340 PD-1 (27-41)
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